7KHR
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![BU of 7khr by Molmil](/molmil-images/mine/7khr) | Cryo-EM structure of bafilomycin A1-bound intact V-ATPase from bovine brain | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, (5R)-2,4-dideoxy-1-C-{(2S,3R,4S)-3-hydroxy-4-[(2R,3S,4E,6E,9R,10S,11R,12E,14Z)-10-hydroxy-3,15-dimethoxy-7,9,11,13-tetramethyl-16-oxo-1-oxacyclohexadeca-4,6,12,14-tetraen-2-yl]pentan-2-yl}-4-methyl-5-propan-2-yl-alpha-D-threo-pentopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Wang, R, Li, X. | Deposit date: | 2020-10-21 | Release date: | 2021-03-17 | Last modified: | 2021-09-29 | Method: | ELECTRON MICROSCOPY (3.62 Å) | Cite: | Molecular basis of V-ATPase inhibition by bafilomycin A1. Nat Commun, 12, 2021
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2N58
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2MZZ
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![BU of 2mzz by Molmil](/molmil-images/mine/2mzz) | NMR structure of APOBEC3G NTD variant, sNTD | Descriptor: | Apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 3G variant, ZINC ION | Authors: | Kouno, T, Luengas, E.M, Shigematu, M, Shandilya, S.M.D, Zhang, J, Chen, L, Hara, M, Schiffer, C.A, Harris, R.S, Matsuo, H. | Deposit date: | 2015-02-28 | Release date: | 2015-05-13 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Structure of the Vif-binding domain of the antiviral enzyme APOBEC3G. Nat.Struct.Mol.Biol., 22, 2015
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2N1G
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6J6L
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6J72
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![BU of 6j72 by Molmil](/molmil-images/mine/6j72) | Crystal structure of IniA from Mycobacterium smegmatis with GTP bound | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, Isoniazid inducible gene protein IniA, L(+)-TARTARIC ACID, ... | Authors: | Wang, M.F, Guo, X.Y, Hu, J.J, Li, J, Rao, Z.H. | Deposit date: | 2019-01-16 | Release date: | 2019-09-11 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Mycobacterial dynamin-like protein IniA mediates membrane fission. Nat Commun, 10, 2019
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6JCR
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![BU of 6jcr by Molmil](/molmil-images/mine/6jcr) | AAV1 in neutral condition at 3.07 Ang | Descriptor: | Capsid protein | Authors: | Lou, Z, Zhang, R. | Deposit date: | 2019-01-30 | Release date: | 2019-10-23 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.07 Å) | Cite: | Divergent engagements between adeno-associated viruses with their cellular receptor AAVR. Nat Commun, 10, 2019
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2O2K
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![BU of 2o2k by Molmil](/molmil-images/mine/2o2k) | Crystal Structure of the Activation Domain of Human Methionine Synthase Isoform/Mutant D963E/K1071N | Descriptor: | Methionine synthase | Authors: | Wolthers, K.R, Toogood, H.S, Jowitt, T.A, Marshall, K.R, Leys, D, Scrutton, N.S. | Deposit date: | 2006-11-30 | Release date: | 2006-12-19 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Crystal structure and solution characterization of the activation domain of human methionine synthase Febs J., 274, 2007
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4D7X
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7JP2
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![BU of 7jp2 by Molmil](/molmil-images/mine/7jp2) | Crystal structure of TP0037 from Treponema pallidum, a D-lactate dehydrogenase | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, D-lactate dehydrogenase | Authors: | Brautigam, C.A, Deka, R.K, Norgard, M.V. | Deposit date: | 2020-08-07 | Release date: | 2020-09-09 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.38 Å) | Cite: | Biophysical and Biochemical Characterization of TP0037, a d-Lactate Dehydrogenase, Supports an Acetogenic Energy Conservation Pathway in Treponema pallidum. Mbio, 11, 2020
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7JW2
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![BU of 7jw2 by Molmil](/molmil-images/mine/7jw2) | Crystal structure of Aedes aegypti Nibbler EXO domain | Descriptor: | Exonuclease mut-7 homolog | Authors: | Xie, W, Sowemimo, I, Hayashi, R, Wang, J, Brennecke, J, Ameres, S.L, Patel, D.J. | Deposit date: | 2020-08-24 | Release date: | 2021-01-20 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Structure-function analysis of microRNA 3'-end trimming by Nibbler. Proc.Natl.Acad.Sci.USA, 117, 2020
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8IC9
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![BU of 8ic9 by Molmil](/molmil-images/mine/8ic9) | Lys48-linked K48C-diubiquitin | Descriptor: | Polyubiquitin-B, Ubiquitin | Authors: | Hiranyakorn, M, Yagi-Utsumi, M, Yanaka, S, Ohtsuka, N, Momiyama, N, Satoh, T, Kato, K. | Deposit date: | 2023-02-11 | Release date: | 2023-04-26 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (1.25 Å) | Cite: | Mutational and Environmental Effects on the Dynamic Conformational Distributions of Lys48-Linked Ubiquitin Chains. Int J Mol Sci, 24, 2023
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8IQU
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![BU of 8iqu by Molmil](/molmil-images/mine/8iqu) | Structure of MtbFadD23 with PhU-AMS | Descriptor: | 5'-O-[(11-phenoxyundecanoyl)sulfamoyl]adenosine, Fatty-acid-CoA ligase FadD23 | Authors: | Yan, M.R, Zhang, W. | Deposit date: | 2023-03-17 | Release date: | 2023-04-26 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.64 Å) | Cite: | Structural basis for the development of potential inhibitors targeting FadD23 from Mycobacterium tuberculosis. Acta Crystallogr.,Sect.F, 79, 2023
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6B45
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![BU of 6b45 by Molmil](/molmil-images/mine/6b45) | Cryo-EM structure of Type I-F CRISPR crRNA-guided Csy surveillance complex | Descriptor: | CRISPR-associated endonuclease Cas6/Csy4, CRISPR-associated protein Csy1, CRISPR-associated protein Csy2, ... | Authors: | Guo, T.W, Bartesaghi, A, Yang, H, Falconieri, V, Rao, P, Merk, A, Fox, T, Earl, L, Patel, D.J, Subramaniam, S. | Deposit date: | 2017-09-25 | Release date: | 2017-10-18 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Cryo-EM Structures Reveal Mechanism and Inhibition of DNA Targeting by a CRISPR-Cas Surveillance Complex. Cell, 171, 2017
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2BZ8
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![BU of 2bz8 by Molmil](/molmil-images/mine/2bz8) | N-terminal Sh3 domain of CIN85 bound to Cbl-b peptide | Descriptor: | SH3-DOMAIN KINASE BINDING PROTEIN 1, SIGNAL TRANSDUCTION PROTEIN CBL-B SH3-BINDING PROTEIN CBL-B, RING FINGER PROTEIN 56, ... | Authors: | Cardenes, N, Moncalian, G, Bravo, J. | Deposit date: | 2005-08-12 | Release date: | 2005-10-05 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Cbl Promotes Clustering of Endocytic Adaptor Proteins Nat.Struct.Mol.Biol., 12, 2005
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4BUU
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![BU of 4buu by Molmil](/molmil-images/mine/4buu) | Crystal structure of human tankyrase 2 in complex with (4-(4-oxo-3,4- dihydroquinazolin-2-yl)phenyl)methanesulfonamide | Descriptor: | DI(HYDROXYETHYL)ETHER, GLYCEROL, SULFATE ION, ... | Authors: | Haikarainen, T, Narwal, M, Lehtio, L. | Deposit date: | 2013-06-24 | Release date: | 2013-10-30 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Para-Substituted 2-Phenyl-3,4-Dihydroquinazolin-4-Ones as Potent and Selective Tankyrase Inhibitors. Chemmedchem, 8, 2013
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4BS4
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![BU of 4bs4 by Molmil](/molmil-images/mine/4bs4) | Crystal structure of human tankyrase 2 in complex with 4'-isopropylflavone | Descriptor: | 4'-ISOPROPYLFLAVONE, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | Authors: | Haikarainen, T, Narwal, M, Lehtio, L. | Deposit date: | 2013-06-07 | Release date: | 2013-10-30 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.89 Å) | Cite: | Discovery of Tankyrase Inhibiting Flavones with Increased Potency and Isoenzyme Selectivity. J.Med.Chem., 56, 2013
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4BU9
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![BU of 4bu9 by Molmil](/molmil-images/mine/4bu9) | Crystal structure of human tankyrase 2 in complex with 2-(4- methoxyphenyl)-3,4-dihydroquinazolin-4-one | Descriptor: | 2-(4-methoxyphenyl)-3,4-dihydroquinazolin-4-one, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | Authors: | Haikarainen, T, Narwal, M, Lehtio, L. | Deposit date: | 2013-06-20 | Release date: | 2013-10-30 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Para-Substituted 2-Phenyl-3,4-Dihydroquinazolin-4-Ones as Potent and Selective Tankyrase Inhibitors. Chemmedchem, 8, 2013
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2OCG
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![BU of 2ocg by Molmil](/molmil-images/mine/2ocg) | Crystal structure of human valacyclovir hydrolase | Descriptor: | GLYCEROL, MAGNESIUM ION, MANGANESE (II) ION, ... | Authors: | Lai, L, Xu, Z, Amidon, G.L. | Deposit date: | 2006-12-20 | Release date: | 2008-02-05 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Molecular basis of prodrug activation by human valacyclovirase, an alpha-amino acid ester hydrolase. J.Biol.Chem., 283, 2008
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4FZZ
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![BU of 4fzz by Molmil](/molmil-images/mine/4fzz) | Exonuclease X in complex with 5' overhanging duplex DNA | Descriptor: | DNA (5'-D(*GP*TP*CP*AP*TP*TP*GP*TP*GP*GP*AP*TP*CP*CP*GP*AP*G)-3'), Exodeoxyribonuclease 10, SODIUM ION | Authors: | Wang, T, Sun, H, Cheng, F, Bi, L, Jiang, T. | Deposit date: | 2012-07-08 | Release date: | 2013-07-03 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Recognition and processing of double-stranded DNA by ExoX, a distributive 3'-5' exonuclease Nucleic Acids Res., 41, 2013
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6HWV
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![BU of 6hwv by Molmil](/molmil-images/mine/6hwv) | Crystal structure of p38alpha in complex with a photoswitchable 2-Azoimidazol-based Inhibitor (compound 3) | Descriptor: | 3-(2,5-dimethoxyphenyl)-~{N}-[4-[5-(4-fluorophenyl)-2-[(~{E})-(4-fluorophenyl)diazenyl]-3-methyl-imidazol-4-yl]pyridin-2-yl]propanamide, Mitogen-activated protein kinase 14, octyl beta-D-glucopyranoside | Authors: | Mueller, M.P, Rauh, D. | Deposit date: | 2018-10-15 | Release date: | 2019-04-17 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | 2-Azo-, 2-diazocine-thiazols and 2-azo-imidazoles as photoswitchable kinase inhibitors: limitations and pitfalls of the photoswitchable inhibitor approach. Photochem. Photobiol. Sci., 18, 2019
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7JNY
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![BU of 7jny by Molmil](/molmil-images/mine/7jny) | Crystal structure of CXCL13 | Descriptor: | C-X-C motif chemokine 13 | Authors: | Rosenberg Jr, E.M, Rajasekaran, D, Murphy, J.W, Pantouris, G, Lolis, E.J. | Deposit date: | 2020-08-05 | Release date: | 2020-10-07 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.88 Å) | Cite: | The N-terminal length and side-chain composition of CXCL13 affect crystallization, structure and functional activity. Acta Crystallogr D Struct Biol, 76, 2020
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1KOO
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![BU of 1koo by Molmil](/molmil-images/mine/1koo) | THE CRYSTAL STRUCTURE AND MUTATIONAL ANALYSIS OF A NOVEL RNA-BINDING DOMAIN FOUND IN THE HUMAN TAP NUCLEAR MRNA EXPORT FACTOR | Descriptor: | TIP ASSOCIATING PROTEIN | Authors: | Ho, D.N, Coburn, G.A, Kang, Y, Cullen, B.R, Georgiadis, M.M. | Deposit date: | 2001-12-21 | Release date: | 2002-02-27 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (3.8 Å) | Cite: | The crystal structure and mutational analysis of a novel RNA-binding domain found in the human Tap nuclear mRNA export factor. Proc.Natl.Acad.Sci.USA, 99, 2002
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4XRR
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![BU of 4xrr by Molmil](/molmil-images/mine/4xrr) | Crystal structure of cals8 from micromonospora echinospora (P294S mutant) | Descriptor: | CalS8, GLYCEROL | Authors: | Michalska, K, Bigelow, L, Endres, M, Babnigg, G, Bingman, C.A, Yennamalli, R.M, Singh, S, Kharel, M.K, Thorson, J.S, Phillips Jr, G.N, Joachimiak, A, Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro) | Deposit date: | 2015-01-21 | Release date: | 2015-02-11 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | Structural Characterization of CalS8, a TDP-alpha-D-Glucose Dehydrogenase Involved in Calicheamicin Aminodideoxypentose Biosynthesis. J. Biol. Chem., 290, 2015
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6B47
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![BU of 6b47 by Molmil](/molmil-images/mine/6b47) | Cryo-EM structure of Type I-F CRISPR crRNA-guided Csy surveillance complex with bound anti-CRISPR protein AcrF2 | Descriptor: | Anti-CRISPR protein AcrF2, CRISPR-associated endonuclease Cas6/Csy4, CRISPR-associated protein Csy1, ... | Authors: | Guo, T.W, Bartesaghi, A, Yang, H, Falconieri, V, Rao, P, Merk, A, Fox, T, Earl, L, Patel, D.J, Subramaniam, S. | Deposit date: | 2017-09-25 | Release date: | 2017-10-18 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Cryo-EM Structures Reveal Mechanism and Inhibition of DNA Targeting by a CRISPR-Cas Surveillance Complex. Cell, 171, 2017
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