6CAM
 
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6SUY
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6GHD
 | | Structural analysis of the ternary complex between lamin A/C, BAF and emerin identifies an interface disrupted in autosomal recessive progeroid diseases | | Descriptor: | 1,2-ETHANEDIOL, Barrier-to-autointegration factor, Emerin, ... | | Authors: | Samson, C, Petitalot, A, Celli, F, Herrada, I, Ropars, V, Ledu, M.H, Nhiri, N, Arteni, A.A, Buendia, B, ZinnJustin, S. | | Deposit date: | 2018-05-07 | | Release date: | 2018-08-08 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Structural analysis of the ternary complex between lamin A/C, BAF and emerin identifies an interface disrupted in autosomal recessive progeroid diseases.
Nucleic Acids Res., 46, 2018
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3KQK
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7ZRX
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7ZSX
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7ZRW
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7ZSV
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7ZS4
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7ZVZ
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7ZTI
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7ZPS
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4Q9S
 | | Crystal Structure of human Focal Adhesion Kinase (Fak) bound to Compound1 (3,5-DIHYDRO[1,2,4]TRIAZINO[3,4-C][1,4]BENZOXAZIN-2(1H)-ONE) | | Descriptor: | 3,5-dihydro[1,2,4]triazino[3,4-c][1,4]benzoxazin-2(1H)-one, Focal adhesion kinase 1 | | Authors: | Argiriadi, M.A, George, D.M. | | Deposit date: | 2014-05-01 | | Release date: | 2014-07-02 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.07 Å) | | Cite: | Discovery of Selective and Orally Bioavailable Protein Kinase C theta (PKC theta ) Inhibitors from a Fragment Hit.
J.Med.Chem., 58, 2015
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3L9H
 | | X-ray structure of mitotic kinesin-5 (KSP, KIF11, Eg5)in complex with the hexahydro-2H-pyrano[3,2-c]quinoline EMD 534085 | | Descriptor: | 1-[2-(dimethylamino)ethyl]-3-{[(2R,4aS,5R,10bS)-5-phenyl-9-(trifluoromethyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-2-yl]methyl}urea, ADENOSINE-5'-DIPHOSPHATE, Kinesin-like protein KIF11 | | Authors: | Knoechel, T. | | Deposit date: | 2010-01-05 | | Release date: | 2010-03-02 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | The discovery and optimization of hexahydro-2H-pyrano[3,2-c]quinolines (HHPQs) as potent and selective inhibitors of the mitotic kinesin-5.
Bioorg.Med.Chem.Lett., 20, 2010
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9J8M
 | | Cryo-EM structure of BAF-Lamin A/C IgF-nucleosome complex (High mobility complex) | | Descriptor: | Barrier-to-autointegration factor, DNA (193-MER), Histone H2A type 1-B/E, ... | | Authors: | Horikoshi, N, Miyake, R, Sogawa-Fujiwara, C, Ogasawara, M, Takizawa, Y, Kurumizaka, H. | | Deposit date: | 2024-08-21 | | Release date: | 2025-02-26 | | Last modified: | 2025-07-02 | | Method: | ELECTRON MICROSCOPY (3.82 Å) | | Cite: | Cryo-EM structures of the BAF-Lamin A/C complex bound to nucleosomes.
Nat Commun, 16, 2025
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9J8O
 | | Cryo-EM structure of BAF-Lamin A/C IgF-H1-nucleosome complex | | Descriptor: | Barrier-to-autointegration factor, DNA (193-MER), Histone H1.1, ... | | Authors: | Horikoshi, N, Miyake, R, Sogawa-Fujiwara, C, Ogasawara, M, Takizawa, Y, Kurumizaka, H. | | Deposit date: | 2024-08-21 | | Release date: | 2025-02-26 | | Last modified: | 2025-07-02 | | Method: | ELECTRON MICROSCOPY (4.05 Å) | | Cite: | Cryo-EM structures of the BAF-Lamin A/C complex bound to nucleosomes.
Nat Commun, 16, 2025
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9J8N
 | | Cryo-EM structure of BAF-Lamin A/C IgF-nucleosome complex (Low mobility complex) | | Descriptor: | Barrier-to-autointegration factor, DNA (193-MER), Histone H2A type 1-B/E, ... | | Authors: | Horikoshi, N, Miyake, R, Sogawa-Fujiwara, C, Ogasawara, M, Takizawa, Y, Kurumizaka, H. | | Deposit date: | 2024-08-21 | | Release date: | 2025-02-26 | | Last modified: | 2025-07-02 | | Method: | ELECTRON MICROSCOPY (7.14 Å) | | Cite: | Cryo-EM structures of the BAF-Lamin A/C complex bound to nucleosomes.
Nat Commun, 16, 2025
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6I7R
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3KQL
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7ZQZ
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7ZSW
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8JAV
 | | Structure of CRL2APPBP2 bound with the C-degron of MRPL28 (tetramer) | | Descriptor: | Amyloid protein-binding protein 2, Cullin-2, E3 ubiquitin-protein ligase RBX1, ... | | Authors: | Zhao, S, Zhang, K, Xu, C. | | Deposit date: | 2023-05-07 | | Release date: | 2023-10-18 | | Last modified: | 2023-10-25 | | Method: | ELECTRON MICROSCOPY (3.44 Å) | | Cite: | Molecular basis for C-degron recognition by CRL2 APPBP2 ubiquitin ligase.
Proc.Natl.Acad.Sci.USA, 120, 2023
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8JAU
 | | Structure of CRL2APPBP2 bound with the C-degron of MRPL28 (dimer) | | Descriptor: | Amyloid protein-binding protein 2, Cullin-2, Elongin-B, ... | | Authors: | Zhao, S, Zhang, K, Xu, C. | | Deposit date: | 2023-05-07 | | Release date: | 2023-10-18 | | Last modified: | 2025-07-16 | | Method: | ELECTRON MICROSCOPY (3.22 Å) | | Cite: | Molecular basis for C-degron recognition by CRL2 APPBP2 ubiquitin ligase.
Proc.Natl.Acad.Sci.USA, 120, 2023
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6I7Q
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5Y6G
 | | PilZ domain with c-di-GMP of YcgR from Escherichia coli | | Descriptor: | 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), Flagellar brake protein YcgR, SULFATE ION | | Authors: | Hou, Y.J, Wang, D.C, Li, D.F. | | Deposit date: | 2017-08-11 | | Release date: | 2018-07-18 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structural insights into the mechanism of c-di-GMP-bound YcgR regulating flagellar motility inEscherichia coli.
J.Biol.Chem., 295, 2020
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