5H3O
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![BU of 5h3o by Molmil](/molmil-images/mine/5h3o) | Structure of a eukaryotic cyclic nucleotide-gated channel | Descriptor: | CYCLIC GUANOSINE MONOPHOSPHATE, Cyclic nucleotide-gated cation channel, SODIUM ION | Authors: | Li, M, Zhou, X, Wang, S, Michailidis, I, Gong, Y, Su, D, Li, H, Li, X, Yang, J. | Deposit date: | 2016-10-26 | Release date: | 2017-01-25 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structure of a eukaryotic cyclic-nucleotide-gated channel. Nature, 542, 2017
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7RNN
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![BU of 7rnn by Molmil](/molmil-images/mine/7rnn) | Human ASIC1a-Nb.C1 complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Acid-sensing ion channel 1, Nanobodies Nb.C1 | Authors: | Wu, Y, Chen, Z, Sigworth, F.J, Canessa, C.M. | Deposit date: | 2021-07-29 | Release date: | 2021-08-11 | Last modified: | 2021-08-25 | Method: | ELECTRON MICROSCOPY (2.86 Å) | Cite: | Structure and analysis of nanobody binding to the human ASIC1a ion channel. Elife, 10, 2021
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4FKK
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![BU of 4fkk by Molmil](/molmil-images/mine/4fkk) | Crystal structure of porcine aminopeptidase-N complexed with bestatin | Descriptor: | 2-(3-AMINO-2-HYDROXY-4-PHENYL-BUTYRYLAMINO)-4-METHYL-PENTANOIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Chen, L, Lin, Y.L, Peng, G, Li, F. | Deposit date: | 2012-06-13 | Release date: | 2012-10-17 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural basis for multifunctional roles of mammalian aminopeptidase N. Proc.Natl.Acad.Sci.USA, 109, 2012
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5GQT
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![BU of 5gqt by Molmil](/molmil-images/mine/5gqt) | |
7A69
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![BU of 7a69 by Molmil](/molmil-images/mine/7a69) | |
8QQ3
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![BU of 8qq3 by Molmil](/molmil-images/mine/8qq3) | Streptavidin with a Ni-cofactor | Descriptor: | 4-[4-[(3~{a}~{S},4~{S},6~{a}~{R})-2-oxidanylidene-1,3,3~{a},4,6,6~{a}-hexahydrothieno[3,4-d]imidazol-4-yl]butylamino]-~{N}1,~{N}1'-di(quinolin-8-yl)cyclohexane-1,1-dicarboxamide, NICKEL (II) ION, Streptavidin | Authors: | Zhang, K, Jakob, R.P, Ward, T.R. | Deposit date: | 2023-10-03 | Release date: | 2024-02-07 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | An artificial nickel chlorinase based on the biotin-streptavidin technology. Chem.Commun.(Camb.), 60, 2024
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4FPV
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![BU of 4fpv by Molmil](/molmil-images/mine/4fpv) | Crystal structure of D. rerio TDP2 complexed with single strand DNA product | Descriptor: | DNA (5'-D(P*TP*GP*CP*AP*G)-3'), GLYCEROL, MAGNESIUM ION, ... | Authors: | Shi, K, Kurahashi, K, Aihara, H. | Deposit date: | 2012-06-22 | Release date: | 2012-10-31 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.73 Å) | Cite: | Structural basis for recognition of 5'-phosphotyrosine adducts by Tdp2. Nat.Struct.Mol.Biol., 19, 2012
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7A6F
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![BU of 7a6f by Molmil](/molmil-images/mine/7a6f) | |
8QYT
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![BU of 8qyt by Molmil](/molmil-images/mine/8qyt) | Human Pyridoxine-5'-phosphate oxidase in complex with PLP | Descriptor: | BETA-MERCAPTOETHANOL, FLAVIN MONONUCLEOTIDE, PYRIDOXAL-5'-PHOSPHATE, ... | Authors: | Antonelli, L, Ilari, A, Fiorillo, A. | Deposit date: | 2023-10-26 | Release date: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.69 Å) | Cite: | Identification of the pyridoxal 5'-phosphate allosteric site in human pyridox(am)ine 5'-phosphate oxidase. Protein Sci., 33, 2024
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7A1H
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![BU of 7a1h by Molmil](/molmil-images/mine/7a1h) | Crystal structure of wild-type CI2 | Descriptor: | SULFATE ION, Subtilisin-chymotrypsin inhibitor-2A | Authors: | Olsen, J.G, Teilum, K, Hamborg, L, Roche, J.V. | Deposit date: | 2020-08-13 | Release date: | 2020-12-09 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Synergistic stabilization of a double mutant in chymotrypsin inhibitor 2 from a library screen in E. coli. Commun Biol, 4, 2021
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8QYW
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7R8A
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![BU of 7r8a by Molmil](/molmil-images/mine/7r8a) | The structure of human ABCG5/ABCG8 purified from mammalian cells | Descriptor: | 2C7 Fab heavy chain, 2C7 Fab light chain, ATP-binding cassette sub-family G member 5, ... | Authors: | Sun, Y, Li, X, Long, T. | Deposit date: | 2021-06-26 | Release date: | 2021-09-08 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Molecular basis of cholesterol efflux via ABCG subfamily transporters. Proc.Natl.Acad.Sci.USA, 118, 2021
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7AE3
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![BU of 7ae3 by Molmil](/molmil-images/mine/7ae3) | Cryo-EM structure of human RNA Polymerase III elongation complex 3 | Descriptor: | DNA-directed RNA polymerase III subunit RPC1, DNA-directed RNA polymerase III subunit RPC10, DNA-directed RNA polymerase III subunit RPC2, ... | Authors: | Girbig, M, Misiaszek, A.D, Vorlaender, M.K, Mueller, C.W. | Deposit date: | 2020-09-17 | Release date: | 2021-02-03 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Cryo-EM structures of human RNA polymerase III in its unbound and transcribing states. Nat.Struct.Mol.Biol., 28, 2021
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7RNI
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6ZR2
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![BU of 6zr2 by Molmil](/molmil-images/mine/6zr2) | Cryo-EM structure of respiratory complex I in the active state from Mus musculus at 3.1 A | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, ADENOSINE-5'-TRIPHOSPHATE, ... | Authors: | Bridges, H.R, Blaza, J.N, Agip, A.N.A, Hirst, J. | Deposit date: | 2020-07-10 | Release date: | 2020-10-21 | Last modified: | 2020-10-28 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structure of inhibitor-bound mammalian complex I. Nat Commun, 11, 2020
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7R8B
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![BU of 7r8b by Molmil](/molmil-images/mine/7r8b) | The structure of human ABCG5/ABCG8 supplemented with cholesterol | Descriptor: | 2C7 Fab heavy chain, 2C7 Fab light chain, ATP-binding cassette sub-family G member 5, ... | Authors: | Sun, Y, Li, X, Long, T. | Deposit date: | 2021-06-26 | Release date: | 2021-09-08 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Molecular basis of cholesterol efflux via ABCG subfamily transporters. Proc.Natl.Acad.Sci.USA, 118, 2021
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7R88
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![BU of 7r88 by Molmil](/molmil-images/mine/7r88) | The structure of human ABCG5-I529W/ABCG8-WT | Descriptor: | 2C7 Fab heavy chain, 2C7 Fab light chain, ATP-binding cassette sub-family G member 5, ... | Authors: | Sun, Y, Li, X, Long, T. | Deposit date: | 2021-06-26 | Release date: | 2021-09-08 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Molecular basis of cholesterol efflux via ABCG subfamily transporters. Proc.Natl.Acad.Sci.USA, 118, 2021
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6ZNN
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![BU of 6znn by Molmil](/molmil-images/mine/6znn) | The pointed end complex of dynactin bound to Hook3 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ARP1 actin related protein 1 homolog A, ... | Authors: | Lau, C.K, Lacey, S.E, Carter, A.P. | Deposit date: | 2020-07-06 | Release date: | 2020-07-29 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (4.5 Å) | Cite: | Cryo-EM reveals the complex architecture of dynactin's shoulder region and pointed end. Embo J., 40, 2021
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8QSO
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![BU of 8qso by Molmil](/molmil-images/mine/8qso) | Crystal structure of human Mcl-1 in complex with compound 1 | Descriptor: | (13S,16R,19S)-16-benzyl-43-ethoxy-N-methyl-7,11,14,17-tetraoxo-13-phenyl-5-oxa-2,8,12,15,18-pentaaza-1(1,4),4(1,2)-dibenzena-9(1,4)-cyclohexanacycloicosaphane-19-carboxamide, Maltose/maltodextrin-binding periplasmic protein,Induced myeloid leukemia cell differentiation protein Mcl-1, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | Authors: | Hekking, K.F.W, Gremmen, S, Maroto, S, Keefe, A.D, Zhang, Y. | Deposit date: | 2023-10-10 | Release date: | 2024-02-14 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.106 Å) | Cite: | Development of Potent Mcl-1 Inhibitors: Structural Investigations on Macrocycles Originating from a DNA-Encoded Chemical Library Screen. J.Med.Chem., 67, 2024
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7PJB
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![BU of 7pjb by Molmil](/molmil-images/mine/7pjb) | Crystal structure of YTHDC1 with compound PSI_DC1_004 | Descriptor: | (R)-homoproline, GLYCEROL, SULFATE ION, ... | Authors: | Bedi, R.K, Huang, D, Caflisch, A. | Deposit date: | 2021-08-23 | Release date: | 2021-10-20 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structure-based design of ligands of the m6A-RNA reader YTHDC1 Eur J Med Chem Rep, 5, 2022
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7PIL
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![BU of 7pil by Molmil](/molmil-images/mine/7pil) | Cryo-EM structure of the Rhodobacter sphaeroides RC-LH1-PufXY monomer complex at 2.5 A | Descriptor: | (2R,5R,11R,14R)-5,8,11-trihydroxy-5,11-dioxido-17-oxo-2,14-bis(tetradecanoyloxy)-4,6,10,12,16-pentaoxa-5,11-diphosphatriacont-1-yl tetradecanoate, 1,2-Distearoyl-sn-glycerophosphoethanolamine, BACTERIOCHLOROPHYLL A, ... | Authors: | Qian, P, Hunter, C.N. | Deposit date: | 2021-08-20 | Release date: | 2021-10-13 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (2.5 Å) | Cite: | Cryo-EM structure of the monomeric Rhodobacter sphaeroides RC-LH1 core complex at 2.5 angstrom. Biochem.J., 478, 2021
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6ZP1
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![BU of 6zp1 by Molmil](/molmil-images/mine/6zp1) | Structure of SARS-CoV-2 Spike Protein Trimer (K986P, V987P, single Arg S1/S2 cleavage site) in Closed State | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein | Authors: | Xiong, X, Qu, K, Scheres, S.H.W, Briggs, J.A.G. | Deposit date: | 2020-07-08 | Release date: | 2020-07-22 | Last modified: | 2021-06-02 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | A thermostable, closed SARS-CoV-2 spike protein trimer. Nat.Struct.Mol.Biol., 27, 2020
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5G0A
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![BU of 5g0a by Molmil](/molmil-images/mine/5g0a) | The crystal structure of a S-selective transaminase from Bacillus megaterium | Descriptor: | DI(HYDROXYETHYL)ETHER, PENTAETHYLENE GLYCOL, PYRIDOXAL-5'-PHOSPHATE, ... | Authors: | van Oosterwijk, N, Willies, S, Hekelaar, J, Terwisscha van Scheltinga, A.C, Turner, N.J, Dijkstra, B.W. | Deposit date: | 2016-03-17 | Release date: | 2016-07-27 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structural Basis of Substrate Range and Enantioselectivity of Two S-Selective Omega- Transaminases Biochemistry, 55, 2016
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4G0K
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![BU of 4g0k by Molmil](/molmil-images/mine/4g0k) | Glutathionyl-hydroquinone reductase, YqjG, of E.coli complexed with GS-menadione | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, L-gamma-glutamyl-S-(3-methyl-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-L-cysteinylglycine, SULFATE ION, ... | Authors: | Green, A.R, Hayes, R.P, Xun, L, Kang, C. | Deposit date: | 2012-07-09 | Release date: | 2012-09-12 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.557 Å) | Cite: | Structural understanding of the glutathione-dependent reduction mechanism of glutathionyl-hydroquinone reductases. J.Biol.Chem., 287, 2012
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8QY4
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![BU of 8qy4 by Molmil](/molmil-images/mine/8qy4) | Structure of interleukin 11 (gp130 P496L mutant). | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-11, ... | Authors: | Gardner, S, Bubeck, D, Jin, Y. | Deposit date: | 2023-10-25 | Release date: | 2024-02-21 | Last modified: | 2024-09-04 | Method: | ELECTRON MICROSCOPY (3.06 Å) | Cite: | Structural insights into IL-11-mediated signalling and human IL6ST variant-associated immunodeficiency. Nat Commun, 15, 2024
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