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6OTO	Carbonic Anhydrase II complexed with ureic benzene sulfonamide MB9-561B Descriptor: 4-hydroxy-3-({[(pyridin-4-yl)methyl]carbamoyl}amino)benzene-1-sulfonamide, Carbonic anhydrase 2, DIMETHYL SULFOXIDE, ... Authors: Kota, A, McKenna, R. Deposit date: 2019-05-03 Release date: 2020-05-06 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.496 Å) Cite: Carbonic Anhydrase II complexed with ureido benzene sulfonamide MB9-561B To Be Published
2OSF	Inhibition of Carbonic Anhydrase II by Thioxolone: A Mechanistic and Structural Study Descriptor: 4-MERCAPTOBENZENE-1,3-DIOL, Carbonic anhydrase 2, S-(2,4-dihydroxyphenyl) hydrogen thiocarbonate, ... Authors: Albert, A.B, Caroli, G, Govindasamy, L, Agbandje-McKenna, M, McKenna, R, Tripp, B.C. Deposit date: 2007-02-05 Release date: 2008-05-27 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Inhibition of carbonic anhydrase II by thioxolone: a mechanistic and structural study. Biochemistry, 47, 2008
6PDV	Cu-Carbonic Anhydrase II, A Nitrite Reductase Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, COPPER (II) ION, Carbonic anhydrase 2, ... Authors: Andring, J.T, McKenna, R. Deposit date: 2019-06-19 Release date: 2020-03-11 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.23 Å) Cite: Structure and mechanism of copper-carbonic anhydrase II: a nitrite reductase. Iucrj, 7, 2020
2NWZ	Structural and kinetic effects of hydrophobic mutations on the active site of human carbonic anhydrase II Descriptor: SULFATE ION, ZINC ION, carbonic anhydrase 2 Authors: Fisher, S.Z, McKenna, R. Deposit date: 2006-11-16 Release date: 2007-04-24 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Speeding Up Proton Transfer in a Fast Enzyme: Kinetic and Crystallographic Studies on the Effect of Hydrophobic Amino Acid Substitutions in the Active Site of Human Carbonic Anhydrase II. Biochemistry, 46, 2007
2NXR	Structural effects of hydrophobic mutations on the active site of human carbonic anhydrase II Descriptor: SULFATE ION, ZINC ION, carbonic anhydrase 2 Authors: Fisher, S.Z, McKenna, R. Deposit date: 2006-11-19 Release date: 2007-04-24 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Speeding Up Proton Transfer in a Fast Enzyme: Kinetic and Crystallographic Studies on the Effect of Hydrophobic Amino Acid Substitutions in the Active Site of Human Carbonic Anhydrase II. Biochemistry, 46, 2007
6OE0	Benzensulfonamides bearing spyrohydantoin moieties act as potent inhibitors of human carbonic anhydrases II and VII and show neuropathic pain attenuating effects Descriptor: 2-(2,4-dioxo-1,3-diazaspiro[4.6]undecan-3-yl)-N-(4-sulfamoylphenyl)acetamide, Carbonic anhydrase 2, GLYCEROL, ... Authors: Peat, T.S. Deposit date: 2019-03-27 Release date: 2019-06-12 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.3 Å) Cite: Benzensulfonamides bearing spyrohydantoin moieties act as potent inhibitors of human carbonic anhydrases II and VII and show neuropathic pain attenuating effects. Eur.J.Med.Chem., 177, 2019
6PGX	Synthesis of novel tellurides bearing benzensulfonamide moiety as carbonic anhydrase inhibitors with antitumor activity Descriptor: 4-[(2S)-2-hydroxy-3-{[(2R)-2-hydroxy-3-(4-sulfamoylphenoxy)propyl]tellanyl}propoxy]benzene-1-sulfonamide, Carbonic anhydrase 2, GLYCEROL, ... Authors: Peat, T.S. Deposit date: 2019-06-25 Release date: 2019-08-21 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.36 Å) Cite: Synthesis of novel tellurides bearing benzensulfonamide moiety as carbonic anhydrase inhibitors with antitumor activity. Eur.J.Med.Chem., 181, 2019
2NWP	Structural and kinetic effects of hydrophobic mutations in the active site of human carbonic anhydrase II Descriptor: SULFATE ION, ZINC ION, carbonic anhydrase 2 Authors: Fisher, S.Z, McKenna, R. Deposit date: 2006-11-16 Release date: 2007-04-24 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Speeding Up Proton Transfer in a Fast Enzyme: Kinetic and Crystallographic Studies on the Effect of Hydrophobic Amino Acid Substitutions in the Active Site of Human Carbonic Anhydrase II. Biochemistry, 46, 2007
2NXT	Structural and kinetic effects of hydrophobic mutations in the active site of human carbonic anhydrase II Descriptor: ZINC ION, carbonic anhydrase 2 Authors: Fisher, S.Z, McKenna, R. Deposit date: 2006-11-19 Release date: 2007-04-24 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.15 Å) Cite: Speeding Up Proton Transfer in a Fast Enzyme: Kinetic and Crystallographic Studies on the Effect of Hydrophobic Amino Acid Substitutions in the Active Site of Human Carbonic Anhydrase II. Biochemistry, 46, 2007
2NWO	Structural and kinetic effect of hydrophobic mutations in the active site of human carbonic anhydrase II Descriptor: Carbonic anhydrase 2, ZINC ION Authors: Fisher, S.Z, McKenna, R. Deposit date: 2006-11-16 Release date: 2007-04-24 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Speeding Up Proton Transfer in a Fast Enzyme: Kinetic and Crystallographic Studies on the Effect of Hydrophobic Amino Acid Substitutions in the Active Site of Human Carbonic Anhydrase II. Biochemistry, 46, 2007
2O4Z	Crystal structure of the Carbonic Anhydrase II complexed with hydroxysulfamide inhibitor Descriptor: Carbonic anhydrase 2, MERCURY (II) ION, N-hydroxysulfamide, ... Authors: Temperini, C, Winum, J.Y, Montero, J.L, Scozzafava, a, Supuran, c.t. Deposit date: 2006-12-05 Release date: 2007-05-15 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Carbonic anhydrase inhibitors: The X-ray crystal structure of the adduct of N-hydroxysulfamide with isozyme II explains why this new zinc binding function is effective in the design of potent inhibitors. Bioorg.Med.Chem.Lett., 17, 2007
6OTI	Carbonic Anhydrase IX mimic complexed with ureic benzene sulfonamide MB9-561B Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 4-hydroxy-3-({[(pyridin-4-yl)methyl]carbamoyl}amino)benzene-1-sulfonamide, Carbonic anhydrase 2, ... Authors: Kota, A, McKenna, R. Deposit date: 2019-05-03 Release date: 2020-05-06 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2 Å) Cite: Carbonic Anhydrase IX mimic complexed with ureido benzene sulfonamide MB9-561B To Be Published
6OTM	Carbonic Anhydrase IX mimic complexed with ureic benzene sulfonamide MB10-586B Descriptor: 4-hydroxy-3-({[2-(pyridin-2-yl)ethyl]carbamoyl}amino)benzene-1-sulfonamide, Carbonic anhydrase 2, GLYCEROL, ... Authors: Kota, A, McKenna, R. Deposit date: 2019-05-03 Release date: 2020-05-06 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.307 Å) Cite: Carbonic Anhydrase IX mimic complexed with ureido benzene sulfonamide MB9-561B To Be Published
6OTP	Carbonic Anhydrase II complexed with ureic benzene sulfonamide MB10-586B Descriptor: 4-hydroxy-3-({[2-(pyridin-2-yl)ethyl]carbamoyl}amino)benzene-1-sulfonamide, Carbonic anhydrase 2, ZINC ION Authors: Kota, A, McKenna, R. Deposit date: 2019-05-03 Release date: 2020-05-06 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.466 Å) Cite: Carbonic Anhydrase IX mimic complexed with ureido benzene sulfonamide MB9-561B To Be Published
6OUI	Carbonic Anhydrase IX mimic complexed with benzene sulfonamide MB11-710A Descriptor: 3-{[(4-hydroxybutyl)carbamoyl]amino}benzene-1-sulfonamide, Carbonic anhydrase 2, DIMETHYL SULFOXIDE, ... Authors: Kota, A, McKenna, R. Deposit date: 2019-05-04 Release date: 2020-05-06 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.528 Å) Cite: Carbonic Anhydrase IX mimic complexed with ureido benzene sulfonamide MB11-710A To Be Published
6OUM	Carbonic Anhydrase IX mimic complexed with benzene sulfonamide MB10-580B Descriptor: (2Z)-2-(hydroxyimino)-2,3-dihydro-1,3-benzoxazole-5-sulfonamide, Carbonic anhydrase 2, GLYCEROL, ... Authors: Kota, A, McKenna, R. Deposit date: 2019-05-04 Release date: 2020-05-06 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.559 Å) Cite: Carbonic Anhydrase IX mimic complexed with ureido benzene sulfonamide MB10-580B To Be Published
2NXS	Structural and kinetic effects of hydrophobic mutations in the active site of human carbonic anhydrase II Descriptor: SULFATE ION, ZINC ION, carbonic anhydrase 2 Authors: Fisher, S.Z, McKenna, R. Deposit date: 2006-11-19 Release date: 2007-04-24 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Speeding Up Proton Transfer in a Fast Enzyme: Kinetic and Crystallographic Studies on the Effect of Hydrophobic Amino Acid Substitutions in the Active Site of Human Carbonic Anhydrase II. Biochemistry, 46, 2007
2Q1B	Carbonic Anhydrase II in Complex with Saccharin Descriptor: 1,2-BENZISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDE, BENZOIC ACID, Carbonic anhydrase 2, ... Authors: Klebe, G, Heine, A, Koehler, K. Deposit date: 2007-05-24 Release date: 2007-09-04 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Saccharin Inhibits Carbonic Anhydrases: Possible Explanation for its Unpleasant Metallic Aftertaste. Angew.Chem.Int.Ed.Engl., 46, 2007
6OE1	Benzensulfonamides bearing spyrohydantoin moieties act as potent inhibitors of human carbonic anhydrases II and VII and show neuropathic pain attenuating effects Descriptor: 2-(2,4-dioxo-1,3-diazaspiro[4.5]decan-3-yl)-N-(4-sulfamoylphenyl)acetamide, Carbonic anhydrase 2, GLYCEROL, ... Authors: Peat, T.S. Deposit date: 2019-03-27 Release date: 2019-06-12 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.45 Å) Cite: Benzensulfonamides bearing spyrohydantoin moieties act as potent inhibitors of human carbonic anhydrases II and VII and show neuropathic pain attenuating effects. Eur.J.Med.Chem., 177, 2019
2OSM	Inhibition of Carbonic Anhydrase II by Thioxolone: A Mechanistic and Structural Study Descriptor: 2-MERCAPTOPHENOL, Carbonic anhydrase 2, ZINC ION Authors: Albert, A.B, Caroli, G, Govindasamy, L, Agbandje-Mckenna, M, McKenna, R, Tripp, B.C. Deposit date: 2007-02-06 Release date: 2008-02-12 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Inhibition of Carbonic Anhydrase II by Thioxolone: A Mechanistic and Structural Study. Biochemistry, 47, 2008
6PEA	High Resolution Apo Carbonic Anhydrase II Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Carbonic anhydrase 2 Authors: Andring, J.T, McKenna, R. Deposit date: 2019-06-20 Release date: 2020-03-11 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.36 Å) Cite: Structure and mechanism of copper-carbonic anhydrase II: a nitrite reductase. Iucrj, 7, 2020
2POW	The crystal structure of the human carbonic anhydrase II in complex with 4-amino-6-trifluoromethyl-benzene-1,3-disulfonamide Descriptor: 4-AMINO-6-(TRIFLUOROMETHYL)BENZENE-1,3-DISULFONAMIDE, Carbonic anhydrase 2, ZINC ION Authors: Alterio, V, De Simone, G. Deposit date: 2007-04-27 Release date: 2007-07-24 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Carbonic anhydrase inhibitors: Inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides-Solution and crystallographic studies. Bioorg.Med.Chem.Lett., 17, 2007
2Q38	Carbonic Anhydrase II in complex with Saccharin at 1.95 Angstrom Descriptor: 1,2-BENZISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDE, BENZOIC ACID, Carbonic anhydrase 2, ... Authors: Schulze Wischeler, J, Heine, A, Klebe, G. Deposit date: 2007-05-30 Release date: 2007-10-02 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Saccharin Inhibits Carbonic Anhydrases: Possible Explanation for its Unpleasant Metallic Aftertaste. Angew.Chem.Int.Ed.Engl., 46, 2007
2NWY	Structural and kinetic effects of hydrophobic mutations on the active site of human carbonic anhydrase II Descriptor: ZINC ION, carbonic anhydrase 2 Authors: Fisher, S.Z, McKenna, R. Deposit date: 2006-11-16 Release date: 2007-04-24 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Speeding Up Proton Transfer in a Fast Enzyme: Kinetic and Crystallographic Studies on the Effect of Hydrophobic Amino Acid Substitutions in the Active Site of Human Carbonic Anhydrase II. Biochemistry, 46, 2007
2POV	The crystal structure of the human carbonic anhydrase II in complex with 4-amino-6-chloro-benzene-1,3-disulfonamide Descriptor: 4-AMINO-6-CHLOROBENZENE-1,3-DISULFONAMIDE, Carbonic anhydrase 2, ZINC ION Authors: Alterio, V, De Simone, G. Deposit date: 2007-04-27 Release date: 2007-07-24 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Carbonic anhydrase inhibitors: Inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides-Solution and crystallographic studies. Bioorg.Med.Chem.Lett., 17, 2007

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