6U72

BRD4-BD1 in complex with the cyclic peptide 3.1_2_AcK5toA

Summary for 6U72

Entry DOI	10.2210/pdb6u72/pdb
Descriptor	Bromodomain-containing protein 4, 3.1_2_AcK5toA, AMINO GROUP, ... (4 entities in total)
Functional Keywords	bet, bromodomain, macrocyclic peptide, brd4, inhibitor, rapid, transcription-inhibitor complex, transcription/inhibitor
Biological source	Homo sapiens (Human) More
Total number of polymer chains	3
Total formula weight	36236.45
Authors	Patel, K.,Walshe, J.L.,Walport, L.J.,Mackay, J.P.,Mouradian, K.S. (deposition date: 2019-08-31, release date: 2020-08-19, Last modification date: 2023-11-15)
Primary citation	Patel, K.,Walport, L.J.,Walshe, J.L.,Solomon, P.D.,Low, J.K.K.,Tran, D.H.,Mouradian, K.S.,Silva, A.P.G.,Wilkinson-White, L.,Norman, A.,Franck, C.,Matthews, J.M.,Guss, J.M.,Payne, R.J.,Passioura, T.,Suga, H.,Mackay, J.P. Cyclic peptides can engage a single binding pocket through highly divergent modes. Proc.Natl.Acad.Sci.USA, 117:26728-26738, 2020 Cited by PubMed: 33046654 DOI: 10.1073/pnas.2003086117 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation