6SGP

X-ray structure of human glutamate carboxypeptidase II (GCPII) - the E424M inactive mutant, in complex with a sulfamide inhibitor GluGlu

Summary for 6SGP

Entry DOI	10.2210/pdb6sgp/pdb
Descriptor	Glutamate carboxypeptidase 2, DI(HYDROXYETHYL)ETHER, (2~{S})-2-[[(2~{S})-1,5-bis(oxidanyl)-1,5-bis(oxidanylidene)pentan-2-yl]sulfamoylamino]pentanedioic acid, ... (13 entities in total)
Functional Keywords	glutamate carboxypeptidase ii (gcpii); naaladase; prostate-specific membrane antigen;sulfamide, hydrolase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	84143.20
Authors	Barinka, C.,Shukla, S.,Motlova, L. (deposition date: 2019-08-05, release date: 2020-08-26, Last modification date: 2024-01-31)
Primary citation	Novakova, Z.,Tehrani, Z.A.,Jurok, R.,Motlova, L.,Kutil, Z.,Pavlicek, J.,Shukla, S.,Choy, C.J.,Havlinova, B.,Baranova, P.,Berkman, C.E.,Kuchar, M.,Cerny, J.,Barinka, C. Structural, Biochemical, and Computational Characterization of Sulfamides as Bimetallic Peptidase Inhibitors. J.Chem.Inf.Model., 2024 Cited by PubMed: 38224368 DOI: 10.1021/acs.jcim.3c01542 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.58 Å)

Structure validation