3AAI
 
 | |
3H3U
 | | Crystal structure of CRP (cAMP receptor Protein) from Mycobacterium tuberculosis | | Descriptor: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY CRP/FNR-FAMILY), SULFATE ION | | Authors: | Kumar, P, Joshi, D.C, Akif, M, Akhter, Y, Hasnain, S.E, Mande, S.C. | | Deposit date: | 2009-04-17 | | Release date: | 2010-02-02 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Mapping conformational transitions in cyclic AMP receptor protein: crystal structure and normal-mode analysis of Mycobacterium tuberculosis apo-cAMP receptor protein
Biophys.J., 98, 2010
|
|
5DOI
 | | Crystal structure of Tetrahymena p45N and p19 | | Descriptor: | Telomerase associated protein p45, Telomerase-associated protein 19 | | Authors: | Wan, B, Tang, T, Wu, J, Lei, M. | | Deposit date: | 2015-09-11 | | Release date: | 2015-11-25 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | The Tetrahymena telomerase p75-p45-p19 subcomplex is a unique CST complex
Nat.Struct.Mol.Biol., 22, 2015
|
|
5DLO
 | | S. aureus MazF in complex with substrate analogue | | Descriptor: | CHLORIDE ION, DNA substrate analogue AUACAUA, Endoribonuclease MazF | | Authors: | Zorzini, V, Loris, R. | | Deposit date: | 2015-09-07 | | Release date: | 2016-09-28 | | Last modified: | 2024-07-24 | | Method: | X-RAY DIFFRACTION (1.401 Å) | | Cite: | Substrate recognition, regulation mechanism and activity regulation of MazF mRNA interferase.
To Be Published
|
|
5DLS
 | | Identification of Novel, in vivo Active Chk1 Inhibitors Utilizing Structure Guided Drug Design | | Descriptor: | 1-benzyl-N-(5-{5-[3-(dimethylamino)-2,2-dimethylpropoxy]-1H-indol-2-yl}-6-oxo-1,6-dihydropyridin-3-yl)-1H-pyrazole-4-carboxamide, SULFATE ION, Serine/threonine-protein kinase Chk1 | | Authors: | Massey, A.J, Stokes, S, Browne, H, Foloppe, N, Fiumana, A, Scrace, S, Fallowfield, M, Bedford, S, Webb, P, Baker, L.M, Christie, M, Drysdale, M.J, Wood, M. | | Deposit date: | 2015-09-07 | | Release date: | 2015-10-14 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Identification of novel, in vivo active Chk1 inhibitors utilizing structure guided drug design.
Oncotarget, 6, 2015
|
|
5DOF
 | | Crystal structure of Tetrahymena p19 | | Descriptor: | Telomerase-associated protein 19 | | Authors: | Wan, B, Tang, T, Wu, J, Lei, M. | | Deposit date: | 2015-09-11 | | Release date: | 2015-11-25 | | Last modified: | 2015-12-23 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | The Tetrahymena telomerase p75-p45-p19 subcomplex is a unique CST complex.
Nat.Struct.Mol.Biol., 22, 2015
|
|
7RWK
 | | Structure of Cap5 from Asticcacaulis sp. | | Descriptor: | MAGNESIUM ION, SAVED domain-containing protein, ZINC ION | | Authors: | Huang, R.H, Fatma, S, Chakravarti, A. | | Deposit date: | 2021-08-20 | | Release date: | 2021-11-10 | | Last modified: | 2024-05-22 | | Method: | X-RAY DIFFRACTION (2.39 Å) | | Cite: | Molecular mechanisms of the CdnG-Cap5 antiphage defense system employing 3',2'-cGAMP as the second messenger.
Nat Commun, 12, 2021
|
|
7RWM
 | | Structure of Cap5 from Lactococcus lactis | | Descriptor: | SAVED domain-containing protein, ZINC ION | | Authors: | Huang, R.H, Fatma, S, Chakravarti, A. | | Deposit date: | 2021-08-20 | | Release date: | 2021-11-10 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (3.4 Å) | | Cite: | Molecular mechanisms of the CdnG-Cap5 antiphage defense system employing 3',2'-cGAMP as the second messenger.
Nat Commun, 12, 2021
|
|
2ZKZ
 | |
1JWL
 | | Structure of the Dimeric lac Repressor/Operator O1/ONPF Complex | | Descriptor: | 2-nitrophenyl beta-D-fucopyranoside, 5'-D(*AP*GP*AP*AP*T*TP*GP*TP*GP*AP*GP*CP*GP*GP*AP*TP*AP*AP*CP*AP*AP*TP*T)-3', 5'-D(*TP*AP*AP*TP*TP*GP*TP*TP*AP*TP*CP*CP*GP*CP*TP*CP*AP*CP*AP*AP*TP*TP*C)-3', ... | | Authors: | Bell, C.E, Lewis, M. | | Deposit date: | 2001-09-04 | | Release date: | 2001-10-05 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (4 Å) | | Cite: | Crystallographic analysis of Lac repressor bound to natural operator O1.
J.Mol.Biol., 312, 2001
|
|
5FRM
 | | Crystal structure of the Prototype Foamy Virus (PFV) intasome in complex with magnesium and the INSTI XZ384 (compound 4a) | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 4-azanylidene-N-[[2,4-bis(fluoranyl)phenyl]methyl]-1-oxidanyl-2-oxidanylidene-1,8-naphthyridine-3-carboxamide, 5'-D(*AP*TP*TP*GP*TP*CP*AP*TP*GP*GP*AP*AP*TP*TP *TP*CP*GP*CP*A)-3', ... | | Authors: | Maskell, D.P, Pye, V.E, Cherepanov, P. | | Deposit date: | 2015-12-18 | | Release date: | 2016-02-17 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.58 Å) | | Cite: | HIV-1 Integrase Strand Transfer Inhibitors with Reduced Susceptibility to Drug Resistant Mutant Integrases.
Acs Chem.Biol., 11, 2016
|
|
2JSC
 | | NMR structure of the cadmium metal-sensor CMTR from Mycobacterium tuberculosis | | Descriptor: | CADMIUM ION, Transcriptional regulator Rv1994c/MT2050 | | Authors: | Banci, L, Bertini, I, Cantini, F, Ciofi-Baffoni, S, Cavet, J.S, Dennison, C, Graham, A.I, Harvie, D.R, Robinson, N.J, Structural Proteomics in Europe (SPINE) | | Deposit date: | 2007-07-02 | | Release date: | 2007-07-31 | | Last modified: | 2023-12-20 | | Method: | SOLUTION NMR | | Cite: | NMR Structural Analysis of Cadmium Sensing by Winged Helix Repressor CmtR.
J.Biol.Chem., 282, 2007
|
|
6PTO
 | | Structure of Ctf4 trimer in complex with three CMG helicases | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein 45, DNA polymerase alpha-binding protein, ... | | Authors: | Yuan, Z, Georgescu, R, Bai, L, Santos, R, Donnell, M, Li, H. | | Deposit date: | 2019-07-16 | | Release date: | 2019-11-20 | | Last modified: | 2019-12-18 | | Method: | ELECTRON MICROSCOPY (7 Å) | | Cite: | Ctf4 organizes sister replisomes and Pol alpha into a replication factory.
Elife, 8, 2019
|
|
6PTJ
 | | Structure of Ctf4 trimer in complex with one CMG helicase | | Descriptor: | Cell division control protein 45, DNA polymerase alpha-binding protein, DNA replication complex GINS protein PSF1, ... | | Authors: | Yuan, Z, Georgescu, R, Bai, L, Santos, R, Donnell, M, Li, H. | | Deposit date: | 2019-07-15 | | Release date: | 2019-11-20 | | Last modified: | 2019-12-18 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Ctf4 organizes sister replisomes and Pol alpha into a replication factory.
Elife, 8, 2019
|
|
5FRO
 | | Crystal structure of the Prototype Foamy Virus (PFV) intasome in complex with magnesium and the INSTI XZ446 (compound 4f) | | Descriptor: | 4-azanyl-N-[[2,4-bis(fluoranyl)phenyl]methyl]-1-oxidanyl-2-oxidanylidene-6-[2-(phenylsulfonyl)ethyl]-1,8-naphthyridine-3-carboxamide, 5'-D(*AP*TP*TP*GP*TP*CP*AP*TP*GP*GP*AP*AP*TP*TP *TP*CP*GP*CP*A)-3', 5'-D(*TP*GP*CP*GP*AP*AP*AP*TP*TP*CP*CP*AP*TP*GP *AP*CP*A)-3', ... | | Authors: | Maskell, D.P, Pye, V.E, Cherepanov, P. | | Deposit date: | 2015-12-18 | | Release date: | 2016-02-17 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.67 Å) | | Cite: | HIV-1 Integrase Strand Transfer Inhibitors with Reduced Susceptibility to Drug Resistant Mutant Integrases.
Acs Chem.Biol., 11, 2016
|
|
6PTN
 | | Structure of Ctf4 trimer in complex with two CMG helicases | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein 45, DNA polymerase alpha-binding protein, ... | | Authors: | Yuan, Z, Georgescu, R, Bai, L, Santos, R, Donnell, M, Li, H. | | Deposit date: | 2019-07-16 | | Release date: | 2019-11-20 | | Last modified: | 2019-12-18 | | Method: | ELECTRON MICROSCOPY (5.8 Å) | | Cite: | Ctf4 organizes sister replisomes and Pol alpha into a replication factory.
Elife, 8, 2019
|
|
3T1B
 | | Crystal structure of the full-length AphB N100E variant | | Descriptor: | Transcriptional regulator, LysR family | | Authors: | Taylor, J.L, De Silva, R.S, Kovacikova, G, Lin, W, Taylor, R.K, Skorupski, K, Kull, F.J. | | Deposit date: | 2011-07-21 | | Release date: | 2011-11-23 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | The crystal structure of AphB, a virulence gene activator from Vibrio cholerae, reveals residues that influence its response to oxygen and pH.
Mol.Microbiol., 83, 2012
|
|
5FRN
 | | Crystal structure of the Prototype Foamy Virus (PFV) intasome in complex with magnesium and the INSTI XZ419 (compound 4c) | | Descriptor: | 4-azanyl-N-[[2,4-bis(fluoranyl)phenyl]methyl]-1-oxidanyl-2-oxidanylidene-6-(5-oxidanylpentyl)-1,8-naphthyridine-3-carboxamide, 5'-D(*AP*TP*TP*GP*TP*CP*AP*TP*GP*GP*AP*AP*TP*TP *TP*CP*GP*CP*A)-3', 5'-D(*TP*GP*CP*GP*AP*AP*AP*TP*TP*CP*CP*AP*TP*GP *AP*CP*A)-3', ... | | Authors: | Maskell, D.P, Pye, V.E, Cherepanov, P. | | Deposit date: | 2015-12-18 | | Release date: | 2016-02-17 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.85 Å) | | Cite: | HIV-1 Integrase Strand Transfer Inhibitors with Reduced Susceptibility to Drug Resistant Mutant Integrases.
Acs Chem.Biol., 11, 2016
|
|
2Y43
 | |
8WJL
 | | Cryo-EM structure of 6-subunit Smc5/6 hinge region | | Descriptor: | E3 SUMO-protein ligase MMS21, Structural maintenance of chromosomes protein 5, Structural maintenance of chromosomes protein 6 | | Authors: | Li, Q, Zhang, J, Zhang, X, Cheng, T, Wang, Z, Jin, D, Chen, Z, Wang, L. | | Deposit date: | 2023-09-26 | | Release date: | 2024-06-26 | | Last modified: | 2024-07-03 | | Method: | ELECTRON MICROSCOPY (6.15 Å) | | Cite: | Cryo-EM structures of Smc5/6 in multiple states reveal its assembly and functional mechanisms.
Nat.Struct.Mol.Biol., 2024
|
|
5LVT
 | |
5M1X
 | | Crystal structure of S. cerevisiae Rfa1 N-OB domain mutant (K45E) | | Descriptor: | Replication factor A protein 1 | | Authors: | Seeber, A, Hegnauer, A.M, Hustedt, N, Deshpande, I, Poli, J, Eglinger, J, Pasero, P, Gut, H, Shinohara, M, Hopfner, K.P, Shimada, K, Gasser, S.M. | | Deposit date: | 2016-10-11 | | Release date: | 2016-12-07 | | Last modified: | 2016-12-14 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | RPA Mediates Recruitment of MRX to Forks and Double-Strand Breaks to Hold Sister Chromatids Together.
Mol. Cell, 64, 2016
|
|
7TAE
 | |
6AYI
 | | Escherichia coli GusR | | Descriptor: | 4-nitrophenyl beta-D-glucopyranosiduronic acid, HTH-type transcriptional regulator UidR | | Authors: | Little, M.S, Pellock, S.J. | | Deposit date: | 2017-09-08 | | Release date: | 2017-12-20 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.09 Å) | | Cite: | Structural basis for the regulation of beta-glucuronidase expression by human gut Enterobacteriaceae.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
|
|
8DH4
 | | T7 RNA polymerase elongation complex with unnatural base dPa-DsTP pair | | Descriptor: | (7P)-3-{5-O-[(R)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl]-beta-D-ribofuranosyl}-7-(thiophen-2-yl)-3H-imidazo[4,5-b]pyridine, MAGNESIUM ION, Non-template strand DNA, ... | | Authors: | Oh, J, Wang, D. | | Deposit date: | 2022-06-24 | | Release date: | 2023-02-01 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structural basis of transcription recognition of a hydrophobic unnatural base pair by T7 RNA polymerase.
Nat Commun, 14, 2023
|
|
