PDB: 2624 resultsInfo pagesStatus searchChemie searchBIRD

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5AIR	Structural analysis of mouse GSK3beta fused with LRP6 peptide. Descriptor: Low-density lipoprotein receptor-related protein 6,Glycogen synthase kinase-3 beta, MALONATE ION Authors: Kim, K.L. Deposit date: 2015-02-17 Release date: 2015-04-01 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2.53 Å) Cite: Structural Analysis of Mouse Gsk3 Beta Fused with Lrp6 Peptide Biodesign, 3, 2015
5H9U	Crystal structure of a thermostable methionine adenosyltransferase Descriptor: S-adenosylmethionine synthase Authors: Feng, Y, Wang, W. Deposit date: 2015-12-29 Release date: 2017-01-18 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (2.667 Å) Cite: Crystal structure of a thermostable methionine adenosyltransferase To Be Published
7KW7	Atomic cryoEM structure of Hsp90-Hsp70-Hop-GR Descriptor: ADENOSINE-5'-DIPHOSPHATE, Glucocorticoid receptor, Heat shock 70 kDa protein 1A, ... Authors: Wang, R.Y, Noddings, C.M, Kirschke, E, Myasnikov, A, Johnson, J.L, Agard, D.A. Deposit date: 2020-11-30 Release date: 2021-12-08 Last modified: 2024-05-29 Method: ELECTRON MICROSCOPY (3.57 Å) Cite: Structure of Hsp90-Hsp70-Hop-GR reveals the Hsp90 client-loading mechanism. Nature, 601, 2022
2C00	Crystal Structure of Biotin Carboxylase from Pseudomonas aeruginosa in apo form Descriptor: BIOTIN CARBOXYLASE, SULFATE ION Authors: Mochalkin, I. Deposit date: 2008-03-21 Release date: 2008-09-09 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Structural Evidence for Substrate-Induced Synergism and Half-Sites Reactivity in Biotin Carboxylase. Protein Sci., 17, 2008
1JDB	CARBAMOYL PHOSPHATE SYNTHETASE FROM ESCHERICHIA COLI Descriptor: ADENOSINE-5'-DIPHOSPHATE, CARBAMOYL PHOSPHATE SYNTHETASE, CHLORIDE ION, ... Authors: Thoden, J.B, Holden, H.M, Wesenberg, G, Raushel, F.M, Rayment, I. Deposit date: 1997-03-25 Release date: 1998-06-17 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.1 Å) Cite: The structure of carbamoyl phosphate synthetase determined to 2.1 A resolution. Acta Crystallogr.,Sect.D, 55, 1999
1ASY	CLASS II AMINOACYL TRANSFER RNA SYNTHETASES: CRYSTAL STRUCTURE OF YEAST ASPARTYL-TRNA SYNTHETASE COMPLEXED WITH TRNA ASP Descriptor: ASPARTYL-tRNA SYNTHETASE, T-RNA (75-MER) Authors: Ruff, M, Cavarelli, J, Rees, B, Krishnaswamy, S, Thierry, J.C, Moras, D. Deposit date: 1995-01-19 Release date: 1995-05-08 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Class II aminoacyl transfer RNA synthetases: crystal structure of yeast aspartyl-tRNA synthetase complexed with tRNA(Asp). Science, 252, 1991
2W70	Crystal structure of Biotin carboxylase from E. coli in complex with the amino-thiazole-pyrimidine fragment Descriptor: 4-(2-amino-1,3-thiazol-4-yl)pyrimidin-2-amine, BIOTIN CARBOXYLASE, CHLORIDE ION Authors: Mochalkin, I, Miller, J.R. Deposit date: 2008-12-19 Release date: 2009-05-19 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (1.77 Å) Cite: Discovery of Antibacterial Biotin Carboxylase Inhibitors by Virtual Screening and Fragment-Based Approaches. Acs Chem.Biol., 4, 2009
2W6N	Crystal structure of Biotin carboxylase from E. coli in complex with amino-oxazole fragment series Descriptor: 2-AMINO-N,N-BIS(PHENYLMETHYL)-1,3-OXAZOLE-5-CARBOXAMIDE, BIOTIN CARBOXYLASE, CHLORIDE ION Authors: Mochalkin, I, Miller, J.R. Deposit date: 2008-12-18 Release date: 2009-05-19 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (1.87 Å) Cite: Discovery of Antibacterial Biotin Carboxylase Inhibitors by Virtual Screening and Fragment-Based Approaches. Acs Chem.Biol., 4, 2009
2W6Q	Crystal structure of Biotin carboxylase from E. coli in complex with the triazine-2,4-diamine fragment Descriptor: 6-(2-phenoxyethoxy)-1,3,5-triazine-2,4-diamine, BIOTIN CARBOXYLASE, CHLORIDE ION Authors: Mochalkin, I, Miller, J.R. Deposit date: 2008-12-18 Release date: 2009-05-19 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Discovery of Antibacterial Biotin Carboxylase Inhibitors by Virtual Screening and Fragment-Based Approaches. Acs Chem.Biol., 4, 2009
2W71	Crystal structure of Biotin carboxylase from E. coli in complex with the imidazole-pyrimidine inhibitor Descriptor: 4-[1-(2,6-dichlorobenzyl)-2-methyl-1H-imidazol-4-yl]pyrimidin-2-amine, BIOTIN CARBOXYLASE, CHLORIDE ION Authors: Mochalkin, I, Miller, J.R. Deposit date: 2008-12-19 Release date: 2009-05-19 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (1.99 Å) Cite: Discovery of Antibacterial Biotin Carboxylase Inhibitors by Virtual Screening and Fragment-Based Approaches. Acs Chem.Biol., 4, 2009
2W6P	Crystal structure of Biotin carboxylase from E. coli in complex with 5-Methyl-6-phenyl-quinazoline-2,4-diamine Descriptor: 5-methyl-6-phenylquinazoline-2,4-diamine, ACETYL-COA CARBOXYLASE Authors: Mochalkin, I, Miller, J.R. Deposit date: 2008-12-18 Release date: 2009-05-19 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Discovery of Antibacterial Biotin Carboxylase Inhibitors by Virtual Screening and Fragment-Based Approaches. Acs Chem.Biol., 4, 2009
2W6M	Crystal structure of Biotin carboxylase from E. coli in complex with amino-oxazole fragment series Descriptor: (2-AMINO-1,3-OXAZOL-5-YL)-(3-BROMOPHENYL)METHANONE, BIOTIN CARBOXYLASE, CHLORIDE ION Authors: Mochalkin, I, Miller, J.R. Deposit date: 2008-12-18 Release date: 2009-05-19 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2 Å) Cite: Discovery of Antibacterial Biotin Carboxylase Inhibitors by Virtual Screening and Fragment-Based Approaches. Acs Chem.Biol., 4, 2009
6HXG	PDX1.2/PDX1.3 complex (intermediate) Descriptor: Pyridoxal 5'-phosphate synthase subunit PDX1.3, Pyridoxal 5'-phosphate synthase-like subunit PDX1.2, SULFATE ION Authors: Robinson, G.C, Kaufmann, M, Roux, C, Martinez-Font, J, Hothorn, M, Thore, S, Fitzpatrick, T.B. Deposit date: 2018-10-17 Release date: 2019-04-17 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Crystal structure of the pseudoenzyme PDX1.2 in complex with its cognate enzyme PDX1.3: a total eclipse. Acta Crystallogr D Struct Biol, 75, 2019
1P5E	The structure of phospho-CDK2/cyclin A in complex with the inhibitor 4,5,6,7-tetrabromobenzotriazole (TBS) Descriptor: 4,5,6,7-TETRABROMOBENZOTRIAZOLE, Cell division protein kinase 2, Cyclin A2 Authors: De Moliner, E, Brown, N.R, Johnson, L.N. Deposit date: 2003-04-26 Release date: 2003-07-01 Last modified: 2016-12-21 Method: X-RAY DIFFRACTION (2.22 Å) Cite: Alternative binding modes of an inhibitor to two different kinases Eur.J.Biochem., 270, 2003
2OI4	Crystal structure of human PIM1 in complex with fluorinated ruthenium pyridocarbazole Descriptor: 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CHLORIDE ION, ... Authors: Maksimoska, J, Meggers, E. Deposit date: 2007-01-10 Release date: 2007-04-10 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Ruthenium half-sandwich complexes as protein kinase inhibitors: derivatization of the pyridocarbazole pharmacophore ligand. Org.Biomol.Chem., 5, 2007
4DIT	Crystal Structure of GSK3beta in complex with a Imidazopyridine inhibitor Descriptor: Glycogen synthase kinase-3 beta, N-(pyridin-3-yl)-2-(thiophen-3-yl)-3H-imidazo[4,5-b]pyridine-7-carboxamide Authors: Kim, H.T, Lee, S.C, Chang, H.J. Deposit date: 2012-01-31 Release date: 2012-02-15 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Crystal Structure of GSK3beta in complex with a Imidazolopyridine inhibitor To be Published
8FFW	Cryo-EM structure of the GR-Hsp90-FKBP51 complex Descriptor: ADENOSINE-5'-TRIPHOSPHATE, DEXAMETHASONE, Glucocorticoid receptor, ... Authors: Noddings, C.M, Agard, D.A. Deposit date: 2022-12-10 Release date: 2023-11-01 Last modified: 2023-12-20 Method: ELECTRON MICROSCOPY (3.23 Å) Cite: Cryo-EM reveals how Hsp90 and FKBP immunophilins co-regulate the glucocorticoid receptor. Nat.Struct.Mol.Biol., 30, 2023
8FFV	Cryo-EM structure of the GR-Hsp90-FKBP52 complex Descriptor: ADENOSINE-5'-TRIPHOSPHATE, DEXAMETHASONE, Glucocorticoid receptor, ... Authors: Noddings, C.M, Agard, D.A. Deposit date: 2022-12-10 Release date: 2023-11-01 Last modified: 2023-12-20 Method: ELECTRON MICROSCOPY (3.01 Å) Cite: Cryo-EM reveals how Hsp90 and FKBP immunophilins co-regulate the glucocorticoid receptor. Nat.Struct.Mol.Biol., 30, 2023
7RRO	Structure of the 48-nm repeat doublet microtubule from bovine tracheal cilia Descriptor: Armadillo repeat containing 4, Chromosome 3 C1orf194 homolog, Cilia and flagella associated protein 161, ... Authors: Gui, M, Anderson, J.R, Botsch, J.J, Meleppattu, S, Singh, S.K, Zhang, Q, Brown, A. Deposit date: 2021-08-10 Release date: 2021-10-27 Last modified: 2024-06-05 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: De novo identification of mammalian ciliary motility proteins using cryo-EM. Cell, 184, 2021
8CIE	Crystal structure of the human CDKL5 kinase domain with compound YL-354 Descriptor: 4-[[3,5-bis(fluoranyl)phenyl]carbonylamino]-~{N}-piperidin-4-yl-1~{H}-pyrazole-3-carboxamide, Cyclin-dependent kinase-like 5, SULFATE ION Authors: Richardson, W, Chen, X, Newman, J.A, Bakshi, S, Lakshminarayana, B, Brooke, L, Bullock, A.N. Deposit date: 2023-02-09 Release date: 2023-06-14 Last modified: 2024-03-27 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Discovery of a Potent and Selective CDKL5/GSK3 Chemical Probe That Is Neuroprotective. Acs Chem Neurosci, 14, 2023
3SDB	Crystal structure of C176A mutant of glutamine-dependent NAD+ synthetase from M. tuberculosis in apo form Descriptor: Glutamine-dependent NAD(+) synthetase Authors: Chuenchor, W, Gerratana, B. Deposit date: 2011-06-09 Release date: 2012-04-11 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.0017 Å) Cite: Regulation of the intersubunit ammonia tunnel in Mycobacterium tuberculosis glutamine-dependent NAD+ synthetase. Biochem.J., 443, 2012
8EZA	NHEJ Long-range complex with PAXX Descriptor: ADENOSINE-5'-TRIPHOSPHATE, DNA (30-MER), DNA (31-MER), ... Authors: Chen, S, He, Y. Deposit date: 2022-10-31 Release date: 2023-06-14 Last modified: 2024-06-19 Method: ELECTRON MICROSCOPY (4.39 Å) Cite: Cryo-EM visualization of DNA-PKcs structural intermediates in NHEJ. Sci Adv, 9, 2023
3SZG	Crystal structure of C176A glutamine-dependent NAD+ synthetase from M. tuberculosis bound to AMP/PPi and NaAD+ Descriptor: ADENOSINE MONOPHOSPHATE, GLYCEROL, Glutamine-dependent NAD(+) synthetase, ... Authors: Chuenchor, W, Doukov, T, Gerratana, B. Deposit date: 2011-07-19 Release date: 2012-04-11 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.25 Å) Cite: Regulation of the intersubunit ammonia tunnel in Mycobacterium tuberculosis glutamine-dependent NAD+ synthetase. Biochem.J., 443, 2012
3SYT	Crystal structure of glutamine-dependent NAD+ synthetase from M. tuberculosis bound to AMP/PPi, NAD+, and glutamate Descriptor: ADENOSINE MONOPHOSPHATE, GLUTAMIC ACID, GLYCEROL, ... Authors: Chuenchor, W, Gerratana, B. Deposit date: 2011-07-18 Release date: 2012-04-11 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.6511 Å) Cite: Regulation of the intersubunit ammonia tunnel in Mycobacterium tuberculosis glutamine-dependent NAD+ synthetase. Biochem.J., 443, 2012
8K5T	The structure of EntE with2-methyl-3-chloro-benzoic acid sulfamoyl adenosine Descriptor: Enterobactin synthase component E, [(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl ~{N}-(3-chloranyl-2-methyl-phenyl)carbonylsulfamate Authors: Miyanaga, A, Ishikawa, F. Deposit date: 2023-07-24 Release date: 2024-07-31 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Reprogrammed aryl acid adenylation domain with an enlarged substrate binding pocket To be published

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