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7BJK	Crystal structure of the chloroplastic Fe superoxide dismutase PAP9 from Arabidopsis thaliana. Descriptor: Superoxide dismutase [Fe] 2, chloroplastic, ZINC ION Authors: Cobessi, D, Blanvillain, R, Pfannschmidt, T. Deposit date: 2021-01-14 Release date: 2021-07-07 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.25 Å) Cite: The Plastid-Encoded RNA Polymerase-Associated Protein PAP9 Is a Superoxide Dismutase With Unusual Structural Features. Front Plant Sci, 12, 2021
8GWB	SARS-CoV-2 E-RTC complex with RNA-nsp9 Descriptor: Helicase, MANGANESE (II) ION, Non-structural protein 7, ... Authors: Yan, L.M, Rao, Z.H, Lou, Z.Y. Deposit date: 2022-09-16 Release date: 2022-12-07 Last modified: 2023-10-25 Method: ELECTRON MICROSCOPY (2.75 Å) Cite: A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analog inhibitors. Cell, 185, 2022
8GWE	SARS-CoV-2 E-RTC complex with RNA-nsp9 and GMPPNP Descriptor: Helicase nsp13, MAGNESIUM ION, Non-structural protein 8, ... Authors: Yan, L.M, Rao, Z.H, Lou, Z.Y. Deposit date: 2022-09-16 Release date: 2023-01-11 Last modified: 2023-10-25 Method: ELECTRON MICROSCOPY (2.66 Å) Cite: A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analog inhibitors. Cell, 185, 2022
8GWF	A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analogue inhibitors Descriptor: GUANOSINE-5'-TRIPHOSPHATE, Helicase, Non-structural protein 7, ... Authors: Yan, L.Y, Huang, Y.C, Rao, Z.H, Lou, Z.Y. Deposit date: 2022-09-17 Release date: 2023-01-11 Last modified: 2024-07-03 Method: ELECTRON MICROSCOPY (3.39 Å) Cite: A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analog inhibitors. Cell, 185, 2022
3LKH	Inhibitors of Hepatitis C Virus Polymerase: Synthesis and Characterization of Novel 6-Fluoro-N-[2-Hydroxy-1(S)-Benzamides Descriptor: 2-(2-{[(1S)-1-benzyl-2-hydroxyethyl]amino}-2-oxoethoxy)-N-butyl-6-fluoro-N-methylbenzamide, RNA-directed RNA polymerase Authors: Lesburg, C.A. Deposit date: 2010-01-27 Release date: 2010-03-23 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Inhibitors of hepatitis C virus polymerase: synthesis and characterization of novel 2-oxy-6-fluoro-N-((S)-1-hydroxy-3-phenylpropan-2-yl)-benzamides. Bioorg.Med.Chem.Lett., 20, 2010
4E76	Apo crystal structure of HCV NS5B genotype 2A JFH-1 isolate with beta hairpin loop deletion Descriptor: 1,2-ETHANEDIOL, RNA-directed RNA polymerase, SULFATE ION Authors: Edwards, T.E, Mosley, R.T. Deposit date: 2012-03-16 Release date: 2012-04-18 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Structure of hepatitis C virus polymerase in complex with primer-template RNA. J.Virol., 86, 2012
7EGS	The crystal structure of lobe domain of E. coli RNA polymerase complexed with the C-terminal domain of UvrD Descriptor: DNA helicase II, DNA-directed RNA polymerase subunit beta, GLYCEROL Authors: Zheng, F, Shen, L, Li, L, Zhang, Y. Deposit date: 2021-03-26 Release date: 2022-04-06 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Crucial role and mechanism of transcription-coupled DNA repair in bacteria. Nature, 604, 2022
2D41	X-ray crystal structure of hepatitis C virus RNA-dependent RNA polymerase in complex with non-nucleoside inhibitor Descriptor: 5'-ACETYL-4-{[(2,4-DIMETHYLPHENYL)SULFONYL]AMINO}-2,2'-BITHIOPHENE-5-CARBOXYLIC ACID, polyprotein Authors: Biswal, B.K, Wang, M, Cherney, M.M, Chan, L, Yannopoulos, C.G, Bilimoria, D, Bedard, J, James, M.N.G. Deposit date: 2005-10-05 Release date: 2006-08-01 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Non-nucleoside Inhibitors Binding to Hepatitis C Virus NS5B Polymerase Reveal a Novel Mechanism of Inhibition J.Mol.Biol., 361, 2006
2D3Z	X-ray crystal structure of hepatitis C virus RNA-dependent RNA polymerase in complex with non-nucleoside analogue inhibitor Descriptor: 5-(4-FLUOROPHENYL)-3-{[(4-METHYLPHENYL)SULFONYL]AMINO}THIOPHENE-2-CARBOXYLIC ACID, polyprotein Authors: Biswal, B.K, Wang, M, Cherney, M.M, Chan, L, Yannopoulos, C.G, Bilimoria, D, Bedard, J, James, M.N.G. Deposit date: 2005-10-04 Release date: 2006-08-01 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Non-nucleoside Inhibitors Binding to Hepatitis C Virus NS5B Polymerase Reveal a Novel Mechanism of Inhibition J.Mol.Biol., 361, 2006
2I1R	Novel Thiazolones as HCV NS5B Polymerase Inhibitors: Further Designs, Synthesis, SAR and X-ray Complex Structure Descriptor: (5Z)-5-[(5-ETHYL-2-FURYL)METHYLENE]-2-{[(S)-(4-FLUOROPHENYL)(1H-TETRAZOL-5-YL)METHYL]AMINO}-1,3-THIAZOL-4(5H)-ONE, RNA-directed RNA polymerase (NS5B) (P68) Authors: Yao, N, Yan, S. Deposit date: 2006-08-14 Release date: 2006-10-31 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Novel thiazolones as HCV NS5B polymerase allosteric inhibitors: Further designs, SAR, and X-ray complex structure. Bioorg.Med.Chem.Lett., 17, 2007
8GWO	A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analogue inhibitors Descriptor: Helicase, Non-structural protein 7, Non-structural protein 8, ... Authors: Yan, L.M, Huang, Y.C, Ge, J, Liu, Z.Y, Gao, Y, Rao, Z.H, Lou, Z.Y. Deposit date: 2022-09-17 Release date: 2022-11-30 Last modified: 2024-01-24 Method: ELECTRON MICROSCOPY (3.8 Å) Cite: A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analog inhibitors. Cell, 185, 2022
8GWG	A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analogue inhibitors Descriptor: GUANOSINE-5'-TRIPHOSPHATE, Helicase, Non-structural protein 7, ... Authors: Yan, L.M, Huang, Y.C, Ge, J, Liu, Z.Y, Gao, Y, Rao, Z.H, Lou, Z.Y. Deposit date: 2022-09-17 Release date: 2022-12-14 Last modified: 2024-07-03 Method: ELECTRON MICROSCOPY (3.37 Å) Cite: A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analog inhibitors. Cell, 185, 2022
8GWI	A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analogue inhibitors Descriptor: GUANOSINE-5'-TRIPHOSPHATE, Helicase, Non-structural protein 7, ... Authors: Yan, L.M, Huang, Y.C, Ge, J, Liu, Z.Y, Gao, Y, Rao, Z.H, Lou, Z.Y. Deposit date: 2022-09-17 Release date: 2022-12-14 Last modified: 2024-07-03 Method: ELECTRON MICROSCOPY (3.18 Å) Cite: A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analog inhibitors. Cell, 185, 2022
8GWN	A mechanism for SARS-CoV-2 RNA capping and its inhibitor of AT-527 Descriptor: Helicase, Non-structural protein 7, Non-structural protein 8, ... Authors: Yan, L.M, Huang, Y.C, Ge, J, Liu, Z.Y, Gao, Y, Rao, Z.H, Lou, Z.Y. Deposit date: 2022-09-17 Release date: 2022-12-14 Last modified: 2023-10-25 Method: ELECTRON MICROSCOPY (3.38 Å) Cite: A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analog inhibitors. Cell, 185, 2022
7CO6	Binary complex of DNA polymerase Mu with 1-nt gapped DNA (templating thymine) Descriptor: CHLORIDE ION, DNA (5'-D(*CP*GP*GP*CP*TP*TP*AP*CP*G)-3'), DNA (5'-D(*CP*GP*TP*A)-3'), ... Authors: Guo, M, Zhao, Y. Deposit date: 2020-08-04 Release date: 2021-06-30 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Mechanism of genome instability mediated by human DNA polymerase mu misincorporation. Nat Commun, 12, 2021
7COD	Post insertion complex of DNA polymerase Mu (K438A/Q441A) with 1-nt gapped DNA Descriptor: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, DNA (5'-D(*CP*GP*GP*CP*TP*TP*AP*CP*G)-3'), DNA (5'-D(*CP*GP*TP*AP*G)-3'), ... Authors: Guo, M, Zhao, Y. Deposit date: 2020-08-04 Release date: 2021-06-30 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Mechanism of genome instability mediated by human DNA polymerase mu misincorporation. Nat Commun, 12, 2021
8GWK	SARS-CoV-2 RNA E-RTC complex with RMP-nsp9 and GMPPNP Descriptor: Helicase, MAGNESIUM ION, Non-structural protein 7, ... Authors: Yan, L.M, Huang, Y.C, Ge, J, Liu, Z.Y, Gao, Y, Rao, Z.H, Lou, Z.Y. Deposit date: 2022-09-17 Release date: 2024-02-28 Method: ELECTRON MICROSCOPY (2.72 Å) Cite: A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analog inhibitors. Cell, 185, 2022
3G86	Hepatitis C virus polymerase NS5B (BK 1-570) with thiazine inhibitor Descriptor: N-{3-[6-fluoro-1-(4-fluorobenzyl)-4-hydroxy-2-oxo-1,2-dihydroquinolin-3-yl]-1,1-dioxido-4H-1,4-benzothiazin-7-yl}methanesulfonamide, NICKEL (II) ION, RNA-directed RNA polymerase Authors: Harris, S.F, Ghate, M. Deposit date: 2009-02-11 Release date: 2009-09-08 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Non-nucleoside inhibitors of HCV polymerase NS5B. Part 2: Synthesis and structure-activity relationships of benzothiazine-substituted quinolinediones Bioorg.Med.Chem.Lett., 19, 2009
8RC4	Structure of Integrator-PP2A complex Descriptor: DSS1, Integrator complex subunit 1, Integrator complex subunit 10, ... Authors: Fianu, I, Ochmann, M, Walshe, J.L, Cramer, P. Deposit date: 2023-12-06 Release date: 2024-02-07 Last modified: 2024-05-15 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: Structural basis of Integrator-dependent RNA polymerase II termination. Nature, 629, 2024
8HSJ	Thermus thermophilus transcription termination factor Rho bound with ADP-BeF3 Descriptor: ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, MAGNESIUM ION, ... Authors: Murayama, Y, Ehara, H, Sekine, S. Deposit date: 2022-12-19 Release date: 2023-05-03 Last modified: 2024-07-03 Method: ELECTRON MICROSCOPY (3.6 Å) Cite: Structural basis of the transcription termination factor Rho engagement with transcribing RNA polymerase from Thermus thermophilus. Sci Adv, 9, 2023
2P1D	Crystal structure of dengue methyltransferase in complex with GTP and S-Adenosyl-L-homocysteine Descriptor: GUANOSINE-5'-MONOPHOSPHATE, S-ADENOSYL-L-HOMOCYSTEINE, SULFATE ION, ... Authors: Egloff, M.P, Benarooch, D, Marseilles Structural Genomics Program @ AFMB (MSGP) Deposit date: 2007-03-05 Release date: 2007-03-20 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.9 Å) Cite: An RNA cap (nucleoside-2'-O)-methyltransferase in the flavivirus RNA polymerase NS5: crystal structure and functional characterization EMBO J., 21, 2002
4LZG	Binary complex of human DNA Polymerase Mu with DNA Descriptor: CHLORIDE ION, DNA-directed DNA/RNA polymerase mu, GLYCEROL, ... Authors: Moon, A.F, Pryor, J.M, Ramsden, D.A, Kunkel, T.A, Bebenek, K, Pedersen, L.C. Deposit date: 2013-07-31 Release date: 2014-02-05 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (1.599 Å) Cite: Sustained active site rigidity during synthesis by human DNA polymerase mu. Nat.Struct.Mol.Biol., 21, 2014
3MF5	Hepatitis C virus polymerase NS5B (BK) with amide bioisostere thumb site inhibitor Descriptor: 3-[2-(trans-4-methylcyclohexyl)phenyl]-5-phenylthiophene-2-carboxylic acid, GLYCEROL, RNA-directed RNA polymerase Authors: Harris, S.F, Tavares, G, Ghate, M. Deposit date: 2010-04-01 Release date: 2010-07-28 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2 Å) Cite: Cyclic amide bioisosterism: Strategic application to the design and synthesis of HCV NS5B polymerase inhibitors. Bioorg.Med.Chem.Lett., 20, 2010
4M0A	Human DNA Polymerase Mu post-catalytic complex Descriptor: 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, DNA-directed DNA/RNA polymerase mu, ... Authors: Moon, A.F, Pryor, J.M, Ramsden, D.A, Kunkel, T.A, Bebenek, K, Pedersen, L.C. Deposit date: 2013-08-01 Release date: 2014-02-05 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Sustained active site rigidity during synthesis by human DNA polymerase mu. Nat.Struct.Mol.Biol., 21, 2014
2D3U	X-ray crystal structure of hepatitis C virus RNA dependent RNA polymerase in complex with non-nucleoside analogue inhibitor Descriptor: 5-(4-CYANOPHENYL)-3-{[(2-METHYLPHENYL)SULFONYL]AMINO}THIOPHENE-2-CARBOXYLIC ACID, polyprotein Authors: Biswal, B.K, Wang, M, Cherney, M.M, Chan, L, Yannopoulos, C.G, Bilimoria, D, Bedard, J, James, M.N.G. Deposit date: 2005-10-02 Release date: 2006-08-01 Last modified: 2017-10-11 Method: X-RAY DIFFRACTION (2 Å) Cite: Non-nucleoside Inhibitors Binding to Hepatitis C Virus NS5B Polymerase Reveal a Novel Mechanism of Inhibition J.Mol.Biol., 361, 2006

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