PDB: 73628 resultsInfo pagesStatus searchChemie searchBIRD

---

5XIQ	Crystal Structure of Toxoplasma gondii Prolyl-tRNA Synthetase (TgPRS) in complex with Halofuginone Descriptor: 7-bromo-6-chloro-3-{3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... Authors: Jain, V, Manickam, Y, Sharma, A. Deposit date: 2017-04-26 Release date: 2018-03-07 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.19 Å) Cite: Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis Structure, 25, 2017
5XII	Crystal Structure of Toxoplasma gondii Prolyl-tRNA Synthetase (TgPRS) in complex with inhibitor 6 Descriptor: 1,2-ETHANEDIOL, 6-chloranyl-7-fluoranyl-3-[3-[(2R)-3-oxidanylidenepiperidin-2-yl]propyl]quinazolin-4-one, CHLORIDE ION, ... Authors: Jain, V, Manickam, Y, Sharma, A. Deposit date: 2017-04-26 Release date: 2018-03-07 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.17 Å) Cite: Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis Structure, 25, 2017
5J5A	Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor (Chem 70786556) Descriptor: METHIONINE, Methionyl-tRNA synthetase, putative, ... Authors: Barros-Alvarez, X, Koh, C.Y, Hol, W.G.J. Deposit date: 2016-04-01 Release date: 2017-01-25 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Structure-guided design of novel Trypanosoma brucei Methionyl-tRNA synthetase inhibitors. Eur J Med Chem, 124, 2016
5XIL	Crystal Structure of Leishmania major Prolyl-tRNA Synthetase (LmPRS) Descriptor: ACETATE ION, MAGNESIUM ION, Putative prolyl-tRNA synthetase, ... Authors: Jain, V, Manickam, Y, Sharma, A. Deposit date: 2017-04-26 Release date: 2018-03-07 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis Structure, 25, 2017
5XIG	Crystal Structure of Toxoplasma gondii Prolyl-tRNA Synthetase (TgPRS) in complex with Inhibitor 1 Descriptor: 3-[3-[(2R)-3-oxidanylidenepiperidin-2-yl]propyl]quinazolin-4-one, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... Authors: Jain, V, Manickam, Y, Sharma, A. Deposit date: 2017-04-26 Release date: 2018-03-07 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.41 Å) Cite: Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis Structure, 25, 2017
5XIP	Crystal Structure of Eimeria tenella Prolyl-tRNA Synthetase (EtPRS) in complex with Halofuginone Descriptor: 7-bromo-6-chloro-3-{3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... Authors: Jain, V, Manickam, Y, Sharma, A. Deposit date: 2017-04-26 Release date: 2018-03-07 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (3.1 Å) Cite: Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis Structure, 25, 2017
5J59	Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor (Chem 1893) Descriptor: 5-chloro-N-(2-{[(3,5-dichlorophenyl)methyl]amino}ethyl)-N-methyl-3H-imidazo[4,5-b]pyridin-2-amine, GLYCEROL, METHIONINE, ... Authors: Barros-Alvarez, X, Hol, W.G.J. Deposit date: 2016-04-01 Release date: 2017-01-25 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Structure-guided design of novel Trypanosoma brucei Methionyl-tRNA synthetase inhibitors. Eur J Med Chem, 124, 2016
5J58	Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor (Chem 1856) Descriptor: (3S)-1-(5-chloro-1H-imidazo[4,5-b]pyridin-2-yl)-N-[(3,5-dichlorophenyl)methyl]piperidin-3-amine, DIMETHYL SULFOXIDE, GLYCEROL, ... Authors: Barros-Alvarez, X, Hol, W.G.J. Deposit date: 2016-04-01 Release date: 2017-01-25 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Structure-guided design of novel Trypanosoma brucei Methionyl-tRNA synthetase inhibitors. Eur J Med Chem, 124, 2016
5XIK	Crystal Structure of Toxoplasma gondii Prolyl-tRNA Synthetase (TgPRS) in complex with tetrahydro quinazolinone febrifugine Descriptor: 3-[2-oxidanylidene-3-[(2R,3R)-3-oxidanylpiperidin-2-yl]propyl]-5,6,7,8-tetrahydroquinazolin-4-one, CHLORIDE ION, MAGNESIUM ION, ... Authors: Jain, V, Manickam, Y, Sharma, A. Deposit date: 2017-04-26 Release date: 2018-03-07 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis Structure, 25, 2017
5XIJ	Crystal Structure of Toxoplasma gondii Prolyl-tRNA Synthetase (TgPRS) in complex with Inhibitor 9 Descriptor: 3-[(2R)-2-oxidanyl-3-[(2R,3R)-3-oxidanylpiperidin-2-yl]propyl]quinazolin-4-one, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... Authors: Jain, V, Manickam, Y, Sharma, A. Deposit date: 2017-04-26 Release date: 2018-03-07 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis Structure, 25, 2017
5XIH	Crystal Structure of Toxoplasma gondii Prolyl-tRNA Synthetase (TgPRS) in complex with inhibitor 5 Descriptor: 6,7-bis(fluoranyl)-3-[3-[(2R)-3-oxidanylidenepiperidin-2-yl]propyl]quinazolin-4-one, CHLORIDE ION, MAGNESIUM ION, ... Authors: Jain, V, Manickam, Y, Sharma, A. Deposit date: 2017-04-26 Release date: 2018-03-07 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis Structure, 25, 2017
3A31	Crystal structure of putative threonyl-tRNA synthetase ThrRS-1 from Aeropyrum pernix (selenomethionine derivative) Descriptor: Probable threonyl-tRNA synthetase 1, SULFATE ION, ZINC ION Authors: Shimizu, S, Juan, E.C.M, Miyashita, Y, Sato, Y, Hoque, M.M, Suzuki, K, Yogiashi, M, Tsunoda, M, Dock-Bregeon, A.-C, Moras, D, Sekiguchi, T, Takenaka, A. Deposit date: 2009-06-07 Release date: 2009-10-27 Last modified: 2013-11-20 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Two complementary enzymes for threonylation of tRNA in crenarchaeota: crystal structure of Aeropyrum pernix threonyl-tRNA synthetase lacking a cis-editing domain J.Mol.Biol., 394, 2009
2DPT	Leucyl/phenylalanyl-tRNA-protein transferase complexed with puromycin Descriptor: D(-)-TARTARIC ACID, Leucyl/phenylalanyl-tRNA--protein transferase, PUROMYCIN Authors: Suto, K, Shimizu, Y, Tomita, K. Deposit date: 2006-05-14 Release date: 2007-01-02 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.75 Å) Cite: Crystal structures of leucyl/phenylalanyl-tRNA-protein transferase and its complex with an aminoacyl-tRNA analog Embo J., 25, 2006
2CJA	Crystal structure of Methanosarcina barkeri seryl-tRNA synthetase complexed with ATP Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, MAGNESIUM ION, ... Authors: Bilokapic, S, Maier, T, Ahel, D, Gruic-Sovulj, I, Soll, D, Weygand-Durasevic, I, Ban, N. Deposit date: 2006-03-30 Release date: 2006-06-26 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Structure of the Unusual Seryl-tRNA Synthetase Reveals a Distinct Zinc-Dependent Mode of Substrate Recognition Embo J., 25, 2006
4QD3	Crystal structure of Peptidyl-tRNA hydrolase from Pseudomonas aeruginosa with 5-azacytidine at 1.89 Angstrom resolution Descriptor: 4-amino-1-(beta-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one, GLYCEROL, Peptidyl-tRNA hydrolase Authors: Singh, A, Gautam, L, Sinha, M, Bhushan, A, Kaur, P, Sharma, S, Singh, T.P. Deposit date: 2014-05-13 Release date: 2014-06-25 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.89 Å) Cite: Structural and binding studies of peptidyl-tRNA hydrolase from Pseudomonas aeruginosa provide a platform for the structure-based inhibitor design against peptidyl-tRNA hydrolase Biochem.J., 463, 2014
2DPS	Structure of Leucyl/phenylalanyl-tRNA-protein transferase Descriptor: Leucyl/phenylalanyl-tRNA--protein transferase Authors: Suto, K, Shimizu, Y, Tomita, K. Deposit date: 2006-05-14 Release date: 2007-01-02 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Crystal structures of leucyl/phenylalanyl-tRNA-protein transferase and its complex with an aminoacyl-tRNA analog Embo J., 25, 2006
1N3L	Crystal structure of a human aminoacyl-tRNA synthetase cytokine Descriptor: GLYCEROL, SULFATE ION, tyrosyl-tRNA synthetase Authors: Yang, X.-L, Skene, R.J, McRee, D.E, Schimmel, P. Deposit date: 2002-10-28 Release date: 2002-11-20 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.18 Å) Cite: Crystal structure of a human aminoacyl-tRNA synthetase cytokine Proc.Natl.Acad.Sci.USA, 99, 2002
4QBK	Crystal structure of the complex of Peptidyl-tRNA hydrolase from Pseudomonas aeruginosa with amino acyl-tRNA analogue at 1.77 Angstrom resolution Descriptor: 3'-deoxy-3'-[(O-methyl-L-tyrosyl)amino]adenosine, GLYCEROL, Peptidyl-tRNA hydrolase Authors: Singh, A, Sinha, M, Bhushan, A, Kaur, P, Sharma, S, Singh, T.P. Deposit date: 2014-05-08 Release date: 2014-05-28 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.77 Å) Cite: Structural and binding studies of peptidyl-tRNA hydrolase from Pseudomonas aeruginosa provide a platform for the structure-based inhibitor design against peptidyl-tRNA hydrolase Biochem.J., 463, 2014
2CJB	Crystal structure of Methanosarcina barkeri seryl-tRNA synthetase complexed with serine Descriptor: CHLORIDE ION, SERINE, SERYL-TRNA SYNTHETASE, ... Authors: Bilokapic, S, Maier, T, Ahel, D, Gruic-Sovulj, I, Soll, D, Weygand-Durasevic, I, Ban, N. Deposit date: 2006-03-30 Release date: 2006-06-26 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Structure of the Unusual Seryl-tRNA Synthetase Reveals a Distinct Zinc-Dependent Mode of Substrate Recognition Embo J., 25, 2006
3A32	Crystal structure of putative threonyl-tRNA synthetase ThrRS-1 from Aeropyrum pernix Descriptor: Probable threonyl-tRNA synthetase 1, SULFATE ION, ZINC ION Authors: Shimizu, S, Juan, E.C.M, Miyashita, Y, Sato, Y, Hoque, M.M, Suzuki, K, Yogiashi, M, Tsunoda, M, Dock-Bregeon, A.-C, Moras, D, Sekiguchi, T, Takenaka, A. Deposit date: 2009-06-07 Release date: 2009-10-27 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Two complementary enzymes for threonylation of tRNA in crenarchaeota: crystal structure of Aeropyrum pernix threonyl-tRNA synthetase lacking a cis-editing domain J.Mol.Biol., 394, 2009
2CJ9	Crystal structure of Methanosarcina barkeri seryl-tRNA synthetase complexed with an analog of seryladenylate Descriptor: 5'-O-(N-(L-SERYL)-SULFAMOYL)ADENOSINE, CHLORIDE ION, SERYL-TRNA SYNTHETASE, ... Authors: Bilokapic, S, Maier, T, Ahel, D, Gruic-Sovulj, I, Soll, D, Weygand-Durasevic, I, Ban, N. Deposit date: 2006-03-29 Release date: 2006-06-26 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structure of the Unusual Seryl-tRNA Synthetase Reveals a Distinct Zinc-Dependent Mode of Substrate Recognition Embo J., 25, 2006
2AJI	Crystal structure of the editing domain of E. coli leucyl-tRNA synthetase complexes with isoleucine Descriptor: ISOLEUCINE, Leucyl-tRNA synthetase Authors: Liu, Y, Liao, J, Zhu, B, Wang, E.D, Ding, J. Deposit date: 2005-08-02 Release date: 2006-01-24 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (3.2 Å) Cite: Crystal structures of the editing domain of Escherichia coli leucyl-tRNA synthetase and its complexes with Met and Ile reveal a lock-and-key mechanism for amino acid discrimination Biochem.J., 394, 2006
2ZCE	Crystal structure of the catalytic domain of pyrrolysyl-tRNA synthetase in complex with pyrrolysine and an ATP analogue Descriptor: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, PYRROLYSINE, ... Authors: Yanagisawa, T, Ishii, R, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2007-11-08 Release date: 2008-04-22 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Crystallographic Studies on Multiple Conformational States of Active-site Loops in Pyrrolysyl-tRNA Synthetase J.Mol.Biol., 378, 2008
4NCX	Crystal Structure of Prolyl-tRNA synthetase (ProRS, Proline--tRNA ligase) from Plasmodium falciparum 3D7 Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, Proline--tRNA ligase Authors: Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2013-10-25 Release date: 2014-10-29 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Biochemical and Structural Characterization of Selective Allosteric Inhibitors of the Plasmodium falciparum Drug Target, Prolyl-tRNA-synthetase. Acs Infect Dis., 3, 2017
4N7R	Crystal structure of Arabidopsis glutamyl-tRNA reductase in complex with its binding protein Descriptor: Genomic DNA, chromosome 3, P1 clone: MXL8, ... Authors: Zhao, A, Fang, Y, Lin, Y, Gong, W, Liu, L. Deposit date: 2013-10-16 Release date: 2014-05-14 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (2.802 Å) Cite: Crystal structure of Arabidopsis glutamyl-tRNA reductase in complex with its stimulator protein Proc.Natl.Acad.Sci.USA, 111, 2014

<20212223242526272829303132333435>