4W7Y

Dimeric BAP29 vDED with disulfide bonds in crystal contacts

Summary for 4W7Y

Entry DOI	10.2210/pdb4w7y/pdb
Descriptor	B-cell receptor-associated protein 29, (4S)-2-METHYL-2,4-PENTANEDIOL, ACETATE ION, ... (4 entities in total)
Functional Keywords	coiled coil, nanomaterial, transport protein
Biological source	Homo sapiens (Human)
Cellular location	Endoplasmic reticulum membrane ; Multi-pass membrane protein : Q9UHQ4
Total number of polymer chains	2
Total formula weight	15757.57
Authors	Quistgaard, E.M. (deposition date: 2014-08-22, release date: 2014-10-29, Last modification date: 2024-11-13)
Primary citation	Quistgaard, E.M. A disulfide polymerized protein crystal. Chem.Commun.(Camb.), 50:14995-14997, 2014 Cited by PubMed Abstract: The vDED coiled coil domain from human BAP29 was crystallized in dimeric and tetrameric forms. For the dimer, a disulfide bond was unexpectedly found to bridge a crystal contact, resulting in complete cross-linking along the c-axis. This indicates that it is in principle possible to design spontaneously polymerizing protein crystals. PubMed: 25327138 DOI: 10.1039/c4cc07326f PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation