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3LVL
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BU of 3lvl by Molmil
Crystal Structure of E.coli IscS-IscU complex
Descriptor: Cysteine desulfurase, NifU-like protein, PYRIDOXAL-5'-PHOSPHATE
Authors:Shi, R, Proteau, A, Matte, A, Cygler, M, Montreal-Kingston Bacterial Structural Genomics Initiative (BSGI)
Deposit date:2010-02-22
Release date:2010-04-21
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural basis for Fe-S cluster assembly and tRNA thiolation mediated by IscS protein-protein interactions.
Plos Biol., 8, 2010
6WIH
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BU of 6wih by Molmil
N-terminal mutation of ISCU2 (L35H36) traps Nfs1 Cys loop in the active site of ISCU2 without metal present. Structure of human mitochondrial complex Nfs1-ISCU2(L35H36)-ISD11 with E.coli ACP1 at 1.9 A resolution (NIAU)2.
Descriptor: 1,2-ETHANEDIOL, 2,5,8,11,14,17-HEXAOXANONADECAN-19-OL, Acyl carrier protein, ...
Authors:Boniecki, M.T, Cygler, M.
Deposit date:2020-04-09
Release date:2020-05-13
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The essential function of ISCU2 and its conserved N-terminus in Fe/S cluster biogenesis
To Be Published
3LVJ
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BU of 3lvj by Molmil
Crystal Structure of E.coli IscS-TusA complex (form 1)
Descriptor: Cysteine desulfurase, PYRIDOXAL-5'-PHOSPHATE, Sulfurtransferase tusA
Authors:Shi, R, Proteau, A, Matte, A, Cygler, M, Montreal-Kingston Bacterial Structural Genomics Initiative (BSGI)
Deposit date:2010-02-22
Release date:2010-04-21
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.435 Å)
Cite:Structural basis for Fe-S cluster assembly and tRNA thiolation mediated by IscS protein-protein interactions.
Plos Biol., 8, 2010
3LVK
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BU of 3lvk by Molmil
Crystal Structure of E.coli IscS-TusA complex (form 2)
Descriptor: Cysteine desulfurase, PYRIDOXAL-5'-PHOSPHATE, Sulfurtransferase tusA
Authors:Shi, R, Proteau, A, Matte, A, Cygler, M, Montreal-Kingston Bacterial Structural Genomics Initiative (BSGI)
Deposit date:2010-02-22
Release date:2010-04-21
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.442 Å)
Cite:Structural basis for Fe-S cluster assembly and tRNA thiolation mediated by IscS protein-protein interactions.
Plos Biol., 8, 2010
6WI2
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BU of 6wi2 by Molmil
Structure of human mitochondrial complex Nfs1-ISCU2-ISD11 with E.coli ACP1 at 1.95 A resolution (NIAU)2. N-terminal mutation of ISCU2 (L35) traps Nfs1 Cys loop in the active site of ISCU2 without metal present.
Descriptor: 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-{2-[2-2-(METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, ...
Authors:Boniecki, M.T, Cygler, M.
Deposit date:2020-04-08
Release date:2020-04-22
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:The essential function of ISCU2 and its conserved N-terminus in Fe/S cluster biogenesis
To Be Published
4KXK
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BU of 4kxk by Molmil
Alanine-glyoxylate aminotransferase variant K390A/K391A in complex with the TPR domain of human Pex5p
Descriptor: BETA-MERCAPTOETHANOL, Peroxisomal targeting signal 1 receptor, SULFATE ION, ...
Authors:Fodor, K, Lou, Y, Wilmanns, M.
Deposit date:2013-05-27
Release date:2014-11-19
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Ligand-Induced Compaction of the PEX5 Receptor-Binding Cavity Impacts Protein Import Efficiency into Peroxisomes.
Traffic, 16, 2015
4KYO
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BU of 4kyo by Molmil
Alanine-glyoxylate aminotransferase variant K390A in complex with the TPR domain of human Pex5p
Descriptor: 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, BETA-MERCAPTOETHANOL, Peroxisomal targeting signal 1 receptor, ...
Authors:Fodor, K, Lou, Y, Wilmanns, M.
Deposit date:2013-05-29
Release date:2014-11-19
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Ligand-Induced Compaction of the PEX5 Receptor-Binding Cavity Impacts Protein Import Efficiency into Peroxisomes.
Traffic, 16, 2015
6NZU
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BU of 6nzu by Molmil
Structure of the human frataxin-bound iron-sulfur cluster assembly complex
Descriptor: Acyl carrier protein, Cysteine desulfurase, mitochondrial, ...
Authors:Fox, N.G, Yu, X, Xidong, F, Alain, M, Joseph, N, Claire, S.D, Christine, B, Han, S, Yue, W.W.
Deposit date:2019-02-14
Release date:2019-05-22
Last modified:2019-07-10
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structure of the human frataxin-bound iron-sulfur cluster assembly complex provides insight into its activation mechanism.
Nat Commun, 10, 2019
5USR
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BU of 5usr by Molmil
Crystal structure of human NFS1-ISD11 in complex with E. coli acyl-carrier protein at 3.09 angstroms
Descriptor: Acyl carrier protein, Cysteine desulfurase, mitochondrial, ...
Authors:Cory, S.A, Barondeau, D.P.
Deposit date:2017-02-13
Release date:2017-06-21
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (3.09 Å)
Cite:Structure of human Fe-S assembly subcomplex reveals unexpected cysteine desulfurase architecture and acyl-ACP-ISD11 interactions.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5WKP
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BU of 5wkp by Molmil
Crystal Structure of the Human mitochondrial Cysteine Desulfurase in complex with ISD11 and Iron-Sulfur Cluster Scaffold Protein ISCU1, and E. coli ACP1 protein at 3.15A
Descriptor: Acyl carrier protein, Cysteine desulfurase, mitochondrial, ...
Authors:Boniecki, M.T, Cygler, M.
Deposit date:2017-07-25
Release date:2017-11-15
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:Structure and functional dynamics of the mitochondrial Fe/S cluster synthesis complex.
Nat Commun, 8, 2017
5WLW
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BU of 5wlw by Molmil
Crystal Structure of the Human Mitochondrial Cysteine Desulfurase with active Cysteine Loop within ISCU1 active site, coordinating Zn ion. Complexed with human ISD11 and E. coli ACP1 at 3.3A.
Descriptor: Acyl carrier protein, Cysteine desulfurase, mitochondrial, ...
Authors:Boniecki, M.T, Cygler, M.
Deposit date:2017-07-27
Release date:2017-11-15
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.317 Å)
Cite:Structure and functional dynamics of the mitochondrial Fe/S cluster synthesis complex.
Nat Commun, 8, 2017
5WGB
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BU of 5wgb by Molmil
Crystal Structure of the Human mitochondrial Cysteine Desulfurase in complex with ISD11 and E. coli ACP1 protein at 2.75A
Descriptor: Acyl carrier protein, Cysteine desulfurase, mitochondrial, ...
Authors:Boniecki, M.T, Cygler, M.
Deposit date:2017-07-13
Release date:2017-07-26
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Structure and functional dynamics of the mitochondrial Fe/S cluster synthesis complex.
Nat Commun, 8, 2017
5XT6
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BU of 5xt6 by Molmil
A sulfur-transferring catalytic intermediate of SufS-SufU complex from Bacillus subtilis
Descriptor: 2-[(3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHYL)-AMINO]-PROPIONIC ACID, Cysteine desulfurase SufS, ZINC ION, ...
Authors:Fujishiro, T, Kunichika, K, Takahashi, Y.
Deposit date:2017-06-17
Release date:2017-12-20
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Zinc-Ligand Swapping Mediated Complex Formation and Sulfur Transfer between SufS and SufU for Iron-Sulfur Cluster Biogenesis in Bacillus subtilis
J. Am. Chem. Soc., 139, 2017
5XT5
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BU of 5xt5 by Molmil
SufS-SufU complex from Bacillus subtilis
Descriptor: Cysteine desulfurase SufS, PYRIDOXAL-5'-PHOSPHATE, ZINC ION, ...
Authors:Fujishiro, T, Takahashi, Y.
Deposit date:2017-06-17
Release date:2017-12-20
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.34 Å)
Cite:Zinc-Ligand Swapping Mediated Complex Formation and Sulfur Transfer between SufS and SufU for Iron-Sulfur Cluster Biogenesis in Bacillus subtilis
J. Am. Chem. Soc., 139, 2017

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