PDB: 5538 resultsInfo pagesStatus searchChemie searchBIRD

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6GMH	Structure of activated transcription complex Pol II-DSIF-PAF-SPT6 Descriptor: CDC73, CTR9,RNA polymerase-associated protein CTR9 homolog,RNA polymerase-associated protein CTR9 homolog, DNA-directed RNA polymerase II subunit RPB9, ... Authors: Vos, S.M, Farnung, L, Boehing, M, Linden, A, Wigge, C, Urlaub, H, Cramer, P. Deposit date: 2018-05-26 Release date: 2018-08-22 Last modified: 2019-12-18 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: Structure of activated transcription complex Pol II-DSIF-PAF-SPT6. Nature, 560, 2018
7YVD	The crystal structure of the progerin C-terminal peptide and the Ig-like domain of lamin A/C Descriptor: Lamin-A/C, SELENOCYSTEINE Authors: Ahn, J, Ha, N.C. Deposit date: 2022-08-19 Release date: 2023-08-30 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.1 Å) Cite: The crystal structure of the progerin C-terminal peptide and the Ig-like domain of lamin A/C To Be Published
2KWO	Solution structure of the double PHD (plant homeodomain) fingers of human transcriptional protein DPF3b bound to a histone H4 peptide containing N-terminal acetylation at Serine 1 Descriptor: Histone peptide, ZINC ION, Zinc finger protein DPF3 Authors: Zeng, L, Zhang, Q, Li, S, Plotnikov, A.N, Walsh, M.J, Zhou, M. Deposit date: 2010-04-14 Release date: 2010-07-14 Last modified: 2013-06-19 Method: SOLUTION NMR Cite: Mechanism and regulation of acetylated histone binding by the tandem PHD finger of DPF3b. Nature, 466, 2010
8EVH	CX3CR1 nucleosome and wild type PU.1 complex Descriptor: DNA (162-MER), Histone H2A type 2-C, Histone H2B type 2-E, ... Authors: Lian, T, Guan, R, Bai, Y. Deposit date: 2022-10-20 Release date: 2023-11-01 Last modified: 2024-05-01 Method: ELECTRON MICROSCOPY (2.85 Å) Cite: Structural mechanism of synergistic targeting of the CX3CR1 nucleosome by PU.1 and C/EBP alpha. Nat.Struct.Mol.Biol., 31, 2024
8SYP	Genomic CX3CR1 nucleosome Descriptor: DNA (162-MER), Histone H2A type 2-C, Histone H2B type 2-E, ... Authors: Lian, T, Guan, R, Bai, Y. Deposit date: 2023-05-25 Release date: 2023-11-01 Last modified: 2024-05-01 Method: ELECTRON MICROSCOPY (2.6 Å) Cite: Structural mechanism of synergistic targeting of the CX3CR1 nucleosome by PU.1 and C/EBP alpha. Nat.Struct.Mol.Biol., 31, 2024
2KWN	Solution structure of the double PHD (plant homeodomain) fingers of human transcriptional protein DPF3b bound to a histone H4 peptide containing acetylation at Lysine 16 Descriptor: Histone peptide, ZINC ION, Zinc finger protein DPF3 Authors: Zeng, L, Zhang, Q, Li, S, Plotnikov, A.N, Walsh, M.J, Zhou, M. Deposit date: 2010-04-13 Release date: 2010-07-14 Last modified: 2023-11-15 Method: SOLUTION NMR Cite: Mechanism and regulation of acetylated histone binding by the tandem PHD finger of DPF3b. Nature, 466, 2010
8EQV	Cryo-EM structure of PRC2 in complex with the long isoform of AEBP2 Descriptor: Histone-binding protein RBBP4, Histone-lysine N-methyltransferase EZH2, Polycomb protein EED, ... Authors: Boudes, M, Zhang, Q, Flanigan, S.F, Davidovich, C. Deposit date: 2022-10-09 Release date: 2024-07-31 Method: ELECTRON MICROSCOPY (3.64 Å) Cite: To be updated To Be Published
8TGP	Crystal structure of SIRT2 with FAM-PEG4-H4K16(myristoyl) peptide Descriptor: H4K16(myristoyl) peptide, MYRISTIC ACID, NAD-dependent protein deacetylase sirtuin-2, ... Authors: Nicely, N.I, Weiser, B.P. Deposit date: 2023-07-12 Release date: 2024-01-24 Method: X-RAY DIFFRACTION (1.76 Å) Cite: Effects of Dimerization on the Deacylase Activities of Human SIRT2. Biochemistry, 62, 2023
2LE0	PARP BRCT Domain Descriptor: Poly [ADP-ribose] polymerase 1 Authors: Mueller, G, Loeffler, P, Cuneo, M, Derose, E, London, R. Deposit date: 2011-06-03 Release date: 2011-10-19 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: Structural studies of the PARP-1 BRCT domain. Bmc Struct.Biol., 11, 2011
8FKW	Human nucleolar pre-60S ribosomal subunit (State D2) Descriptor: 28S rRNA, 5.8S rRNA, 60S ribosomal protein L10a, ... Authors: Vanden Broeck, A, Klinge, S. Deposit date: 2022-12-21 Release date: 2023-07-12 Last modified: 2023-08-16 Method: ELECTRON MICROSCOPY (2.5 Å) Cite: Principles of human pre-60 S biogenesis. Science, 381, 2023
8G0H	Human PARP1 deltaV687-E688 bound to UKTT5 (compound 10) and to a DNA double strand break. Descriptor: 2-(4-{[2-(1H-benzimidazol-2-yl)ethyl]carbamoyl}phenyl)-1H-benzimidazole-7-carboxamide, DNA (5'-D(*CP*GP*AP*CP*G)-3'), DNA (5'-D(*CP*GP*TP*CP*G)-3'), ... Authors: Rouleau-Turcotte, E, Pascal, J.M. Deposit date: 2023-01-31 Release date: 2024-02-07 Last modified: 2024-03-27 Method: X-RAY DIFFRACTION (3.8 Å) Cite: Novel modifications of PARP inhibitor veliparib increase PARP1 binding to DNA breaks. Biochem.J., 481, 2024
2MKS	NMR structure of the RRM domain of RBMX from homo sapiens Descriptor: RNA-binding motif protein, X chromosome Authors: Serrano, P, Geralt, M, Wuthrich, K, Joint Center for Structural Genomics (JCSG), Partnership for T-Cell Biology (TCELL) Deposit date: 2014-02-14 Release date: 2014-03-12 Last modified: 2024-05-01 Method: SOLUTION NMR Cite: NMR structure of the first RRM domain of the protein RBM39 from Homo sapiens To be Published
8G61	mRNA decoding in human is kinetically and structurally distinct from bacteria (AC state) Descriptor: 1,4-DIAMINOBUTANE, 18S rRNA, 28S rRNA, ... Authors: Holm, M, Natchiar, K.S, Rundlet, E.J, Myasnikov, A.G, Altman, R.B, Blanchard, S.C. Deposit date: 2023-02-14 Release date: 2023-04-19 Last modified: 2023-11-15 Method: ELECTRON MICROSCOPY (2.94 Å) Cite: mRNA decoding in human is kinetically and structurally distinct from bacteria. Nature, 617, 2023
8G2E	PKM2 bound to compound 2 Descriptor: 1,2-ETHANEDIOL, 3-[(3-aminophenyl)methyl]-5-methyl-7-[methyl(oxidanyl)-$l^{3}-sulfanyl]pyridazino[4,5-b]indol-4-one, MAGNESIUM ION, ... Authors: Stuckey, J.A. Deposit date: 2023-02-03 Release date: 2023-05-17 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (1.838 Å) Cite: Development of Novel Small-Molecule Activators of Pyruvate Kinase Muscle Isozyme 2, PKM2, to Reduce Photoreceptor Apoptosis. Pharmaceuticals, 16, 2023
8U17	The ternary complex structure of DDB1-CRBN-SALL4(ZF1,2)-long bound to Pomalidomide Descriptor: DNA damage-binding protein 1, Protein cereblon, S-Pomalidomide, ... Authors: Clifton, M.C, Ma, X, Ornelas, E. Deposit date: 2023-08-30 Release date: 2023-12-27 Method: X-RAY DIFFRACTION (3.1 Å) Cite: Structural and biophysical comparisons of the pomalidomide- and CC-220-induced interactions of SALL4 with cereblon. Sci Rep, 13, 2023
8UIS	Structure of transcription complex Pol II-DSIF-NELF-TFIIS Descriptor: DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit RPB3, DNA-directed RNA polymerase II subunit RPB7, ... Authors: Su, B.G, Vos, S.M. Deposit date: 2023-10-10 Release date: 2024-03-20 Last modified: 2024-04-17 Method: ELECTRON MICROSCOPY (3.23 Å) Cite: Distinct negative elongation factor conformations regulate RNA polymerase II promoter-proximal pausing. Mol.Cell, 84, 2024
2MB0	Solution structure of hnRNP G RRM in complex with the RNA 5'-AUCAAA-3' Descriptor: RNA-binding motif protein, X chromosome, RNA_(5'-R(*AP*UP*CP*AP*AP*A)-3') Authors: Moursy, A, Allain, F.H.-T, Clery, A. Deposit date: 2013-07-22 Release date: 2014-04-09 Last modified: 2024-05-01 Method: SOLUTION NMR Cite: Characterization of the RNA recognition mode of hnRNP G extends its role in SMN2 splicing regulation. Nucleic Acids Res., 42, 2014
8GUK	Human nucleosome core particle (free form) Descriptor: DNA (147-mer), Histone H2A type 1, Histone H2B type 1-J, ... Authors: Onishi, S, Sato, K, Nishizawa, T, Nureki, O, Ogata, K, Sengoku, T. Deposit date: 2022-09-12 Release date: 2023-09-20 Last modified: 2024-04-03 Method: ELECTRON MICROSCOPY (2.51 Å) Cite: Structure of the human Bre1 complex bound to the nucleosome. Nat Commun, 15, 2024
8H0W	RNA polymerase II transcribing a chromatosome (type II) Descriptor: DNA (261-MER), DNA-directed RNA polymerase subunit, DNA-directed RNA polymerase subunit beta, ... Authors: Hirano, R, Ehara, H, Tomoya, K, Takizawa, Y, Sekine, S, Kurumizaka, H. Deposit date: 2022-09-30 Release date: 2022-12-07 Last modified: 2024-07-03 Method: ELECTRON MICROSCOPY (4.6 Å) Cite: Structural basis of RNA polymerase II transcription on the chromatosome containing linker histone H1. Nat Commun, 13, 2022
8H0V	RNA polymerase II transcribing a chromatosome (type I) Descriptor: DNA (261-MER), DNA-directed RNA polymerase subunit, DNA-directed RNA polymerase subunit beta, ... Authors: Hirano, R, Ehara, H, Tomoya, K, Takizawa, Y, Sekine, S, Kurumizaka, H. Deposit date: 2022-09-30 Release date: 2022-12-07 Last modified: 2024-07-03 Method: ELECTRON MICROSCOPY (3.8 Å) Cite: Structural basis of RNA polymerase II transcription on the chromatosome containing linker histone H1. Nat Commun, 13, 2022
8HMS	Crystal Structure of PKM2 mutant C474S Descriptor: 1,2-ETHANEDIOL, 1,6-di-O-phosphono-beta-D-fructofuranose, GLYCEROL, ... Authors: Upadhyay, S, Kumar, A, Patel, A.K. Deposit date: 2022-12-05 Release date: 2023-01-11 Last modified: 2024-05-29 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Structural and mechanistic insights into cancer patient-derived mutations in Pyruvate Kinase muscle isoform 2 To Be Published
8HMQ	Crystal Structure of PKM2 mutant P403A Descriptor: 1,2-ETHANEDIOL, 1,6-di-O-phosphono-beta-D-fructofuranose, GLYCEROL, ... Authors: Upadhyay, S, Kumar, A, Patel, A.K. Deposit date: 2022-12-05 Release date: 2023-01-11 Last modified: 2024-05-29 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Structural and mechanistic insights into cancer patient-derived mutations in Pyruvate Kinase muscle isoform 2 To Be Published
8HMR	Crystal Structure of PKM2 mutant L144P Descriptor: 1,2-ETHANEDIOL, 1,6-di-O-phosphono-beta-D-fructofuranose, MAGNESIUM ION, ... Authors: Upadhyay, S, Kumar, A, Patel, A.K. Deposit date: 2022-12-05 Release date: 2023-01-11 Last modified: 2024-05-29 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Structural and mechanistic insights into cancer patient-derived mutations in Pyruvate Kinase muscle isoform 2 To Be Published
8FL9	Human nuclear pre-60S ribosomal subunit (State J3) Descriptor: 28S rRNA, 5.8S rRNA, 5S rRNA, ... Authors: Vanden Broeck, A, Klinge, S. Deposit date: 2022-12-21 Release date: 2023-07-12 Last modified: 2023-07-26 Method: ELECTRON MICROSCOPY (2.75 Å) Cite: Principles of human pre-60 S biogenesis. Science, 381, 2023
8HMU	Crystal Structure of PKM2 mutant R516C Descriptor: 1,2-ETHANEDIOL, 1,6-di-O-phosphono-beta-D-fructofuranose, GLYCEROL, ... Authors: Upadhyay, S, Kumar, A, Patel, A.K. Deposit date: 2022-12-05 Release date: 2023-01-11 Last modified: 2024-05-29 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Structural and mechanistic insights into cancer patient-derived mutations in Pyruvate Kinase muscle isoform 2 To Be Published

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