PDB: 682 resultsInfo pagesStatus searchChemie searchBIRD

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6QS4	Two-Step Activation Mechanism of the ClpB Disaggregase for Sequential Substrate Threading by the Main ATPase Motor. Descriptor: ADENOSINE-5'-DIPHOSPHATE, Chaperone protein ClpB, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... Authors: Deville, C, Saibil, H.R. Deposit date: 2019-02-20 Release date: 2019-07-03 Last modified: 2024-05-15 Method: ELECTRON MICROSCOPY (4.2 Å) Cite: Two-Step Activation Mechanism of the ClpB Disaggregase for Sequential Substrate Threading by the Main ATPase Motor. Cell Rep, 27, 2019
5FTJ	Cryo-EM structure of human p97 bound to UPCDC30245 inhibitor Descriptor: 1-(3-(5-FLUORO-1H-INDOL-2-YL)PHENYL)PIPERIDIN-4-YL)(2-(4-ISOPROPYL-PIPERAZIN1-YL)ETHYL)-CARBAMATE, ADENOSINE-5'-DIPHOSPHATE, TRANSITIONAL ENDOPLASMIC RETICULUM ATPASE Authors: Banerjee, S, Bartesaghi, A, Merk, A, Rao, P, Bulfer, S.L, Yan, Y, Green, N, Mroczkowski, B, Neitz, R.J, Wipf, P, Falconieri, V, Deshaies, R.J, Milne, J.L.S, Huryn, D, Arkin, M, Subramaniam, S. Deposit date: 2016-01-14 Release date: 2016-01-27 Last modified: 2024-05-08 Method: ELECTRON MICROSCOPY (2.3 Å) Cite: 2.3 A Resolution Cryo-Em Structure of Human P97 and Mechanism of Allosteric Inhibition Science, 351, 2016
5KWA	complete structure of the Mycobacterium tuberculosis proteasomal ATPase Mpa Descriptor: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Proteasome-associated ATPase Authors: Wang, T, WU, Y.J. Deposit date: 2016-07-17 Release date: 2017-06-07 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Mycobacterium tuberculosis proteasomal ATPase Mpa has a beta-grasp domain that hinders docking with the proteasome core protease Mol. Microbiol., 105, 2017
5FTL	Cryo-EM structure of human p97 bound to ATPgS (Conformation I) Descriptor: ADENOSINE-5'-DIPHOSPHATE, TRANSITIONAL ENDOPLASMIC RETICULUM ATPASE Authors: Banerjee, S, Bartesaghi, A, Merk, A, Rao, P, Bulfer, S.L, Yan, Y, Green, N, Mroczkowski, B, Neitz, R.J, Wipf, P, Falconieri, V, Deshaies, R.J, Milne, J.L.S, Huryn, D, Arkin, M, Subramaniam, S. Deposit date: 2016-01-14 Release date: 2016-01-27 Last modified: 2024-05-08 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: 2.3 A Resolution Cryo-Em Structure of Human P97 and Mechanism of Allosteric Inhibition Science, 351, 2016
5FTN	Cryo-EM structure of human p97 bound to ATPgS (Conformation III) Descriptor: MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, TRANSITIONAL ENDOPLASMIC RETICULUM ATPASE Authors: Banerjee, S, Bartesaghi, A, Merk, A, Rao, P, Bulfer, S.L, Yan, Y, Green, N, Mroczkowski, B, Neitz, R.J, Wipf, P, Falconieri, V, Deshaies, R.J, Milne, J.L.S, Huryn, D, Arkin, M, Subramaniam, S. Deposit date: 2016-01-14 Release date: 2016-01-27 Last modified: 2024-05-08 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: 2.3 A Resolution Cryo-Em Structure of Human P97 and Mechanism of Allosteric Inhibition Science, 351, 2016
5KIW	p97 ND1-L198W in complex with VIMP Descriptor: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Selenoprotein S, ... Authors: Tang, W.K, Xia, D. Deposit date: 2016-06-17 Release date: 2018-03-07 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (3.41 Å) Cite: Structural basis for nucleotide-modulated p97 association with the ER membrane. Cell Discov, 3, 2017
6QS7	ClpB (DWB and K476C mutant) bound to casein in presence of ATPgammaS - state KC-2A Descriptor: ADENOSINE-5'-DIPHOSPHATE, Chaperone protein ClpB, MAGNESIUM ION, ... Authors: Deville, C, Saibil, H.R. Deposit date: 2019-02-20 Release date: 2019-07-03 Last modified: 2024-05-15 Method: ELECTRON MICROSCOPY (3.8 Å) Cite: Two-Step Activation Mechanism of the ClpB Disaggregase for Sequential Substrate Threading by the Main ATPase Motor. Cell Rep, 27, 2019
6QS6	ClpB (DWB and K476C mutant) bound to casein in presence of ATPgammaS - state KC-1 Descriptor: ADENOSINE-5'-DIPHOSPHATE, Chaperone protein ClpB, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... Authors: Deville, C, Saibil, H.R. Deposit date: 2019-02-20 Release date: 2019-07-03 Last modified: 2024-05-15 Method: ELECTRON MICROSCOPY (3.9 Å) Cite: Two-Step Activation Mechanism of the ClpB Disaggregase for Sequential Substrate Threading by the Main ATPase Motor. Cell Rep, 27, 2019
6SH4	Structure of the Apo1 state of the heptameric Bcs1 AAA-ATPase. Descriptor: Mitochondrial chaperone BCS1 Authors: Kater, L, Beckmann, R. Deposit date: 2019-08-05 Release date: 2020-02-05 Last modified: 2024-05-22 Method: ELECTRON MICROSCOPY (4.4 Å) Cite: Structure of the Bcs1 AAA-ATPase suggests an airlock-like translocation mechanism for folded proteins. Nat.Struct.Mol.Biol., 27, 2020
6PXL	3.74 Angstroms resolution structure of HlsU with an axial-channel plug Descriptor: ADENOSINE-5'-DIPHOSPHATE, ATP-dependent protease ATPase subunit HslU, MAGNESIUM ION, ... Authors: Baytshtok, V, Grant, R.A, Sauer, R.T. Deposit date: 2019-07-26 Release date: 2020-07-29 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (3.741 Å) Cite: Heat activates the AAA+ HslUV protease by melting an axial autoinhibitory plug. Cell Rep, 34, 2021
6PXK	3.65 Angstroms resolution structure of HslU with an axial-channel plug Descriptor: ADENOSINE-5'-DIPHOSPHATE, ATP-dependent protease ATPase subunit HslU, SULFATE ION, ... Authors: Baytshtok, V, Grant, R.A, Sauer, R.T. Deposit date: 2019-07-26 Release date: 2020-07-29 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (3.647 Å) Cite: Heat activates the AAA+ HslUV protease by melting an axial autoinhibitory plug. Cell Rep, 34, 2021
5FTM	Cryo-EM structure of human p97 bound to ATPgS (Conformation II) Descriptor: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... Authors: Banerjee, S, Bartesaghi, A, Merk, A, Rao, P, Bulfer, S.L, Yan, Y, Green, N, Mroczkowski, B, Neitz, R.J, Wipf, P, Falconieri, V, Deshaies, R.J, Milne, J.L.S, Huryn, D, Arkin, M, Subramaniam, S. Deposit date: 2016-01-14 Release date: 2016-01-27 Last modified: 2024-05-08 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: 2.3 A Resolution Cryo-Em Structure of Human P97 and Mechanism of Allosteric Inhibition Science, 351, 2016
6SH5	Structure of the Apo2 state of the heptameric Bcs1 AAA-ATPase Descriptor: Mitochondrial chaperone BCS1 Authors: Kater, L, Beckmann, R. Deposit date: 2019-08-05 Release date: 2020-02-05 Last modified: 2024-05-22 Method: ELECTRON MICROSCOPY (4.6 Å) Cite: Structure of the Bcs1 AAA-ATPase suggests an airlock-like translocation mechanism for folded proteins. Nat.Struct.Mol.Biol., 27, 2020
5FTK	Cryo-EM structure of human p97 bound to ADP Descriptor: ADENOSINE-5'-DIPHOSPHATE, TRANSITIONAL ENDOPLASMIC RETICULUM ATPASE Authors: Banerjee, S, Bartesaghi, A, Merk, A, Rao, P, Bulfer, S.L, Yan, Y, Green, N, Mroczkowski, B, Neitz, R.J, Wipf, P, Falconieri, V, Deshaies, R.J, Milne, J.L.S, Huryn, D, Arkin, M, Subramaniam, S. Deposit date: 2016-01-14 Release date: 2016-01-27 Last modified: 2024-05-08 Method: ELECTRON MICROSCOPY (2.4 Å) Cite: 2.3 A Resolution Cryo-Em Structure of Human P97 and Mechanism of Allosteric Inhibition Science, 351, 2016
5L4G	The human 26S proteasome at 3.9 A Descriptor: 26S protease regulatory subunit 10B, 26S protease regulatory subunit 4, 26S protease regulatory subunit 6A, ... Authors: Schweitzer, A, Aufderheide, A, Rudack, T, Beck, F. Deposit date: 2016-05-25 Release date: 2016-09-07 Last modified: 2024-05-08 Method: ELECTRON MICROSCOPY (3.9 Å) Cite: Structure of the human 26S proteasome at a resolution of 3.9 angstrom. Proc.Natl.Acad.Sci.USA, 113, 2016
5KNE	CryoEM Reconstruction of Hsp104 Hexamer Descriptor: Heat shock protein 104, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER Authors: Yokom, A.L, Gates, S.N, Jackrel, M.E, Mack, K.L, Su, M, Shorter, J, Southworth, D.R. Deposit date: 2016-06-28 Release date: 2016-07-27 Last modified: 2024-03-06 Method: ELECTRON MICROSCOPY (5.64 Å) Cite: Spiral architecture of the Hsp104 disaggregase reveals the basis for polypeptide translocation. Nat.Struct.Mol.Biol., 23, 2016
5JI2	HslU L199Q in HslUV complex Descriptor: ADENOSINE-5'-DIPHOSPHATE, ATP-dependent protease ATPase subunit HslU, ATP-dependent protease subunit HslV, ... Authors: Grant, R.A, Sauer, R.T, Schmitz, K.R, Baytshtok, V. Deposit date: 2016-04-21 Release date: 2016-11-30 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (3.307 Å) Cite: A Structurally Dynamic Region of the HslU Intermediate Domain Controls Protein Degradation and ATP Hydrolysis. Structure, 24, 2016
5GJQ	Structure of the human 26S proteasome bound to USP14-UbAl Descriptor: 26S protease regulatory subunit 10B, 26S protease regulatory subunit 4, 26S protease regulatory subunit 6A, ... Authors: Huang, X.L, Luan, B, Wu, J.P, Shi, Y.G. Deposit date: 2016-07-01 Release date: 2016-08-17 Last modified: 2019-11-06 Method: ELECTRON MICROSCOPY (4.5 Å) Cite: An atomic structure of the human 26S proteasome. Nat. Struct. Mol. Biol., 23, 2016
5KZF	Crystal structure of near full-length hexameric Mycobacterium tuberculosis proteasomal ATPase Mpa in apo form Descriptor: Proteasome-associated ATPase Authors: Li, H, Hu, K, Yang, S, Bai, L. Deposit date: 2016-07-25 Release date: 2017-05-17 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (3.49 Å) Cite: Mycobacterium tuberculosis proteasomal ATPase Mpa has a beta-grasp domain that hinders docking with the proteasome core protease. Mol. Microbiol., 105, 2017
5KIY	p97 ND1-A232E in complex with VIMP Descriptor: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Selenoprotein S, ... Authors: Tang, W.K, Xia, D. Deposit date: 2016-06-17 Release date: 2017-12-20 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.79 Å) Cite: Structural basis for nucleotide-modulated p97 association with the ER membrane. Cell Discov, 3, 2017
5JI3	HslUV complex Descriptor: 2'-DEOXYADENOSINE-5'-DIPHOSPHATE, ATP-dependent protease ATPase subunit HslU, ATP-dependent protease subunit HslV Authors: Grant, R.A, Sauer, R.T, Schmitz, K.R, Baytshtok, V. Deposit date: 2016-04-21 Release date: 2016-12-07 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (3 Å) Cite: A Structurally Dynamic Region of the HslU Intermediate Domain Controls Protein Degradation and ATP Hydrolysis. Structure, 24, 2016
5IFW	Quantitative interaction mapping reveals an extended ubiquitin regulatory domain in ASPL that disrupts functional p97 hexamers and induces cell death Descriptor: ADENOSINE-5'-DIPHOSPHATE, Tether containing UBX domain for GLUT4, Transitional endoplasmic reticulum ATPase Authors: Roske, Y, Heinemann, U. Deposit date: 2016-02-26 Release date: 2016-10-26 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (3.4 Å) Cite: Quantitative interaction mapping reveals an extended UBX domain in ASPL that disrupts functional p97 hexamers. Nat Commun, 7, 2016
3WHL	Crystal structure of Nas2 N-terminal domain complexed with PAN-Rpt5C chimera Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Probable 26S proteasome regulatory subunit p27, Proteasome-activating nucleotidase, ... Authors: Satoh, T, Saeki, Y, Hiromoto, T, Wang, Y.-H, Uekusa, Y, Yagi, H, Yoshihara, H, Yagi-Utsumi, M, Mizushima, T, Tanaka, K, Kato, K. Deposit date: 2013-08-26 Release date: 2014-03-26 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (4 Å) Cite: Structural basis for proteasome formation controlled by an assembly chaperone nas2. Structure, 22, 2014
7OAT	Structural basis for targeted p97 remodelling by ASPL as prerequisite for p97 trimethylation by METTL21D Descriptor: 1,2-ETHANEDIOL, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... Authors: Petrovic, S, Heinemann, U, Roske, Y. Deposit date: 2021-04-20 Release date: 2022-08-03 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.995 Å) Cite: Structural remodeling of AAA+ ATPase p97 by adaptor protein ASPL facilitates posttranslational methylation by METTL21D. Proc.Natl.Acad.Sci.USA, 120, 2023
7P0M	Human mitochondrial Lon protease with substrate in the ATPase and protease domains Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Lon protease homolog, ... Authors: Valentin Gese, G, Shahzad, S, Hallberg, B.M. Deposit date: 2021-06-30 Release date: 2021-08-11 Last modified: 2024-07-17 Method: ELECTRON MICROSCOPY (2.75 Å) Cite: A dual allosteric pathway drives human mitochondrial Lon To Be Published

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