6L17

Crystal structure of Ser/Thr kinase Pim1 in complex with 10-DEBC derivatives

Summary for 6L17

Entry DOI	10.2210/pdb6l17/pdb
Descriptor	Serine/threonine-protein kinase pim-1, 7-chloranyl-5-[3-[(3~{S})-piperidin-3-yl]propyl]pyrido[3,4-b][1,4]benzoxazin-8-amine (3 entities in total)
Functional Keywords	pim-1 kinase, 10-debc, transferase-inhibitor complex, transferase/inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	33651.58
Authors	Zhang, W.,Xie, Y.,Cao, R.,Huang, N.,Zhou, Y. (deposition date: 2019-09-27, release date: 2020-09-02)
Primary citation	Li, G.,Zhang, W.,Xie, Y.,Li, Y.,Cao, R.,Zheng, G.,Huang, N.,Zhou, Y. Structure-Based Optimization of 10-DEBC Derivatives as Potent and Selective Pim-1 Kinase Inhibitors. J.Chem.Inf.Model., 60:3287-3294, 2020 Cited by PubMed: 32407627 DOI: 10.1021/acs.jcim.0c00245 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.75 Å)

Structure validation