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7Z4T	AAL160 FAB IN COMPLEX WITH HUMAN INTERLEUKIN-1 BETA Descriptor: AAL160 Fab heavy-chain, AAL160 light-chain, Interleukin-1 beta Authors: Rondeau, J.M, Lehmann, S. Deposit date: 2022-03-04 Release date: 2023-02-08 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (3.3 Å) Cite: "Redirecting an anti-IL-1 beta antibody to bind a new, unrelated and computationally predicted epitope on hIL-17A". Commun Biol, 6, 2023
8C3U	Crystal Structure of human IL-1beta in complex with a low molecular weight antagonist Descriptor: (S)-4'-hydroxy-3'-(6-methyl-2-oxo-3-(1H-pyrazol-4-yl)indolin-3-yl)-[1,1'-biphenyl]-2,4-dicarboxylic acid, Interleukin-1 beta Authors: Rondeau, J.-M, Lehmann, S, Koch, E. Deposit date: 2022-12-28 Release date: 2023-09-13 Last modified: 2024-03-27 Method: X-RAY DIFFRACTION (1.945 Å) Cite: Discovery of a selective and biologically active low-molecular weight antagonist of human interleukin-1 beta. Nat Commun, 14, 2023
8SPB	Caspase-4/Pro-IL-18 complex Descriptor: Caspase-4 subunit p10, Caspase-4 subunit p20, Interleukin-18 Authors: Pascal, D, Dong, Y, Wu, H, Jon, K. Deposit date: 2023-05-02 Release date: 2023-11-22 Last modified: 2023-12-27 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Structural insights into cytokine cleavage by inflammatory caspase-4. Nature, 624, 2023
8J6K	Crystal structure of pro-interleukin-18 and caspase-4 complex Descriptor: Arginine ADP-riboxanase OspC3, Caspase-4 subunit p10, Caspase-4 subunit p20, ... Authors: Sun, Q, Hou, Y.J, Ding, J. Deposit date: 2023-04-26 Release date: 2023-11-29 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (3.12 Å) Cite: Recognition and maturation of IL-18 by caspase-4 noncanonical inflammasome. Nature, 624, 2023
8RYS	Human IL-1beta, unliganded Descriptor: Interleukin-1 beta, SULFATE ION Authors: Rondeau, J.-M, Lehmann, S. Deposit date: 2024-02-09 Release date: 2024-03-06 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (1.16 Å) Cite: Ligandability Assessment of IL-1 beta by Integrated Hit Identification Approaches. J.Med.Chem., 67, 2024
8SV1	Caspase-1 complex with interleukin-18 Descriptor: Caspase-1, Interleukin-18 Authors: Dong, Y, Pascal, D, Jon, K, Wu, H. Deposit date: 2023-05-15 Release date: 2024-05-08 Method: ELECTRON MICROSCOPY (3.5 Å) Cite: Caspase-1 complex with interleukin-18 To Be Published
8RZB	IL-1beta in complex with covalent DEL hit Descriptor: 8-[4-methyl-3-(trifluoromethyl)phenyl]-2-[[(7S)-7-(2-morpholin-4-ylethylcarbamoyl)-4-(phenylsulfonyl)-1,4-diazepan-1-yl]carbonyl]imidazo[1,2-a]pyridine-6-carboxylic acid, Interleukin-1 beta Authors: Rondeau, J.-M, Lehmann, S. Deposit date: 2024-02-12 Release date: 2024-05-22 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (1.836 Å) Cite: Ligandability Assessment of IL-1 beta by Integrated Hit Identification Approaches. J.Med.Chem., 67, 2024
8RYK	IL-1beta in complex with macrocyclic peptide hit Descriptor: Interleukin-1 beta, Macrocyclic peptide Authors: Rondeau, J.-M, Lehmann, S. Deposit date: 2024-02-09 Release date: 2024-05-22 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Ligandability Assessment of IL-1 beta by Integrated Hit Identification Approaches. J.Med.Chem., 67, 2024
8URV	Solution NMR structure of pro-IL-18 Descriptor: Interleukin-18 Authors: Bonin, J.P, Aramini, J.M, Kay, L.E. Deposit date: 2023-10-26 Release date: 2024-05-29 Method: SOLUTION NMR Cite: Structural transitions enable interleukin-18 maturation and signaling. Immunity, 2024

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