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2WGE	Crystal structure of KasA of Mycobacterium tuberculosis with bound TLM Descriptor: 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE 1, GLYCEROL, ISOPROPYL ALCOHOL, ... Authors: Luckner, S.R, Kisker, C. Deposit date: 2009-04-17 Release date: 2009-07-21 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Crystal Structures of Mycobacterium Tuberculosis Kasa Show Mode of Action within Cell Wall Biosynthesis and its Inhibition by Thiolactomycin Structure, 17, 2009
2WGF	Crystal structure of Mycobacterium tuberculosis C171Q KasA variant Descriptor: 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE 1, DI(HYDROXYETHYL)ETHER, SODIUM ION, ... Authors: Luckner, S.R, Kisker, C. Deposit date: 2009-04-17 Release date: 2009-07-21 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Crystal Structures of Mycobacterium Tuberculosis Kasa Show Mode of Action within Cell Wall Biosynthesis and its Inhibition by Thiolactomycin Structure, 17, 2009
2WGD	Crystal structure of KasA of Mycobacterium tuberculosis Descriptor: 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE 1, GLYCEROL, ISOPROPYL ALCOHOL, ... Authors: Luckner, S.R, Kisker, C. Deposit date: 2009-04-17 Release date: 2009-07-21 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.01 Å) Cite: Crystal Structures of Mycobacterium Tuberculosis Kasa Show Mode of Action within Cell Wall Biosynthesis and its Inhibition by Thiolactomycin Structure, 17, 2009
2WGG	Crystal Structure of Mycobacterium tuberculosis C171Q KasA variant with bound TLM Descriptor: 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE 1, DI(HYDROXYETHYL)ETHER, NONAETHYLENE GLYCOL, ... Authors: Luckner, S.R, Kisker, C. Deposit date: 2009-04-17 Release date: 2009-07-21 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2 Å) Cite: Crystal Structures of Mycobacterium Tuberculosis Kasa Show Mode of Action within Cell Wall Biosynthesis and its Inhibition by Thiolactomycin Structure, 17, 2009
2FNQ	Insights from the X-ray crystal structure of coral 8R-lipoxygenase: calcium activation via A C2-like domain and a structural basis of product chirality Descriptor: Allene oxide synthase-lipoxygenase protein, CALCIUM ION, FE (II) ION Authors: Oldham, M.L, Brash, A.R, Newcomer, M.E. Deposit date: 2006-01-11 Release date: 2006-02-28 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (3.2 Å) Cite: Insights from the X-ray crystal structure of coral 8R-lipoxygenase: calcium activation via a C2-like domain and a structural basis of product chirality. J.Biol.Chem., 280, 2005
3IL9	Structure of E. coli FabH Descriptor: 3-oxoacyl-[acyl-carrier-protein] synthase 3 Authors: Gajiwala, K.S, Margosiak, S, Lu, J, Cortez, J, Su, Y, Nie, Z, Appelt, K. Deposit date: 2009-08-06 Release date: 2009-08-25 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Crystal structures of bacterial FabH suggest a molecular basis for the substrate specificity of the enzyme. Febs Lett., 583, 2009
7OC1	Structure of Pseudomonas aeruginosa FabF mutant C164Q in complex with Platensimycin Descriptor: 3-oxoacyl-[acyl-carrier-protein] synthase 2, DIMETHYL SULFOXIDE, GLYCEROL, ... Authors: Georgiou, C, Brenk, R, Espeland, L.O, Klein, R. Deposit date: 2021-04-25 Release date: 2021-08-25 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.8 Å) Cite: An Experimental Toolbox for Structure-Based Hit Discovery for P. aeruginosa FabF, a Promising Target for Antibiotics. Chemmedchem, 16, 2021
3IL7	Crystal structure of S. aureus FabH Descriptor: 3-oxoacyl-[acyl-carrier-protein] synthase 3 Authors: Gajiwala, K.S, Margosiak, S, Lu, J, Cortez, J, Su, Y, Nie, Z, Appelt, K. Deposit date: 2009-08-06 Release date: 2009-08-25 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Crystal structures of bacterial FabH suggest a molecular basis for the substrate specificity of the enzyme. Febs Lett., 583, 2009
3IL3	Structure of Haemophilus influenzae FabH Descriptor: 3-oxoacyl-[acyl-carrier-protein] synthase 3 Authors: Gajiwala, K.S, Margosiak, S, Lu, J, Cortez, J, Su, Y, Nie, Z, Appelt, K. Deposit date: 2009-08-06 Release date: 2009-08-25 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Crystal structures of bacterial FabH suggest a molecular basis for the substrate specificity of the enzyme. Febs Lett., 583, 2009
3IL4	Structure of E. faecalis FabH in complex with acetyl CoA Descriptor: 3-oxoacyl-[acyl-carrier-protein] synthase 3, ACETYL COENZYME *A Authors: Gajiwala, K.S, Margosiak, S, Lu, J, Cortez, J, Su, Y, Nie, Z, Appelt, K. Deposit date: 2009-08-06 Release date: 2009-08-25 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (3 Å) Cite: Crystal structures of bacterial FabH suggest a molecular basis for the substrate specificity of the enzyme. Febs Lett., 583, 2009
4LS5	Crystal structure of beta-ketoacyl-ACP synthase II (FabF) from Bacillus subtilis Descriptor: 3-oxoacyl-[acyl-carrier-protein] synthase 2, GLYCEROL, POTASSIUM ION Authors: Trajtenberg, F, Larrieux, N, Buschiazzo, A. Deposit date: 2013-07-22 Release date: 2014-04-02 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.803 Å) Cite: Structural insights into bacterial resistance to cerulenin. Febs J., 281, 2014
4LS8	Crystal structure of Bacillus subtilis beta-ketoacyl-ACP synthase II (FabF) in a covalent complex with cerulenin Descriptor: (3R,7E,10E)-3-hydroxy-4-oxododeca-7,10-dienamide, 1,2-ETHANEDIOL, 3-oxoacyl-[acyl-carrier-protein] synthase 2, ... Authors: Trajtenberg, F, Larrieux, N, Buschiazzo, A. Deposit date: 2013-07-22 Release date: 2014-04-02 Last modified: 2014-06-04 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Structural insights into bacterial resistance to cerulenin. Febs J., 281, 2014
4LS6	Crystal structure of beta-ketoacyl-ACP synthase II (FabF) I108F mutant from Bacillus subtilis Descriptor: 3-oxoacyl-[acyl-carrier-protein] synthase 2, CHLORIDE ION, GLYCEROL, ... Authors: Trajtenberg, F, Larrieux, N, Buschiazzo, A. Deposit date: 2013-07-22 Release date: 2014-04-02 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.56 Å) Cite: Structural insights into bacterial resistance to cerulenin. Febs J., 281, 2014
5W2P	Crystal structure of Mycobacterium tuberculosis KasA in complex with 6U5 Descriptor: 3,3',3''-phosphanetriyltripropanoic acid, 3-oxoacyl-[acyl-carrier-protein] synthase 1, GLYCEROL, ... Authors: Capodagli, G.C, Neiditch, M.B. Deposit date: 2017-06-06 Release date: 2018-12-05 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2 Å) Cite: Synergistic Lethality of a Binary Inhibitor of Mycobacterium tuberculosis KasA. MBio, 9, 2018
5W2Q	Crystal structure of Mycobacterium tuberculosis KasA in complex with 6U5 Descriptor: 3,3',3''-phosphanetriyltripropanoic acid, 3-oxoacyl-[acyl-carrier-protein] synthase 1, GLYCEROL, ... Authors: Capodagli, G.C, Neiditch, M.B. Deposit date: 2017-06-06 Release date: 2018-12-05 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Synergistic Lethality of a Binary Inhibitor of Mycobacterium tuberculosis KasA. MBio, 9, 2018
4LS7	Crystal structure of Bacillus subtilis beta-ketoacyl-ACP synthase II (FabF) in a non-covalent complex with cerulenin Descriptor: 3-oxoacyl-[acyl-carrier-protein] synthase 2, Cerulenin, GLYCEROL, ... Authors: Trajtenberg, F, Larrieux, N, Buschiazzo, A. Deposit date: 2013-07-22 Release date: 2014-04-02 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.674 Å) Cite: Structural insights into bacterial resistance to cerulenin. Febs J., 281, 2014
7U0O	Crystal structure of an enoyl-[acyl-carrier-protein] reductase InhA from Mycobacterium fortuitum bound to NAD and NITD-916 Descriptor: 6-[(4,4-dimethylcyclohexyl)methyl]-4-hydroxy-3-phenylpyridin-2(1H)-one, CHLORIDE ION, Enoyl-[acyl-carrier-protein] reductase [NADH], ... Authors: Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2022-02-18 Release date: 2023-02-22 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.05 Å) Cite: In Vitro and In Vivo Efficacy of NITD-916 against Mycobacterium fortuitum. Antimicrob.Agents Chemother., 67, 2023
8GHC	The structure of h12-LOX in dimeric form Descriptor: FE (II) ION, Polyunsaturated fatty acid lipoxygenase ALOX12 Authors: Black, K.A, Mobbs, J.I, Venugopal, H, Thal, D.M, Glukhova, A. Deposit date: 2023-03-09 Release date: 2023-08-09 Last modified: 2023-10-11 Method: ELECTRON MICROSCOPY (2.3 Å) Cite: Cryo-EM structures of human arachidonate 12S-lipoxygenase bound to endogenous and exogenous inhibitors. Blood, 142, 2023
8GHE	The structure of h12-LOX in tetrameric form bound to endogenous inhibitor oleoyl-CoA Descriptor: FE (II) ION, Polyunsaturated fatty acid lipoxygenase ALOX12, S-{(3R,5R,9R)-1-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9-trihydroxy-8,8-dimethyl-3,5-dioxido-10,14-dioxo-2,4,6-trioxa-11,15-diaza-3lambda~5~,5lambda~5~-diphosphaheptadecan-17-yl} (9Z)-octadec-9-enethioate (non-preferred name) Authors: Black, K.A, Mobbs, J.I, Venugopal, H, Thal, D.M, Glukhova, A. Deposit date: 2023-03-09 Release date: 2023-08-09 Last modified: 2023-10-11 Method: ELECTRON MICROSCOPY (2.05 Å) Cite: Cryo-EM structures of human arachidonate 12S-lipoxygenase bound to endogenous and exogenous inhibitors. Blood, 142, 2023
8GHB	The structure of h12-LOX in monomeric form Descriptor: FE (II) ION, Polyunsaturated fatty acid lipoxygenase ALOX12 Authors: Black, K.A, Mobbs, J.I, Venugopal, H, Thal, D.M, Glukhova, A. Deposit date: 2023-03-09 Release date: 2023-08-09 Last modified: 2024-05-01 Method: ELECTRON MICROSCOPY (2.76 Å) Cite: Cryo-EM structures of human arachidonate 12S-lipoxygenase bound to endogenous and exogenous inhibitors. Blood, 142, 2023
2WDY	Crystal structure of the Streptomyces coelicolor D111A AcpS mutant in complex with cofactor CoA at 1.4 A Descriptor: COENZYME A, HOLO-[ACYL-CARRIER-PROTEIN] SYNTHASE, MAGNESIUM ION, ... Authors: Dall'Aglio, P, Arthur, C, Crump, M.P, Crosby, J, Hadfield, A.T. Deposit date: 2009-03-27 Release date: 2010-04-21 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Analysis of Streptomyces Coelicolor Phosphopantetheinyl Transferase, Acps, Reveals the Basis for Relaxed Substrate Specificity. Biochemistry, 50, 2011
2WDS	Crystal structure of the Streptomyces coelicolor H110A AcpS mutant in complex with cofactor CoA at 1.3 A Descriptor: COENZYME A, HOLO-[ACYL-CARRIER-PROTEIN] SYNTHASE, MAGNESIUM ION Authors: Dall'Aglio, P, Arthur, C, Crump, M.P, Crosby, J, Hadfield, A.T. Deposit date: 2009-03-26 Release date: 2010-04-21 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (1.35 Å) Cite: Analysis of Streptomyces Coelicolor Phosphopantetheinyl Transferase, Acps, Reveals the Basis for Relaxed Substrate Specificity. Biochemistry, 50, 2011
2WDO	Crystal structure of the S. coelicolor AcpS in complex with acetyl- CoA at 1.5 A Descriptor: ACETYL COENZYME *A, COENZYME A, GLYCEROL, ... Authors: Dall'Aglio, P, Arthur, C, Crump, M.P, Crosby, J, Hadfield, A.T. Deposit date: 2009-03-25 Release date: 2010-04-21 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (1.56 Å) Cite: Analysis of Streptomyces Coelicolor Phosphopantetheinyl Transferase, Acps, Reveals the Basis for Relaxed Substrate Specificity. Biochemistry, 50, 2011
8A82	Fe(II)/aKG-dependent halogenase OocPQ Descriptor: Cupin_8 domain-containing protein, FE (III) ION, GLYCEROL, ... Authors: Fraley, A.E, Meoded, R.A, Schmalhofer, M, Bergande, C, Groll, M, Piel, J. Deposit date: 2022-06-21 Release date: 2023-03-08 Last modified: 2024-06-19 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Heterocomplex structure of a polyketide synthase component involved in modular backbone halogenation. Structure, 31, 2023
3DY5	Allene oxide synthase 8R-lipoxygenase from Plexaura homomalla Descriptor: Allene oxide synthase-lipoxygenase protein, FE (II) ION, PROTOPORPHYRIN IX CONTAINING FE Authors: Gilbert, N.C, Niebuhr, M, Tsuruta, H, Newcomer, M.E. Deposit date: 2008-07-25 Release date: 2008-10-07 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (3.51 Å) Cite: A covalent linker allows for membrane targeting of an oxylipin biosynthetic complex. Biochemistry, 47, 2008

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