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8U1L
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BU of 8u1l by Molmil
Cryo-EM structure of the RAF1-HSP90-CDC37 complex in the closed state
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Heat shock protein 83, Hsp90 co-chaperone Cdc37, ...
Authors:Finci, L.I, Simanshu, D.K.
Deposit date:2023-09-01
Release date:2024-03-13
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Structural dynamics of RAF1-HSP90-CDC37 and HSP90 complexes reveal asymmetric client interactions and key structural elements.
Commun Biol, 7, 2024
8U1G
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BU of 8u1g by Molmil
Prefusion-stabilized SARS-CoV-2 S2 subunit
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S2
Authors:Hsieh, C.-L, McLellan, J.S.
Deposit date:2023-08-31
Release date:2024-01-24
Last modified:2024-08-07
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Prefusion-stabilized SARS-CoV-2 S2-only antigen provides protection against SARS-CoV-2 challenge.
Nat Commun, 15, 2024
8U1F
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BU of 8u1f by Molmil
FGFR2 Kinase Domain Bound to Irreversible Inhibitor Cmpd 10
Descriptor: Fibroblast growth factor receptor 2, GLYCEROL, N-[4-(4-amino-7-methyl-5-{4-[(4-methylpyrimidin-2-yl)oxy]phenyl}-7H-pyrrolo[2,3-d]pyrimidin-6-yl)phenyl]-2-methylpropanamide, ...
Authors:Valverde, R, Foster, L.
Deposit date:2023-08-31
Release date:2024-02-14
Method:X-RAY DIFFRACTION (3.33 Å)
Cite:Discovery of lirafugratinib (RLY-4008), a highly selective irreversible small-molecule inhibitor of FGFR2.
Proc.Natl.Acad.Sci.USA, 121, 2024
8U1D
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BU of 8u1d by Molmil
Cryo-EM structure of vaccine-elicited CD4 binding site antibody DH1285 bound to HIV-1 CH505TFchim.6R.SOSIP.664v4.1 Env Local Refinement
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, DH1285 Heavy Chain, DH1285 Light Chain, ...
Authors:Thakur, B, Stalls, V.D, Acharya, P.
Deposit date:2023-08-31
Release date:2024-01-03
Last modified:2024-07-17
Method:ELECTRON MICROSCOPY (4.25 Å)
Cite:Vaccine induction of CD4-mimicking HIV-1 broadly neutralizing antibody precursors in macaques.
Cell, 187, 2024
8U17
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BU of 8u17 by Molmil
The ternary complex structure of DDB1-CRBN-SALL4(ZF1,2)-long bound to Pomalidomide
Descriptor: DNA damage-binding protein 1, Protein cereblon, S-Pomalidomide, ...
Authors:Clifton, M.C, Ma, X, Ornelas, E.
Deposit date:2023-08-30
Release date:2023-12-27
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural and biophysical comparisons of the pomalidomide- and CC-220-induced interactions of SALL4 with cereblon.
Sci Rep, 13, 2023
8U16
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The ternary complex structure of DDB1-CRBN-SALL4(ZF1,2)-short bound to Pomalidomide
Descriptor: 1,2-ETHANEDIOL, DNA damage-binding protein 1, Protein cereblon, ...
Authors:Clifton, M.C, Ma, X, Ornelas, E.
Deposit date:2023-08-30
Release date:2023-12-27
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural and biophysical comparisons of the pomalidomide- and CC-220-induced interactions of SALL4 with cereblon.
Sci Rep, 13, 2023
8U15
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BU of 8u15 by Molmil
The ternary complex structure of DDB1-CRBN-SALL4(ZF1,2)-short bound to CC-220
Descriptor: (3S)-3-[4-({4-[(morpholin-4-yl)methyl]phenyl}methoxy)-1-oxo-1,3-dihydro-2H-isoindol-2-yl]piperidine-2,6-dione, DDB1, Protein cereblon, ...
Authors:Clifton, M.C, Ma, X, Ornelas, E.
Deposit date:2023-08-30
Release date:2023-12-27
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Structural and biophysical comparisons of the pomalidomide- and CC-220-induced interactions of SALL4 with cereblon.
Sci Rep, 13, 2023
8U0Z
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BU of 8u0z by Molmil
CRYSTAL STRUCTURE OF THE OROTIDINE 5'-MONOPHOSPHATE DECARBOXYLASE DOMAIN OF Coffea arabica UMP SYNTHASE
Descriptor: 1,2-ETHANEDIOL, ANY 5'-MONOPHOSPHATE NUCLEOTIDE, DI(HYDROXYETHYL)ETHER, ...
Authors:Hinojosa-Cruz, A, Diaz-Vilchis, A, Gonzalez-Segura, L.
Deposit date:2023-08-29
Release date:2024-01-17
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.399 Å)
Cite:Structural and functional properties of uridine 5'-monophosphate synthase from Coffea arabica.
Int.J.Biol.Macromol., 259, 2024
8U0W
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BU of 8u0w by Molmil
DdmD monomer in complex with ssDNA
Descriptor: DNA (5'-D(P*TP*TP*AP*TP*TP*TP*TP*TP*TP*TP*TP*T)-3'), Helicase/UvrB N-terminal domain-containing protein
Authors:Bravo, J.P.K.
Deposit date:2023-08-29
Release date:2024-07-10
Method:ELECTRON MICROSCOPY (2.99 Å)
Cite:Plasmid targeting and destruction by the DdmDE bacterial defence system.
Nature, 630, 2024
8U0U
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BU of 8u0u by Molmil
DdmD dimer in complex with ssDNA
Descriptor: DNA (5'-D(P*TP*TP*AP*TP*TP*TP*TP*TP*TP*TP*T)-3'), Helicase/UvrB N-terminal domain-containing protein
Authors:Bravo, J.P.K.
Deposit date:2023-08-29
Release date:2024-07-10
Method:ELECTRON MICROSCOPY (3.04 Å)
Cite:Plasmid targeting and destruction by the DdmDE bacterial defence system.
Nature, 630, 2024
8U0T
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BU of 8u0t by Molmil
PRD-0038 RBD bound to Rhinolophus alcyone ACE2 (local refinement)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme, PRD-0038, ...
Authors:Park, Y.J, Veesler, D, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2023-08-29
Release date:2023-12-06
Last modified:2023-12-27
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Broad receptor tropism and immunogenicity of a clade 3 sarbecovirus.
Cell Host Microbe, 31, 2023
8U0Q
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BU of 8u0q by Molmil
Co-crystal structure of optimized analog TDI-13537 provided new insights into the potency determinants of the sulfonamide inhibitor series
Descriptor: Dihydrolipoyl dehydrogenase, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, ...
Authors:Dementiev, A.A, Michino, M, Vendome, J, Ginn, J, Bryk, R, Olland, A.
Deposit date:2023-08-29
Release date:2024-01-03
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:Shape-Based Virtual Screening of a Billion-Compound Library Identifies Mycobacterial Lipoamide Dehydrogenase Inhibitors.
Acs Bio Med Chem Au, 3, 2023
8U0J
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BU of 8u0j by Molmil
DdmE in complex with guide and target DNA
Descriptor: DNA (5'-D(P*AP*CP*TP*TP*AP*AP*AP*GP*TP*CP*TP*AP*AP*CP*CP*TP*AP*TP*AP*GP*GP*AP*T)-3'), DNA (5'-D(P*AP*TP*CP*CP*TP*AP*TP*AP*GP*GP*A)-3'), DNA (5'-D(P*GP*TP*TP*AP*GP*AP*CP*TP*TP*TP*AP*AP*GP*T)-3'), ...
Authors:Bravo, J.P.K.
Deposit date:2023-08-29
Release date:2024-07-03
Last modified:2024-07-10
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Plasmid targeting and destruction by the DdmDE bacterial defence system.
Nature, 630, 2024
8U0G
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BU of 8u0g by Molmil
Full-length dimer of DNA-Damage Response Protein C from Deinococcus radiodurans - Crystal form xMJ7124
Descriptor: DNA damage response protein C
Authors:Szabla, R, Li, M.C, Junop, M.S.
Deposit date:2023-08-29
Release date:2023-09-06
Last modified:2024-07-31
Method:X-RAY DIFFRACTION (4.28 Å)
Cite:DdrC, a unique DNA repair factor from D. radiodurans, senses and stabilizes DNA breaks through a novel lesion-recognition mechanism.
Nucleic Acids Res., 2024
8U09
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BU of 8u09 by Molmil
Crystal structure of substrate-free SyoA
Descriptor: ACETATE ION, Cytochrome P450, GLYCEROL, ...
Authors:Harlington, A.H, Shearwin, K.E, Bell, S.G, Whelan, F.
Deposit date:2023-08-28
Release date:2024-07-24
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Structural insights into the S-lignin O-demethylase SyoA
To Be Published
8U08
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BU of 8u08 by Molmil
Crystal structure of 10E8-GT11 scaffold in complex with a human 10E8 inferred germline (10E8-iGL1)
Descriptor: 10E8-GT11 epitope scaffold, 10E8-IGL1 heavy chain, 10E8-IGL1 light chain, ...
Authors:Irimia, A, Wilson, I.A.
Deposit date:2023-08-28
Release date:2024-06-12
Last modified:2024-06-19
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Vaccination induces broadly neutralizing antibody precursors to HIV gp41.
Nat.Immunol., 25, 2024
8U01
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BU of 8u01 by Molmil
Crystal Structure of the Glycoside Hydrolase Family 2 TIM Barrel-domain Containing Protein from Phocaeicola plebeius
Descriptor: 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ACETATE ION, ...
Authors:Kim, Y, Joachimiak, G, Endres, M, Joachimiak, A, Midwest Center for Structural Genomics (MCSG)
Deposit date:2023-08-28
Release date:2023-09-27
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal Structure of the Glycoside Hydrolase Family 2 TIM Barrel-domain Containing Protein from Phocaeicola plebeius
To Be Published
8U00
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BU of 8u00 by Molmil
Crystal structure of metallo-beta-lactamase superfamily protein from Caulobacter vibrioides
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, GLYCEROL, ...
Authors:Kim, Y, Maltseva, N, Endres, M, Joachimiak, A, Center for Structural Biology of Infectious Diseases (CSBID)
Deposit date:2023-08-28
Release date:2023-09-27
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crystal structure of metallo-beta-lactamase superfamily protein from Caulobacter vibrioides
To Be Published
8TZX
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BU of 8tzx by Molmil
Ternary complex structure of Cereblon-DDB1 bound to WIZ(ZF7) and the molecular glue dWIZ-1
Descriptor: (3S)-3-(5-{(1R)-1-[(2R)-1-ethylpiperidin-2-yl]ethoxy}-1-oxo-1,3-dihydro-2H-isoindol-2-yl)piperidine-2,6-dione, 1,2-ETHANEDIOL, DNA damage-binding protein 1, ...
Authors:Clifton, M.C, Ma, X, Ornelas, E.
Deposit date:2023-08-28
Release date:2024-07-10
Last modified:2024-07-17
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:A molecular glue degrader of the WIZ transcription factor for fetal hemoglobin induction.
Science, 385, 2024
8TZU
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BU of 8tzu by Molmil
OC43 S1b domain in complex with WNb 293 and WNb 317
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ...
Authors:Pymm, P, Feng, J, Tham, W.H.
Deposit date:2023-08-27
Release date:2024-05-01
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:OC43 S1b domain in complex with WNb 293 and WNb 317
To Be Published
8TZS
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BU of 8tzs by Molmil
Structure of human WLS
Descriptor: Protein wntless homolog
Authors:Qi, X, Hu, Q, Li, X.
Deposit date:2023-08-27
Release date:2023-10-18
Last modified:2024-05-08
Method:ELECTRON MICROSCOPY (3.84 Å)
Cite:Molecular basis of Wnt biogenesis, secretion, and Wnt7-specific signaling.
Cell, 186, 2023
8TZR
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BU of 8tzr by Molmil
Structure of human Wnt3a bound to WLS and CALR
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Calreticulin, PALMITOLEIC ACID, ...
Authors:Qi, X, Hu, Q, Li, X.
Deposit date:2023-08-27
Release date:2023-10-18
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structure of human Wnt3a bound to WLS and CALR
To Be Published
8TZP
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BU of 8tzp by Molmil
Structure of human Wnt7a bound to WLS and RECK
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, PALMITOLEIC ACID, Protein Wnt-7a, ...
Authors:Qi, X, Hu, Q, Li, X.
Deposit date:2023-08-27
Release date:2023-10-18
Last modified:2024-05-08
Method:ELECTRON MICROSCOPY (3.23 Å)
Cite:Molecular basis of Wnt biogenesis, secretion, and Wnt7-specific signaling.
Cell, 186, 2023
8TZO
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BU of 8tzo by Molmil
Structure of human Wnt7a bound to WLS and CALR
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, CALCIUM ION, Calreticulin, ...
Authors:Qi, X, Hu, Q, Li, X.
Deposit date:2023-08-27
Release date:2023-10-18
Last modified:2024-05-08
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Molecular basis of Wnt biogenesis, secretion, and Wnt7-specific signaling.
Cell, 186, 2023
8TZH
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BU of 8tzh by Molmil
Structure of full-length LRRK2 bound to MLi-2 (I2020T mutant)
Descriptor: (2~{R},6~{S})-2,6-dimethyl-4-[6-[5-(1-methylcyclopropyl)oxy-1~{H}-indazol-3-yl]pyrimidin-4-yl]morpholine, E11 DARPin, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Sanz-Murillo, M, Villagran-Suarez, A, Alegrio Louro, J, Leschziner, A.
Deposit date:2023-08-26
Release date:2023-12-06
Last modified:2023-12-13
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Inhibition of Parkinson's disease-related LRRK2 by type I and type II kinase inhibitors: Activity and structures.
Sci Adv, 9, 2023

223532

건을2024-08-07부터공개중

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