1ZB7
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![BU of 1zb7 by Molmil](/molmil-images/mine/1zb7) | Crystal Structure of Botulinum Neurotoxin Type G Light Chain | Descriptor: | CITRATE ANION, ZINC ION, neurotoxin | Authors: | Arndt, J.W, Yu, W, Bi, F, Stevens, R.C. | Deposit date: | 2005-04-07 | Release date: | 2005-07-05 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Crystal structure of botulinum neurotoxin type g light chain: serotype divergence in substrate recognition Biochemistry, 44, 2005
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3ODY
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![BU of 3ody by Molmil](/molmil-images/mine/3ody) | Crystal structure of p38alpha Y323Q active mutant | Descriptor: | Mitogen-activated protein kinase 14, octyl beta-D-glucopyranoside | Authors: | Livnah, O, Tzarum, N. | Deposit date: | 2010-08-12 | Release date: | 2011-01-12 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Active mutants of the TCR-mediated p38alpha alternative activation site show changes in the phosphorylation lip and DEF site formation. J.Mol.Biol., 405, 2011
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1ZXY
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![BU of 1zxy by Molmil](/molmil-images/mine/1zxy) | Anthranilate Phosphoribosyltransferase from Sulfolobus solfataricus in complex with PRPP and Magnesium | Descriptor: | 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, Anthranilate phosphoribosyltransferase, MAGNESIUM ION | Authors: | Marino, M, Deuss, M, Sterner, R, Mayans, O. | Deposit date: | 2005-06-09 | Release date: | 2006-05-23 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.56 Å) | Cite: | Structural and mutational analysis of substrate complexation by anthranilate phosphoribosyltransferase from Sulfolobus solfataricus. J.Biol.Chem., 281, 2006
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1ZZN
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2A2A
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1GRX
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![BU of 1grx by Molmil](/molmil-images/mine/1grx) | STRUCTURE OF E. COLI GLUTAREDOXIN | Descriptor: | GLUTAREDOXIN, GLUTATHIONE | Authors: | Bushweller, J.H, Billeter, M, Holmgren, L.A, Wuthrich, K. | Deposit date: | 1993-10-01 | Release date: | 1994-01-31 | Last modified: | 2021-11-03 | Method: | SOLUTION NMR | Cite: | NMR structure of oxidized Escherichia coli glutaredoxin: comparison with reduced E. coli glutaredoxin and functionally related proteins. Protein Sci., 1, 1992
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6XUA
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![BU of 6xua by Molmil](/molmil-images/mine/6xua) | Human myelin protein P2 mutant K21Q | Descriptor: | CITRIC ACID, Myelin P2 protein, PALMITIC ACID | Authors: | Ruskamo, S, Lehtimaki, M, Kursula, P. | Deposit date: | 2020-01-17 | Release date: | 2020-04-08 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Cryo-EM, X-ray diffraction, and atomistic simulations reveal determinants for the formation of a supramolecular myelin-like proteolipid lattice. J.Biol.Chem., 295, 2020
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6XW9
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![BU of 6xw9 by Molmil](/molmil-images/mine/6xw9) | Human myelin protein P2 mutant K120S | Descriptor: | CHLORIDE ION, Myelin P2 protein, PALMITIC ACID | Authors: | Ruskamo, S, Lehtimaki, M, Kursula, P. | Deposit date: | 2020-01-23 | Release date: | 2020-04-08 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Cryo-EM, X-ray diffraction, and atomistic simulations reveal determinants for the formation of a supramolecular myelin-like proteolipid lattice. J.Biol.Chem., 295, 2020
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6TYH
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![BU of 6tyh by Molmil](/molmil-images/mine/6tyh) | Four-Disulfide Insulin Analog A22/B22 | Descriptor: | ACETONE, CHLORIDE ION, GLYCEROL, ... | Authors: | Blakely, A.D, Xiong, X. | Deposit date: | 2019-08-08 | Release date: | 2019-11-13 | Last modified: | 2020-03-11 | Method: | X-RAY DIFFRACTION (1.600019 Å) | Cite: | Novel four-disulfide insulin analog with high aggregation stability and potency. Chem Sci, 11, 2020
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3V4J
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![BU of 3v4j by Molmil](/molmil-images/mine/3v4j) | First-In-Class Small Molecule Inhibitors of the Single-strand DNA Cytosine Deaminase APOBEC3G | Descriptor: | 4-[methyl(nitroso)amino]benzene-1,2-diol, DNA dC->dU-editing enzyme APOBEC-3G, ZINC ION | Authors: | Shandilya, S.M.D, Ali, A, Schiffer, C.A. | Deposit date: | 2011-12-15 | Release date: | 2012-02-01 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.04 Å) | Cite: | First-In-Class Small Molecule Inhibitors of the Single-Strand DNA Cytosine Deaminase APOBEC3G. Acs Chem.Biol., 7, 2012
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6XZ8
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![BU of 6xz8 by Molmil](/molmil-images/mine/6xz8) | Structure of aldosterone synthase (CYP11B2) in complex with N-[(1R)-1-[5-(6-chloro-1,1-dimethyl-3-oxo-isoindolin-2-yl)-3-pyridyl]ethyl]methanesulfonamide | Descriptor: | Cytochrome P450 11B2, mitochondrial, HEME C, ... | Authors: | Kuglstatter, A, Joseph, C, Benz, J. | Deposit date: | 2020-02-03 | Release date: | 2020-06-24 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Discovery of 3-Pyridyl Isoindolin-1-one Derivatives as Potent, Selective, and Orally Active Aldosterone Synthase (CYP11B2) Inhibitors. J.Med.Chem., 63, 2020
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6U57
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6U48
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![BU of 6u48 by Molmil](/molmil-images/mine/6u48) | E. coli 50S with phazolicin (PHZ) bound in exit tunnel | Descriptor: | 23S rRNA, 50S ribosomal protein bL17, 50S ribosomal protein bL19, ... | Authors: | Watson, Z.L, Cate, J.H.D, Polikanov, Y.S, Severinov, K. | Deposit date: | 2019-08-23 | Release date: | 2019-09-18 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (2.87 Å) | Cite: | Structure of ribosome-bound azole-modified peptide phazolicin rationalizes its species-specific mode of bacterial translation inhibition. Nat Commun, 10, 2019
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6U4A
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![BU of 6u4a by Molmil](/molmil-images/mine/6u4a) | BRD3-BD1 in complex with the cyclic peptide 3.1_3 | Descriptor: | Bromodomain-containing protein 3, GLYCEROL, SULFATE ION, ... | Authors: | Patel, K, Walshe, J.L, Walport, L.J, Mackay, J.P. | Deposit date: | 2019-08-24 | Release date: | 2020-08-19 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.88 Å) | Cite: | Cyclic peptides can engage a single binding pocket through highly divergent modes. Proc.Natl.Acad.Sci.USA, 117, 2020
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6U6K
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![BU of 6u6k by Molmil](/molmil-images/mine/6u6k) | BRD4-BD1 in complex with the cyclic peptide 3.1_3 | Descriptor: | Bromodomain-containing protein 4, cyclic peptide 3.1_3 | Authors: | Patel, K, Walshe, J.L, Walport, L.J, Mackay, J.P. | Deposit date: | 2019-08-30 | Release date: | 2020-08-19 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Cyclic peptides can engage a single binding pocket through highly divergent modes. Proc.Natl.Acad.Sci.USA, 117, 2020
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6XJR
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6U71
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![BU of 6u71 by Molmil](/molmil-images/mine/6u71) | BRD2-BD2 in complex with the cyclic peptide 3.1_3 | Descriptor: | Bromodomain-containing protein 2, cyclic peptide 3.1_3 | Authors: | Patel, K, Walshe, J.L, Walport, L.J, Mackay, J.P. | Deposit date: | 2019-08-31 | Release date: | 2020-08-19 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.47 Å) | Cite: | Cyclic peptides can engage a single binding pocket through highly divergent modes. Proc.Natl.Acad.Sci.USA, 117, 2020
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6XLI
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![BU of 6xli by Molmil](/molmil-images/mine/6xli) | CRYSTAL STRUCTURE OF ANTI-TAU ANTIBODY PT3 Fab+pT212/pT217-TAU PEPTIDE | Descriptor: | GLYCEROL, PT3 Fab Heavy Chain, PT3 Fab Light Chain, ... | Authors: | Malia, T.J, Teplyakov, A, Luo, J. | Deposit date: | 2020-06-28 | Release date: | 2020-09-23 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Discovery and Functional Characterization of hPT3, a Humanized Anti-Phospho Tau Selective Monoclonal Antibody. J Alzheimers Dis, 77, 2020
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3V9O
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6U8G
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![BU of 6u8g by Molmil](/molmil-images/mine/6u8g) | BRD4-BD2 in complex with the cyclic peptide 3.1_2_AcK7toA | Descriptor: | Bromodomain-containing protein 4, cyclic peptide 3.1_2_AcK7toA | Authors: | Patel, K, Walshe, J.L, Walport, L.J, Mackay, J.P, Mouradian, K.S. | Deposit date: | 2019-09-05 | Release date: | 2020-08-19 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Cyclic peptides can engage a single binding pocket through highly divergent modes. Proc.Natl.Acad.Sci.USA, 117, 2020
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3VBE
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6U72
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![BU of 6u72 by Molmil](/molmil-images/mine/6u72) | BRD4-BD1 in complex with the cyclic peptide 3.1_2_AcK5toA | Descriptor: | 3.1_2_AcK5toA, AMINO GROUP, Bromodomain-containing protein 4 | Authors: | Patel, K, Walshe, J.L, Walport, L.J, Mackay, J.P, Mouradian, K.S. | Deposit date: | 2019-08-31 | Release date: | 2020-08-19 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Cyclic peptides can engage a single binding pocket through highly divergent modes. Proc.Natl.Acad.Sci.USA, 117, 2020
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1QX2
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![BU of 1qx2 by Molmil](/molmil-images/mine/1qx2) | X-ray Structure of Calcium-loaded Calbindomodulin (A Calbindin D9k Re-engineered to Undergo a Conformational Opening) at 1.44 A Resolution | Descriptor: | CALCIUM ION, Vitamin D-dependent calcium-binding protein, intestinal, ... | Authors: | Bunick, C.G, Nelson, M.R, Mangahas, S, Mizoue, L.S, Bunick, G.J, Chazin, W.J. | Deposit date: | 2003-09-04 | Release date: | 2004-05-25 | Last modified: | 2021-10-27 | Method: | X-RAY DIFFRACTION (1.44 Å) | Cite: | Designing Sequence to Control Protein Function in an EF-Hand Protein J.Am.Chem.Soc., 126, 2004
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6XZ9
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![BU of 6xz9 by Molmil](/molmil-images/mine/6xz9) | Structure of aldosterone synthase (CYP11B2) in complex with 5-chloro-3,3-dimethyl-2-[5-[1-(1-methylpyrazole-4-carbonyl)azetidin-3-yl]oxy-3-pyridyl]isoindolin-1-one | Descriptor: | 5-chloranyl-3,3-dimethyl-2-[5-[1-(1-methylpyrazol-4-yl)carbonylazetidin-3-yl]oxypyridin-3-yl]isoindol-1-one, Cytochrome P450 11B2, mitochondrial, ... | Authors: | Kuglstatter, A, Joseph, C, Benz, J. | Deposit date: | 2020-02-03 | Release date: | 2020-06-24 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.77 Å) | Cite: | Discovery of 3-Pyridyl Isoindolin-1-one Derivatives as Potent, Selective, and Orally Active Aldosterone Synthase (CYP11B2) Inhibitors. J.Med.Chem., 63, 2020
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6XJU
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![BU of 6xju by Molmil](/molmil-images/mine/6xju) | Crystal Structure of KPT-8602 bound to CRM1 (E582K, 537-DLTVK-541 to GLCEQ) | Descriptor: | (2R)-3-{3-[3,5-bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl}-2-(pyrimidin-5-yl)propanamide, Exportin-1, GTP-binding nuclear protein Ran, ... | Authors: | Baumhardt, J.M, Chook, Y.M. | Deposit date: | 2020-06-24 | Release date: | 2021-01-27 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.193 Å) | Cite: | Recurrent XPO1 mutations alter pathogenesis of chronic lymphocytic leukemia. J Hematol Oncol, 14, 2021
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