6PGX

Synthesis of novel tellurides bearing benzensulfonamide moiety as carbonic anhydrase inhibitors with antitumor activity

Summary for 6PGX

Entry DOI	10.2210/pdb6pgx/pdb
Descriptor	Carbonic anhydrase 2, ZINC ION, 4-[(2S)-2-hydroxy-3-{[(2R)-2-hydroxy-3-(4-sulfamoylphenoxy)propyl]tellanyl}propoxy]benzene-1-sulfonamide, ... (5 entities in total)
Functional Keywords	carbonic anhydrase inhibitors (cais), tellurium, metalloenzymes, lyase-lyase inhibitor complex, lyase/lyase inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	31303.02
Authors	Peat, T.S. (deposition date: 2019-06-25, release date: 2019-08-21, Last modification date: 2023-10-11)
Primary citation	Tanini, D.,Ricci, L.,Capperucci, A.,Di Cesare Mannelli, L.,Ghelardini, C.,Peat, T.S.,Carta, F.,Angeli, A.,Supuran, C.T. Synthesis of novel tellurides bearing benzensulfonamide moiety as carbonic anhydrase inhibitors with antitumor activity. Eur.J.Med.Chem., 181:111586-111586, 2019 Cited by PubMed: 31401537 DOI: 10.1016/j.ejmech.2019.111586 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.36 Å)

Structure validation