PDB: 66478 resultsInfo pagesStatus searchChemie searchBIRD

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3LOK	Drug resistant cSrc kinase domain in complex with covalent inhibitor PD168393 Descriptor: N-[4-(3-BROMO-PHENYLAMINO)-QUINAZOLIN-6-YL]-ACRYLAMIDE, Proto-oncogene tyrosine-protein kinase Src Authors: Gruetter, C, Rode, H.B, Rauh, D. Deposit date: 2010-02-04 Release date: 2010-12-22 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.48 Å) Cite: Characterization of irreversible kinase inhibitors by directly detecting covalent bond formation: a tool for dissecting kinase drug resistance Chembiochem, 11, 2010
3L7P	Crystal structure of SMU.1657c, Putative nitrogen regulatory protein PII from streptococcus mutans Descriptor: Putative nitrogen regulatory protein PII Authors: Fan, X.-X, Wang, K.-T, Su, X.-D. Deposit date: 2009-12-29 Release date: 2010-12-29 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (2 Å) Cite: Crystal structure of SMU.1657c, Putative nitrogen regulatory protein PII from streptococcus mutans To be Published
3KHP	Crystal structure of a possible dehydrogenase from Mycobacterium tuberculosis at 2.3A resolution Descriptor: CHLORIDE ION, L(+)-TARTARIC ACID, MaoC family protein Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID), Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2009-10-30 Release date: 2009-12-01 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Increasing the structural coverage of tuberculosis drug targets. Tuberculosis (Edinb), 95, 2015
3KM6	Crystal Structure of the Human GST Pi C47S/Y108V Double Mutant in Complex with the Ethacrynic Acid-Glutathione Conjugate Descriptor: CALCIUM ION, ETHACRYNIC ACID, GLUTATHIONE, ... Authors: Parker, L.J. Deposit date: 2009-11-10 Release date: 2010-03-23 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Diuretic drug binding to human glutathione transferase P1-1: potential role of Cys-101 revealed in the double mutant C47S/Y108V. J.Mol.Recognit., 24
3KOB	DTD from Plasmodium falciparum in complex with D-Glutamic acid Descriptor: D-GLUTAMIC ACID, D-tyrosyl-tRNA(Tyr) deacylase Authors: Manickam, Y, Bhatt, T.K, Sharma, A. Deposit date: 2009-11-13 Release date: 2009-12-08 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (2.99 Å) Cite: Ligand-bound Structures Provide Atomic Snapshots for the Catalytic Mechanism of D-Amino Acid Deacylase J.Biol.Chem., 285, 2010
3KEK	Crystal Structure of Human MMP-13 complexed with a (pyridin-4-yl)-2H-tetrazole compound Descriptor: CALCIUM ION, Collagenase 3, ZINC ION, ... Authors: Shieh, H.-S, Collins, B, Schnute, M.E. Deposit date: 2009-10-26 Release date: 2010-11-10 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.97 Å) Cite: Discovery of (pyridin-4-yl)-2H-tetrazole as a novel scaffold to identify highly selective matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis. Bioorg.Med.Chem.Lett., 20, 2009
3KHC	Crystal Structure of Escherichia coli AlkB in complex with ssDNA containing a 1-methylguanine lesion Descriptor: 2-OXOGLUTARIC ACID, Alpha-ketoglutarate-dependent dioxygenase alkB, COBALT (II) ION, ... Authors: Hollis, T, Holland, P.J. Deposit date: 2009-10-30 Release date: 2010-01-12 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Structural and mutational analysis of Escherichia coli AlkB provides insight into substrate specificity and DNA damage searching. Plos One, 5, 2010
3KOC	DTD from Plasmodium falciparum in complex with D-Histidine Descriptor: D-HISTIDINE, D-tyrosyl-tRNA(Tyr) deacylase Authors: Manickam, Y, Bhatt, T.K, Sharma, A. Deposit date: 2009-11-13 Release date: 2009-12-08 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (2.91 Å) Cite: Ligand-bound Structures Provide Atomic Snapshots for the Catalytic Mechanism of D-Amino Acid Deacylase J.Biol.Chem., 285, 2010
3I0J	Crystal structure of GTB C80S/C196S/C209S + H antigen Descriptor: ABO glycosyltransferase, alpha-L-fucopyranose-(1-2)-hexyl beta-D-galactopyranoside Authors: Schuman, B, Persson, M, Landry, R.C, Polakowski, R, Weadge, J.T, Seto, N.O.L, Borisova, S, Palcic, M.M, Evans, S.V. Deposit date: 2009-06-25 Release date: 2010-08-11 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.48 Å) Cite: Cysteine-to-serine mutants dramatically reorder the active site of human ABO(H) blood group B glycosyltransferase without affecting activity: structural insights into cooperative substrate binding. J.Mol.Biol., 402, 2010
3I1C	Crystal Structure of a Novel Engineered Diels-Alderase: DA_20_00_A74I Descriptor: Diisopropyl-fluorophosphatase, GLYCEROL Authors: Lambert, A.R, Stoddard, B.L. Deposit date: 2009-06-26 Release date: 2009-08-18 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Computational design of an enzyme catalyst for a stereoselective bimolecular Diels-Alder reaction. Science, 329, 2010
3I5W	Crystal structure of human alpha-defensin 5 (mutant R13H) Descriptor: CHLORIDE ION, CITRATE ANION, Defensin-5 Authors: Pazgier, M, Lu, W. Deposit date: 2009-07-06 Release date: 2009-07-28 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.63 Å) Cite: Selective arginines are important for the antibacterial activity and host cell interaction of human alpha-defensin 5 Febs Lett., 583, 2009
3IHZ	Crystal structure of the FK506 binding domain of Plasmodium vivax FKBP35 in complex with FK506 Descriptor: 70 kDa peptidylprolyl isomerase, putative, 8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN Authors: Qureshi, I.A, Alag, R, Yoon, H.S, Lescar, J. Deposit date: 2009-07-31 Release date: 2010-06-16 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (1.67 Å) Cite: NMR and crystallographic structures of the FK506 binding domain of human malarial parasite Plasmodium vivax FKBP35 Protein Sci., 19, 2010
3IWY	Crystal structure of human MDM2 complexed with D-peptide (12 residues) Descriptor: D-peptide inhibitor, E3 ubiquitin-protein ligase Mdm2 Authors: Pazgier, M, Lu, W. Deposit date: 2009-09-03 Release date: 2010-04-21 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.93 Å) Cite: D-peptide inhibitors of the p53-MDM2 interaction for targeted molecular therapy of malignant neoplasms. Proc.Natl.Acad.Sci.USA, 398, 2010
3GJP	Crystal structure of mutant coiled coil GCN4 leucine zipper Descriptor: General control protein GCN4 Authors: Honnappa, S, Steinmetz, M.O. Deposit date: 2009-03-09 Release date: 2010-03-09 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2 Å) Cite: Molecular basis of coiled-coil oligomerization-state specificity Proc.Natl.Acad.Sci.USA, 107, 2010
3GNU	Toxin fold as basis for microbial attack and plant defense Descriptor: 25 kDa protein elicitor, CHLORIDE ION, GUANIDINE Authors: Ottmann, C, Luberacki, B, Kuefner, I, Koch, W, Brunner, F, Weyand, M, Mattinen, L, Pirhonen, M, Anderluh, G, Seitz, H.U, Nuernberger, T, Oecking, C. Deposit date: 2009-03-18 Release date: 2009-06-09 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (1.9 Å) Cite: A common toxin fold mediates microbial attack and plant defense Proc.Natl.Acad.Sci.USA, 106, 2009
3LO1	Crystal structure of human alpha-defensin 1 (Y16A mutant) Descriptor: 2-(2-METHOXYETHOXY)ETHANOL, AZIDE ION, Neutrophil defensin 1 Authors: Pazgier, M, Lu, W. Deposit date: 2010-02-03 Release date: 2010-03-09 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Trp-26 imparts functional versatility to human alpha-defensin HNP1. J.Biol.Chem., 285, 2010
3LOG	Crystal structure of MbtI from Mycobacterium tuberculosis Descriptor: CARBONATE ION, GLYCEROL, Isochorismate synthase/isochorismate-pyruvate lyase mbtI, ... Authors: Bulloch, E.M.M, Lott, J.S, Baker, E.N, Johnston, J.M. Deposit date: 2010-02-03 Release date: 2011-02-09 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (1.73 Å) Cite: Inhibition studies of Mycobacterium tuberculosis salicylate synthase (MbtI). Chemmedchem, 5, 2010
3LNZ	Crystal structure of human MDM2 with a 12-mer peptide inhibitor PMI (N8A mutant) Descriptor: 12-mer peptide inhibitor, CHLORIDE ION, E3 ubiquitin-protein ligase Mdm2 Authors: Pazgier, M, Lu, W. Deposit date: 2010-02-03 Release date: 2010-03-09 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Systematic mutational analysis of peptide inhibition of the p53-MDM2/MDMX interactions. J.Mol.Biol., 398, 2010
3LOE	Crystal structure of human alpha-defensin 1 (F28A mutant) Descriptor: GLYCEROL, Neutrophil defensin 1, SULFATE ION Authors: Pazgier, M, Lu, W. Deposit date: 2010-02-03 Release date: 2010-03-09 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.56 Å) Cite: Trp-26 imparts functional versatility to human alpha-defensin HNP1. J.Biol.Chem., 285, 2010
3L7O	Crystal structure of Ribose-5-phosphate isomerase A from streptococcus mutans UA159 Descriptor: Ribose-5-phosphate isomerase A Authors: Fan, X.X, Wang, K.T, Su, X.D. Deposit date: 2009-12-29 Release date: 2011-01-05 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Crystal structure of Ribose-5-phosphate isomerase A from streptococcus mutans UA159 TO BE PUBLISHED
3H1G	Crystal structure of Chey mutant T84A of helicobacter pylori Descriptor: Chemotaxis protein cheY homolog, MAGNESIUM ION, SULFATE ION Authors: Lam, K.H, Ling, T.K, Au, S.W. Deposit date: 2009-04-12 Release date: 2010-03-09 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Crystal structure of activated CheY1 from Helicobacter pylori. J.Bacteriol., 192, 2010
3LA2	Crystal structure of NtcA in complex with 2-oxoglutarate Descriptor: 2-OXOGLUTARIC ACID, Global nitrogen regulator Authors: Zhao, M.X, Jiang, Y.L, He, Y.X, Chen, Y.F, Teng, Y.B, Chen, Y.X, Zhang, C.C, Zhou, C.Z. Deposit date: 2010-01-06 Release date: 2010-07-14 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Structural basis for the allosteric control of the global transcription factor NtcA by the nitrogen starvation signal 2-oxoglutarate. Proc.Natl.Acad.Sci.USA, 107, 2010
3GRR	Crystal Structure of the complex between S-Adenosyl Homocysteine and Methanocaldococcus jannaschi Dim1. Descriptor: Dimethyladenosine transferase, S-ADENOSYL-L-HOMOCYSTEINE Authors: Scarsdale, J.N, Musayev, F.N, Rife, J.P. Deposit date: 2009-03-26 Release date: 2010-03-31 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Binding of adenosine-based ligands to the MjDim1 rRNA methyltransferase: implications for reaction mechanism and drug design. Biochemistry, 49, 2010
3GRV	Crystal Structure of the Complex between Adenosine and Methanocaldococcus jannaschi Dim1 Descriptor: ADENOSINE, Dimethyladenosine transferase, SULFATE ION Authors: Scarsdale, J.N, Musayev, F.N, Rife, J.P. Deposit date: 2009-03-26 Release date: 2010-03-31 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Binding of adenosine-based ligands to the MjDim1 rRNA methyltransferase: implications for reaction mechanism and drug design. Biochemistry, 49, 2010
3LA9	Crystal structure of the trimeric autotransporter adhesin head domain BpaA from Burkholderia pseudomallei, iodide phased Descriptor: Haemagglutinin family protein, IODIDE ION Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2010-01-06 Release date: 2010-05-12 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Structure of a Burkholderia pseudomallei trimeric autotransporter adhesin head. Plos One, 5, 2010

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