PDB: 2849 resultsInfo pagesStatus searchChemie searchBIRD

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3RDE	Crystal structure of the catalytic domain of porcine leukocyte 12-lipoxygenase Descriptor: 3-{4-[(tridec-2-yn-1-yloxy)methyl]phenyl}propanoic acid, Arachidonate 12-lipoxygenase, 12S-type, ... Authors: Funk, M.O, Xu, S, Marnett, L.J, Mueser, T.C. Deposit date: 2011-04-01 Release date: 2012-04-18 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.892 Å) Cite: Crystal structure of 12-lipoxygenase catalytic-domain-inhibitor complex identifies a substrate-binding channel for catalysis. Structure, 20, 2012
5DBR	Ca2+ CaM with human cardiac Na+ channel (NaV1.5) inactivation gate Descriptor: CALCIUM ION, Calmodulin, Sodium channel protein type 5 subunit alpha Authors: Johnson, C.N, Thompson, M.K, Chazin, W.J. Deposit date: 2015-08-21 Release date: 2017-02-22 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.25 Å) Cite: Enhanced Understanding of Ca2+ Modulation of the Human Cardiac Sodium Channel: Tight Binding of Calmodulin to the Inactivation Gate To Be Published
3SFH	Crystal Structure of Human HDAC8 Inhibitor Complex, an Amino Acid Derived Inhibitor Descriptor: (2R)-2-amino-3-(2,4-dichlorophenyl)-1-(1,3-dihydro-2H-isoindol-2-yl)propan-1-one, ACETATE ION, Histone deacetylase 8, ... Authors: Stams, T, Vash, B. Deposit date: 2011-06-13 Release date: 2011-07-20 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Human HDAC isoform selectivity achieved via exploitation of the acetate release channel with structurally unique small molecule inhibitors. Bioorg.Med.Chem., 19, 2011
3SFF	Crystal Structure of Human HDAC8 Inhibitor Complex, an Amino Acid Derived Inhibitor Descriptor: (2R)-2-amino-3-(3-chlorophenyl)-1-[4-(2,5-difluorobenzoyl)piperazin-1-yl]propan-1-one, Histone deacetylase 8, POTASSIUM ION, ... Authors: Stams, T, Vash, B. Deposit date: 2011-06-13 Release date: 2011-07-20 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2 Å) Cite: Human HDAC isoform selectivity achieved via exploitation of the acetate release channel with structurally unique small molecule inhibitors. Bioorg.Med.Chem., 19, 2011
4NMC	Crystal structure of oxidized proline utilization A (PutA) from Geobacter sulfurreducens PCA complexed with Zwittergent 3-12 Descriptor: (2S)-2-HYDROXYPROPANOIC ACID, FLAVIN-ADENINE DINUCLEOTIDE, N-DODECYL-N,N-DIMETHYL-3-AMMONIO-1-PROPANESULFONATE, ... Authors: Singh, H, Tanner, J.J. Deposit date: 2013-11-14 Release date: 2014-02-19 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.901 Å) Cite: Structures of the PutA peripheral membrane flavoenzyme reveal a dynamic substrate-channeling tunnel and the quinone-binding site. Proc.Natl.Acad.Sci.USA, 111, 2014
7M1E	Structural and functional studies about scorpine showed the presence of blocking channel and cytolytic activities as well as two different structural domains Descriptor: Scorpine Authors: del Rio, J.F, Lopez, A.E, Titaux, G. Deposit date: 2021-03-12 Release date: 2022-01-19 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: Structural and functional studies of scorpine: A channel blocker and cytolytic peptide. Toxicon, 222, 2022
7M1D	Structural and functional studies about scorpine showed the presence of blocking channel and cytolytic activities as well as two different structural domains Descriptor: Scorpine Authors: del Rio-Portilla, F, Lopez-Giraldo, A.E. Deposit date: 2021-03-12 Release date: 2022-01-19 Last modified: 2023-06-14 Method: SOLUTION NMR Cite: Structural and functional studies of scorpine: A channel blocker and cytolytic peptide. Toxicon, 222, 2022
3BXK	Crystal structure of the P/Q-type calcium channel (CaV2.1) IQ domain and CA2+calmodulin complex Descriptor: CALCIUM ION, Calmodulin, SULFATE ION, ... Authors: Mori, M.X, Vander Kooi, C.W, Leahy, D.J, Yue, D.T. Deposit date: 2008-01-14 Release date: 2008-03-25 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.55 Å) Cite: Crystal structure of the P/Q-type calcium channel (CaV2.1) IQ domain and CA2+calmodulin complex To be Published
4J90	Square-shaped octameric structure of KtrA with ATP bound Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Ktr system potassium uptake protein A Authors: Vieira-Pires, R.S, Morais-Cabral, J.H. Deposit date: 2013-02-15 Release date: 2013-04-17 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (3.24 Å) Cite: The structure of the KtrAB potassium transporter Nature, 496, 2013
4J91	Diamond-shaped octameric structure of KtrA with ADP bound Descriptor: ADENOSINE-5'-DIPHOSPHATE, Ktr system potassium uptake protein A Authors: Vieira-Pires, R.S, Morais-Cabral, J.H. Deposit date: 2013-02-15 Release date: 2013-04-17 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.93 Å) Cite: The structure of the KtrAB potassium transporter Nature, 496, 2013
6ESQ	Structure of the acetoacetyl-CoA thiolase/HMG-CoA synthase complex from Methanothermococcus thermolithotrophicus soaked with acetyl-CoA Descriptor: CHLORIDE ION, COENZYME A, HydroxyMethylGlutaryl-CoA synthase, ... Authors: Voegeli, B, Engilberge, S, Girard, E, Riobe, F, Maury, O, Erb, J.T, Shima, S, Wagner, T. Deposit date: 2017-10-24 Release date: 2018-03-14 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2.95 Å) Cite: Archaeal acetoacetyl-CoA thiolase/HMG-CoA synthase complex channels the intermediate via a fused CoA-binding site. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
1UYU	Xenon COMPLEX OF wildtype P450CAM FROM PSEUDOMONAS PUTIDA Descriptor: CAMPHOR, CYTOCHROME P450-CAM, POTASSIUM ION, ... Authors: Wade, R.C, Winn, P.J, Schlichting, I, Sudarko, X. Deposit date: 2004-03-02 Release date: 2005-03-07 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2 Å) Cite: A Survey of Active Site Access Channels in Cytochromes P450 J.Inorg.Biochem., 98, 2004
6ET9	Structure of the acetoacetyl-CoA-thiolase/HMG-CoA-synthase complex from Methanothermococcus thermolithotrophicus at 2.75 A Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Acetyl-CoA acetyltransferase thiolase, CHLORIDE ION, ... Authors: Engilberge, S, Voegeli, B, Girard, E, Riobe, F, Maury, O, Erb, T.J, Shima, S, Wagner, T. Deposit date: 2017-10-25 Release date: 2018-03-14 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2.75 Å) Cite: Archaeal acetoacetyl-CoA thiolase/HMG-CoA synthase complex channels the intermediate via a fused CoA-binding site. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
7L8V	NMR Structure of half-calcified calmodulin mutant (CaMEF12) bound to the IQ-motif of CaV1.2 Descriptor: CALCIUM ION, Calmodulin-1, Voltage-dependent L-type calcium channel subunit alpha-1C Authors: Ames, J.B. Deposit date: 2021-01-01 Release date: 2022-07-06 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: Half-calcified calmodulin promotes basal activity and inactivation of the L-type calcium channel Ca V 1.2. J.Biol.Chem., 298, 2022
6BBI	The CRAC channel Orai in an unlatched-closed conformation; K163W loss-of-function mutation; P42212 crystal form Descriptor: Calcium release-activated calcium channel protein 1 Authors: Long, S.B, Hou, X, Burstein, S. Deposit date: 2017-10-18 Release date: 2018-09-12 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (4.35 Å) Cite: Structures reveal opening of the store-operated calcium channel Orai. Elife, 7, 2018
6BBG	The CRAC channel Orai in an unlatched-closed conformation Descriptor: Calcium release-activated calcium channel protein 1 Authors: Long, S.B, Hou, X, Burstein, S. Deposit date: 2017-10-18 Release date: 2018-09-12 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (6.9 Å) Cite: Structures reveal opening of the store-operated calcium channel Orai. Elife, 7, 2018
5KHI	HCN2 CNBD in complex with purine riboside-3', 5'-cyclic monophosphate (cPuMP) Descriptor: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2, Purine riboside-3',5'-cyclic monophosphate Authors: Ng, L.C.T, Putrenko, I, Baronas, V, Van Petegem, F, Accili, E.A. Deposit date: 2016-06-14 Release date: 2016-09-14 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Cyclic Purine and Pyrimidine Nucleotides Bind to the HCN2 Ion Channel and Variably Promote C-Terminal Domain Interactions and Opening. Structure, 24, 2016
5KHJ	HCN2 CNBD in complex with uridine-3', 5'-cyclic monophosphate (cUMP) Descriptor: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2, Uridine-3',5'-cyclic monophosphate Authors: Ng, L.C.T, Putrenko, I, Baronas, V, Van Petegem, F, Accili, E.A. Deposit date: 2016-06-14 Release date: 2016-09-14 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.01 Å) Cite: Cyclic Purine and Pyrimidine Nucleotides Bind to the HCN2 Ion Channel and Variably Promote C-Terminal Domain Interactions and Opening. Structure, 24, 2016
6MZT	Solution structure of alpha-KTx-6.21 (UroTx) from Urodacus yaschenkoi Descriptor: Potassium channel toxin alpha-KTx 6.21 Authors: Chin, Y.K.-Y, Luna-Ramirez, K, Anangi, R, King, G.F. Deposit date: 2018-11-05 Release date: 2020-03-11 Last modified: 2023-06-14 Method: SOLUTION NMR Cite: Structural basis of the potency and selectivity of Urotoxin, a potent Kv1 blocker from scorpion venom. Biochem. Pharmacol., 174, 2020
8XMI	Potassium transporter KtrAB from Bacillus subtilis in ATP-bound state with addition of EDTA and EGTA, C1 symmetry Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Ktr system potassium uptake protein A, Ktr system potassium uptake protein B, ... Authors: Chang, Y.K, Chiang, W.T, Hu, N.J, Tsai, M.D. Deposit date: 2023-12-27 Release date: 2024-04-03 Last modified: 2024-05-22 Method: ELECTRON MICROSCOPY (3 Å) Cite: Structural basis and synergism of ATP and Na + activation in bacterial K + uptake system KtrAB. Nat Commun, 15, 2024
8XMH	Potassium transporter KtrAB from Bacillus subtilis in ATP-bound state with addition of EDTA and EGTA, vertical C2 symmetry axis Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Ktr system potassium uptake protein A, Ktr system potassium uptake protein B, ... Authors: Chang, Y.K, Chiang, W.T, Hu, N.J, Tsai, M.D. Deposit date: 2023-12-27 Release date: 2024-04-03 Last modified: 2024-05-22 Method: ELECTRON MICROSCOPY (2.85 Å) Cite: Structural basis and synergism of ATP and Na + activation in bacterial K + uptake system KtrAB. Nat Commun, 15, 2024
7E1Z	Cryo EM structure of a Na+-bound Na+,K+-ATPase in the E1 state Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Guo, Y.Y, Zhang, Y.Y, Yan, R.H, Huang, B.D, Ye, F.F, Wu, L.S, Chi, X.M, Zhou, Q. Deposit date: 2021-02-04 Release date: 2022-06-15 Last modified: 2022-07-20 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Cryo-EM structures of recombinant human sodium-potassium pump determined in three different states. Nat Commun, 13, 2022
7E21	Cryo EM structure of a Na+-bound Na+,K+-ATPase in the E1 state with ATP-gamma-S Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Guo, Y.Y, Zhang, Y.Y, Yan, R.H, Huang, B.D, Ye, F.F, Wu, L.S, Chi, X.M, Zhou, Q. Deposit date: 2021-02-04 Release date: 2022-06-15 Last modified: 2022-07-20 Method: ELECTRON MICROSCOPY (2.9 Å) Cite: Cryo-EM structures of recombinant human sodium-potassium pump determined in three different states. Nat Commun, 13, 2022
7ZRU	Solution structure of Pi6, a low affinity blocking kappa-K+-channel peptide from the scorpion Pandinus imperator Descriptor: Potassium channel toxin kappa-KTx 2.9 Authors: Delepierre, M, Olamendi Portugal, T, Possani, L.D, Guijarro, J.I. Deposit date: 2022-05-05 Release date: 2022-05-18 Last modified: 2023-06-14 Method: SOLUTION NMR Cite: Not applicable Not Published
7NMN	Rabbit HCN4 stabilised in amphipol A8-35 Descriptor: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4,Rabbit HCN4 Authors: Chaves-Sanjuan, A. Deposit date: 2021-02-23 Release date: 2021-06-30 Last modified: 2024-07-10 Method: ELECTRON MICROSCOPY (3.6 Å) Cite: Gating movements and ion permeation in HCN4 pacemaker channels. Mol.Cell, 81, 2021

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