6LMS
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6LR2
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6LYY
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![BU of 6lyy by Molmil](/molmil-images/mine/6lyy) | Cryo-EM structure of the human MCT1/Basigin-2 complex in the presence of anti-cancer drug candidate AZD3965 in the outward-open conformation. | Descriptor: | 3-methyl-5-[[(4~{R})-4-methyl-4-oxidanyl-1,2-oxazolidin-2-yl]carbonyl]-6-[[5-methyl-3-(trifluoromethyl)-1~{H}-pyrazol-4-yl]methyl]-1-propan-2-yl-thieno[2,3-d]pyrimidine-2,4-dione, Basigin, Monocarboxylate transporter 1 | Authors: | Wang, N, Jiang, X, Zhang, S, Zhu, A, Yuan, Y, Lei, J, Yan, C. | Deposit date: | 2020-02-16 | Release date: | 2020-12-23 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structural basis of human monocarboxylate transporter 1 inhibition by anti-cancer drug candidates. Cell, 184, 2021
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6MW3
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![BU of 6mw3 by Molmil](/molmil-images/mine/6mw3) | EM structure of Bacillus subtilis ribonucleotide reductase inhibited filament composed of NrdE alpha subunit and NrdF beta subunit with dATP | Descriptor: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, Ribonucleoside-diphosphate reductase, Ribonucleoside-diphosphate reductase NrdF beta subunit | Authors: | Thomas, W.C, Bacik, J.P, Kaelber, J.T, Ando, N. | Deposit date: | 2018-10-29 | Release date: | 2019-06-19 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (4.65 Å) | Cite: | Convergent allostery in ribonucleotide reductase. Nat Commun, 10, 2019
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6N3F
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![BU of 6n3f by Molmil](/molmil-images/mine/6n3f) | Structure of HIV Tat-specific factor 1 U2AF Homology Motif bound to SF3b1 ULM5 | Descriptor: | DI(HYDROXYETHYL)ETHER, GLYCEROL, HIV Tat-specific factor 1, ... | Authors: | Leach, J.R, Jenkins, J.L, Kielkopf, C.L. | Deposit date: | 2018-11-15 | Release date: | 2019-01-02 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.099 Å) | Cite: | The pre-mRNA splicing and transcription factor Tat-SF1 is a functional partner of the spliceosome SF3b1 subunit via a U2AF homology motif interface. J. Biol. Chem., 294, 2019
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6N4R
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![BU of 6n4r by Molmil](/molmil-images/mine/6n4r) | CryoEM structure of Nav1.7 VSD2 (deactived state) in complex with the gating modifier toxin ProTx2 | Descriptor: | Beta/omega-theraphotoxin-Tp2a, Fab heavy chain, Fab light chain, ... | Authors: | Xu, H, Rohou, A, Arthur, C.P, Estevez, A, Ciferri, C, Payandeh, J, Koth, C.M. | Deposit date: | 2018-11-20 | Release date: | 2019-01-23 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Structural Basis of Nav1.7 Inhibition by a Gating-Modifier Spider Toxin. Cell, 176, 2019
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6N3E
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![BU of 6n3e by Molmil](/molmil-images/mine/6n3e) | Structure of HIV Tat-specific factor 1 U2AF Homology Motif bound to U2AF ligand motif 4 | Descriptor: | FORMIC ACID, GLYCEROL, HIV Tat-specific factor 1, ... | Authors: | Loerch, S, Jenkins, J.L, Kielkopf, C.L. | Deposit date: | 2018-11-15 | Release date: | 2019-01-02 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.893 Å) | Cite: | The pre-mRNA splicing and transcription factor Tat-SF1 is a functional partner of the spliceosome SF3b1 subunit via a U2AF homology motif interface. J. Biol. Chem., 294, 2019
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6KDJ
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![BU of 6kdj by Molmil](/molmil-images/mine/6kdj) | HIV-1 reverse transcriptase with Q151M/Y115F/F116Y:DNA:lamivudine 5'-triphosphate ternary complex | Descriptor: | DNA/RNA (38-MER), GLYCEROL, HIV-1 RT p51 subunit, ... | Authors: | Yasutake, Y, Hattori, S.I, Tamura, N, Maeda, K. | Deposit date: | 2019-07-02 | Release date: | 2020-03-04 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.51 Å) | Cite: | Structural features in common of HBV and HIV-1 resistance against chirally-distinct nucleoside analogues entecavir and lamivudine. Sci Rep, 10, 2020
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6K4J
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![BU of 6k4j by Molmil](/molmil-images/mine/6k4j) | Crystal Structure of the the CD9 | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, CD9 antigen, NICKEL (II) ION, ... | Authors: | Umeda, R, Nishizawa, T, Sato, K, Nureki, O. | Deposit date: | 2019-05-24 | Release date: | 2020-05-13 | Method: | X-RAY DIFFRACTION (2.701 Å) | Cite: | Structural insights into tetraspanin CD9 function. Nat Commun, 11, 2020
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6K4N
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![BU of 6k4n by Molmil](/molmil-images/mine/6k4n) | Cryo-EM structure of p300 | Descriptor: | Histone acetyltransferase p300 | Authors: | Ghosh, R, Roy, S, Sengupta, J. | Deposit date: | 2019-05-24 | Release date: | 2019-06-19 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (9.8 Å) | Cite: | Tumor Suppressor p53-Mediated Structural Reorganization of the Transcriptional Coactivator p300. Biochemistry, 58, 2019
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6K5E
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![BU of 6k5e by Molmil](/molmil-images/mine/6k5e) | Crystal structure of BioH from Klebsiella pneumonia | Descriptor: | Pimeloyl-[acyl-carrier protein] methyl ester esterase | Authors: | Wang, L, Chen, Y. | Deposit date: | 2019-05-28 | Release date: | 2019-07-17 | Last modified: | 2020-05-06 | Method: | X-RAY DIFFRACTION (2.257 Å) | Cite: | Structural insight into the carboxylesterase BioH from Klebsiella pneumoniae. Biochem.Biophys.Res.Commun., 520, 2019
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6JYU
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![BU of 6jyu by Molmil](/molmil-images/mine/6jyu) | Crystal structure of Human G6PD Canton | Descriptor: | Glucose-6-phosphate 1-dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | Authors: | Au, S.W.N. | Deposit date: | 2019-04-28 | Release date: | 2020-04-29 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (1.89 Å) | Cite: | Crystal structure of Human G6PD Canton To Be Published
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6K2G
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6K33
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![BU of 6k33 by Molmil](/molmil-images/mine/6k33) | Structure of PSI-isiA supercomplex from Thermosynechococcus vulcanus | Descriptor: | 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, 1,2-DISTEAROYL-MONOGALACTOSYL-DIGLYCERIDE, BETA-CAROTENE, ... | Authors: | Akita, F, Nagao, R, Kato, K, Shen, J.R, Miyazaki, N. | Deposit date: | 2019-05-16 | Release date: | 2020-05-20 | Last modified: | 2020-05-27 | Method: | ELECTRON MICROSCOPY (2.74 Å) | Cite: | Structure of a cyanobacterial photosystem I surrounded by octadecameric IsiA antenna proteins. Commun Biol, 3, 2020
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6KAJ
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![BU of 6kaj by Molmil](/molmil-images/mine/6kaj) | Crystal structure of FKRP in complex with Ba ion | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, BARIUM ION, CYTIDINE-5'-DIPHOSPHATE, ... | Authors: | Kuwabara, N. | Deposit date: | 2019-06-23 | Release date: | 2020-01-29 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.2249 Å) | Cite: | Crystal structures of fukutin-related protein (FKRP), a ribitol-phosphate transferase related to muscular dystrophy. Nat Commun, 11, 2020
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6KAD
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![BU of 6kad by Molmil](/molmil-images/mine/6kad) | Cryo-EM structure of the C2S2M2L2-type PSII-LHCII supercomplex from Chlamydomonas reihardtii | Descriptor: | (1R,3R)-6-{(3E,5E,7E,9E,11E,13E,15E,17E)-18-[(1S,4R,6R)-4-HYDROXY-2,2,6-TRIMETHYL-7-OXABICYCLO[4.1.0]HEPT-1-YL]-3,7,12,16-TETRAMETHYLOCTADECA-1,3,5,7,9,11,13,15,17-NONAENYLIDENE}-1,5,5-TRIMETHYLCYCLOHEXANE-1,3-DIOL, (3R,3'R,6S)-4,5-DIDEHYDRO-5,6-DIHYDRO-BETA,BETA-CAROTENE-3,3'-DIOL, (3S,5R,6S,3'S,5'R,6'S)-5,6,5',6'-DIEPOXY-5,6,5',6'- TETRAHYDRO-BETA,BETA-CAROTENE-3,3'-DIOL, ... | Authors: | Sheng, X, Watanabe, A, Li, A.J, Kim, E, Song, C, Murata, K, Song, D.F, Minagawa, J, Liu, Z.F. | Deposit date: | 2019-06-21 | Release date: | 2019-10-23 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structural insight into light harvesting for photosystem II in green algae. Nat.Plants, 5, 2019
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6KG7
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![BU of 6kg7 by Molmil](/molmil-images/mine/6kg7) | Cryo-EM Structure of the Mammalian Tactile Channel Piezo2 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Piezo-type mechanosensitive ion channel component 2 | Authors: | Wang, L, Zhou, H, Zhang, M, Liu, W, Deng, T, Zhao, Q, Li, Y, Lei, J, Li, X, Xiao, B. | Deposit date: | 2019-07-11 | Release date: | 2019-09-04 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Structure and mechanogating of the mammalian tactile channel PIEZO2. Nature, 573, 2019
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6JUW
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![BU of 6juw by Molmil](/molmil-images/mine/6juw) | BOVINE HEART CYTOCHROME C OXIDASE IN CATALITIC INTERMEDIATES AT 1.80 ANGSTROM RESOLUTION | Descriptor: | (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE, (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE, (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE, ... | Authors: | Shimada, A, Muramoto, K, Shinzawa-Itoh, K, Yoshikawa, S, Tsukihara, T. | Deposit date: | 2019-04-15 | Release date: | 2020-03-25 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | X-ray structures of catalytic intermediates of cytochromecoxidase provide insights into its O2activation and unidirectional proton-pump mechanisms. J.Biol.Chem., 295, 2020
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6MK5
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6NCM
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![BU of 6ncm by Molmil](/molmil-images/mine/6ncm) | Crystal structure of the human FOXN3 DNA binding domain in complex with a forkhead-like (FHL) DNA sequence | Descriptor: | DNA (5'-D(*AP*TP*AP*GP*CP*GP*TP*CP*TP*TP*AP*GP*CP*AP*TP*G)-3'), DNA (5'-D(*TP*CP*AP*TP*GP*CP*TP*AP*AP*GP*AP*CP*GP*CP*TP*A)-3'), Forkhead box protein N3, ... | Authors: | Rogers, J.M, Jarrett, S.M, Seegar, T.C, Waters, C.T, Hallworth, A.N, Blacklow, S.C, Bulyk, M.L. | Deposit date: | 2018-12-11 | Release date: | 2019-02-27 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.704 Å) | Cite: | Bispecific Forkhead Transcription Factor FoxN3 Recognizes Two Distinct Motifs with Different DNA Shapes. Mol. Cell, 74, 2019
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6NBW
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![BU of 6nbw by Molmil](/molmil-images/mine/6nbw) | Ternary Complex of Beta/Gamma-Actin with Profilin and AnCoA-NAA80 | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ADENOSINE-5'-TRIPHOSPHATE, Actin, ... | Authors: | Rebowski, G, Boczkowska, M, Dominguez, R. | Deposit date: | 2018-12-10 | Release date: | 2020-01-29 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Mechanism of actin N-terminal acetylation. Sci Adv, 6, 2020
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6NGA
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![BU of 6nga by Molmil](/molmil-images/mine/6nga) | Structure of human neuronal nitric oxide synthase R354A/G357D mutant heme domain in complex with 6-(3-(3-(dimethylamino)propyl)-2,6-difluorophenethyl)-4-methylpyridin-2-amine | Descriptor: | 5,6,7,8-TETRAHYDROBIOPTERIN, 6-(2-{3-[3-(dimethylamino)propyl]-2,6-difluorophenyl}ethyl)-4-methylpyridin-2-amine, Nitric oxide synthase, ... | Authors: | Li, H, Poulos, T.L. | Deposit date: | 2018-12-21 | Release date: | 2019-03-13 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.98 Å) | Cite: | Optimization of Blood-Brain Barrier Permeability with Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibitors Having a 2-Aminopyridine Scaffold. J. Med. Chem., 62, 2019
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6NGK
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![BU of 6ngk by Molmil](/molmil-images/mine/6ngk) | Structure of rat neuronal nitric oxide synthase heme domain in complex with 6-(3-(3-(dimethylamino)prop-1-yn-1-yl)-5-fluorophenethyl)-4-methylpyridin-2-amine | Descriptor: | 5,6,7,8-TETRAHYDROBIOPTERIN, 6-(2-{3-[3-(dimethylamino)prop-1-yn-1-yl]-5-fluorophenyl}ethyl)-4-methylpyridin-2-amine, ACETATE ION, ... | Authors: | Li, H, Poulos, T.L. | Deposit date: | 2018-12-21 | Release date: | 2019-03-13 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.83 Å) | Cite: | Optimization of Blood-Brain Barrier Permeability with Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibitors Having a 2-Aminopyridine Scaffold. J. Med. Chem., 62, 2019
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6NGY
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![BU of 6ngy by Molmil](/molmil-images/mine/6ngy) | Structure of rat neuronal nitric oxide synthase heme domain in complex with (R)-6-(2,3-difluoro-5-(2-(1-methylpyrrolidin-2-yl)ethyl)phenethyl)-4-methylpyridin-2-amine | Descriptor: | 5,6,7,8-TETRAHYDROBIOPTERIN, 6-[2-(2,3-difluoro-5-{2-[(2R)-1-methylpyrrolidin-2-yl]ethyl}phenyl)ethyl]-4-methylpyridin-2-amine, ACETATE ION, ... | Authors: | Li, H, Poulos, T.L. | Deposit date: | 2018-12-21 | Release date: | 2019-03-13 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.928 Å) | Cite: | Optimization of Blood-Brain Barrier Permeability with Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibitors Having a 2-Aminopyridine Scaffold. J. Med. Chem., 62, 2019
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6NHE
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![BU of 6nhe by Molmil](/molmil-images/mine/6nhe) | Structure of rat neuronal nitric oxide synthase heme domain in complex with 6-(5-(2-((2S,4R)-4-ethoxy-1-methylpyrrolidin-2-yl)ethyl)-2,3-difluorophenethyl)-4-methylpyridin-2-amine | Descriptor: | 5,6,7,8-TETRAHYDROBIOPTERIN, 6-[2-(5-{2-[(2S,4R)-4-ethoxy-1-methylpyrrolidin-2-yl]ethyl}-2,3-difluorophenyl)ethyl]-4-methylpyridin-2-amine, ACETATE ION, ... | Authors: | Li, H, Poulos, T.L. | Deposit date: | 2018-12-21 | Release date: | 2019-03-13 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.999 Å) | Cite: | Optimization of Blood-Brain Barrier Permeability with Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibitors Having a 2-Aminopyridine Scaffold. J. Med. Chem., 62, 2019
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