PDB: 72308 resultsInfo pagesStatus searchChemie searchBIRD

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5GXH	The structure of the Gemin5 WD40 domain with AAUUUUUG Descriptor: GLYCEROL, Gem-associated protein 5, RNA (5'-R(*A*AP*UP*UP*UP*UP*UP*G)-3'), ... Authors: Xu, C, He, H, Li, Y, Dong, A, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) Deposit date: 2016-09-17 Release date: 2016-10-26 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Structural insights into Gemin5-guided selection of pre-snRNAs for snRNP assembly Genes Dev., 30, 2016
6TG6	Toprim domain of RNase M5 Descriptor: Ribonuclease M5 Authors: Oerum, S, Catala, M, Tisne, C. Deposit date: 2019-11-15 Release date: 2020-09-23 Last modified: 2024-05-01 Method: X-RAY DIFFRACTION (1.3 Å) Cite: Structures of B. subtilis Maturation RNases Captured on 50S Ribosome with Pre-rRNAs. Mol.Cell, 80, 2020
5GXI	Structure of the Gemin5 WD40 domain in complex with AAUUUUUGAG Descriptor: Gem-associated protein 5, RNA (5'-R(*A*AP*UP*UP*UP*UP*UP*GP*AP*G)-3'), UNKNOWN ATOM OR ION Authors: Xu, C, He, H, Li, Y, Dong, A, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) Deposit date: 2016-09-18 Release date: 2016-10-26 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Structural insights into Gemin5-guided selection of pre-snRNAs for snRNP assembly Genes Dev., 30, 2016
5KNN	Evolutionary gain of alanine mischarging to non-cognate tRNAs with a G4:U69 base pair Descriptor: '5'-O-(N-(L-ALANYL)-SULFAMOYL)ADENOSINE, Alanine--tRNA ligase, cytoplasmic Authors: Sun, L, He, W, Yang, X.-L. Deposit date: 2016-06-28 Release date: 2016-09-28 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.68 Å) Cite: Evolutionary Gain of Alanine Mischarging to Noncognate tRNAs with a G4:U69 Base Pair. J.Am.Chem.Soc., 138, 2016
8HUD	Cryo-EM structure of the EvCas9-sgRNA-target DNA ternary complex Descriptor: CRISPR-associated endonuclease Cas9, Non-target DNA strand, Target DNA strand, ... Authors: Tang, N, Wu, Z, Gao, Y, Chen, W, Su, M, Wang, Z, Ji, Q. Deposit date: 2022-12-23 Release date: 2023-12-27 Method: ELECTRON MICROSCOPY (3.43 Å) Cite: Cryo-EM structure of the EvCas9-sgRNA-target DNA ternary complex To Be Published
6GD2	Structure of HuR RRM3 in complex with RNA Descriptor: ELAV-like protein 1, RNA (5'-R(P*UP*UP*UP*AP*UP*UP*U)-3') Authors: Pabis, M, Sattler, M. Deposit date: 2018-04-21 Release date: 2018-10-31 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.9 Å) Cite: HuR biological function involves RRM3-mediated dimerization and RNA binding by all three RRMs. Nucleic Acids Res., 47, 2019
6GD3	Structure of HuR RRM3 in complex with RNA (UAUUUA) Descriptor: ELAV-like protein 1, RNA (5'-R(P*UP*AP*UP*UP*UP*A)-3'), SODIUM ION Authors: Pabis, M, Sattler, M. Deposit date: 2018-04-21 Release date: 2018-10-31 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.35 Å) Cite: HuR biological function involves RRM3-mediated dimerization and RNA binding by all three RRMs. Nucleic Acids Res., 47, 2019
6G2K	Structure of HuR RRM3 in complex with RNA (UUUUUU) Descriptor: ELAV-like protein 1, RNA (5'-R(P*UP*UP*UP*UP*UP*U)-3'), SULFATE ION Authors: Pabis, M, Sattler, M. Deposit date: 2018-03-23 Release date: 2018-10-31 Last modified: 2019-05-15 Method: X-RAY DIFFRACTION (2.01 Å) Cite: HuR biological function involves RRM3-mediated dimerization and RNA binding by all three RRMs. Nucleic Acids Res., 47, 2019
7NIC	CryoEM structure of disease related M854K MDA5-dsRNA filament in complex with ADP-AlF4(minor class) Descriptor: ADENOSINE-5'-DIPHOSPHATE, Interferon-induced helicase C domain-containing protein 1, RNA (5'-R(P*GP*UP*CP*AP*AP*GP*CP*CP*GP*AP*GP*GP*AP*GP*A)-3'), ... Authors: Yu, Q, Modis, Y. Deposit date: 2021-02-11 Release date: 2021-11-17 Last modified: 2024-07-10 Method: ELECTRON MICROSCOPY (4.3 Å) Cite: MDA5 disease variant M854K prevents ATP-dependent structural discrimination of viral and cellular RNA. Nat Commun, 12, 2021
7NGA	CryoEM structure of the MDA5-dsRNA filament in complex with ADP with 88-degree helical twist Descriptor: ADENOSINE-5'-DIPHOSPHATE, Interferon-induced helicase C domain-containing protein 1, RNA (5'-R(P*AP*CP*GP*UP*CP*AP*UP*GP*CP*GP*CP*AP*UP*GP*G)-3'), ... Authors: Yu, Q, Modis, Y. Deposit date: 2021-02-08 Release date: 2021-11-17 Last modified: 2024-07-10 Method: ELECTRON MICROSCOPY (3.9 Å) Cite: MDA5 disease variant M854K prevents ATP-dependent structural discrimination of viral and cellular RNA. Nat Commun, 12, 2021
7NIQ	CryoEM structure of disease related M854K MDA5-dsRNA filament in complex with ADP-AlF4(Major class) Descriptor: ADENOSINE-5'-DIPHOSPHATE, Interferon-induced helicase C domain-containing protein 1, RNA (5'-R(P*AP*UP*CP*UP*CP*CP*UP*CP*GP*GP*CP*UP*UP*G)-3'), ... Authors: Yu, Q, Modis, Y. Deposit date: 2021-02-13 Release date: 2021-11-17 Last modified: 2024-07-10 Method: ELECTRON MICROSCOPY (4.3 Å) Cite: MDA5 disease variant M854K prevents ATP-dependent structural discrimination of viral and cellular RNA. Nat Commun, 12, 2021
6NE0	Structure of double-stranded target DNA engaged Csy complex from Pseudomonas aeruginosa (PA-14) Descriptor: CRISPR RNA (60-MER), CRISPR target DNA (44-MER), CRISPR-associated endonuclease Cas6/Csy4, ... Authors: Chowdhury, S, Rollins, M.F, Carter, J, Golden, S.M, Miettinen, H.M, Santiago-Frangos, A, Faith, D, Lawrence, M.C, Wiedenheft, B, Lander, G.C. Deposit date: 2018-12-15 Release date: 2018-12-26 Last modified: 2024-03-13 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: Structure Reveals a Mechanism of CRISPR-RNA-Guided Nuclease Recruitment and Anti-CRISPR Viral Mimicry. Mol. Cell, 74, 2019
6J7Y	Human mitochondrial Oligoribonuclease in complex with DNA Descriptor: DNA (5'-D(P*TP*T)-3'), MAGNESIUM ION, Oligoribonuclease, ... Authors: Chu, L.Y, Agrawal, S, Yuan, H.S. Deposit date: 2019-01-18 Release date: 2019-08-28 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.203 Å) Cite: Structural insights into nanoRNA degradation by human Rexo2. Rna, 25, 2019
6J80	Human mitochondrial Oligoribonuclease in complex with poly-dT DNA Descriptor: CITRIC ACID, DNA (5'-D(P*TP*TP*TP*TP*TP*TP*T)-3'), MAGNESIUM ION, ... Authors: Chu, L.Y, Agrawal, S, Yuan, H.S. Deposit date: 2019-01-18 Release date: 2019-08-28 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.812 Å) Cite: Structural insights into nanoRNA degradation by human Rexo2. Rna, 25, 2019
3DH3	Crystal Structure of RluF in complex with a 22 nucleotide RNA substrate Descriptor: Ribosomal large subunit pseudouridine synthase F, stem loop fragment of E. Coli 23S RNA Authors: Alian, A, DeGiovanni, A, Stroud, R.M, Finer-Moore, J.S. Deposit date: 2008-06-16 Release date: 2009-04-28 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (3 Å) Cite: Crystal structure of an RluF-RNA complex: a base-pair rearrangement is the key to selectivity of RluF for U2604 of the ribosome. J.Mol.Biol., 388, 2009
2F4V	30S ribosome + designer antibiotic Descriptor: (2R)-4-AMINO-N-{(1R,2S,3R,4R,5S)-5-AMINO-2-{2-[(2-AMINOETHYL)AMINO]ETHOXY}-4-[(2,6-DIAMINO-2,6-DIDEOXY-ALPHA-D-GLUCOPYRANOSYL)OXY]-3-HYDROXYCYCLOHEXYL}-2-HYDROXYBUTANAMIDE, (2S,4S,4AR,5AS,6S,11R,11AS,12R,12AR)-7-CHLORO-4-(DIMETHYLAMINO)-6,10,11,12-TETRAHYDROXY-1,3-DIOXO-1,2,3,4,4A,5,5A,6,11,11A,12,12A-DODECAHYDROTETRACENE-2-CARBOXAMIDE, 16S ribosomal RNA, ... Authors: Murray, J.B, Meroueh, S.O, Russell, R.J, Lentzen, G, Haddad, J, Mobashery, S. Deposit date: 2005-11-24 Release date: 2006-07-04 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (3.8 Å) Cite: Interactions of designer antibiotics and the bacterial ribosome aminoacyl-tRNA site Chem.Biol., 13, 2006
8JA0	Cryo-EM structure of the NmeCas9-sgRNA-AcrIIC4 ternary complex Descriptor: CRISPR-associated endonuclease Cas9, RNA (117-MER), Uncharacterized protein Authors: Yin, H, Li, Z, Yu, G.M, Li, X.Z. Deposit date: 2023-05-05 Release date: 2023-08-09 Last modified: 2024-07-03 Method: ELECTRON MICROSCOPY (3.52 Å) Cite: Cryo-EM structure of the NmeCas9-sgRNA-AcrIIC4 ternary complex To Be Published
7N3O	Cryo-EM structure of the Cas12k-sgRNA complex Descriptor: Cas12k, Single guide RNA Authors: Chang, L, Li, Z, Xiao, R, Wang, S, Han, R. Deposit date: 2021-06-01 Release date: 2021-09-01 Last modified: 2024-05-29 Method: ELECTRON MICROSCOPY (3.8 Å) Cite: Structural basis of target DNA recognition by CRISPR-Cas12k for RNA-guided DNA transposition. Mol.Cell, 81, 2021
7N3P	Cryo-EM structure of the Cas12k-sgRNA-dsDNA complex Descriptor: Cas12k, DNA (5'-D(*CP*AP*TP*GP*AP*CP*TP*TP*CP*TP*CP*AP*AP*CP*CP*GP*AP*GP*TP*TP*T)-3'), DNA (5'-D(P*AP*AP*AP*CP*TP*CP*GP*GP*TP*T)-3'), ... Authors: Chang, L, Li, Z, Xiao, R, Wang, S, Han, R. Deposit date: 2021-06-01 Release date: 2021-09-01 Last modified: 2024-05-29 Method: ELECTRON MICROSCOPY (3.65 Å) Cite: Structural basis of target DNA recognition by CRISPR-Cas12k for RNA-guided DNA transposition. Mol.Cell, 81, 2021
8WUT	SpCas9-MMLV RT-pegRNA-target DNA complex (initiation) Descriptor: CRISPR-associated endonuclease Cas9/Csn1, DNA (5'-D(*TP*GP*AP*TP*GP*GP*CP*AP*GP*AP*GP*TP*AP*CP*TP*AP*G)-3'), DNA (51-MER), ... Authors: Shuto, Y, Nakagawa, R, Hoki, M, Omura, S.N, Hirano, H, Itoh, Y, Nureki, O. Deposit date: 2023-10-21 Release date: 2024-06-05 Last modified: 2024-06-12 Method: ELECTRON MICROSCOPY (3 Å) Cite: Structural basis for pegRNA-guided reverse transcription by a prime editor. Nature, 2024
8WUS	SpCas9-MMLV RT-pegRNA-target DNA complex (termination) Descriptor: CRISPR-associated endonuclease Cas9/Csn1, DNA (40-MER), DNA (5'-D(*TP*GP*AP*TP*GP*GP*CP*AP*GP*AP*GP*TP*AP*CP*TP*AP*G)-3'), ... Authors: Shuto, Y, Nakagawa, R, Hoki, M, Omura, S.N, Hirano, H, Itoh, Y, Nureki, O. Deposit date: 2023-10-21 Release date: 2024-06-05 Last modified: 2024-06-12 Method: ELECTRON MICROSCOPY (2.9 Å) Cite: Structural basis for pegRNA-guided reverse transcription by a prime editor. Nature, 2024
8WUV	SpCas9-MMLV RT-pegRNA-target DNA complex (elongation 16-nt) Descriptor: CRISPR-associated endonuclease Cas9/Csn1, DNA (5'-D(*TP*GP*AP*TP*GP*GP*CP*AP*GP*AP*GP*TP*AP*CP*TP*AP*G)-3'), DNA (50-MER), ... Authors: Shuto, Y, Nakagawa, R, Hoki, M, Omura, S.N, Hirano, H, Itoh, Y, Nureki, O. Deposit date: 2023-10-21 Release date: 2024-06-05 Last modified: 2024-06-12 Method: ELECTRON MICROSCOPY (3 Å) Cite: Structural basis for pegRNA-guided reverse transcription by a prime editor. Nature, 2024
6F89	Structure of H234A/Y235A P.abyssi Sua5 Descriptor: BICARBONATE ION, THREONINE, Threonylcarbamoyl-AMP synthase Authors: Pichard-Kostuch, A, Zhang, W, Liger, D, Daugeron, M.C, Letoquart, J, Li de la Sierra-Gallay, I, Forterre, P, Collinet, B, van Tilbeurgh, H, Basta, T. Deposit date: 2017-12-12 Release date: 2018-04-25 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.81 Å) Cite: Structure-function analysis of Sua5 protein reveals novel functional motifs required for the biosynthesis of the universal t6A tRNA modification. RNA, 24, 2018
6F87	Crystal structure of P. abyssi Sua5 complexed with L-threonine and PPi Descriptor: PYROPHOSPHATE 2-, THREONINE, Threonylcarbamoyl-AMP synthase Authors: Pichard-Kostuch, A, Zhang, W, Liger, D, Daugeron, M.C, Letoquart, J, Li de la Sierra-Gallay, I, Forterre, P, Collinet, B, van Tilbeurgh, H, Basta, T. Deposit date: 2017-12-12 Release date: 2018-04-25 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.62 Å) Cite: Structure-function analysis of Sua5 protein reveals novel functional motifs required for the biosynthesis of the universal t6A tRNA modification. RNA, 24, 2018
6F8Y	Crystal structure of P. abyssi Sua5 complexed with L-threonine Descriptor: THREONINE, Threonylcarbamoyl-AMP synthase Authors: Pichard-Kostuch, A, Zhang, W, Liger, D, Daugeron, M.C, Letoquart, J, Li de la Sierra-Gallay, I, Forterre, P, Collinet, B, van Tilbeurgh, H, Basta, T. Deposit date: 2017-12-13 Release date: 2018-04-25 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.86 Å) Cite: Structure-function analysis of Sua5 protein reveals novel functional motifs required for the biosynthesis of the universal t6A tRNA modification. RNA, 24, 2018

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