7Q64
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![BU of 7q64 by Molmil](/molmil-images/mine/7q64) | Cryo-em structure of the Nup98 fibril polymorph 1 | Descriptor: | Nuclear pore complex protein Nup98 | Authors: | Ibanez de Opakua, A, Geraets, J.A, Frieg, B, Dienemann, C, Savastano, A, Rankovic, M, Cima-Omori, M.-S, Schroeder, G.F, Zweckstetter, M. | Deposit date: | 2021-11-05 | Release date: | 2022-10-12 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (2.76 Å) | Cite: | Molecular interactions of FG nucleoporin repeats at high resolution. Nat.Chem., 14, 2022
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6ZGE
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![BU of 6zge by Molmil](/molmil-images/mine/6zge) | Uncleavable Spike Protein of SARS-CoV-2 in Closed Conformation | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein | Authors: | Wrobel, A.G, Benton, D.J, Rosenthal, P.B, Gamblin, S.J. | Deposit date: | 2020-06-18 | Release date: | 2020-07-01 | Last modified: | 2020-09-16 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | SARS-CoV-2 and bat RaTG13 spike glycoprotein structures inform on virus evolution and furin-cleavage effects. Nat.Struct.Mol.Biol., 27, 2020
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8QDB
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![BU of 8qdb by Molmil](/molmil-images/mine/8qdb) | Wdyg1p Ser256DHA (PSF) | Descriptor: | 1,2-ETHANEDIOL, Yellowish-green 1-like protein | Authors: | Schmalhofer, M, Vagstad, A.L, Zhou, Q, Bode, H.B, Groll, M. | Deposit date: | 2023-08-28 | Release date: | 2024-03-13 | Last modified: | 2024-06-19 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Polyketide Trimming Shapes Dihydroxynaphthalene-Melanin and Anthraquinone Pigments. Adv Sci, 11, 2024
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6NLH
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![BU of 6nlh by Molmil](/molmil-images/mine/6nlh) | Structure of human triose phosphate isomerase R189A | Descriptor: | BROMIDE ION, PHOSPHATE ION, SODIUM ION, ... | Authors: | Richards, K.R, Roland, B.P, Palladino, M.J, VanDemark, A.P. | Deposit date: | 2019-01-08 | Release date: | 2019-06-19 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.199 Å) | Cite: | Missense variant in TPI1 (Arg189Gln) causes neurologic deficits through structural changes in the triosephosphate isomerase catalytic site and reduced enzyme levels in vivo. Biochim Biophys Acta Mol Basis Dis, 1865, 2019
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8QD8
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![BU of 8qd8 by Molmil](/molmil-images/mine/8qd8) | Wdyg1p in complex with 1,3-Dihydroxynaphthalene | Descriptor: | 1,2-ETHANEDIOL, Yellowish-green 1-like protein, naphthalene-1,3-diol | Authors: | Schmalhofer, M, Vagstad, A.L, Zhou, Q, Bode, H.B, Groll, M. | Deposit date: | 2023-08-28 | Release date: | 2024-03-13 | Last modified: | 2024-06-19 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Polyketide Trimming Shapes Dihydroxynaphthalene-Melanin and Anthraquinone Pigments. Adv Sci, 11, 2024
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8QD2
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![BU of 8qd2 by Molmil](/molmil-images/mine/8qd2) | Ayg1p in complex with 1,3-Dihydroxynaphthalene | Descriptor: | Pigment biosynthesis protein yellowish-green 1, naphthalene-1,3-diol | Authors: | Schmalhofer, M, Vagstad, A.L, Zhou, Q, Bode, H.B, Groll, M. | Deposit date: | 2023-08-28 | Release date: | 2024-03-13 | Last modified: | 2024-06-19 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Polyketide Trimming Shapes Dihydroxynaphthalene-Melanin and Anthraquinone Pigments. Adv Sci, 11, 2024
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5LOQ
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![BU of 5loq by Molmil](/molmil-images/mine/5loq) | Structure of coproheme bound HemQ from Listeria monocytogenes | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 1,3,5,8-TETRAMETHYL-PORPHINE-2,4,6,7-TETRAPROPIONIC ACID FERROUS COMPLEX, Putative heme-dependent peroxidase lmo2113, ... | Authors: | Puehringer, D, Mlynek, G, Hofbauer, S, Djinovic-Carugo, K, Obinger, C. | Deposit date: | 2016-08-09 | Release date: | 2016-10-26 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.69 Å) | Cite: | Hydrogen peroxide-mediated conversion of coproheme to heme b by HemQ-lessons from the first crystal structure and kinetic studies. FEBS J., 283, 2016
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5JER
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![BU of 5jer by Molmil](/molmil-images/mine/5jer) | Structure of Rotavirus NSP1 bound to IRF-3 | Descriptor: | Interferon regulatory factor 3, Rotavirus NSP1 peptide | Authors: | Zhao, B, Li, P. | Deposit date: | 2016-04-18 | Release date: | 2016-06-15 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.913 Å) | Cite: | Structural basis for concerted recruitment and activation of IRF-3 by innate immune adaptor proteins. Proc.Natl.Acad.Sci.USA, 113, 2016
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8QYF
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![BU of 8qyf by Molmil](/molmil-images/mine/8qyf) | |
7TU0
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![BU of 7tu0 by Molmil](/molmil-images/mine/7tu0) | Structure of the L. blandensis dGTPase bound to Mn | Descriptor: | MANGANESE (II) ION, SULFATE ION, dGTP triphosphohydrolase | Authors: | Sikkema, A.P, Klemm, B.P, Horng, J.C, Hall, T.M.T. | Deposit date: | 2022-02-02 | Release date: | 2022-06-01 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.04 Å) | Cite: | High-resolution structures of the SAMHD1 dGTPase homolog from Leeuwenhoekiella blandensis reveal a novel mechanism of allosteric activation by dATP. J.Biol.Chem., 298, 2022
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7TU1
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![BU of 7tu1 by Molmil](/molmil-images/mine/7tu1) | Structure of the L. blandensis dGTPase R37A mutant | Descriptor: | 1,2-ETHANEDIOL, SULFATE ION, dGTP triphosphohydrolase | Authors: | Sikkema, A.P, Klemm, B.P, Horng, J.C, Hall, T.M.T. | Deposit date: | 2022-02-02 | Release date: | 2022-06-01 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | High-resolution structures of the SAMHD1 dGTPase homolog from Leeuwenhoekiella blandensis reveal a novel mechanism of allosteric activation by dATP. J.Biol.Chem., 298, 2022
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8USF
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7TU2
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![BU of 7tu2 by Molmil](/molmil-images/mine/7tu2) | Structure of the L. blandensis dGTPase R37A mutant bound to Mn | Descriptor: | MANGANESE (II) ION, SULFATE ION, dGTP triphosphohydrolase | Authors: | Sikkema, A.P, Klemm, B.P, Horng, J.C, Hall, T.M.T. | Deposit date: | 2022-02-02 | Release date: | 2022-06-01 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.13 Å) | Cite: | High-resolution structures of the SAMHD1 dGTPase homolog from Leeuwenhoekiella blandensis reveal a novel mechanism of allosteric activation by dATP. J.Biol.Chem., 298, 2022
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8B5B
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![BU of 8b5b by Molmil](/molmil-images/mine/8b5b) | Human BRD4 bromdomain 1 in complex with a H4 peptide containing acetyl lysine and ApmTri (H4K5acK8ApmTri) | Descriptor: | Bromodomain-containing protein 4, DI(HYDROXYETHYL)ETHER, H4K5acK8ApmTri | Authors: | Braun, M.B, Bartlick, N, Stehle, T. | Deposit date: | 2022-09-22 | Release date: | 2023-01-11 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.92 Å) | Cite: | Synthesis, Biochemical Characterization, and Genetic Encoding of a 1,2,4-Triazole Amino Acid as an Acetyllysine Mimic for Bromodomains of the BET Family. Angew.Chem.Int.Ed.Engl., 62, 2023
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7TPT
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![BU of 7tpt by Molmil](/molmil-images/mine/7tpt) | Single-particle Cryo-EM structure of Arp2/3 complex at branched-actin junction. | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ... | Authors: | Ding, B, Narvaez-Ortiz, H.Y, Nolen, B.J, Chowdhury, S. | Deposit date: | 2022-01-26 | Release date: | 2022-05-25 | Last modified: | 2022-06-08 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Structure of Arp2/3 complex at a branched actin filament junction resolved by single-particle cryo-electron microscopy. Proc.Natl.Acad.Sci.USA, 119, 2022
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1AL4
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![BU of 1al4 by Molmil](/molmil-images/mine/1al4) | GRAMICIDIN D FROM BACILLUS BREVIS (N-PROPANOL SOLVATE) | Descriptor: | GRAMICIDIN D, N-PROPANOL | Authors: | Burkhart, B.M, Gassman, R.M, Pangborn, W.A, Duax, W.L. | Deposit date: | 1997-06-11 | Release date: | 1998-03-04 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.13 Å) | Cite: | Heterodimer Formation and Crystal Nucleation of Gramicidin D Biophys.J., 75, 1998
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6W51
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![BU of 6w51 by Molmil](/molmil-images/mine/6w51) | |
7TU3
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![BU of 7tu3 by Molmil](/molmil-images/mine/7tu3) | Structure of the L. blandensis dGTPase del55-58 mutant | Descriptor: | 1,2-ETHANEDIOL, MAGNESIUM ION, SULFATE ION, ... | Authors: | Sikkema, A.P, Klemm, B.P, Horng, J.C, Hall, T.M.T. | Deposit date: | 2022-02-02 | Release date: | 2022-06-01 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.17 Å) | Cite: | High-resolution structures of the SAMHD1 dGTPase homolog from Leeuwenhoekiella blandensis reveal a novel mechanism of allosteric activation by dATP. J.Biol.Chem., 298, 2022
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8GH4
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![BU of 8gh4 by Molmil](/molmil-images/mine/8gh4) | Complex of Adam 10 disentegrin cysteine rich domains with human monoclonal antibody | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody heavy chain, Antibody light chain, ... | Authors: | Nikolov, D.B, Saha, N, Xu, K, Goldgur, Y. | Deposit date: | 2023-03-09 | Release date: | 2023-08-30 | Method: | X-RAY DIFFRACTION (3.8 Å) | Cite: | Fully human monoclonal antibody targeting activated ADAM10 on colorectal cancer cells. Biomed Pharmacother, 161, 2023
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7P2W
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![BU of 7p2w by Molmil](/molmil-images/mine/7p2w) | E.coli GyrB24 with inhibitor LMD92 (EBL2682) | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-[[3,4-bis(chloranyl)-5-methyl-1H-pyrrol-2-yl]carbonylamino]-4-[(3-carboxyphenyl)methoxy]-1,3-benzothiazole-6-carboxylic acid, DNA gyrase subunit B, ... | Authors: | Stevenson, C.E.M, Lawson, D.M, Maxwell, A.M, Henderson, S.R, Kikelj, D, Durcik, M, Zega, A, Zidar, N, Ilas, J, Tomasic, T, Masic, L.P. | Deposit date: | 2021-07-06 | Release date: | 2022-07-20 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Discovery and Hit-to-Lead Optimization of Benzothiazole Scaffold-Based DNA Gyrase Inhibitors with Potent Activity against Acinetobacter baumannii and Pseudomonas aeruginosa. J.Med.Chem., 66, 2023
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7P2M
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![BU of 7p2m by Molmil](/molmil-images/mine/7p2m) | E.coli GyrB24 with inhibitor LMD43 (EBL2560) | Descriptor: | 2-[[3,4-bis(chloranyl)-5-methyl-1~{H}-pyrrol-2-yl]carbonylamino]-4-phenylmethoxy-1,3-benzothiazole-6-carboxylic acid, DNA gyrase subunit B, PHOSPHATE ION | Authors: | Stevenson, C.E.M, Lawson, D.M, Maxwell, A.M, Henderson, S.R, Kikelj, D, Durcik, M, Zega, A, Zidar, N, Ilas, J, Tomasic, T, Masic, L.P. | Deposit date: | 2021-07-06 | Release date: | 2022-07-20 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.16 Å) | Cite: | Discovery and Hit-to-Lead Optimization of Benzothiazole Scaffold-Based DNA Gyrase Inhibitors with Potent Activity against Acinetobacter baumannii and Pseudomonas aeruginosa. J.Med.Chem., 66, 2023
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8RCQ
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![BU of 8rcq by Molmil](/molmil-images/mine/8rcq) | Structural flexibility of Nucleoprotein of the Toscana virus in the presence of a nanobody. | Descriptor: | Nucleoprotein, VHH | Authors: | Papageorgiou, N, Ferron, F, Coutard, B, Lichiere, J, Baklouti, A. | Deposit date: | 2023-12-06 | Release date: | 2024-01-31 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (3.8 Å) | Cite: | Structural flexibility of Toscana virus nucleoprotein in the presence of a single-chain camelid antibody. Acta Crystallogr D Struct Biol, 80, 2024
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4YE1
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![BU of 4ye1 by Molmil](/molmil-images/mine/4ye1) | A cytochrome c plus calixarene structure - alternative ligand binding mode | Descriptor: | 25,26,27,28-tetrahydroxypentacyclo[19.3.1.1~3,7~.1~9,13~.1~15,19~]octacosa-1(25),3(28),4,6,9(27),10,12,15(26),16,18,21,23-dodecaene-5,11,17,23-tetrasulfonic acid, Cytochrome c iso-1, GLYCEROL, ... | Authors: | Mallon, M.M, McGovern, R.E, McCarty, A.A, Crowley, P.B. | Deposit date: | 2015-02-23 | Release date: | 2015-05-13 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.39 Å) | Cite: | A cytochrome c-calixarene structure To Be Published
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7U3Q
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![BU of 7u3q by Molmil](/molmil-images/mine/7u3q) | [4T7] Self-assembling tensegrity triangle with four turns of DNA per axis with R3 symmetry | Descriptor: | DNA (29-MER), DNA (42-MER), DNA (5'-D(P*AP*CP*A)-3'), ... | Authors: | Woloszyn, K, Vecchioni, S, Lu, B, Ma, Y, Seeman, N.C, Sha, R, Ohayon, Y.P, Huang, Q. | Deposit date: | 2022-02-28 | Release date: | 2022-09-28 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (9.32 Å) | Cite: | Augmented DNA Nanoarchitectures: A Structural Library of 3D Self-Assembling Tensegrity Triangle Variants. Adv Mater, 34, 2022
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1AL0
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![BU of 1al0 by Molmil](/molmil-images/mine/1al0) | PROCAPSID OF BACTERIOPHAGE PHIX174 | Descriptor: | CAPSID PROTEIN GPF, SCAFFOLDING PROTEIN GPB, SCAFFOLDING PROTEIN GPD, ... | Authors: | Rossmann, M.G, Dokland, T. | Deposit date: | 1997-06-06 | Release date: | 1998-01-28 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Structure of a viral procapsid with molecular scaffolding. Nature, 389, 1997
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