PDB: 93656 resultsInfo pagesStatus searchChemie searchBIRD

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6VT5	Naegleria gruberi RNA ligase R4a K121A mutant apo Descriptor: RNA Ligase Authors: Unciuleac, M.C, Goldgur, Y, Shuman, S. Deposit date: 2020-02-12 Release date: 2020-04-08 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Caveat mutator: alanine substitutions for conserved amino acids in RNA ligase elicit unexpected rearrangements of the active site for lysine adenylylation. Nucleic Acids Res., 48, 2020
6VTF	Naegleria gruberi RNA ligase with PPi Descriptor: PYROPHOSPHATE 2-, RNA ligase Authors: Unciuleac, M.C, Goldgur, Y, Shuman, S. Deposit date: 2020-02-12 Release date: 2020-04-08 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.71 Å) Cite: Caveat mutator: alanine substitutions for conserved amino acids in RNA ligase elicit unexpected rearrangements of the active site for lysine adenylylation. Nucleic Acids Res., 48, 2020
6VT9	Naegleria gruberi RNA ligase E227A mutant with ATP and Mn Descriptor: ADENOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, RNA ligase Authors: Unciuleac, M.C, Goldgur, Y, Shuman, S. Deposit date: 2020-02-12 Release date: 2020-04-08 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.49 Å) Cite: Caveat mutator: alanine substitutions for conserved amino acids in RNA ligase elicit unexpected rearrangements of the active site for lysine adenylylation. Nucleic Acids Res., 48, 2020
6VT6	Naegleria gruberi RNA ligase K170A mutant with ATP and Mn Descriptor: ADENOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, RNA Ligase Authors: Unciuleac, M.C, Goldgur, Y, Shuman, S. Deposit date: 2020-02-12 Release date: 2020-04-08 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.969 Å) Cite: Caveat mutator: alanine substitutions for conserved amino acids in RNA ligase elicit unexpected rearrangements of the active site for lysine adenylylation. Nucleic Acids Res., 48, 2020
6VTG	Naegleria gruberi RNA ligase E227A mutant apo Descriptor: RNA ligase Authors: Unciuleac, M.C, Goldgur, Y, Shuman, S. Deposit date: 2020-02-12 Release date: 2020-04-08 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.49 Å) Cite: Caveat mutator: alanine substitutions for conserved amino acids in RNA ligase elicit unexpected rearrangements of the active site for lysine adenylylation. Nucleic Acids Res., 48, 2020
6VT1	Naegleria gruberi RNA ligase D172A mutant apo Descriptor: ADENOSINE MONOPHOSPHATE, RNA Ligase Authors: Unciuleac, M.C, Goldgur, Y, Shuman, S. Deposit date: 2020-02-12 Release date: 2020-04-08 Last modified: 2024-10-23 Method: X-RAY DIFFRACTION (2.381 Å) Cite: Caveat mutator: alanine substitutions for conserved amino acids in RNA ligase elicit unexpected rearrangements of the active site for lysine adenylylation. Nucleic Acids Res., 48, 2020
6N67	Crystal structure of the ligase domain of fungal tRNA ligase Trl1 Descriptor: CHLORIDE ION, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, GLYCEROL, ... Authors: Peschek, J, Walter, P. Deposit date: 2018-11-26 Release date: 2019-07-03 Last modified: 2024-10-23 Method: X-RAY DIFFRACTION (1.9 Å) Cite: tRNA ligase structure reveals kinetic competition between non-conventional mRNA splicing and mRNA decay. Elife, 8, 2019
6VT0	Naegleria gruberi RNA ligase K170A mutant apo Descriptor: RNA Ligase Authors: Unciuleac, M.C, Goldgur, Y, Shuman, S. Deposit date: 2020-02-12 Release date: 2020-04-08 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.002 Å) Cite: Caveat mutator: alanine substitutions for conserved amino acids in RNA ligase elicit unexpected rearrangements of the active site for lysine adenylylation. Nucleic Acids Res., 48, 2020
6VTB	Naegleria gruberi RNA ligase K326A mutant with ATP and Mn Descriptor: ADENOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, RNA ligase Authors: Unciuleac, M.C, Goldgur, Y, Shuman, S. Deposit date: 2020-02-12 Release date: 2020-04-08 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.547 Å) Cite: Caveat mutator: alanine substitutions for conserved amino acids in RNA ligase elicit unexpected rearrangements of the active site for lysine adenylylation. Nucleic Acids Res., 48, 2020
3R5X	Crystal Structure of D-alanine--D-Alanine Ligase from Bacillus anthracis complexed with ATP Descriptor: 1,2-ETHANEDIOL, ACETIC ACID, ADENOSINE-5'-TRIPHOSPHATE, ... Authors: Kim, Y, Mulligan, R, Hasseman, J, Anderson, W.F, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) Deposit date: 2011-03-20 Release date: 2011-04-06 Last modified: 2015-07-01 Method: X-RAY DIFFRACTION (2 Å) Cite: Crystal Structure of D-alanine--D-Alanine Ligase from Bacillus anthracis complexed with ATP To be Published
6U19	Solution Structure of the RAZUL domain from 26S proteasome subunit hRpn10/S5a complexed with the AZUL domain from E3 ligase E6AP/UBE3A Descriptor: 26S proteasome non-ATPase regulatory subunit 4, Ubiquitin-protein ligase E3A, ZINC ION Authors: Chen, X, Walters, K.J. Deposit date: 2019-08-15 Release date: 2020-03-18 Last modified: 2024-05-22 Method: SOLUTION NMR Cite: Structure of E3 ligase E6AP with a proteasome-binding site provided by substrate receptor hRpn10. Nat Commun, 11, 2020
4CC5	Fragment-Based Discovery of 6 Azaindazoles As Inhibitors of Bacterial DNA Ligase Descriptor: 2-chloranyl-6-(1H-1,2,4-triazol-3-yl)pyrazine, DNA LIGASE, SULFATE ION Authors: Howard, S, Amin, N, Benowitz, A.B, Chiarparin, E, Cui, H, Deng, X, Heightman, T.D, Holmes, D.J, Hopkins, A, Huang, J, Jin, Q, Kreatsoulas, C, Martin, A.C.L, Massey, F, McCloskey, L, Mortenson, P.N, Pathuri, P, Tisi, D, Williams, P.A. Deposit date: 2013-10-18 Release date: 2014-06-18 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (1.88 Å) Cite: Fragment-Based Discovery of 6-Azaindazoles as Inhibitors of Bacterial DNA Ligase. Acs Med.Chem.Lett., 4, 2013
2V7B	Crystal structures of a benzoate CoA ligase from Burkholderia xenovorans LB400 Descriptor: BENZOATE-COENZYME A LIGASE, BENZOIC ACID Authors: J Boulanger, M, Bains, J. Deposit date: 2007-07-27 Release date: 2007-10-02 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (1.84 Å) Cite: Biochemical and Structural Characterization of the Paralogous Benzoate Coa Ligases from Burkholderia Xenovorans Lb400: Defining the Entry Point Into the Novel Benzoate Oxidation (Box) Pathway. J.Mol.Biol., 373, 2007
4DWR	RNA ligase RtcB/Mn2+ complex Descriptor: MANGANESE (II) ION, SULFATE ION, beta-D-fructofuranose-(2-1)-alpha-D-glucopyranose, ... Authors: Xia, S, Englert, M, Soll, D, Wang, J. Deposit date: 2012-02-26 Release date: 2012-09-05 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.48 Å) Cite: Structural and mechanistic insights into guanylylation of RNA-splicing ligase RtcB joining RNA between 3'-terminal phosphate and 5'-OH. Proc.Natl.Acad.Sci.USA, 109, 2012
6VT8	Naegleria gruberi RNA ligase E312A mutant with AMP and Mn Descriptor: ADENOSINE MONOPHOSPHATE, MANGANESE (II) ION, RNA Ligase Authors: Unciuleac, M.C, Goldgur, Y, Shuman, S. Deposit date: 2020-02-12 Release date: 2020-04-08 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (1.998 Å) Cite: Caveat mutator: alanine substitutions for conserved amino acids in RNA ligase elicit unexpected rearrangements of the active site for lysine adenylylation. Nucleic Acids Res., 48, 2020
3FAH	Glycerol inhibited form of Aldehyde oxidoreductase from Desulfovibrio gigas Descriptor: (MOLYBDOPTERIN-CYTOSINE DINUCLEOTIDE-S,S)-DIOXO-AQUA-MOLYBDENUM(V), Aldehyde oxidoreductase, CHLORIDE ION, ... Authors: Santos-Silva, T, Romao, M.J. Deposit date: 2008-11-17 Release date: 2009-10-06 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (1.72 Å) Cite: Kinetic, structural, and EPR studies reveal that aldehyde oxidoreductase from Desulfovibrio gigas does not need a sulfido ligand for catalysis and give evidence for a direct Mo-C interaction in a biological system. J.Am.Chem.Soc., 131, 2009
3FC4	Ethylene glycol inhibited form of Aldehyde oxidoreductase from Desulfovibrio gigas Descriptor: (MOLYBDOPTERIN-CYTOSINE DINUCLEOTIDE-S,S)-DIOXO-AQUA-MOLYBDENUM(V), 1,2-ETHANEDIOL, Aldehyde oxidoreductase, ... Authors: Santos-Silva, T, Romao, M.J. Deposit date: 2008-11-21 Release date: 2009-10-06 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (1.79 Å) Cite: Kinetic, structural, and EPR studies reveal that aldehyde oxidoreductase from Desulfovibrio gigas does not need a sulfido ligand for catalysis and give evidence for a direct Mo-C interaction in a biological system. J.Am.Chem.Soc., 131, 2009
5YWR	Crystal Structure of RING E3 ligase ZNRF1 in complex with Ube2N (Ubc13) Descriptor: E3 ubiquitin-protein ligase ZNRF1, FORMIC ACID, TRIETHYLENE GLYCOL, ... Authors: Behera, A.P, Naskar, P, Datta, A.B. Deposit date: 2017-11-30 Release date: 2018-06-06 Last modified: 2024-03-27 Method: X-RAY DIFFRACTION (1.47 Å) Cite: Structural insights into the nanomolar affinity of RING E3 ligase ZNRF1 for Ube2N and its functional implications. Biochem. J., 475, 2018
3UQ8	Structure of adenylation domain of Haemophilus influenzae DNA ligases bound to NAD+ in adenylated state. Descriptor: ADENOSINE MONOPHOSPHATE, DNA ligase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE Authors: Lahiri, S.D. Deposit date: 2011-11-19 Release date: 2012-01-25 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Structure Guided Understanding of NAD(+) Recognition in Bacterial DNA Ligases. Acs Chem.Biol., 7, 2012
3A9V	Crystal structures and enzymatic mechanisms of a Populus tomentosa 4-coumarate--CoA ligase Descriptor: 4-coumarate--CoA ligase, ADENOSINE MONOPHOSPHATE Authors: Hu, Y. Deposit date: 2009-11-06 Release date: 2010-09-08 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Crystal structures of a Populus tomentosa 4-coumarate:CoA ligase shed light on its enzymatic mechanisms Plant Cell, 22, 2010
3A7R	Crystal structure of E. coli lipoate-protein ligase A in complex with lipoyl-AMP. Descriptor: 5'-O-[(R)-({5-[(3R)-1,2-DITHIOLAN-3-YL]PENTANOYL}OXY)(HYDROXY)PHOSPHORYL]ADENOSINE, Lipoate-protein ligase A, MAGNESIUM ION, ... Authors: Fujiwara, K, Hosaka, H. Deposit date: 2009-10-01 Release date: 2010-01-19 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Global conformational change associated with the two-step reaction catalyzed by Escherichia coli lipoate-protein ligase A. J.Biol.Chem., 285, 2010
2PVP	Crystal structure of D-Alanine-D-Alanine Ligase from Helicobacter pylori Descriptor: D-alanine-D-alanine ligase Authors: Wu, D, Zhang, L, Jiang, H, Shen, X. Deposit date: 2007-05-10 Release date: 2008-04-01 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Enzymatic characterization and crystal structure analysis of the D-alanine-D-alanine ligase from Helicobacter pylori. Proteins, 72, 2008
5N4W	Crystal structure of the Cul2-Rbx1-EloBC-VHL ubiquitin ligase complex Descriptor: Cullin-2, E3 ubiquitin-protein ligase RBX1, Elongin-B, ... Authors: Cardote, T.A.F, Gadd, M.S, Ciulli, A. Deposit date: 2017-02-11 Release date: 2017-06-07 Last modified: 2024-05-01 Method: X-RAY DIFFRACTION (3.9 Å) Cite: Crystal Structure of the Cul2-Rbx1-EloBC-VHL Ubiquitin Ligase Complex. Structure, 25, 2017
6JOM	Crystal structure of lipoate protein ligase from Mycoplasma hyopneumoniae Descriptor: 5'-O-[(R)-({5-[(3R)-1,2-DITHIOLAN-3-YL]PENTANOYL}OXY)(HYDROXY)PHOSPHORYL]ADENOSINE, Lipoate--protein ligase Authors: Zhang, H, Chen, H, Ma, G. Deposit date: 2019-03-22 Release date: 2020-03-25 Last modified: 2024-03-27 Method: X-RAY DIFFRACTION (2.45 Å) Cite: Functional Identification and Structural Analysis of a New Lipoate Protein Ligase inMycoplasma hyopneumoniae. Front Cell Infect Microbiol, 10, 2020
2RNN	Solution Structure of the N-terminal SAP Domain of SUMO E3 Ligases from Saccharomyces cerevisiae Descriptor: E3 SUMO-protein ligase SIZ1 Authors: Suzuki, R, Shindo, H, Tase, A, Yamazaki, T. Deposit date: 2008-01-30 Release date: 2008-12-30 Last modified: 2024-05-01 Method: SOLUTION NMR Cite: Solution structures and DNA binding properties of the N-terminal SAP domains of SUMO E3 ligases from Saccharomyces cerevisiae and Oryza sativa. Proteins, 75, 2009

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