PDB: 5725 resultsInfo pagesStatus searchChemie searchBIRD

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8FBN	Improving the secretion of designed protein assemblies through negative design of cryptic transmembrane domains Descriptor: KWOCA_73 Authors: Wang, J.Y, Khmelinskaia, A, Bera, A.K, King, N.P. Deposit date: 2022-11-29 Release date: 2023-03-22 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (3.04 Å) Cite: Improving the secretion of designed protein assemblies through negative design of cryptic transmembrane domains. Proc.Natl.Acad.Sci.USA, 120, 2023
8FBJ	Improving the secretion of designed protein assemblies through negative design of cryptic transmembrane domains Descriptor: KWOCA_60 Authors: Wang, J.Y, Khmelinskaia, A, Bera, A.K, King, N.P. Deposit date: 2022-11-29 Release date: 2023-03-22 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (3.25 Å) Cite: Improving the secretion of designed protein assemblies through negative design of cryptic transmembrane domains. Proc.Natl.Acad.Sci.USA, 120, 2023
8FBI	Improving the secretion of designed protein assemblies through negative design of cryptic transmembrane domains Descriptor: KWOCA_39 Authors: Wang, J.Y, Khmelinskaia, A, Bera, A.K, King, N.P. Deposit date: 2022-11-29 Release date: 2023-03-22 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (3.61 Å) Cite: Improving the secretion of designed protein assemblies through negative design of cryptic transmembrane domains. Proc.Natl.Acad.Sci.USA, 120, 2023
8FBK	Improving the secretion of designed protein assemblies through negative design of cryptic transmembrane domains Descriptor: KWOCA_65 Authors: Wang, J.Y, Khmelinskaia, A, Bera, A.K, King, N.P. Deposit date: 2022-11-29 Release date: 2023-03-22 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (3.15 Å) Cite: Improving the secretion of designed protein assemblies through negative design of cryptic transmembrane domains. Proc.Natl.Acad.Sci.USA, 120, 2023
5TX8	Solution structure of the de novo mini protein gHH_44 Descriptor: HH2 Authors: Buchko, G.W, Bahl, C.D, Baker, D. Deposit date: 2016-11-15 Release date: 2017-09-27 Last modified: 2023-06-14 Method: SOLUTION NMR Cite: Cytosolic expression, solution structures, and molecular dynamics simulation of genetically encodable disulfide-rich de novo designed peptides. Protein Sci., 27, 2018
2JWU	Solution NMR structures of two designed proteins with 88% sequence identity but different fold and function Descriptor: Gb88 Authors: He, Y, Chen, Y, Alexander, P, Bryan, P, Orban, J. Deposit date: 2007-10-25 Release date: 2008-09-09 Last modified: 2024-05-01 Method: SOLUTION NMR Cite: NMR structures of two designed proteins with high sequence identity but different fold and function Proc.Natl.Acad.Sci.Usa, 105, 2008
3P6I	Crystal structure of Symfoil-4T Permutation #2: de novo designed beta-trefoil architecture with symmetric primary structure Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, SULFATE ION, de novo designed beta-trefoil architecture with symmetric primary structure Authors: Blaber, M, Lee, J. Deposit date: 2010-10-11 Release date: 2011-10-12 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.32 Å) Cite: Permutations study of de novo designed symmetric beta-trefoil architecture To be Published
6Q5S	Crystal structure of a de novo designed antiparallel four-helix coiled coil apCC-Tet Descriptor: apCC-Tet Authors: Beesley, J.L, Guto, G.R, Wood, C.W, Brady, R.L, Woolfson, D.N. Deposit date: 2018-12-09 Release date: 2019-05-22 Last modified: 2019-06-19 Method: X-RAY DIFFRACTION (1.89 Å) Cite: Navigating the Structural Landscape of De Novo alpha-Helical Bundles. J.Am.Chem.Soc., 141, 2019
5EZ8	A de novo designed heptameric coiled coil CC-Hept-I-C-I Descriptor: CC-Hept-I-C-I Authors: Burton, A.J, Brady, R.L, Woolfson, D.N. Deposit date: 2015-11-26 Release date: 2016-07-06 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Installing hydrolytic activity into a completely de novo protein framework. Nat.Chem., 8, 2016
5EZE	A de novo designed heptameric coiled coil CC-Hept-I18betaMeCys-L22H-I25E Descriptor: CC-Hept-bMeCys-His-Glu, GLYCEROL Authors: Burton, A.J, Brady, R.L, Woolfson, D.N. Deposit date: 2015-11-26 Release date: 2016-07-06 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Installing hydrolytic activity into a completely de novo protein framework. Nat.Chem., 8, 2016
5EZ9	A de novo designed heptameric coiled coil CC-Hept-I-H-I Descriptor: CC-Hept-L22H, HEXANE-1,6-DIOL Authors: Burton, A.J, Brady, R.L, Woolfson, D.N. Deposit date: 2015-11-26 Release date: 2016-07-06 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Installing hydrolytic activity into a completely de novo protein framework. Nat.Chem., 8, 2016
5F2Y	A de novo designed heptameric coiled coil CC-Hept-homoCys-H-E Descriptor: CC-Hept-hCys-H-E Authors: Burton, A.J, Brady, R.L, Woolfson, D.N. Deposit date: 2015-12-02 Release date: 2016-07-06 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Installing hydrolytic activity into a completely de novo protein framework. Nat.Chem., 8, 2016
5EZA	A de novo designed heptameric coiled coil CC-Hept-I18C-L22H Descriptor: CC-Hept-C-H-I, GLYCEROL Authors: Burton, A.J, Brady, R.L, Woolfson, D.N. Deposit date: 2015-11-26 Release date: 2016-07-06 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.76 Å) Cite: Installing hydrolytic activity into a completely de novo protein framework. Nat.Chem., 8, 2016
5EZC	A de novo designed heptameric coiled coil CC-Hept-I18C-L22H-I25E Descriptor: CC-Hept-C-H-E Authors: Burton, A.J, Brady, R.L, Woolfson, D.N. Deposit date: 2015-11-26 Release date: 2016-07-06 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Installing hydrolytic activity into a completely de novo protein framework. Nat.Chem., 8, 2016
5EON	Crystal structure of a de novo antiparallel coiled-coil hexamer - ACC-Hex Descriptor: ACC-Hex Authors: Spencer, R.K, Hochbaum, A.I. Deposit date: 2015-11-10 Release date: 2016-05-25 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.696 Å) Cite: X-ray Crystallographic Structure and Solution Behavior of an Antiparallel Coiled-Coil Hexamer Formed by de Novo Peptides. Biochemistry, 55, 2016
6W6X	Crystal Structure of ABLE Apo-protein Descriptor: ACETATE ION, De novo designed ABLE protein, SULFATE ION Authors: Polizzi, N.F. Deposit date: 2020-03-18 Release date: 2020-08-26 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (1.297 Å) Cite: A defined structural unit enables de novo design of small-molecule-binding proteins. Science, 369, 2020
6W70	Crystal Structure of apixaban-bound ABLE Descriptor: 1-(4-METHOXYPHENYL)-7-OXO-6-[4-(2-OXOPIPERIDIN-1-YL)PHENYL]-4,5,6,7-TETRAHYDRO-1H-PYRAZOLO[3,4-C]PYRIDINE-3-CARBOXAMIDE, ACETATE ION, De novo designed ABLE, ... Authors: Polizzi, N.F. Deposit date: 2020-03-18 Release date: 2020-08-26 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (1.296 Å) Cite: A defined structural unit enables de novo design of small-molecule-binding proteins. Science, 369, 2020
5EHB	A de novo designed hexameric coiled-coil peptide with iodotyrosine Descriptor: pHiosYI Authors: Lizatovic, R, Aurelius, O, Stenstrom, O, Drakenberg, T, Akke, M, Logan, D.T, Andre, I. Deposit date: 2015-10-28 Release date: 2016-06-15 Last modified: 2018-01-17 Method: X-RAY DIFFRACTION (3.19 Å) Cite: A De Novo Designed Coiled-Coil Peptide with a Reversible pH-Induced Oligomerization Switch. Structure, 24, 2016
7BIM	A de novo designed nonameric coiled coil, CC-Type2-(GgLaId)4 Descriptor: GLYCEROL, ISOPROPYL ALCOHOL, Nonameric de novo coiled coil CC-Type2-(GgLaId)4 Authors: Shelley, K.L, Rhys, G.G, Dawson, W.M, Brady, R.L, Woolfson, D.N. Deposit date: 2021-01-12 Release date: 2021-04-21 Last modified: 2021-11-17 Method: X-RAY DIFFRACTION (1.64 Å) Cite: Coiled coils 9-to-5: rational de novo design of alpha-helical barrels with tunable oligomeric states. Chem Sci, 12, 2021
7AH0	Crystal structure of the de novo designed two-heme binding protein, 4D2 Descriptor: 4D2, PROTOPORPHYRIN IX CONTAINING FE Authors: Hutchins, G.H, Parnell, A.E, Anderson, J.L.R. Deposit date: 2020-09-23 Release date: 2021-10-06 Last modified: 2024-06-19 Method: X-RAY DIFFRACTION (1.91 Å) Cite: An expandable, modular de novo protein platform for precision redox engineering. Proc.Natl.Acad.Sci.USA, 120, 2023
7OSU	sTIM11noCys-SB, a de novo designed TIM barrel with a salt-bridge cluster (crystal form 1) Descriptor: CHLORIDE ION, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... Authors: Romero-Romero, S, Kordes, S, Hocker, B. Deposit date: 2021-06-09 Release date: 2021-12-15 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.37 Å) Cite: A newly introduced salt bridge cluster improves structural and biophysical properties of de novo TIM barrels. Protein Sci., 31, 2022
7OT7	sTIM11noCys-SB, a de novo designed TIM barrel with a salt-bridge cluster (crystal form 2) Descriptor: sTIM11noCys-SB Authors: Romero-Romero, S, Kordes, S, Hocker, B. Deposit date: 2021-06-09 Release date: 2021-12-15 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.51 Å) Cite: A newly introduced salt bridge cluster improves structural and biophysical properties of de novo TIM barrels. Protein Sci., 31, 2022
7NFJ	A heptameric barrel state of a de novo coiled-coil assembly: CC-Type2-(LaId)4-L28Y. Descriptor: CC-Type2-(LaId)4-L28Y Authors: Rhys, G.G, Dawson, W.M, Brady, R.L, Woolfson, D.N. Deposit date: 2021-02-07 Release date: 2022-03-02 Last modified: 2024-05-01 Method: X-RAY DIFFRACTION (1.19 Å) Cite: Differential sensing with arrays of de novo designed peptide assemblies. Nat Commun, 14, 2023
7NFL	An octameric barrel state of a de novo coiled-coil assembly: CC-Type2-(LaId)4-I24N. Descriptor: CC-Type2-(LaId)4-I24N Authors: Rhys, G.G, Dawson, W.M, Brady, R.L, Woolfson, D.N. Deposit date: 2021-02-07 Release date: 2022-03-02 Last modified: 2024-05-01 Method: X-RAY DIFFRACTION (1.44 Å) Cite: Differential sensing with arrays of de novo designed peptide assemblies. Nat Commun, 14, 2023
7NFF	An octameric barrel state of a de novo coiled-coil assembly: CC-Type2-(LaId)4-I24A. Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CC-Type2-(LaId)4-I24A, GLYCEROL Authors: Rhys, G.G, Dawson, W.M, Brady, R.L, Woolfson, D.N. Deposit date: 2021-02-07 Release date: 2022-03-02 Last modified: 2024-05-01 Method: X-RAY DIFFRACTION (1.55 Å) Cite: Differential sensing with arrays of de novo designed peptide assemblies. Nat Commun, 14, 2023

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