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6ZYJ
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BU of 6zyj by Molmil
Crystal structure of Hsc70 ATPase domain in complex with ADP and calcium
Descriptor: ACETATE ION, ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, ...
Authors:Yan, Y, Preissler, S, Ron, D.
Deposit date:2020-08-01
Release date:2020-12-16
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Calcium depletion challenges endoplasmic reticulum proteostasis by destabilising BiP-substrate complexes.
Elife, 9, 2020
6ZYI
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BU of 6zyi by Molmil
Crystal structure of HSP70 ATPase domain in complex with ADP and calcium
Descriptor: ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, Heat shock 70kDa protein 1A variant
Authors:Yan, Y, Preissler, S, Ron, D.
Deposit date:2020-08-01
Release date:2020-12-16
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.52 Å)
Cite:Calcium depletion challenges endoplasmic reticulum proteostasis by destabilising BiP-substrate complexes.
Elife, 9, 2020
6DFO
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BU of 6dfo by Molmil
Crystal structure of human GRP78 in complex with 8-bromoadenosine
Descriptor: 8-bromoadenosine, Endoplasmic reticulum chaperone BiP
Authors:Ferrie, R.P, Chen, Y, Antoshchenko, T, Cooney, O.M, Huang, Y, Park, H.W.
Deposit date:2018-05-15
Release date:2019-05-15
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.54 Å)
Cite:Crystal structure of human GRP78 in complex with 8-bromoadenosine
To be Published
6DO2
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BU of 6do2 by Molmil
Crystal structure of human GRP78 in complex with 7-deaza-2'-C-methyladenosine
Descriptor: 7-(2-C-methyl-beta-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine, Endoplasmic reticulum chaperone BiP
Authors:Ferrie, R.P, Chen, Y, Antoshchenko, T, Cooney, O.M, Huang, Y, Park, H.W.
Deposit date:2018-06-08
Release date:2019-06-12
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structure of human GRP78 in complex with 7-deaza-2'-C-methyladenosine
To Be Published
6DFM
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BU of 6dfm by Molmil
Crystal structure of human GRP78 in complex with 8-aminoadenosine
Descriptor: (2R,3R,4S,5R)-2-(6,8-diaminopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol, Endoplasmic reticulum chaperone BiP
Authors:Ferrie, R.P, Chen, Y, Antoshchenko, T, Cooney, O.M, Huang, Y, Park, H.W.
Deposit date:2018-05-15
Release date:2019-05-15
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:Crystal structure of human GRP78 in complex with 8-aminoadenosine
To be Published
7A4V
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BU of 7a4v by Molmil
Crystal structure of lid-truncated ADP-bound BiP in an oligomeric state
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Endoplasmic reticulum chaperone BiP, GLYCEROL, ...
Authors:Perera, L.A, Ron, D.
Deposit date:2020-08-20
Release date:2020-12-16
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Calcium depletion challenges endoplasmic reticulum proteostasis by destabilising BiP-substrate complexes.
Elife, 9, 2020
6EOE
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BU of 6eoe by Molmil
Crystal structure of AMPylated GRP78 with nucleotide
Descriptor: 78 kDa glucose-regulated protein, ADENOSINE-5'-DIPHOSPHATE, CITRATE ANION, ...
Authors:Yan, Y, Preissler, S, Ron, D, Read, R.J.
Deposit date:2017-10-09
Release date:2017-11-01
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.71 Å)
Cite:AMPylation targets the rate-limiting step of BiP's ATPase cycle for its functional inactivation.
Elife, 6, 2017
6EOB
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BU of 6eob by Molmil
Crystal structure of AMPylated GRP78 in apo form (Crystal form 1)
Descriptor: 78 kDa glucose-regulated protein, PHOSPHATE ION
Authors:Yan, Y, Preissler, S, Ron, D, Read, R.J.
Deposit date:2017-10-09
Release date:2017-11-01
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2 Å)
Cite:AMPylation targets the rate-limiting step of BiP's ATPase cycle for its functional inactivation.
Elife, 6, 2017
6ZYH
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BU of 6zyh by Molmil
Crystal structure of GRP78 (70kDa heat shock protein 5 / BiP) ATPase domain in complex with ADP and calcium
Descriptor: ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, Endoplasmic reticulum chaperone BiP
Authors:Yan, Y, Preissler, S, Ron, D.
Deposit date:2020-08-01
Release date:2020-12-16
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Calcium depletion challenges endoplasmic reticulum proteostasis by destabilising BiP-substrate complexes.
Elife, 9, 2020
7A4U
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BU of 7a4u by Molmil
Crystal structure of lid-truncated apo BiP in an oligomeric state
Descriptor: Endoplasmic reticulum chaperone BiP, GLYCEROL
Authors:Perera, L.A, Ron, D.
Deposit date:2020-08-20
Release date:2020-12-16
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Calcium depletion challenges endoplasmic reticulum proteostasis by destabilising BiP-substrate complexes.
Elife, 9, 2020
6EOC
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BU of 6eoc by Molmil
Crystal structure of AMPylated GRP78 in apo form (Crystal form 2)
Descriptor: 78 kDa glucose-regulated protein, CITRATE ANION, SULFATE ION
Authors:Yan, Y, Preissler, S, Ron, D, Read, R.J.
Deposit date:2017-10-09
Release date:2017-11-01
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.67 Å)
Cite:AMPylation targets the rate-limiting step of BiP's ATPase cycle for its functional inactivation.
Elife, 6, 2017
6FHK
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BU of 6fhk by Molmil
Structure of a modified protein containing a genetically encoded phosphoserine
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Heat shock 70 kDa protein 1A, MAGNESIUM ION, ...
Authors:Mukherjee, M, Bayliss, R.
Deposit date:2018-01-14
Release date:2018-10-24
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.657 Å)
Cite:Mitotic phosphorylation regulates Hsp72 spindle localization by uncoupling ATP binding from substrate release.
Sci Signal, 11, 2018
3KVG
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BU of 3kvg by Molmil
Crystal structure of the N-terminal domain of Hsp70 (cgd2_20) from Cryptosporidium parvum in complex with AMPPNP
Descriptor: 1,2-ETHANEDIOL, Heat shock 70 (HSP70) protein, PHOSPHATE ION, ...
Authors:Wernimont, A.K, Hutchinson, A, Sullivan, H, Lew, J, Bochkarev, A, Arrowsmith, C.H, Bountra, C, Weigelt, J, Edwards, A.M, Hui, R, Pizarro, J.C, Hills, T, Structural Genomics Consortium (SGC)
Deposit date:2009-11-30
Release date:2010-01-19
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Crystal structure of the N-terminal domain of Hsp70 (cgd2_20) from Cryptosporidium parvum in complex with AMPPNP
To be Published
3ATV
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BU of 3atv by Molmil
Crystal structure of human Hsp70 NBD in the ADP-bound and Mg ion-free state
Descriptor: ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, Heat shock 70 kDa protein 1A/1B, ...
Authors:Arakawa, A, Handa, N, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2011-01-13
Release date:2011-12-28
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.58 Å)
Cite:Biochemical and structural studies on the high affinity of Hsp70 for ADP.
Protein Sci., 20, 2011
3ATU
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BU of 3atu by Molmil
Crystal structure of human Hsp70 NBD in the ADP- and Mg ion-bound state
Descriptor: 2-(2-METHOXYETHOXY)ETHANOL, ADENOSINE-5'-DIPHOSPHATE, Heat shock 70 kDa protein 1A/1B, ...
Authors:Arakawa, A, Handa, N, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2011-01-13
Release date:2011-12-28
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Biochemical and structural studies on the high affinity of Hsp70 for ADP.
Protein Sci., 20, 2011
7NQZ
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BU of 7nqz by Molmil
Plasmodium falciparum Hsp70-x chaperone nucleotide binding domain in complex with Z1827898537
Descriptor: (3S)-N-benzylpyrrolidin-3-amine, AMP PHOSPHORAMIDATE, CHLORIDE ION, ...
Authors:Mohamad, N, O'Donoghue, A, Kantsadi, A.L, Vakonakis, I.
Deposit date:2021-03-02
Release date:2021-03-10
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.319 Å)
Cite:Structures of P. falciparum Hsp70-x nucleotide binding domain with small molecule ligands
To Be Published
7NQR
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BU of 7nqr by Molmil
Plasmodium falciparum Hsp70-x chaperone nucleotide binding domain in complex with Z287256168
Descriptor: (S)-N-(1-cyclopropylethyl)-6-methylpicolinamide, 1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE, AMP PHOSPHORAMIDATE, ...
Authors:Mohamad, N, O'Donoghue, A, Kantsadi, A.L, Vakonakis, I.
Deposit date:2021-03-02
Release date:2021-03-10
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.22 Å)
Cite:Structures of P. falciparum Hsp70-x nucleotide binding domain with small molecule ligands
To Be Published
7NQU
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BU of 7nqu by Molmil
Plasmodium falciparum Hsp70-x chaperone nucleotide binding domain in complex with Z396380540
Descriptor: AMP PHOSPHORAMIDATE, CHLORIDE ION, GLYCEROL, ...
Authors:Mohamad, N, O'Donoghue, A, Kantsadi, A.L, Vakonakis, I.
Deposit date:2021-03-02
Release date:2021-03-10
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.13 Å)
Cite:Structures of P. falciparum Hsp70-x nucleotide binding domain with small molecule ligands
To Be Published
7NQS
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BU of 7nqs by Molmil
Plasmodium falciparum Hsp70-x chaperone nucleotide binding domain in complex with Z1203107138
Descriptor: 1-ethyl-N-[(4-fluorophenyl)methyl]-1H-pyrazole-4-carboxamide, AMP PHOSPHORAMIDATE, GLYCEROL, ...
Authors:Mohamad, N, O'Donoghue, A, Kantsadi, A.L, Vakonakis, I.
Deposit date:2021-03-02
Release date:2021-03-17
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.56 Å)
Cite:Structures of P. falciparum Hsp70-x nucleotide binding domain with small molecule ligands
To Be Published
7N6M
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BU of 7n6m by Molmil
Crystal structure of the substrate-binding domain of E. coli DnaK in complex with the peptide RQKPLLGLSR
Descriptor: Alkaline phosphatase peptide, Chaperone protein DnaK, SULFATE ION
Authors:Jansen, R.M, Ozden, C, Gierasch, L.M, Garman, S.C.
Deposit date:2021-06-08
Release date:2021-06-23
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Selective promiscuity in the binding of E. coli Hsp70 to an unfolded protein.
Proc.Natl.Acad.Sci.USA, 118, 2021
7N6K
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BU of 7n6k by Molmil
Crystal structure of the substrate-binding domain of E. coli DnaK in complex with the peptide RALALLPLSR
Descriptor: Alkaline phosphatase peptide, Chaperone protein DnaK, SULFATE ION
Authors:Jansen, R.M, Ozden, C, Gierasch, L.M, Garman, S.C.
Deposit date:2021-06-08
Release date:2021-06-23
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Selective promiscuity in the binding of E. coli Hsp70 to an unfolded protein.
Proc.Natl.Acad.Sci.USA, 118, 2021
7N6J
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BU of 7n6j by Molmil
Crystal structure of the substrate-binding domain of E. coli DnaK in complex with the peptide RKQSTIALALLPLLFTPRR
Descriptor: Alkaline phosphatase peptide, Chaperone protein DnaK, SULFATE ION
Authors:Jansen, R.M, Ozden, C, Gierasch, L.M, Garman, S.C.
Deposit date:2021-06-08
Release date:2021-06-23
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2 Å)
Cite:Selective promiscuity in the binding of E. coli Hsp70 to an unfolded protein.
Proc.Natl.Acad.Sci.USA, 118, 2021
7N6L
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BU of 7n6l by Molmil
Crystal structure of the substrate-binding domain of E. coli DnaK in complex with the peptide EANQQKPLLGLFADG
Descriptor: Alkaline phosphatase peptide, Chaperone protein DnaK, GLYCEROL, ...
Authors:Jansen, R.M, Ozden, C, Gierasch, L.M, Garman, S.C.
Deposit date:2021-06-08
Release date:2021-06-23
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Selective promiscuity in the binding of E. coli Hsp70 to an unfolded protein.
Proc.Natl.Acad.Sci.USA, 118, 2021
3D2E
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BU of 3d2e by Molmil
Crystal structure of a complex of Sse1p and Hsp70, Selenomethionine-labeled crystals
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, GLYCEROL, Heat shock 70 kDa protein 1, ...
Authors:Polier, S, Bracher, A.
Deposit date:2008-05-08
Release date:2008-06-17
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structural basis for the cooperation of Hsp70 and Hsp110 chaperones in protein folding.
Cell(Cambridge,Mass.), 133, 2008
3D2F
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BU of 3d2f by Molmil
Crystal structure of a complex of Sse1p and Hsp70
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, GLYCEROL, Heat shock 70 kDa protein 1, ...
Authors:Polier, S, Bracher, A.
Deposit date:2008-05-08
Release date:2008-06-17
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural basis for the cooperation of Hsp70 and Hsp110 chaperones in protein folding.
Cell(Cambridge,Mass.), 133, 2008

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