3ZLH
 
 | | Structure of group A Streptococcal enolase | | Descriptor: | ENOLASE | | Authors: | Cork, A.J, Ericsson, D.J, Law, R.H.P, Casey, L.W, Valkov, E, Bertozzi, C, Stamp, A, Aquilina, J.A, Whisstock, J.C, Walker, M.J, Kobe, B. | | Deposit date: | 2013-01-31 | | Release date: | 2014-02-05 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Stability of the Octameric Structure Affects Plasminogen-Binding Capacity of Streptococcal Enolase.
Plos One, 10, 2015
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7Z4D
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6L2Z
 | | IlvC, a ketol-acid reductoisomerase, from Streptococcus pnuemoniae_D191G | | Descriptor: | AMMONIUM ION, GLYCEROL, Ketol-acid reductoisomerase (NADP(+)), ... | | Authors: | Gyuhee, K, Donghyuk, S, Sumin, L, Jaesook, Y, Sangho, L. | | Deposit date: | 2019-10-07 | | Release date: | 2020-08-12 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.02 Å) | | Cite: | Crystal Structure of IlvC, a Ketol-Acid Reductoisomerase, from Streptococcus Pneumoniae.
Crystals, 9, 2019
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6L2I
 | | IlvC, a ketol-acid reductoisomerase, from Streptococcus pneumoniae_WT | | Descriptor: | GLYCEROL, Ketol-acid reductoisomerase (NADP(+)), MAGNESIUM ION, ... | | Authors: | Gyuhee, K, Donghyuk, S, Sumin, L, Jaesook, Y, Sangho, L. | | Deposit date: | 2019-10-04 | | Release date: | 2020-08-12 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.69 Å) | | Cite: | Crystal Structure of IlvC, a Ketol-Acid Reductoisomerase, from Streptococcus Pneumoniae.
Crystals, 9, 2019
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6L2S
 | | IlvC, a ketol-acid reductoisomerase, from Streptococcus pneumoniae_D83G | | Descriptor: | Ketol-acid reductoisomerase (NADP(+)) | | Authors: | Gyuhee, K, Donghyuk, S, Sumin, L, Jaesook, Y, Sangho, L. | | Deposit date: | 2019-10-06 | | Release date: | 2020-08-12 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.29 Å) | | Cite: | Crystal Structure of IlvC, a Ketol-Acid Reductoisomerase, from Streptococcus Pneumoniae.
Crystals, 9, 2019
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6L2R
 | | IlvC, a ketol-acid reductoisomerase, from Streptococcus pneumoniae_E195S | | Descriptor: | Ketol-acid reductoisomerase (NADP(+)) | | Authors: | Gyuhee, K, Donghyuk, S, Sumin, L, Jaesook, Y, Sangho, L. | | Deposit date: | 2019-10-06 | | Release date: | 2020-08-12 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.02 Å) | | Cite: | Crystal Structure of IlvC, a Ketol-Acid Reductoisomerase, from Streptococcus Pneumoniae.
Crystals, 9, 2019
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7S4U
 | | Cryo-EM structure of Cas9 in complex with 12-14MM DNA substrate, 5 minute time-point | | Descriptor: | CRISPR-associated endonuclease Cas9/Csn1, Non-target strand, Target strand, ... | | Authors: | Bravo, J.P.K, Taylor, D.W, Liu, M.S, Johnson, K.A. | | Deposit date: | 2021-09-09 | | Release date: | 2022-03-02 | | Last modified: | 2024-06-05 | | Method: | ELECTRON MICROSCOPY (3.56 Å) | | Cite: | Structural basis for mismatch surveillance by CRISPR-Cas9.
Nature, 603, 2022
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7S4V
 | | Cas9 bound to 12-14MM DNA, 60 min time-point, kinked conformation | | Descriptor: | CRISPR-associated endonuclease Cas9/Csn1, NTS, TS, ... | | Authors: | Bravo, J.P.K, Taylor, D.W, Liu, M.S, Johnson, K.A. | | Deposit date: | 2021-09-09 | | Release date: | 2022-03-02 | | Last modified: | 2024-06-05 | | Method: | ELECTRON MICROSCOPY (3.28 Å) | | Cite: | Structural basis for mismatch surveillance by CRISPR-Cas9.
Nature, 603, 2022
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7S4X
 | | Cas9:gRNA in complex with 18-20MM DNA, 1 minute time-point, kinked active conformation | | Descriptor: | CRISPR-associated endonuclease Cas9/Csn1, MAGNESIUM ION, NTS, ... | | Authors: | Bravo, J.P.K, Taylor, D.W, Liu, M.S, Johnson, K.A. | | Deposit date: | 2021-09-09 | | Release date: | 2022-03-02 | | Last modified: | 2024-06-05 | | Method: | ELECTRON MICROSCOPY (2.76 Å) | | Cite: | Structural basis for mismatch surveillance by CRISPR-Cas9.
Nature, 603, 2022
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7S37
 | | Cas9:sgRNA (S. pyogenes) in the open-protein conformation | | Descriptor: | CRISPR-associated endonuclease Cas9/Csn1, Single-guide RNA | | Authors: | Cofsky, J.C, Soczek, K.M, Knott, G.J, Nogales, E, Doudna, J.A. | | Deposit date: | 2021-09-04 | | Release date: | 2022-04-20 | | Last modified: | 2024-06-05 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | CRISPR-Cas9 bends and twists DNA to read its sequence.
Nat.Struct.Mol.Biol., 29, 2022
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7S38
 | | Cas9:sgRNA:DNA (S. pyogenes) forming a 3-base-pair R-loop | | Descriptor: | CRISPR-associated endonuclease Cas9/Csn1, Non-target DNA strand, Single-guide RNA, ... | | Authors: | Cofsky, J.C, Soczek, K.M, Knott, G.J, Nogales, E, Doudna, J.A. | | Deposit date: | 2021-09-04 | | Release date: | 2022-04-20 | | Last modified: | 2022-05-04 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | CRISPR-Cas9 bends and twists DNA to read its sequence.
Nat.Struct.Mol.Biol., 29, 2022
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7S3H
 | | Cas9:sgRNA:DNA (S. pyogenes) with 0 RNA:DNA base pairs, open-protein/linear-DNA conformation | | Descriptor: | CRISPR-associated endonuclease Cas9/Csn1, Non-target DNA strand, Single-guide RNA, ... | | Authors: | Cofsky, J.C, Soczek, K.M, Knott, G.J, Nogales, E, Doudna, J.A. | | Deposit date: | 2021-09-06 | | Release date: | 2022-04-20 | | Last modified: | 2022-05-04 | | Method: | ELECTRON MICROSCOPY (2.5 Å) | | Cite: | CRISPR-Cas9 bends and twists DNA to read its sequence.
Nat.Struct.Mol.Biol., 29, 2022
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7S36
 | | Cas9:sgRNA:DNA (S. pyogenes) with 0 RNA:DNA base pairs, closed-protein/bent-DNA conformation | | Descriptor: | CRISPR-associated endonuclease Cas9/Csn1, Non-target DNA strand, Single-guide RNA, ... | | Authors: | Cofsky, J.C, Soczek, K.M, Knott, G.J, Nogales, E, Doudna, J.A. | | Deposit date: | 2021-09-04 | | Release date: | 2022-04-20 | | Last modified: | 2022-05-04 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | CRISPR-Cas9 bends and twists DNA to read its sequence.
Nat.Struct.Mol.Biol., 29, 2022
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4W5J
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4WXH
 | | Carminomycin-4-O-methyltransferase (DnrK) variant (298Ser insert) in complex with S-adenosyl-L-homocysteine (SAH) and aclacinomycin T | | Descriptor: | (2R,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL, Carminomycin 4-O-methyltransferase DnrK, S-ADENOSYL-L-HOMOCYSTEINE, ... | | Authors: | Metsa-Ketela, M, Niiranen, L. | | Deposit date: | 2014-11-13 | | Release date: | 2015-07-29 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Divergent evolution of an atypical S-adenosyl-l-methionine-dependent monooxygenase involved in anthracycline biosynthesis.
Proc.Natl.Acad.Sci.USA, 112, 2015
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4X36
 | | Crystal structure of the autolysin LytA from Streptococcus pneumoniae TIGR4 | | Descriptor: | Autolysin, CHOLINE ION, GLYCEROL, ... | | Authors: | Cheng, W, Li, Q, Zhou, C.Z, Chen, Y.X. | | Deposit date: | 2014-11-28 | | Release date: | 2015-05-27 | | Last modified: | 2015-06-24 | | Method: | X-RAY DIFFRACTION (2.101 Å) | | Cite: | Full-length structure of the major autolysin LytA.
Acta Crystallogr.,Sect.D, 71, 2015
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3L8C
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3LGX
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5CTV
 | | Catalytic domain of LytA, the major autolysin of Streptococcus pneumoniae, (C60A, H133A, C136A mutant) complexed with peptidoglycan fragment | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-methyl 2-acetamido-3-O-[(1R)-1-carboxyethyl]-2-deoxy-beta-D-glucopyranoside-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-methyl 2-acetamido-3-O-[(1R)-1-carboxyethyl]-2-deoxy-beta-D-glucopyranoside, Autolysin, fragment of peptidoglycan | | Authors: | Achour, A, Sandalova, T, Mellroth, P. | | Deposit date: | 2015-07-24 | | Release date: | 2016-06-15 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (1.05 Å) | | Cite: | The crystal structure of the major pneumococcal autolysin LytA in complex with a large peptidoglycan fragment reveals the pivotal role of glycans for lytic activity.
Mol.Microbiol., 101, 2016
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4UN5
 | | Crystal structure of Cas9 bound to PAM-containing DNA target containing mismatches at positions 1-3 | | Descriptor: | CRISPR-ASSOCIATED ENDONUCLEASE CAS9/CSN1, MAGNESIUM ION, NON-TARGET DNA STRAND, ... | | Authors: | Anders, C, Niewoehner, O, Duerst, A, Jinek, M. | | Deposit date: | 2014-05-25 | | Release date: | 2014-07-23 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structural Basis of Pam-Dependent Target DNA Recognition by the Cas9 Endonuclease
Nature, 513, 2014
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4UN4
 | | Crystal structure of Cas9 bound to PAM-containing DNA target with mismatches at positions 1-2 | | Descriptor: | CRISPR-ASSOCIATED ENDONUCLEASE CAS9/CSN1, MAGNESIUM ION, NON-TARGET DNA STRAND, ... | | Authors: | Anders, C, Niewoehner, O, Duerst, A, Jinek, M. | | Deposit date: | 2014-05-25 | | Release date: | 2014-07-23 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.371 Å) | | Cite: | Structural Basis of Pam-Dependent Target DNA Recognition by the Cas9 Endonuclease
Nature, 513, 2014
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4UN3
 | | Crystal structure of Cas9 bound to PAM-containing DNA target | | Descriptor: | CRISPR-ASSOCIATED ENDONUCLEASE CAS9/CSN1, MAGNESIUM ION, NON-TARGET DNA STRAND, ... | | Authors: | Anders, C, Niewoehner, O, Duerst, A, Jinek, M. | | Deposit date: | 2014-05-25 | | Release date: | 2014-07-23 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.593 Å) | | Cite: | Structural Basis of Pam-Dependent Target DNA Recognition by the Cas9 Endonuclease
Nature, 513, 2014
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6FZH
 | | Crystal structure of a streptococcal dehydrogenase at 1.5 Angstroem resolution | | Descriptor: | DI(HYDROXYETHYL)ETHER, GLYCEROL, Glyceraldehyde-3-phosphate dehydrogenase, ... | | Authors: | Gomez, S, Querol-Garcia, J, Sanchez-Barron, G, Subias, M, Gonzalez-Alsina, A, Melchor-Tafur, C, Franco-Hidalgo, V, Alberti, S, Rodriguez de Cordoba, S, Fernandez, F.J, Vega, M.C. | | Deposit date: | 2018-03-14 | | Release date: | 2019-03-27 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | The Antimicrobials Anacardic Acid and Curcumin Are Not-Competitive Inhibitors of Gram-Positive Bacterial Pathogenic Glyceraldehyde-3-Phosphate Dehydrogenase by a Mechanism Unrelated to Human C5a Anaphylatoxin Binding.
Front Microbiol, 10, 2019
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5EEH
 | | Crystal structure of carminomycin-4-O-methyltransferase DnrK in complex with SAH and 2-chloro-4-nitrophenol | | Descriptor: | 2-chloranyl-4-nitro-phenol, Carminomycin 4-O-methyltransferase DnrK, S-ADENOSYL-L-HOMOCYSTEINE, ... | | Authors: | Wang, F, Singh, S, Thorson, J.S, Phillips Jr, G.N, Enzyme Discovery for Natural Product Biosynthesis (NatPro) | | Deposit date: | 2015-10-22 | | Release date: | 2015-12-16 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (1.82 Å) | | Cite: | Functional AdoMet Isosteres Resistant to Classical AdoMet Degradation Pathways.
Acs Chem.Biol., 11, 2016
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3MYO
 | | Crystal structure of tagatose-1,6-bisphosphate aldolase from Streptococcus pyogenes | | Descriptor: | Tagatose 1,6-diphosphate aldolase 1 | | Authors: | Lee, S.J, Kim, H.S, Kim, D.J, Yoon, H.J, Kim, K.H, Yoon, J.Y, Suh, S.W. | | Deposit date: | 2010-05-10 | | Release date: | 2011-01-26 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Crystal structures of LacD from Staphylococcus aureus and LacD.1 from Streptococcus pyogenes: Insights into substrate specificity and virulence gene regulation
Febs Lett., 585, 2011
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