6VTE

Naegleria gruberi RNA Ligase K170M mutant with AMP and Mn

Summary for 6VTE

Entry DOI	10.2210/pdb6vte/pdb
Descriptor	RNA ligase, ADENOSINE MONOPHOSPHATE, MANGANESE (II) ION, ... (4 entities in total)
Functional Keywords	rna repair, adenylyltransferase, ligase
Biological source	Naegleria gruberi (Amoeba)
Total number of polymer chains	1
Total formula weight	39066.01
Authors	Unciuleac, M.C.,Goldgur, Y.,Shuman, S. (deposition date: 2020-02-12, release date: 2020-04-08, Last modification date: 2023-10-11)
Primary citation	Unciuleac, M.C.,Goldgur, Y.,Shuman, S. Caveat mutator: alanine substitutions for conserved amino acids in RNA ligase elicit unexpected rearrangements of the active site for lysine adenylylation. Nucleic Acids Res., 48:5603-5615, 2020 Cited by PubMed: 32315072 DOI: 10.1093/nar/gkaa238 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation