PDB: 2596 resultsInfo pagesStatus searchChemie searchBIRD

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7QZ7	Transcriptional regulator LmrR with bound daunomycin and with Trp-67 and Trp-96 replaced by 5,6,7-trifluoroTrp Descriptor: DAUNOMYCIN, Transcriptional regulator, PadR-like family Authors: Thunnissen, A.M.W.H. Deposit date: 2022-01-30 Release date: 2022-11-23 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.3 Å) Cite: The Role of Tryptophan in pi Interactions in Proteins: An Experimental Approach. J.Am.Chem.Soc., 144, 2022
7QZ9	Transcriptional regulator LmrR with Trp-67 and Trp-96 replaced by the unnatural amino acid 5,6-difluoroTrp Descriptor: Transcriptional regulator, PadR-like family Authors: Thunnissen, A.M.W.H. Deposit date: 2022-01-30 Release date: 2022-11-23 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.31 Å) Cite: The Role of Tryptophan in pi Interactions in Proteins: An Experimental Approach. J.Am.Chem.Soc., 144, 2022
7QZ5	Transcriptional regulator LmrR with Trp-67 and Trp-96 replaced by the unnatural amino acid 5-fluoroTrp Descriptor: Transcriptional regulator, PadR-like family Authors: Thunnissen, A.M.W.H. Deposit date: 2022-01-30 Release date: 2022-11-23 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.8 Å) Cite: The Role of Tryptophan in pi Interactions in Proteins: An Experimental Approach. J.Am.Chem.Soc., 144, 2022
2BNZ	Structural basis for cooperative binding of Ribbon-Helix-Helix Omega repressor to inverted DNA heptad repeats Descriptor: 5'-D(*CP*TP*AP*AP*TP*CP*AP*CP*TP*TP *GP*TP*GP*AP*TP*TP*CP*G)-3', 5'-D(*GP*AP*AP*TP*CP*AP*CP*AP*AP*GP *TP*GP*AP*TP*TP*AP*GP*C)-3', ORF OMEGA Authors: Weihofen, W.A, Cicek, A, Pratto, F, Alonso, J.C, Saenger, W. Deposit date: 2005-04-06 Release date: 2006-03-15 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Structures of Omega Repressors Bound to Direct and Inverted DNA Repeats Explain Modulation of Transcription. Nucleic Acids Res., 34, 2006
2BNW	Structural basis for cooperative binding of Ribbon-Helix-Helix Omega repressor to direct DNA heptad repeats Descriptor: 5'-D(*CP*TP*TP*GP*TP*GP*AP*TP*TP*TP *GP*TP*GP*AP*TP*TP*CP*G)-3', 5'-D(*GP*AP*AP*TP*CP*AP*CP*AP*AP*AP *TP*CP*AP*CP*AP*AP*GP*C)-3', ORF OMEGA Authors: Weihofen, W.A, Cicek, A, Pratto, F, Alonso, J.C, Saenger, W. Deposit date: 2005-04-05 Release date: 2006-03-15 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.45 Å) Cite: Structures of Omega Repressors Bound to Direct and Inverted DNA Repeats Explain Modulation of Transcription. Nucleic Acids Res., 34, 2006
3P9T	SmeT-Triclosan complex Descriptor: Repressor, SULFATE ION, TRICLOSAN Authors: Hernandez, A, Ruiz, F.M, Romero, A, Martinez, J.L. Deposit date: 2010-10-18 Release date: 2011-08-10 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.02 Å) Cite: The Binding of Triclosan to SmeT, the Repressor of the Multidrug Efflux Pump SmeDEF, Induces Antibiotic Resistance in Stenotrophomonas maltophilia. Plos Pathog., 7, 2011
7F5W	Conserved and divergent strigolactone signaling in Saccharum spontaneum Descriptor: High tillering and dwarf 2 protein Authors: Zhao, Q.Q, Ming, Z.H. Deposit date: 2021-06-23 Release date: 2022-05-04 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.654 Å) Cite: Identification of Conserved and Divergent Strigolactone Receptors in Sugarcane Reveals a Key Residue Crucial for Plant Branching Control. Front Plant Sci, 12, 2021
1YPV	Structure of human thymidylate synthase at low salt conditions Descriptor: PHOSPHATE ION, Thymidylate synthase Authors: Lovelace, L.L, Minor, W, Lebioda, L. Deposit date: 2005-01-31 Release date: 2005-04-26 Last modified: 2022-04-13 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Structure of human thymidylate synthase under low-salt conditions. Acta Crystallogr.,Sect.D, 61, 2005
3EHI	Crystal Structure of Human Thymidyalte Synthase M190K with Loop 181-197 stabilized in the inactive conformation Descriptor: 1,2-ETHANEDIOL, SULFATE ION, Thymidylate synthase Authors: Lovelace, L.L, Gibson, L.M, Johnson, S.R, Berger, S.H, Lebioda, L. Deposit date: 2008-09-12 Release date: 2009-08-18 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2 Å) Cite: Variants of human thymidylate synthase with loop 181-197 stabilized in the inactive conformation. Protein Sci., 18, 2009
2ONB	Human Thymidylate Synthase at low salt conditions with PDPA bound Descriptor: 1,2-ETHANEDIOL, PROPANE-1,3-DIYLBIS(PHOSPHONIC ACID), SULFATE ION, ... Authors: Lovelace, L.L, Gibson, L.M, Lebioda, L. Deposit date: 2007-01-23 Release date: 2007-04-10 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Cooperative Inhibition of Human Thymidylate Synthase by Mixtures of Active Site Binding and Allosteric Inhibitors Biochemistry, 46, 2007
3WIO	Crystal structure of OSD14 in complex with hydroxy D-ring Descriptor: (5R)-5-hydroxy-3-methylfuran-2(5H)-one, Probable strigolactone esterase D14 Authors: Xue, Y.-L, Miyakawa, T, Hou, F, Qin, H.-M, Tanokura, M. Deposit date: 2013-09-22 Release date: 2013-10-23 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Molecular mechanism of strigolactone perception by DWARF14 Nat Commun, 4, 2013
6CBQ	Crystal structure of QscR bound to agonist S3 Descriptor: (2S)-2-hexyl-N-[(3S)-2-oxooxolan-3-yl]decanamide, LuxR family transcriptional regulator Authors: Churchill, M.E.A, Wysoczynski-Horita, C.L. Deposit date: 2018-02-05 Release date: 2018-02-28 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Mechanism of agonism and antagonism of the Pseudomonas aeruginosa quorum sensing regulator QscR with non-native ligands. Mol. Microbiol., 108, 2018
8A39	Crystal Structure of PaaX from Escherichia coli W Descriptor: DNA-binding transcriptional repressor of phenylacetic acid degradation, aryl-CoA responsive, GLYCEROL, ... Authors: Molina, R, Alba-Perez, A, Hermoso, J.A. Deposit date: 2022-06-07 Release date: 2023-07-05 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structural characterization of PaaX, the main repressor of the phenylacetate degradation pathway in Escherichia coli W: A novel fold of transcription regulator proteins. Int.J.Biol.Macromol., 254, 2024
5D4S	Crystal Structure of AraR(DBD) in complex with operator ORX1 Descriptor: Arabinose metabolism transcriptional repressor, DNA (5'-D(*AP*AP*AP*TP*AP*CP*AP*TP*AP*CP*GP*TP*AP*CP*AP*AP*AP*TP*AP*TP*T)-3'), DNA (5'-D(*TP*AP*AP*TP*AP*TP*TP*TP*GP*TP*AP*CP*GP*TP*AP*TP*GP*TP*AP*TP*T)-3') Authors: Jain, D, Narayanan, N, Nair, D.T. Deposit date: 2015-08-08 Release date: 2015-11-04 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.972 Å) Cite: Plasticity in Repressor-DNA Interactions Neutralizes Loss of Symmetry in Bipartite Operators. J.Biol.Chem., 291, 2016
5D4R	Crystal Structure of AraR(DBD) in complex with operator ORE1 Descriptor: Arabinose metabolism transcriptional repressor, DNA (5'-D(*AP*TP*AP*TP*TP*TP*GP*TP*AP*CP*GP*TP*AP*CP*TP*AP*AP*TP*TP*AP*T)-3'), DNA (5'-D(*TP*AP*TP*AP*AP*TP*TP*AP*GP*TP*AP*CP*GP*TP*AP*CP*AP*AP*AP*TP*A)-3') Authors: Jain, D, Narayanan, N, Nair, D.T. Deposit date: 2015-08-08 Release date: 2015-11-04 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.07 Å) Cite: Plasticity in Repressor-DNA Interactions Neutralizes Loss of Symmetry in Bipartite Operators. J.Biol.Chem., 291, 2016
8QA9	Crystal structure of the RK2 plasmid encoded co-complex of the C-terminally truncated transcriptional repressor protein KorB complexed with the partner repressor protein KorA bound to OA-DNA Descriptor: DNA (5'-D(*TP*GP*TP*TP*TP*AP*GP*CP*TP*AP*AP*AP*CP*A)-3'), SULFATE ION, Transcriptional repressor protein KorB, ... Authors: McLean, T.C, Mundy, J.E.A, Lawson, D.M, Le, T.B.K. Deposit date: 2023-08-22 Release date: 2024-02-21 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Crystal structure of the RK2 plasmid encoded co-complex of the C-terminally truncated transcriptional repressor protein KorB complexed with the partner repressor protein KorA bound to OA-DNA To Be Published
6J05	Structures of two ArsR As(III)-responsive repressors: implications for the mechanism of derepression Descriptor: ARSENIC, SODIUM ION, Transcriptional regulator ArsR Authors: Prabaharan, C, Kandavelu, P, Packianathan, C, Rosen, P.B, Thiyagarajan, S. Deposit date: 2018-12-21 Release date: 2019-07-03 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.86 Å) Cite: Structures of two ArsR As(III)-responsive transcriptional repressors: Implications for the mechanism of derepression. J.Struct.Biol., 207, 2019
7DOB	Crystal structure of Catabolite repressor activator (Apo) Descriptor: 1,2-ETHANEDIOL, Catabolite repressor/activator, MAGNESIUM ION, ... Authors: Neetu, N, Katiki, M, Kumar, P. Deposit date: 2020-12-13 Release date: 2021-12-22 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Crystal structure of Catabolite repressor activator (Apo) To Be Published
7DOA	Crystal structure of Catabolite repressor acivator from E. coli in complex with HEPES Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Catabolite repressor/activator, GLYCEROL Authors: Neetu, N, Katiki, M, Kumar, P. Deposit date: 2020-12-13 Release date: 2021-12-22 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Crystal structure of Catabolite repressor acivator from E. coli in complex with HEPES To Be Published
4U52	Crystal structure of Nagilactone C bound to the yeast 80S ribosome Descriptor: 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ... Authors: Garreau de Loubresse, N, Prokhorova, I, Yusupova, G, Yusupov, M. Deposit date: 2014-07-24 Release date: 2014-10-22 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (3 Å) Cite: Structural basis for the inhibition of the eukaryotic ribosome. Nature, 513, 2014
6WMQ	Crystal Structure of Human REV-ERBbeta Ligand Binding Domain Co-Bound to Heme and NCoR ID1 Peptide Descriptor: Nuclear receptor Rev-ErbA beta variant 1, Nuclear receptor corepressor 1, PROTOPORPHYRIN IX CONTAINING FE Authors: Mosure, S.A, Shang, J, Kojetin, D.J. Deposit date: 2020-04-21 Release date: 2021-02-17 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.55 Å) Cite: Structural basis for heme-dependent NCoR binding to the transcriptional repressor REV-ERB beta. Sci Adv, 7, 2021
8QA8	Crystal structure of the C-terminally truncated transcriptional repressor protein KorB from the RK2 plasmid complexed with CTP-gamma-S Descriptor: CHLORIDE ION, CYTIDINE-5'-TRIPHOSPHATE, Transcriptional repressor protein KorB Authors: McLean, T.C, Mundy, J.E.A, Lawson, D.M, Le, T.B.K. Deposit date: 2023-08-22 Release date: 2024-02-21 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Crystal structure of the C-terminally truncated transcriptional repressor protein KorB from the RK2 plasmid complexed with CTP-gamma-S To Be Published
6FPL	TETR(D) E147A MUTANT IN COMPLEX WITH TETRACYCLINE AND MAGNESIUM Descriptor: CHLORIDE ION, MAGNESIUM ION, TETRACYCLINE, ... Authors: Hinrichs, W, Palm, G.J, Berndt, L, Girbardt, B. Deposit date: 2018-02-11 Release date: 2019-03-13 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.602 Å) Cite: Thermodynamics, cooperativity and stability of the tetracycline repressor (TetR) upon tetracycline binding. Biochim Biophys Acta Proteins Proteom, 1868, 2020
6FPM	TetR(D) T103A mutant in complex with tetracycline and magnesium Descriptor: CHLORIDE ION, MAGNESIUM ION, TETRACYCLINE, ... Authors: Hinrichs, W, Palm, G.J, Berndt, L, Girbardt, B. Deposit date: 2018-02-11 Release date: 2019-03-13 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Thermodynamics, cooperativity and stability of the tetracycline repressor (TetR) upon tetracycline binding. Biochim Biophys Acta Proteins Proteom, 1868, 2020
6FTS	TETR(D) N82A MUTANT IN COMPLEX WITH PEG4 Descriptor: CHLORIDE ION, TETRAETHYLENE GLYCOL, Tetracycline repressor protein class D Authors: Hinrichs, W, Palm, G.J, Berndt, L, Girbardt, B. Deposit date: 2018-02-23 Release date: 2019-02-20 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2 Å) Cite: Thermodynamics, cooperativity and stability of the tetracycline repressor (TetR) upon tetracycline binding. Biochim Biophys Acta Proteins Proteom, 1868, 2020

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