PDB: 615 resultsInfo pagesStatus searchChemie searchBIRD

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4N84	Crystal structure of 14-3-3zeta in complex with a 12-carbon-linker cyclic peptide derived from ExoS Descriptor: 14-3-3 protein zeta/delta, Exoenzyme S Authors: Bier, D, Glas, A, Hahne, G, Grossmann, T, Ottmann, C. Deposit date: 2013-10-17 Release date: 2014-02-19 Last modified: 2014-03-12 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Constrained peptides with target-adapted cross-links as inhibitors of a pathogenic protein-protein interaction. Angew.Chem.Int.Ed.Engl., 53, 2014
4N7Y	Crystal structure of 14-3-3zeta in complex with a 8-carbon-linker cyclic peptide derived from ExoS Descriptor: 14-3-3 protein zeta/delta, Exoenzyme S Authors: Bier, D, Glas, A, Hahne, G, Grossmann, T, Ottmann, C. Deposit date: 2013-10-16 Release date: 2014-02-19 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.16 Å) Cite: Constrained peptides with target-adapted cross-links as inhibitors of a pathogenic protein-protein interaction. Angew.Chem.Int.Ed.Engl., 53, 2014
4N7G	Crystal structure of 14-3-3zeta in complex with a peptide derived from ExoS Descriptor: 14-3-3 protein zeta/delta, Exoenzyme S, HEXAETHYLENE GLYCOL Authors: Bier, D, Glas, A, Hahne, G, Grossmann, T, Ottmann, C. Deposit date: 2013-10-15 Release date: 2014-02-19 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.25 Å) Cite: Constrained peptides with target-adapted cross-links as inhibitors of a pathogenic protein-protein interaction. Angew.Chem.Int.Ed.Engl., 53, 2014
4BG6	14-3-3 interaction with Rnd3 prenyl-phosphorylation motif Descriptor: 14-3-3 PROTEIN ZETA/DELTA, 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, FARNESYL, ... Authors: Riou, P, Kjaer, S, Purkiss, A, O'Reilly, N, McDonald, N.Q. Deposit date: 2013-03-23 Release date: 2013-05-29 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.3 Å) Cite: 14-3-3 Proteins Interact with a Hybrid Prenyl-Phosphorylation Motif to Inhibit G Proteins. Cell(Cambridge,Mass.), 153, 2013
4JDD	14-3-3 protein interaction with Estrogen Receptor Alpha provides a novel drug target interface Descriptor: 14-3-3 protein sigma, Estrogen receptor Peptide, FUSICOCCIN Authors: Bier, D, Ottmann, C. Deposit date: 2013-02-25 Release date: 2013-05-15 Last modified: 2017-06-07 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Interaction of 14-3-3 proteins with the estrogen receptor alpha F domain provides a drug target interface. Proc. Natl. Acad. Sci. U.S.A., 110, 2013
4JC3	14-3-3 protein interaction with Estrogen Receptor Alpha provides a novel drug target interface Descriptor: 14-3-3 protein sigma, Estrogen receptor Peptide, MAGNESIUM ION Authors: Bier, D, Ottmann, C. Deposit date: 2013-02-21 Release date: 2013-05-15 Last modified: 2017-06-07 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Interaction of 14-3-3 proteins with the estrogen receptor alpha F domain provides a drug target interface. Proc. Natl. Acad. Sci. U.S.A., 110, 2013
4J6S	14-3-3gamma complexed with the N-terminal sequence of tyrosine hydroxylase (residues 1-43) Descriptor: 14-3-3 protein gamma, N-terminal motif of tyrosine hydroxylase Authors: Mileni, M, Martinez, A, Stevens, R.C. Deposit date: 2013-02-11 Release date: 2013-10-02 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (3.08 Å) Cite: The N-terminal sequence of tyrosine hydroxylase is a conformationally versatile motif that binds 14-3-3 proteins and membranes. J.Mol.Biol., 426, 2014
4IHL	Human 14-3-3 isoform zeta in complex with a diphoyphorylated C-RAF peptide and Cotylenin A Descriptor: (1R,3aS,4R,5R,6R,9aR,10E)-6-({(1S,2R,4S,5R,6R,8S,9S)-5-hydroxy-2-(methoxymethyl)-9-methyl-9-[(2S)-oxiran-2-yl]-3,7,10,1 1-tetraoxatricyclo[6.2.1.0~1,6~]undec-4-yl}oxy)-1-(methoxymethyl)-4,9a-dimethyl-7-(propan-2-yl)-1,2,3,3a,4,5,6,8,9,9a-de cahydrodicyclopenta[a,d][8]annulene-1,5-diol, 14-3-3 protein zeta/delta, POTASSIUM ION, ... Authors: Molzan, M, Ottmann, C. Deposit date: 2012-12-19 Release date: 2013-09-25 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Stabilization of Physical RAF/14-3-3 Interaction by Cotylenin A as Treatment Strategy for RAS Mutant Cancers. Acs Chem.Biol., 8, 2013
4IEA	14-3-3 isoform sigma in complex with a phosphorylated C-RAF peptide Descriptor: 14-3-3 protein sigma, RAF proto-oncogene serine/threonine-protein kinase Authors: Molzan, M, Ottmann, C. Deposit date: 2012-12-13 Release date: 2013-09-25 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Stabilization of Physical RAF/14-3-3 Interaction by Cotylenin A as Treatment Strategy for RAS Mutant Cancers. Acs Chem.Biol., 8, 2013
4HKC	14-3-3-zeta in complex with S1011 phosphorylated integrin alpha-4 peptide Descriptor: 14-3-3 protein zeta/delta, GLYCEROL, alpha-4 integrin derived phosphorylated peptide Authors: Bonet, R, Campbell, I.D. Deposit date: 2012-10-15 Release date: 2013-06-26 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Characterization of 14-3-3-zeta Interactions with integrin tails J.Mol.Biol., 425, 2013
4GNT	Complex of ChREBP and 14-3-3beta Descriptor: 14-3-3 protein beta/alpha, Carbohydrate-responsive element-binding protein, SULFATE ION Authors: Zhang, H, Huang, N. Deposit date: 2012-08-17 Release date: 2012-10-24 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.41 Å) Cite: Crystal Structure of Carbohydrate Response Element Binding Protein (ChREBP) in complex with 14-3-3b To be Published
4FR3	Crystal structure of human 14-3-3 sigma in complex with TASK-3 peptide and stabilizer 16-O-Me-FC-H Descriptor: (4R,5R,6R,6aS,9S,9aE,10aR)-5-hydroxy-9-(methoxymethyl)-6,10a-dimethyl-3-(propan-2-yl)-1,2,4,5,6,6a,7,8,9,10a-decahydrodicyclopenta[a,d][8]annulen-4-yl alpha-D-glucopyranoside, 14-3-3 protein sigma, MAGNESIUM ION, ... Authors: Ottmann, C, Anders, C, Schumacher, B. Deposit date: 2012-06-26 Release date: 2013-05-08 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (1.9 Å) Cite: A semisynthetic fusicoccane stabilizes a protein-protein interaction and enhances the expression of k(+) channels at the cell surface. Chem.Biol., 20, 2013
4FL5	Crystal structure of human 14-3-3 sigma in complex with a Tau-protein peptide surrounding pS214 Descriptor: 14-3-3 protein sigma, CALCIUM ION, CHLORIDE ION, ... Authors: Schumacher, B, Ottmann, C. Deposit date: 2012-06-14 Release date: 2013-12-11 Last modified: 2017-06-07 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Involvement of 14-3-3 in tubulin instability and impaired axon development is mediated by Tau. FASEB J., 29, 2015
4FJ3	14-3-3 isoform zeta in complex with a diphoyphorylated C-RAF peptide Descriptor: 14-3-3 protein zeta/delta, RAF proto-oncogene serine/threonine-protein kinase Authors: Ottmann, C, Molzan, M. Deposit date: 2012-06-11 Release date: 2012-09-05 Last modified: 2013-07-10 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Synergistic binding of the phosphorylated S233- and S259-binding sites of C-RAF to one 14-3-3zeta dimer J.Mol.Biol., 423, 2012
4F7R	Crystal structure of 14-3-3 protein from Giardia intestinalis Descriptor: 14-3-3 protein, SULFATE ION Authors: Fiorillo, A, Ilari, A, Lalle, M. Deposit date: 2012-05-16 Release date: 2013-05-22 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (3.2 Å) Cite: The Crystal Structure of Giardia duodenalis 14-3-3 in the Apo Form: When Protein Post-Translational Modifications Make the Difference. Plos One, 9, 2014
4E2E	Crystal structure of a tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide (YWHAG) from Homo sapiens at 2.25 A resolution Descriptor: 1,2-ETHANEDIOL, 14-3-3 protein gamma Authors: Joint Center for Structural Genomics (JCSG), Partnership for T-Cell Biology (TCELL) Deposit date: 2012-03-08 Release date: 2012-03-21 Last modified: 2023-02-01 Method: X-RAY DIFFRACTION (2.25 Å) Cite: Crystal structure of a tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activa tion protein, gamma polypeptide (YWHAG) from Homo sapiens at 2.25 A resolution To be published
4DX0	Structure of the 14-3-3/PMA2 complex stabilized by a pyrazole derivative Descriptor: 14-3-3-like protein E, 4-[(4R)-4-(4-nitrophenyl)-6-oxidanylidene-3-phenyl-1,4-dihydropyrrolo[3,4-c]pyrazol-5-yl]benzoic acid, N.plumbaginifolia H+-translocating ATPase mRNA Authors: Richter, A, Rose, R, Hedberg, C, Waldmann, H, Ottmann, C. Deposit date: 2012-02-27 Release date: 2012-05-30 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (3.4 Å) Cite: An Optimised Small-Molecule Stabiliser of the 14-3-3-PMA2 Protein-Protein Interaction. Chemistry, 18, 2012
4DNK	Crystal structure of a tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide (YWHAB) from homo sapiens at 2.20 A resolution. Descriptor: 1,2-ETHANEDIOL, 14-3-3 protein beta/alpha, PHOSPHATE ION Authors: Joint Center for Structural Genomics (JCSG), Partnership for T-Cell Biology (TCELL) Deposit date: 2012-02-08 Release date: 2012-02-22 Last modified: 2023-02-01 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Crystal structure of a tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide (YWHAQ) from Homo sapiens at 2.20 A resolution To be published
4DHS	Small-molecule inhibitors of 14-3-3 protein-protein interactions from virtual screening Descriptor: (2-{2-[(3,5-dichlorophenyl)amino]-2-oxoethoxy}phenyl)phosphonic acid, 14-3-3 PROTEIN SIGMA, CHLORIDE ION, ... Authors: Thiel, P, Roeglin, L, Kohlbacher, O, Ottmann, C. Deposit date: 2012-01-30 Release date: 2013-07-31 Last modified: 2013-09-04 Method: X-RAY DIFFRACTION (1.74 Å) Cite: Virtual screening and experimental validation reveal novel small-molecule inhibitors of 14-3-3 protein-protein interactions. Chem.Commun.(Camb.), 49, 2013
4DHN	Small-molecule inhibitors of 14-3-3 protein-protein interactions from virtual screening Descriptor: 14-3-3 protein sigma, CHLORIDE ION, GLYCEROL, ... Authors: Thiel, P, Roeglin, L, Kohlbacher, O, Ottmann, C. Deposit date: 2012-01-30 Release date: 2013-07-31 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Virtual screening and experimental validation reveal novel small-molecule inhibitors of 14-3-3 protein-protein interactions. Chem.Commun.(Camb.), 49, 2013
4DHR	Small-molecule inhibitors of 14-3-3 protein-protein interactions from virtual screening Descriptor: (2-{2-[(2-chlorophenyl)amino]-2-oxoethoxy}phenyl)phosphonic acid, 14-3-3 protein sigma, CHLORIDE ION, ... Authors: Thiel, P, Roeglin, L, Kohlbacher, O, Ottmann, C. Deposit date: 2012-01-30 Release date: 2013-07-31 Last modified: 2013-09-04 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Virtual screening and experimental validation reveal novel small-molecule inhibitors of 14-3-3 protein-protein interactions. Chem.Commun.(Camb.), 49, 2013
4DHO	Small-molecule inhibitors of 14-3-3 protein-protein interactions from virtual screening Descriptor: (2-{2-[(3-methoxyphenyl)amino]-2-oxoethoxy}phenyl)phosphonic acid, 14-3-3 protein sigma, CHLORIDE ION, ... Authors: Thiel, P, Roeglin, L, Kohlbacher, O, Ottmann, C. Deposit date: 2012-01-30 Release date: 2013-07-31 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Virtual screening and experimental validation reveal novel small-molecule inhibitors of 14-3-3 protein-protein interactions. Chem.Commun.(Camb.), 49, 2013
4DHU	Small-molecule inhibitors of 14-3-3 protein-protein interactions from virtual screening Descriptor: (2-{2-[(2,3-dichlorophenyl)amino]-2-oxoethoxy}phenyl)phosphonic acid, 14-3-3 PROTEIN SIGMA, CHLORIDE ION, ... Authors: Thiel, P, Roeglin, L, Kohlbacher, O, Ottmann, C. Deposit date: 2012-01-30 Release date: 2013-07-31 Last modified: 2013-09-04 Method: X-RAY DIFFRACTION (1.67 Å) Cite: Virtual screening and experimental validation reveal novel small-molecule inhibitors of 14-3-3 protein-protein interactions. Chem.Commun.(Camb.), 49, 2013
4DHP	Small-molecule inhibitors of 14-3-3 protein-protein interactions from virtual screening Descriptor: 14-3-3 protein sigma, CHLORIDE ION, GLYCEROL, ... Authors: Thiel, P, Roeglin, L, Kohlbacher, O, Ottmann, C. Deposit date: 2012-01-30 Release date: 2013-07-31 Last modified: 2013-09-04 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Virtual screening and experimental validation reveal novel small-molecule inhibitors of 14-3-3 protein-protein interactions. Chem.Commun.(Camb.), 49, 2013
4DHQ	Small-molecule inhibitors of 14-3-3 protein-protein interactions from virtual screening Descriptor: (2-{2-[(3-chlorophenyl)amino]-2-oxoethoxy}phenyl)phosphonic acid, 14-3-3 protein sigma, CHLORIDE ION, ... Authors: Thiel, P, Roeglin, L, Kohlbacher, O, Ottmann, C. Deposit date: 2012-01-30 Release date: 2013-07-31 Last modified: 2013-09-04 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Virtual screening and experimental validation reveal novel small-molecule inhibitors of 14-3-3 protein-protein interactions. Chem.Commun.(Camb.), 49, 2013

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