4UY8
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![BU of 4uy8 by Molmil](/molmil-images/mine/4uy8) | Molecular basis for the ribosome functioning as a L-tryptophan sensor - Cryo-EM structure of a TnaC stalled E.coli ribosome | Descriptor: | 50S RIBOSOMAL PROTEIN L10, 50S RIBOSOMAL PROTEIN L11, 50S RIBOSOMAL PROTEIN L13, ... | Authors: | Bischoff, L, Berninghausen, O, Beckmann, R. | Deposit date: | 2014-08-29 | Release date: | 2014-10-29 | Last modified: | 2018-10-03 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Molecular Basis for the Ribosome Functioning as an L-Tryptophan Sensor. Cell Rep., 9, 2014
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4V3G
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![BU of 4v3g by Molmil](/molmil-images/mine/4v3g) | Crystal structure of CymA from Klebsiella oxytoca | Descriptor: | (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE, CYMA PROTEIN | Authors: | van den Berg, B, Bhamidimarri, S.P, Kleinekathoefer, U, Winterhalter, M. | Deposit date: | 2014-10-18 | Release date: | 2015-06-03 | Last modified: | 2018-02-21 | Method: | X-RAY DIFFRACTION (2.513 Å) | Cite: | Outer-membrane translocation of bulky small molecules by passive diffusion. Proc. Natl. Acad. Sci. U.S.A., 112, 2015
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1FSA
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![BU of 1fsa by Molmil](/molmil-images/mine/1fsa) | THE T-STATE STRUCTURE OF LYS 42 TO ALA MUTANT OF THE PIG KIDNEY FRUCTOSE 1,6-BISPHOSPHATASE EXPRESSED IN E. COLI | Descriptor: | 6-O-phosphono-beta-D-fructofuranose, ADENOSINE MONOPHOSPHATE, FRUCTOSE 1,6-BISPHOSPHATASE, ... | Authors: | Lu, G, Stec, B, Giroux, E, Kantrowitz, E.R. | Deposit date: | 1996-08-24 | Release date: | 1997-09-04 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Evidence for an active T-state pig kidney fructose 1,6-bisphosphatase: interface residue Lys-42 is important for allosteric inhibition and AMP cooperativity. Protein Sci., 5, 1996
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4W7Y
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4US7
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![BU of 4us7 by Molmil](/molmil-images/mine/4us7) | Sulfur SAD Phased Structure of a Type IV Pilus Protein from Shewanella oneidensis | Descriptor: | PILD PROCESSED PROTEIN, SODIUM ION, SULFATE ION | Authors: | Gorgel, M, Boeggild, A, Ulstrup, J.J, Mueller, U, Weiss, M, Nissen, P, Boesen, T. | Deposit date: | 2014-07-03 | Release date: | 2015-04-29 | Method: | X-RAY DIFFRACTION (1.96 Å) | Cite: | High-Resolution Structure of a Type Iv Pilin from the Metal- Reducing Bacterium Shewanella Oneidensis. Bmc Struct.Biol., 15, 2015
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4V0O
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6YDE
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![BU of 6yde by Molmil](/molmil-images/mine/6yde) | X-ray structure of LPMO | Descriptor: | COPPER (II) ION, LPMO lytic polysaccharide monooxygenase, SULFATE ION, ... | Authors: | Tandrup, T, Tryfona, T, Frandsen, K.E.H, Johansen, K.S, Dupree, P, Lo Leggio, L. | Deposit date: | 2020-03-20 | Release date: | 2020-09-16 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Oligosaccharide Binding and Thermostability of Two Related AA9 Lytic Polysaccharide Monooxygenases. Biochemistry, 59, 2020
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1FJ6
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![BU of 1fj6 by Molmil](/molmil-images/mine/1fj6) | FRUCTOSE-1,6-BISPHOSPHATASE (MUTANT Y57W) PRODUCT/ZN COMPLEX (R-STATE) | Descriptor: | 6-O-phosphono-beta-D-fructofuranose, FRUCTOSE-1,6-BISPHOSPHATASE, PHOSPHATE ION, ... | Authors: | Iancu, C.V, Choe, J.Y, Honzatko, R.B. | Deposit date: | 2000-08-07 | Release date: | 2000-10-18 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Tryptophan fluorescence reveals the conformational state of a dynamic loop in recombinant porcine fructose-1,6-bisphosphatase. Biochemistry, 39, 2000
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1FPB
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![BU of 1fpb by Molmil](/molmil-images/mine/1fpb) | CRYSTAL STRUCTURE OF THE NEUTRAL FORM OF FRUCTOSE 1,6-BISPHOSPHATASE COMPLEXED WITH REGULATORY INHIBITOR FRUCTOSE 2,6-BISPHOSPHATE AT 2.6-ANGSTROMS RESOLUTION | Descriptor: | 2,6-di-O-phosphono-beta-D-fructofuranose, FRUCTOSE 1,6-BISPHOSPHATASE | Authors: | Liang, J.Y, Huang, S, Zhang, Y, Ke, H, Lipscomb, W.N. | Deposit date: | 1992-02-03 | Release date: | 1993-10-31 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Crystal structure of the neutral form of fructose 1,6-bisphosphatase complexed with regulatory inhibitor fructose 2,6-bisphosphate at 2.6-A resolution. Proc.Natl.Acad.Sci.USA, 89, 1992
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4UXE
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![BU of 4uxe by Molmil](/molmil-images/mine/4uxe) | Crystal structure of the carboxy-terminal region of the bacteriophage T4 proximal long tail fibre protein gp34, P21 selenomethionine crystal | Descriptor: | GLYCEROL, LARGE TAIL FIBER PROTEIN P34 | Authors: | Granell, M, Alvira, S, Garcia-Doval, C, Singh, A.K, van Raaij, M.J. | Deposit date: | 2014-08-22 | Release date: | 2015-08-19 | Last modified: | 2017-07-19 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal Structure of the Carboxy-Terminal Region of the Bacteriophage T4 Proximal Long Tail Fiber Protein Gp34. Viruses, 9, 2017
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4V0G
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![BU of 4v0g by Molmil](/molmil-images/mine/4v0g) | JAK3 in complex with a covalent EGFR inhibitor | Descriptor: | N-[3-(2-{3-amino-6-[1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl]pyrazin-2-yl}-1H-benzimidazol-1-yl)phenyl]propanamide, TYROSINE-PROTEIN KINASE JAK3 | Authors: | Debreczeni, J.E, Hennessy, E.J, Chuaquini, C, Ashton, S, Coclough, N, Cross, D.A.E, Eberlein, C, Gingipalli, L, Klinowska, T.C.M, Orme, J.P, Sha, L, Wu, X. | Deposit date: | 2014-09-16 | Release date: | 2016-01-13 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Utilisation of Structure Based Design to Identify Novel, Irreversible Inhibitors of the Epidermal Growth Factor Receptor (Egfr) Harboring the Gatekeeper T790M Mutation To be Published
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4UVQ
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![BU of 4uvq by Molmil](/molmil-images/mine/4uvq) | PatG Domain of Unknown Function | Descriptor: | THIAZOLINE OXIDASE/SUBTILISIN-LIKE PROTEASE, ZINC ION | Authors: | Mann, G, Koehnke, J, Bent, A.F, Graham, R, Schwarz-Linek, U, Naismith, J.H. | Deposit date: | 2014-08-07 | Release date: | 2014-09-17 | Last modified: | 2014-12-17 | Method: | X-RAY DIFFRACTION (1.724 Å) | Cite: | The Structure of the Cyanobactin Domain of Unknown Function from Patg in the Patellamide Gene Cluster Acta Crystallogr.,Sect.F, 70, 2014
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4UW2
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![BU of 4uw2 by Molmil](/molmil-images/mine/4uw2) | Crystal structure of Csm1 in T.onnurineus | Descriptor: | CSM1 | Authors: | Jung, T.Y, An, Y, Park, K.H, Lee, M.H, Oh, B.H, Woo, E.J. | Deposit date: | 2014-08-08 | Release date: | 2015-03-25 | Last modified: | 2015-09-23 | Method: | X-RAY DIFFRACTION (2.632 Å) | Cite: | Crystal Structure of the Csm1 Subunit of the Csm Complex and its Single-Stranded DNA-Specific Nuclease Activity. Structure, 23, 2015
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4UZ0
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![BU of 4uz0 by Molmil](/molmil-images/mine/4uz0) | Crystal Structure of apoptosis repressor with CARD (ARC) | Descriptor: | GLYCEROL, NUCLEOLAR PROTEIN 3 | Authors: | Kim, S.H, Jeong, J.H, Jang, T.H, Kim, Y.G, Park, H.H. | Deposit date: | 2014-09-04 | Release date: | 2015-07-01 | Last modified: | 2017-07-12 | Method: | X-RAY DIFFRACTION (2.399 Å) | Cite: | Crystal Structure of Caspase Recruiting Domain (Card) of Apoptosis Repressor with Card (Arc) and its Implication in Inhibition of Apoptosis. Sci.Rep., 5, 2015
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1FBH
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![BU of 1fbh by Molmil](/molmil-images/mine/1fbh) | CRYSTALLOGRAPHIC STUDIES OF THE CATALYTIC MECHANISM OF THE NEUTRAL FORM OF FRUCTOSE-1,6-BISPHOSPHATASE | Descriptor: | 1,6-di-O-phosphono-alpha-D-fructofuranose, 1,6-di-O-phosphono-beta-D-fructofuranose, FRUCTOSE 1,6-BISPHOSPHATASE | Authors: | Zhang, Y, Liang, J.-Y, Huang, S, Ke, H, Lipscomb, W.N. | Deposit date: | 1992-10-16 | Release date: | 1993-10-31 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystallographic studies of the catalytic mechanism of the neutral form of fructose-1,6-bisphosphatase. Biochemistry, 32, 1993
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7QVZ
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![BU of 7qvz by Molmil](/molmil-images/mine/7qvz) | ARUK3001043_Notum | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, DIMETHYL SULFOXIDE, ... | Authors: | Zhao, Y, Hillier, J, Willis, N.J, Mahy, W, Fish, P, Jones, E.Y. | Deposit date: | 2022-01-24 | Release date: | 2022-05-04 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.47 Å) | Cite: | Structure Activity Analysis of Notum Fragment Screen Hits with Development To Be Published
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6YDC
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![BU of 6ydc by Molmil](/molmil-images/mine/6ydc) | X-ray structure of LPMO | Descriptor: | COPPER (II) ION, LPMO lytic polysaccharide monooxygenase, SULFATE ION, ... | Authors: | Tandrup, T, Tryfona, T, Frandsen, K.E.H, Johansen, K.S, Dupree, P, Lo Leggio, L. | Deposit date: | 2020-03-20 | Release date: | 2020-09-16 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Oligosaccharide Binding and Thermostability of Two Related AA9 Lytic Polysaccharide Monooxygenases. Biochemistry, 59, 2020
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5MY6
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![BU of 5my6 by Molmil](/molmil-images/mine/5my6) | Crystal structure of a HER2-Nb complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ... | Authors: | Sterckx, Y.G.-J, D'Huyvetter, M, Devoogdt, N. | Deposit date: | 2017-01-25 | Release date: | 2017-08-09 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.246 Å) | Cite: | (131)I-labeled Anti-HER2 Camelid sdAb as a Theranostic Tool in Cancer Treatment. Clin. Cancer Res., 23, 2017
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6SGP
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![BU of 6sgp by Molmil](/molmil-images/mine/6sgp) | X-ray structure of human glutamate carboxypeptidase II (GCPII) - the E424M inactive mutant, in complex with a sulfamide inhibitor GluGlu | Descriptor: | (2~{S})-2-[[(2~{S})-1,5-bis(oxidanyl)-1,5-bis(oxidanylidene)pentan-2-yl]sulfamoylamino]pentanedioic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Barinka, C, Shukla, S, Motlova, L. | Deposit date: | 2019-08-05 | Release date: | 2020-08-26 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.58 Å) | Cite: | Structural, Biochemical, and Computational Characterization of Sulfamides as Bimetallic Peptidase Inhibitors. J.Chem.Inf.Model., 2024
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7APZ
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8OWP
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8OWQ
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8OWR
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8P01
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![BU of 8p01 by Molmil](/molmil-images/mine/8p01) | Crystal structure of human STING ectodomain in complex with BI 7446, a potent cyclic dinucleotide STING agonist with broad-spectrum variant activity for the treatment of cancer | Descriptor: | 3-[(1~{R},3~{R},6~{R},8~{R},9~{R},10~{R},12~{R},15~{R},17~{R},18~{R})-8-(6-aminopurin-9-yl)-9-fluoranyl-18-oxidanyl-3,12-bis(oxidanylidene)-3,12-bis(sulfanyl)-2,4,7,11,13,16-hexaoxa-3$l^{5},12$l^{5}-diphosphatricyclo[13.2.1.0^{6,10}]octadecan-17-yl]-6~{H}-imidazo[4,5-d]pyridazin-7-one, Stimulator of interferon genes protein | Authors: | Nar, H. | Deposit date: | 2023-05-09 | Release date: | 2023-07-26 | Last modified: | 2024-06-19 | Method: | X-RAY DIFFRACTION (2.094 Å) | Cite: | Discovery of BI 7446: A Potent Cyclic Dinucleotide STING Agonist with Broad-Spectrum Variant Activity for the Treatment of Cancer. J.Med.Chem., 66, 2023
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6ZUG
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![BU of 6zug by Molmil](/molmil-images/mine/6zug) | Crystal Structure of Thrombin in complex with compound10 | Descriptor: | 2-[(3-chlorophenyl)methylamino]-7-methoxy-~{N}-[[(3~{S})-oxolan-3-yl]methyl]-~{N}-propyl-1,3-benzoxazole-5-carboxamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, Hirudin-2, ... | Authors: | Schafer, M. | Deposit date: | 2020-07-22 | Release date: | 2020-08-26 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Design, Synthesis, and Pharmacological Characterization of a Neutral, Non-Prodrug Thrombin Inhibitor with Good Oral Pharmacokinetics. J.Med.Chem., 63, 2020
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