PDB: 620 resultsInfo pagesStatus searchChemie searchBIRD

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4JDD	14-3-3 protein interaction with Estrogen Receptor Alpha provides a novel drug target interface Descriptor: 14-3-3 protein sigma, Estrogen receptor Peptide, FUSICOCCIN Authors: Bier, D, Ottmann, C. Deposit date: 2013-02-25 Release date: 2013-05-15 Last modified: 2017-06-07 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Interaction of 14-3-3 proteins with the estrogen receptor alpha F domain provides a drug target interface. Proc. Natl. Acad. Sci. U.S.A., 110, 2013
1O9E	Structural view of a fungal toxin acting on a 14-3-3 regulatory complex Descriptor: 14-3-3-LIKE PROTEIN C, CITRATE ANION, FUSICOCCIN Authors: Wurtele, M, Jelich-Ottmann, C, Wittinghofer, A, Oecking, C. Deposit date: 2002-12-12 Release date: 2003-03-06 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Structural View of a Fungal Toxin Acting on a 14-3-3 Regulatory Complex Embo J., 22, 2003
1O9D	Structural view of a fungal toxin acting on a 14-3-3 regulatory complex Descriptor: 14-3-3-LIKE PROTEIN C, PLASMA MEMBRANE H+ ATPASE Authors: Wurtele, M, Jelich-Ottmann, C, Wittinghofer, A, Oecking, C. Deposit date: 2002-12-12 Release date: 2003-03-06 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structural View of a Fungal Toxin Acting on a 14-3-3 Regulatory Complex Embo J., 22, 2003
4IEA	14-3-3 isoform sigma in complex with a phosphorylated C-RAF peptide Descriptor: 14-3-3 protein sigma, RAF proto-oncogene serine/threonine-protein kinase Authors: Molzan, M, Ottmann, C. Deposit date: 2012-12-13 Release date: 2013-09-25 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Stabilization of Physical RAF/14-3-3 Interaction by Cotylenin A as Treatment Strategy for RAS Mutant Cancers. Acs Chem.Biol., 8, 2013
1QJB	14-3-3 ZETA/PHOSPHOPEPTIDE COMPLEX (MODE 1) Descriptor: 14-3-3 PROTEIN ZETA/DELTA, PHOSPHOPEPTIDE Authors: Rittinger, K, Budman, J, Xu, J, Volinia, S, Cantley, L.C, Smerdon, S.J, Gamblin, S.J, Yaffe, M.B. Deposit date: 1999-06-23 Release date: 1999-09-15 Last modified: 2024-05-01 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural Analysis of 14-3-3 Phosphopeptide Complexes Identifies a Dual Role for the Nuclear Export Signal of 14-3-3 in Ligand Binding Mol.Cell, 4, 1999
4IHL	Human 14-3-3 isoform zeta in complex with a diphoyphorylated C-RAF peptide and Cotylenin A Descriptor: (1R,3aS,4R,5R,6R,9aR,10E)-6-({(1S,2R,4S,5R,6R,8S,9S)-5-hydroxy-2-(methoxymethyl)-9-methyl-9-[(2S)-oxiran-2-yl]-3,7,10,1 1-tetraoxatricyclo[6.2.1.0~1,6~]undec-4-yl}oxy)-1-(methoxymethyl)-4,9a-dimethyl-7-(propan-2-yl)-1,2,3,3a,4,5,6,8,9,9a-de cahydrodicyclopenta[a,d][8]annulene-1,5-diol, 14-3-3 protein zeta/delta, POTASSIUM ION, ... Authors: Molzan, M, Ottmann, C. Deposit date: 2012-12-19 Release date: 2013-09-25 Last modified: 2024-10-09 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Stabilization of Physical RAF/14-3-3 Interaction by Cotylenin A as Treatment Strategy for RAS Mutant Cancers. Acs Chem.Biol., 8, 2013
1QJA	14-3-3 ZETA/PHOSPHOPEPTIDE COMPLEX (MODE 2) Descriptor: 14-3-3 PROTEIN ZETA, PHOSPHOPEPTIDE Authors: Rittinger, K, Budman, J, Xu, J, Volinia, S, Cantley, L.C, Smerdon, S.J, Gamblin, S.J, Yaffe, M.B. Deposit date: 1999-06-23 Release date: 1999-09-15 Last modified: 2024-05-01 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural Analysis of 14-3-3 Phosphopeptide Complexes Identifies a Dual Role for the Nuclear Export Signal of 14-3-3 in Ligand Binding Mol.Cell, 4, 1999
7BMC	Crystal structure of 14-3-3 sigma in complex with CIP2ApS904 peptide and stabilizing Fusicoccin A Descriptor: 14-3-3 protein sigma, CHLORIDE ION, FUSICOCCIN, ... Authors: Centorrino, F, Andlovic, B, Ottmann, C. Deposit date: 2021-01-19 Release date: 2022-03-02 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2 Å) Cite: Fusicoccin-A Targets Cancerous Inhibitor of Protein Phosphatase 2A by Stabilizing a C-Terminal Interaction with 14-3-3. Acs Chem.Biol., 17, 2022
7BM9	Crystal structure of 14-3-3 sigma in complex with CIP2ApS904 peptide Descriptor: 14-3-3 protein sigma, CHLORIDE ION, MAGNESIUM ION, ... Authors: Centorrino, F, Andlovic, B, Ottmann, C. Deposit date: 2021-01-19 Release date: 2022-03-02 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Fusicoccin-A Targets Cancerous Inhibitor of Protein Phosphatase 2A by Stabilizing a C-Terminal Interaction with 14-3-3. Acs Chem.Biol., 17, 2022
7C8E	Crystal Structure of 14-3-3 epsilon with 9J10 peptide Descriptor: 14-3-3 protein epsilon, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 9J10 Authors: Mathivanan, S, Sudhakar, S, Bairy, S, Kamariah, N, Venkitaraman, A. Deposit date: 2020-05-30 Release date: 2021-06-02 Last modified: 2024-10-09 Method: X-RAY DIFFRACTION (3.16 Å) Cite: Target identification for small-molecule discovery in the FOXO3a tumor-suppressor pathway using a biodiverse peptide library. Cell Chem Biol, 28, 2021
6HMT	Ternary complex of Estrogen Receptor alpha peptide and 14-3-3 sigma C42 mutant bound to disulfide fragment PPI stabilizer 2 Descriptor: 14-3-3 protein sigma, 2-(4-chloranylphenoxy)-2-methyl-~{N}-(2-sulfanylethyl)propanamide, Estrogen Receptor, ... Authors: Sijbesma, E, Hallenbeck, K.K, Leysen, S, Arkin, M.R, Ottmann, C. Deposit date: 2018-09-12 Release date: 2019-02-27 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.1 Å) Cite: Site-Directed Fragment-Based Screening for the Discovery of Protein-Protein Interaction Stabilizers. J. Am. Chem. Soc., 141, 2019
7EXE	Crystal structure of mouse 14-3-3zeta in complex with doubly phosphorylated ADAM22 peptide Descriptor: 14-3-3 protein zeta/delta, Disintegrin and metalloproteinase domain-containing protein 22 Authors: Yan, L, Okatsu, K, Fukai, S. Deposit date: 2021-05-27 Release date: 2021-11-24 Last modified: 2024-10-09 Method: X-RAY DIFFRACTION (2.75 Å) Cite: LGI1-ADAM22 levels regulate seizure thresholds through 14-3-3 in mice Cell Rep, 2021
6HN2	Ternary complex of Estrogen Receptor alpha peptide and 14-3-3 sigma C42 mutant bound to disulfide fragment PPI stabilizer 5 Descriptor: 14-3-3 protein sigma, 2-(3,4-dichlorophenyl)-~{N}-(2-sulfanylethyl)ethanamide, Estrogen Receptor, ... Authors: Sijbesma, E, Hallenbeck, K.K, Leysen, S, Arkin, M.R, Ottmann, C. Deposit date: 2018-09-13 Release date: 2019-02-27 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Site-Directed Fragment-Based Screening for the Discovery of Protein-Protein Interaction Stabilizers. J. Am. Chem. Soc., 141, 2019
6HKB	Ternary complex of Estrogen Receptor alpha peptide and 14-3-3 sigma C42 mutant bound to disulfide fragment PPI stabilizer 3 Descriptor: (1~{R},2~{S})-2-[methyl-[(~{R})-(2-methylpropan-2-yl)oxy-oxidanyl-methyl]amino]-2-phenyl-1-(2-sulfanylethylamino)ethanol, 14-3-3 protein sigma, Estrogen receptor, ... Authors: Sijbesma, E, Hallenbeck, K.K, Leysen, S, Arkin, M.R, Ottmann, C. Deposit date: 2018-09-06 Release date: 2019-02-27 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Site-Directed Fragment-Based Screening for the Discovery of Protein-Protein Interaction Stabilizers. J. Am. Chem. Soc., 141, 2019
7D9V	CRTC1 pSer245 peptide in complex with 14-3-3 zeta Descriptor: 14-3-3 protein zeta/delta, CRTC1 pSer245 peptide, GLYCEROL Authors: Chen, H, Zhang, H, Xiang, S. Deposit date: 2020-10-14 Release date: 2021-02-24 Last modified: 2024-10-09 Method: X-RAY DIFFRACTION (2.21 Å) Cite: Structural Insights into the Interaction Between CRTCs and 14-3-3. J.Mol.Biol., 433, 2021
7D8P	CRTC1 pSer151 peptide in complex with 14-3-3 zeta Descriptor: 14-3-3 protein zeta/delta, CRTC1 pSer151 peptide, GLYCEROL Authors: Chen, H, Zhang, H, Xiang, S. Deposit date: 2020-10-08 Release date: 2021-02-24 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural Insights into the Interaction Between CRTCs and 14-3-3. J.Mol.Biol., 433, 2021
7D8H	CRTC1 pSer64 peptide in complex with 14-3-3 zeta Descriptor: 14-3-3 protein zeta/delta, CRTC1 pSer64 peptide Authors: Chen, H, Zhang, H, Xiang, S. Deposit date: 2020-10-08 Release date: 2021-02-24 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.42 Å) Cite: Structural Insights into the Interaction Between CRTCs and 14-3-3. J.Mol.Biol., 433, 2021
6HHP	Ternary complex of Estrogen Receptor alpha peptide and 14-3-3 sigma C42 mutant bound to disulfide fragment PPI stabilizer 1 Descriptor: (1~{R})-2-(4-chloranylphenoxy)-2-methyl-1-[methyl(2-sulfanylethyl)amino]propan-1-ol, 14-3-3 protein sigma, Estrogen receptor, ... Authors: Sijbesma, E, Hallenbeck, K.K, Leysen, S, Arkin, M.R, Ottmann, C. Deposit date: 2018-08-28 Release date: 2019-02-27 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.802 Å) Cite: Site-Directed Fragment-Based Screening for the Discovery of Protein-Protein Interaction Stabilizers. J. Am. Chem. Soc., 141, 2019
6HKF	Ternary complex of Estrogen Receptor alpha peptide and 14-3-3 sigma C42 mutant bound to disulfide fragment PPI stabilizer 4 Descriptor: (1~{S})-2,2-diphenyl-1-(2-sulfanylethylamino)propan-1-ol, 14-3-3 protein sigma, Estrogen receptor, ... Authors: Sijbesma, E, Hallenbeck, K.K, Leysen, S, Arkin, M.R, Ottmann, C. Deposit date: 2018-09-06 Release date: 2019-02-27 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.801 Å) Cite: Site-Directed Fragment-Based Screening for the Discovery of Protein-Protein Interaction Stabilizers. J. Am. Chem. Soc., 141, 2019
6HEP	Crystal structure of human 14-3-3 beta in complex with CFTR R-domain peptide pS753-pS768 Descriptor: 14-3-3 protein beta/alpha, 2-{2-[2-2-(METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, Cystic fibrosis transmembrane conductance regulator Authors: Stevers, L.M, Ottmann, C, Brunsveld, L. Deposit date: 2018-08-20 Release date: 2018-10-24 Last modified: 2018-11-07 Method: X-RAY DIFFRACTION (1.86 Å) Cite: A Thermodynamic Model for Multivalency in 14-3-3 Protein-Protein Interactions. J. Am. Chem. Soc., 140, 2018
6HMU	Ternary complex of Estrogen Receptor alpha peptide and 14-3-3 sigma C45 mutant bound to disulfide fragment PPI stabilizer 6 Descriptor: 14-3-3 protein sigma, 2-(4-chloranylphenoxy)-2-methyl-~{N}-(3-sulfanylpropyl)propanamide, Estrogen receptor, ... Authors: Sijbesma, E, Hallenbeck, K.K, Leysen, S, Arkin, M.R, Ottmann, C. Deposit date: 2018-09-12 Release date: 2019-02-27 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.2 Å) Cite: Site-Directed Fragment-Based Screening for the Discovery of Protein-Protein Interaction Stabilizers. J. Am. Chem. Soc., 141, 2019
2C63	14-3-3 Protein Eta (Human) Complexed to Peptide Descriptor: 14-3-3 PROTEIN ETA, CONSENSUS PEPTIDE FOR 14-3-3 PROTEINS Authors: Elkins, J.M, Yang, X, Smee, C.E.A, Johansson, C, Sundstrom, M, Edwards, A, Weigelt, J, Arrowsmith, C, Doyle, D.A. Deposit date: 2005-11-07 Release date: 2005-11-21 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Structural Basis for Protein-Protein Interactions in the 14-3-3 Protein Family. Proc.Natl.Acad.Sci.USA, 103, 2006
2BQ0	14-3-3 Protein Beta (Human) Descriptor: 14-3-3 BETA/ALPHA Authors: Yang, X, Elkins, J.M, Fedorov, O, Longman, E.J, Sobott, L, Ball, L.J, Sundstrom, M, Arrowsmith, C, Edwards, A, Doyle, D.A. Deposit date: 2005-04-26 Release date: 2005-05-06 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Structural Basis for Protein-Protein Interactions in the 14-3-3 Protein Family. Proc.Natl.Acad.Sci.USA, 103, 2006
2BR9	14-3-3 Protein Epsilon (Human) Complexed to Peptide Descriptor: 14-3-3 PROTEIN EPSILON, CONSENSUS PEPTIDE FOR 14-3-3 PROTEINS Authors: Yang, X, Elkins, J.M, Soundararajan, M, Fedorov, O, Sundstrom, M, Edwards, A, Arrowsmith, C, Doyle, D.A. Deposit date: 2005-05-03 Release date: 2005-05-12 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Structural Basis for Protein-Protein Interactions in the 14-3-3 Protein Family. Proc.Natl.Acad.Sci.USA, 103, 2006
2C23	14-3-3 Protein Beta (Human) in complex with exoenzyme S peptide Descriptor: 14-3-3 BETA/ALPHA, EXOENZYME S PEPTIDE Authors: Elkins, J.M, Schoch, G.A, Yang, X, Sundstrom, M, Arrowsmith, C, Edwards, A, Doyle, D.A. Deposit date: 2005-09-26 Release date: 2005-09-29 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.65 Å) Cite: Structural Basis for Protein-Protein Interactions in the 14-3-3 Protein Family. Proc.Natl.Acad.Sci.USA, 103, 2006

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