8G2E

PKM2 bound to compound 2

Summary for 8G2E

Entry DOI	10.2210/pdb8g2e/pdb
Descriptor	Pyruvate kinase PKM, 3-[(3-aminophenyl)methyl]-5-methyl-7-[methyl(oxidanyl)-$l^{3}-sulfanyl]pyridazino[4,5-b]indol-4-one, 1,2-ETHANEDIOL, ... (8 entities in total)
Functional Keywords	activator, small molecule, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	61698.69
Authors	Stuckey, J.A. (deposition date: 2023-02-03, release date: 2023-05-17, Last modification date: 2023-06-07)
Primary citation	Wubben, T.J.,Chaudhury, S.,Watch, B.T.,Stuckey, J.A.,Weh, E.,Fernando, R.,Goswami, M.,Pawar, M.,Rech, J.C.,Besirli, C.G. Development of Novel Small-Molecule Activators of Pyruvate Kinase Muscle Isozyme 2, PKM2, to Reduce Photoreceptor Apoptosis. Pharmaceuticals, 16:-, 2023 Cited by PubMed: 37242488 DOI: 10.3390/ph16050705 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.838 Å)

Structure validation