1VFX
| Crystal Structure of the Kif1A Motor Domain Complexed With ADP-Mg-AlFx | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, ... | Authors: | Nitta, R, Kikkawa, M, Okada, Y, Hirokawa, N. | Deposit date: | 2004-04-19 | Release date: | 2004-08-10 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | KIF1A Alternately Uses Two Loops to Bind Microtubules Science, 305, 2004
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1V8K
| The Crystal Structure of the Minimal Functional Domain of the Microtubule Destabilizer KIF2C Complexed with Mg-AMPPNP | Descriptor: | Kinesin-like protein KIF2C, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | Authors: | Ogawa, T, Nitta, R, Okada, Y, Hirokawa, N. | Deposit date: | 2004-01-09 | Release date: | 2004-03-02 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | A common mechanism for microtubule destabilizers-M type kinesins stabilize curling of the protofilament using the class-specific neck and loops. Cell(Cambridge,Mass.), 116, 2004
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1VFZ
| Crystal Structure of the Kif1A Motor Domain Complexed With ADP-Mg-VO4 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PROTEIN (Fusion protein consisting of Kinesin-like protein KIF1A, ... | Authors: | Nitta, R, Kikkawa, M, Okada, Y, Hirokawa, N. | Deposit date: | 2004-04-19 | Release date: | 2004-08-10 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.24 Å) | Cite: | KIF1A Alternately Uses Two Loops to Bind Microtubules Science, 305, 2004
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2Y65
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3H4S
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2ZFJ
| Crystal Structure of the Kif1A Motor Domain during Mg release: Mg-releasing Transition-1 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Kinesin-like protein KIF1A, Kinesin heavy chain isoform 5C, ... | Authors: | Nitta, R, Okada, Y, Hirokawa, N. | Deposit date: | 2008-01-08 | Release date: | 2008-09-23 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structural model for strain-dependent microtubule activation of Mg-ADP release from kinesin. Nat.Struct.Mol.Biol., 15, 2008
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2ZFI
| Crystal Structure of the Kif1A Motor Domain Before Mg Release | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Kinesin-like protein KIF1A, Kinesin heavy chain isoform 5C, ... | Authors: | Nitta, R, Okada, Y, Hirokawa, N. | Deposit date: | 2008-01-07 | Release date: | 2008-09-23 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Structural model for strain-dependent microtubule activation of Mg-ADP release from kinesin. Nat.Struct.Mol.Biol., 15, 2008
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2ZFK
| Crystal Structure of the Kif1A Motor Domain during Mg release: Mg-releasing Transition-2 | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ADENOSINE-5'-DIPHOSPHATE, Kinesin-like protein KIF1A, ... | Authors: | Nitta, R, Okada, Y, Hirokawa, N. | Deposit date: | 2008-01-08 | Release date: | 2008-09-23 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (3.61 Å) | Cite: | Structural model for strain-dependent microtubule activation of Mg-ADP release from kinesin. Nat.Struct.Mol.Biol., 15, 2008
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2UYI
| Crystal structure of KSP in complex with ADP and thiophene containing inhibitor 33 | Descriptor: | (5R)-N,N-DIETHYL-5-METHYL-2-[(THIOPHEN-2-YLCARBONYL)AMINO]-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBOXAMIDE, ADENOSINE-5'-DIPHOSPHATE, KINESIN-LIKE PROTEIN KIF11, ... | Authors: | Lee, T.T. | Deposit date: | 2007-04-07 | Release date: | 2007-05-22 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Synthesis and Sar of Thiophene Containing Kinesin Spindle Protein (Ksp) Inhibitors. Bioorg.Med.Chem.Lett., 17, 2007
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2Y5W
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2XT3
| HUMAN KIF7, A KINESIN INVOLVED IN HEDGEHOG SIGNALLING | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, KINESIN-LIKE PROTEIN KIF7, MAGNESIUM ION | Authors: | Klejnot, M, Kozielski, F. | Deposit date: | 2010-10-04 | Release date: | 2011-12-14 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.882 Å) | Cite: | Structural Insights Into Human Kif7, a Kinesin Involved in Hedgehog Signalling. Acta Crystallogr.,Sect.D, 68, 2012
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2UYM
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3K3B
| Co-crystal structure of the human kinesin Eg5 with a novel tetrahydro-beta-carboline | Descriptor: | 3-[(1R)-2-acetyl-6-methyl-2,3,4,9-tetrahydro-1H-beta-carbolin-1-yl]phenol, ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, ... | Authors: | Bussiere, D.E, Bellamacina, C, Le, V. | Deposit date: | 2009-10-02 | Release date: | 2009-12-15 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | The discovery of tetrahydro-beta-carbolines as inhibitors of the kinesin Eg5. Bioorg.Med.Chem.Lett., 20, 2010
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2ZFL
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2X7E
| Crystal structure of human kinesin Eg5 in complex with (R)-fluorastrol | Descriptor: | (4R)-5-[(S)-(3,4-DIFLUOROPHENYL)(HYDROXY)METHYL]-4-(3-HYDROXYPHENYL)-1,6-DIMETHYL-3,4-DIHYDROPYRIMIDINE-2(1H)-THIONE, ADENOSINE-5'-DIPHOSPHATE, KINESIN-LIKE PROTEIN KIF11, ... | Authors: | Kaan, H.Y.K, Ulaganathan, V, Rath, O, Laggner, C, Prokopcova, H, Dallinger, D, Kappe, C.O, Kozielski, F. | Deposit date: | 2010-02-26 | Release date: | 2010-07-14 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural Basis for Inhibition of Eg5 by Dihydropyrimidines: Stereoselectivity of Antimitotic Inhibitors Enastron, Dimethylenastron and Fluorastrol. J.Med.Chem., 53, 2010
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3HQD
| Human kinesin Eg5 motor domain in complex with AMPPNP and Mg2+ | Descriptor: | Kinesin-like protein KIF11, MAGNESIUM ION, PHOSPHATE ION, ... | Authors: | Parke, C.L, Wojcik, E.J, Kim, S, Worthylake, D.K. | Deposit date: | 2009-06-05 | Release date: | 2009-12-08 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.19 Å) | Cite: | ATP Hydrolysis in Eg5 Kinesin Involves a Catalytic Two-water Mechanism. J.Biol.Chem., 285, 2010
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2ZFM
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2XAE
| Crystal structure of human kinesin Eg5 in complex with (R)-2-amino-3-((S)-2-methyl-1,1-diphenylbutylthio)propanoic acid | Descriptor: | (2R)-2-AMINO-3-[(4-CHLOROPHENYL)-DIPHENYL-METHYL]SULFANYL-PROPANOIC ACID, ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, ... | Authors: | Kaan, H.Y.K, Weiss, J, Menger, D, Ulaganathan, V, Tkocz, K, Laggner, C, Popowycz, F, Joseph, B, Kozielski, F. | Deposit date: | 2010-03-31 | Release date: | 2011-03-30 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structure-Activity Relationship and Multidrug Resistance Study of New S-Trityl-L-Cysteine Derivatives as Inhibitors of Eg5. J.Med.Chem., 54, 2011
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2X7C
| Crystal structure of human kinesin Eg5 in complex with (S)-enastron | Descriptor: | (S)-4-(3-HYDROXYPHENYL)-2-THIOXO-1,2,3,4,7,8-HEXAHYDROQUINAZOLIN-5(6H)-ONE, ADENOSINE-5'-DIPHOSPHATE, KINESIN-LIKE PROTEIN KIF11, ... | Authors: | Kaan, H.Y.K, Ulaganathan, V, Rath, O, Laggner, C, Prokopcova, H, Dallinger, D, Kappe, C.O, Kozielski, F. | Deposit date: | 2010-02-26 | Release date: | 2010-07-14 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural Basis for Inhibition of Eg5 by Dihydropyrimidines: Stereoselectivity of Antimitotic Inhibitors Enastron, Dimethylenastron and Fluorastrol. J.Med.Chem., 53, 2010
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2X7D
| Crystal structure of human kinesin Eg5 in complex with (S)-dimethylenastron | Descriptor: | (4S)-4-(3-HYDROXYPHENYL)-7,7-DIMETHYL-2-THIOXO-2,3,4,6,7,8-HEXAHYDROQUINAZOLIN-5(1H)-ONE, ADENOSINE-5'-DIPHOSPHATE, KINESIN-LIKE PROTEIN KIF11, ... | Authors: | Kaan, H.Y.K, Ulaganathan, V, Rath, O, Laggner, C, Prokopcova, H, Dallinger, D, Kappe, C.O, Kozielski, F. | Deposit date: | 2010-02-26 | Release date: | 2010-07-14 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural Basis for Inhibition of Eg5 by Dihydropyrimidines: Stereoselectivity of Antimitotic Inhibitors Enastron, Dimethylenastron and Fluorastrol. J.Med.Chem., 53, 2010
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2X2R
| Crystal structure of human kinesin Eg5 in complex with (R)-2-amino-3-((4-chlorophenyl)diphenylmethylthio)propanoic acid | Descriptor: | (2R)-2-AMINO-3-[(2R)-2-METHYL-1,1-DIPHENYL-BUTYL]SULFANYL-PROPANOIC ACID, ADENOSINE-5'-DIPHOSPHATE, KINESIN-LIKE PROTEIN KIF11, ... | Authors: | Kaan, H.Y.K, Weiss, J, Menger, D, Ulaganathan, V, Laggner, C, Popowycz, F, Joseph, B, Kozielski, F. | Deposit date: | 2010-01-15 | Release date: | 2011-01-26 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structure-Activity Relationship and Multidrug Resistance Study of New S-Trityl-L-Cysteine Derivatives as Inhibitors of Eg5. J.Med.Chem., 54, 2011
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3K5E
| The structure of human kinesin-like motor protein Kif11/KSP/Eg5 in complex with ADP and enastrol. | Descriptor: | (4S,5R)-5-hydroxy-4-(3-hydroxyphenyl)-3,4,5,6,7,8-hexahydroquinazoline-2(1H)-thione, ADENOSINE-5'-DIPHOSPHATE, Kinesin-like protein KIF11, ... | Authors: | Crawley, L, Cheng, R.K.Y, Wood, M, Barker, J, Felicetti, B, Whittaker, M. | Deposit date: | 2009-10-07 | Release date: | 2009-10-20 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.97 Å) | Cite: | The structure of human kinesin-like motor protein Kif11/KSP/Eg5 in complex with ADP and enastrol. To be Published
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2VVG
| Crystal Structure of the G.intestinalis Kinesin 2 GiKIN2a Motor Domain | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, KINESIN-2, MAGNESIUM ION | Authors: | Hoeng, J.C, Loewe, J, Dawson, S.C, Cande, W.Z, Sagolla, M.S, Mancuso, J.J. | Deposit date: | 2008-06-08 | Release date: | 2008-07-08 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | High-Resolution Crystal Structure and in Vivo Function of a Kinesin-2 Homologue in Giardia Intestinalis. Mol.Biol.Cell, 19, 2008
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2WOG
| Intermediate and final states of human kinesin Eg5 in complex with S-trityl-L-cysteine | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, KINESIN-LIKE PROTEIN KIF11, MAGNESIUM ION, ... | Authors: | Kaan, H.Y.K, Ulaganathan, V, Hackney, D.D, Kozielski, F. | Deposit date: | 2009-07-23 | Release date: | 2010-08-04 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | An Allosteric Transition Trapped in an Intermediate State of a New Kinesin-Inhibitor Complex. Biochem.J., 425, 2010
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3KEN
| Human Eg5 in complex with S-trityl-L-cysteine | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Kinesin-like protein KIF11, MAGNESIUM ION, ... | Authors: | Parke, C.L, Wojcik, E.J, Kim, S, Worthylake, D.K. | Deposit date: | 2009-10-26 | Release date: | 2010-03-16 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Allosteric drug discrimination is coupled to mechanochemical changes in the kinesin-5 motor core. J.Biol.Chem., 285, 2010
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