5O4Y

Structure of human PD-L1 in complex with inhibitor

Summary for 5O4Y

Entry DOI	10.2210/pdb5o4y/pdb
Descriptor	Programmed cell death 1 ligand 1, PHE-MAA-ASN-PRO-HIS-LEU-SER-TRP-SER-TRP-9KK-9KK-ARG-CCS-GLY-NH2 (3 entities in total)
Functional Keywords	pd-1, programmed death 1, pd-l1, programmed death ligand 1, immune checkpoint, cancer, cell cycle
Biological source	Homo sapiens (Human) More
Total number of polymer chains	6
Total formula weight	45979.82
Authors	Magiera, K.,Grudnik, P.,Dubin, G.,Holak, T.A. (deposition date: 2017-05-31, release date: 2017-09-20, Last modification date: 2024-01-17)
Primary citation	Magiera-Mularz, K.,Skalniak, L.,Zak, K.M.,Musielak, B.,Rudzinska-Szostak, E.,Kocik, J.,Grudnik, P.,Sala, D.,Zarganes-Tzitzikas, T.,Shaabani, S.,Domling, A.,Dubin, G.,Holak, T.A. Bioactive Macrocyclic Inhibitors of the PD-1/PD-L1 Immune Checkpoint. Angew. Chem. Int. Ed. Engl., 56:13732-13735, 2017 Cited by PubMed: 28881104 DOI: 10.1002/anie.201707707 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation