PDB: 144 resultsInfo pagesStatus searchChemie searchBIRD

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8Q1G	LSD1-CoREST bound to Acetylated K14 of Histone H3 Descriptor: FLAVIN-ADENINE DINUCLEOTIDE, Histone H3.3C, Lysine-specific histone demethylase 1A, ... Authors: Barone, M, Mattevi, A. Deposit date: 2023-07-31 Release date: 2024-05-15 Last modified: 2024-07-17 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Uncoupling histone modification crosstalk by engineering lysine demethylase LSD1. Nat.Chem.Biol., 2024
8Q1J	LSD1 Y391K-CoREST bound to Acetylated K14 of Histone H3 Descriptor: FLAVIN-ADENINE DINUCLEOTIDE, Histone H3.3C, Lysine-specific histone demethylase 1A, ... Authors: Barone, M, Mattevi, A. Deposit date: 2023-07-31 Release date: 2024-05-15 Last modified: 2024-07-17 Method: X-RAY DIFFRACTION (2.87 Å) Cite: Uncoupling histone modification crosstalk by engineering lysine demethylase LSD1. Nat.Chem.Biol., 2024
8RBX	Structure of Integrator-PP2A bound to a paused RNA polymerase II-DSIF-NELF-nucleosome complex Descriptor: DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit RPB11-a, DNA-directed RNA polymerase II subunit RPB3, ... Authors: Fianu, I, Ochmann, M, Walshe, J.L, Cramer, P. Deposit date: 2023-12-05 Release date: 2024-02-07 Last modified: 2024-05-15 Method: ELECTRON MICROSCOPY (4.1 Å) Cite: Structural basis of Integrator-dependent RNA polymerase II termination. Nature, 629, 2024
7W6L	The crystal structure of MLL3-RBBP5-ASH2L in complex with H3K4me0 peptide Descriptor: Histone H3.3C, Histone-lysine N-methyltransferase 2C, Retinoblastoma-binding protein 5, ... Authors: Zhao, L, Li, Y, Chen, Y. Deposit date: 2021-12-01 Release date: 2022-09-07 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.26 Å) Cite: Structural basis for product specificities of MLL family methyltransferases. Mol.Cell, 82, 2022
7W6I	The crystal structure of MLL1 (N3861I/Q3867L/C3882SS)-RBBP5-ASH2L in complex with H3K4me1 peptide Descriptor: Histone H3.3C, Histone-lysine N-methyltransferase 2A, Retinoblastoma-binding protein 5, ... Authors: Zhao, L, Li, Y, Chen, Y. Deposit date: 2021-12-01 Release date: 2022-09-07 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.56 Å) Cite: Structural basis for product specificities of MLL family methyltransferases. Mol.Cell, 82, 2022
7W6J	The crystal structure of MLL1 (N3861I/Q3867L/C3882SS)-RBBP5-ASH2L in complex with H3K4me2 peptide Descriptor: Histone H3.3C, Histone-lysine N-methyltransferase 2A, Retinoblastoma-binding protein 5, ... Authors: Zhao, L, Li, Y, Chen, Y. Deposit date: 2021-12-01 Release date: 2022-09-07 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.68 Å) Cite: Structural basis for product specificities of MLL family methyltransferases. Mol.Cell, 82, 2022
7W67	The crystal structure of MLL1 (N3861I/Q3867L/C3882SS)-RBBP5-ASH2L in complex with H3K4me0 peptide Descriptor: Histone H3.3C, Histone-lysine N-methyltransferase 2A, Retinoblastoma-binding protein 5, ... Authors: Zhao, L, Li, Y, Chen, Y. Deposit date: 2021-12-01 Release date: 2022-09-07 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.194 Å) Cite: Structural basis for product specificities of MLL family methyltransferases. Mol.Cell, 82, 2022
3AV1	The human nucleosome structure containing the histone variant H3.2 Descriptor: 146-MER DNA, Histone H2A type 1-B/E, Histone H2B type 1-J, ... Authors: Tachiwana, H, Osakabe, A, Shiga, T, Miya, Y, Kimura, H, Kagawa, W, Kurumizaka, H. Deposit date: 2011-02-18 Release date: 2011-06-01 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Structures of human nucleosomes containing major histone H3 variants Acta Crystallogr.,Sect.D, 67, 2011
5AY8	Crystal structure of human nucleosome containing H3.Y Descriptor: CHLORIDE ION, DNA (146-MER), H3.Y, ... Authors: Kujirai, T, Horikoshi, N, Sato, K, Maehara, K, Machida, S, Osakabe, A, Kimura, H, Ohkawa, Y, Kurumizaka, H. Deposit date: 2015-08-10 Release date: 2016-04-06 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Structure and function of human histone H3.Y nucleosome Nucleic Acids Res., 44, 2016
5GXQ	The crystal structure of the nucleosome containing H3.6 Descriptor: DNA (146-MER), Histone H2A type 1-B/E, Histone H2B type 1-J, ... Authors: Taguchi, H, Xie, Y, Horikoshi, N, Kurumizaka, H. Deposit date: 2016-09-19 Release date: 2017-04-19 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.85 Å) Cite: Crystal Structure and Characterization of Novel Human Histone H3 Variants, H3.6, H3.7, and H3.8 Biochemistry, 56, 2017
8KB5	Cryo-EM structure of the human nucleosome containing H3.8 Descriptor: DNA (145-MER), Histone H2A type 1-B/E, Histone H2B type 1-J, ... Authors: Hirai, H, Kujirai, T, Takizawa, Y, Kurumizaka, H. Deposit date: 2023-08-03 Release date: 2023-10-18 Last modified: 2023-12-27 Method: ELECTRON MICROSCOPY (2.26133 Å) Cite: Cryo-EM and biochemical analyses of the nucleosome containing the human histone H3 variant H3.8. J.Biochem., 174, 2023
4O30	Crystal structure of ATXR5 in complex with histone H3.1 and AdoHcy Descriptor: BETA-MERCAPTOETHANOL, DIMETHYL SULFOXIDE, Histone-lysine N-methyltransferase ATXR6, ... Authors: Bergamin, E, Mongeon, V, Couture, J.F. Deposit date: 2013-12-17 Release date: 2014-03-26 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Selective methylation of histone H3 variant H3.1 regulates heterochromatin replication. Science, 343, 2014
7EA5	Yeast Set2 bound to a nucleosome containing oncohistone mutations Descriptor: 601-DNA, Histone H2A, Histone H2B, ... Authors: Jing, H, Liu, Y. Deposit date: 2021-03-06 Release date: 2021-07-14 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: Cryo-EM structure of SETD2/Set2 methyltransferase bound to a nucleosome containing oncohistone mutations. Cell Discov, 7, 2021
2CU9	Crystal structure of Histone chaperone cia1 Descriptor: 2-(2-METHOXYETHOXY)ETHANOL, Histone chaperone cia1 Authors: Padmanabhan, B, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2005-05-25 Release date: 2006-08-29 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Crystal Structures of Fission Yeast Histone Chaperone Asf1 Complexed with the Hip1 B-domain or the Cac2 C Terminus J.Biol.Chem., 283, 2008
5TPX	Bromodomain from Plasmodium Faciparum Gcn5, complexed with compound Descriptor: (1S,2S)-N~1~,N~1~-dimethyl-N~2~-(3-methyl[1,2,4]triazolo[3,4-a]phthalazin-6-yl)-1-phenylpropane-1,2-diamine, CHLORIDE ION, Histone acetyltransferase GCN5, ... Authors: Lin, Y.H, Hou, C.F.D, MOUSTAKIM, M, DIXON, D.J, Loppnau, P, Tempel, W, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Hui, R, BRENNAN, P.E, Walker, J.R, Structural Genomics Consortium (SGC) Deposit date: 2016-10-21 Release date: 2017-01-04 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Discovery of a PCAF Bromodomain Chemical Probe. Angew. Chem. Int. Ed. Engl., 56, 2017
5MG2	Crystal structure of the second bromodomain of human TAF1 in complex with BAY-299 chemical probe Descriptor: 1,2-ETHANEDIOL, 6-(3-oxidanylpropyl)-2-(1,3,6-trimethyl-2-oxidanylidene-benzimidazol-5-yl)benzo[de]isoquinoline-1,3-dione, Transcription initiation factor TFIID subunit 1 Authors: Tallant, C, Bouche, L, Holton, S.J, Fedorov, O, Siejka, P, Picaud, S, Krojer, T, Srikannathasan, V, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Hartung, I.V, Haendler, B, Muller, S, Huber, K.V.M, Structural Genomics Consortium (SGC) Deposit date: 2016-11-20 Release date: 2017-05-03 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Benzoisoquinolinediones as Potent and Selective Inhibitors of BRPF2 and TAF1/TAF1L Bromodomains. J. Med. Chem., 60, 2017
5N49	BRPF2 in complex with Compound 7 Descriptor: 2-(1,3,6-trimethyl-2-oxidanylidene-benzimidazol-5-yl)benzo[de]isoquinoline-1,3-dione, Bromodomain-containing protein 1 Authors: Bouche, L, Christ, C.D, Siegel, S, Fernandez-Montalvan, A.E, Holton, S.J, Fedorov, O, ter Laak, A, Sugawara, T, Stoeckigt, D, Tallant, C, Bennett, J, Monteiro, O, Saez, L.D, Siejka, P, Meier, J, Puetter, V, Weiske, J, Mueller, S, Huber, K.V.M, Hartung, I.V, Haendler, B. Deposit date: 2017-02-10 Release date: 2017-05-03 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (1.94 Å) Cite: Benzoisoquinolinediones as Potent and Selective Inhibitors of BRPF2 and TAF1/TAF1L Bromodomains. J. Med. Chem., 60, 2017
2LBM	Solution structure of the ADD domain of ATRX complexed with histone tail H3 1-15 K9me3 Descriptor: Transcriptional regulator ATRX, ZINC ION, histone tail H3 K9me3 Authors: Eustermann, S, Yang, J, Neuhaus, D. Deposit date: 2011-04-08 Release date: 2011-06-29 Last modified: 2011-07-13 Method: SOLUTION NMR Cite: Combinatorial readout of histone H3 modifications specifies localization of ATRX to heterochromatin Nat.Struct.Mol.Biol., 2011
2RI5	Crystal structure of the 3-MBT repeats from human L3MBTL1 with N358A point mutation Descriptor: DI(HYDROXYETHYL)ETHER, Lethal(3)malignant brain tumor-like protein, TRIETHYLENE GLYCOL Authors: Li, H, Patel, D.J. Deposit date: 2007-10-10 Release date: 2007-12-11 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural Basis for Lower Lysine Methylation State-Specific Readout by MBT Repeats of L3MBTL1 and an Engineered PHD Finger. Mol.Cell, 28, 2007
2RI2	Crystal structure of the 3-MBT repeats from human L3MBTL1 with D355A point mutation Descriptor: DI(HYDROXYETHYL)ETHER, Lethal(3)malignant brain tumor-like protein, SULFATE ION, ... Authors: Li, H, Patel, D.J. Deposit date: 2007-10-10 Release date: 2007-12-11 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Structural Basis for Lower Lysine Methylation State-Specific Readout by MBT Repeats of L3MBTL1 and an Engineered PHD Finger. Mol.Cell, 28, 2007
7T7T	Structure of TSK/BRU1 bound to histone H3.1 Descriptor: Histone H3.1, Protein TONSOKU Authors: Davarinejad, H, Couture, J.F. Deposit date: 2021-12-15 Release date: 2022-03-30 Method: X-RAY DIFFRACTION (3.17 Å) Cite: The histone H3.1 variant regulates TONSOKU-mediated DNA repair during replication. Science, 375, 2022
2RHI	Crystal structure of the 3-MBT domain from human L3MBTL1 in complex with H1.5K27me2 at 1.66 angstrom Descriptor: DI(HYDROXYETHYL)ETHER, Histone H1.5, Lethal(3)malignant brain tumor-like protein, ... Authors: Li, H, Patel, D.J. Deposit date: 2007-10-09 Release date: 2007-12-11 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.66 Å) Cite: Structural Basis for Lower Lysine Methylation State-Specific Readout by MBT Repeats of L3MBTL1 and an Engineered PHD Finger. Mol.Cell, 28, 2007
2RHY	Crystal structure of the 3-MBT repeats from human L3MBTL1 bound to monomethyl-lysine Descriptor: DI(HYDROXYETHYL)ETHER, Lethal(3)malignant brain tumor-like protein, N-METHYL-LYSINE Authors: Li, H, Patel, D.J. Deposit date: 2007-10-09 Release date: 2007-12-11 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structural Basis for Lower Lysine Methylation State-Specific Readout by MBT Repeats of L3MBTL1 and an Engineered PHD Finger. Mol.Cell, 28, 2007
2RHX	Crystal structure of the 3-MBT repeats from human L3MBTL1 bound to dimethyl-lysine Descriptor: Lethal(3)malignant brain tumor-like protein, N-DIMETHYL-LYSINE, SULFATE ION, ... Authors: Li, H, Patel, D.J. Deposit date: 2007-10-09 Release date: 2007-12-11 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Structural Basis for Lower Lysine Methylation State-Specific Readout by MBT Repeats of L3MBTL1 and an Engineered PHD Finger. Mol.Cell, 28, 2007
2RI3	Crystal structure of the 3-MBT repeats from human L3MBTL1 with N358Q point mutation Descriptor: DI(HYDROXYETHYL)ETHER, Lethal(3)malignant brain tumor-like protein Authors: Li, H, Patel, D.J. Deposit date: 2007-10-10 Release date: 2007-12-11 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural Basis for Lower Lysine Methylation State-Specific Readout by MBT Repeats of L3MBTL1 and an Engineered PHD Finger. Mol.Cell, 28, 2007

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