PDB: 501 resultsInfo pagesStatus searchChemie searchBIRD

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6J51	RNA polymerase II elongation complex bound with Spt4/5 and foreign DNA, stalled at SHL(-1) of the nucleosome, weak Elf1 (+1 position) Descriptor: DNA (198-MER), DNA (36-MER), DNA-directed RNA polymerase subunit, ... Authors: Ehara, H, Kujirai, T, Fujino, Y, Shirouzu, M, Kurumizaka, H, Sekine, S. Deposit date: 2019-01-10 Release date: 2019-02-20 Last modified: 2024-03-27 Method: ELECTRON MICROSCOPY (4.2 Å) Cite: Structural insight into nucleosome transcription by RNA polymerase II with elongation factors. Science, 363, 2019
6J4Y	RNA polymerase II elongation complex bound with Elf1 and Spt4/5, stalled at SHL(-1) of the nucleosome (+1B) Descriptor: DNA (198-MER), DNA-directed RNA polymerase subunit, DNA-directed RNA polymerase subunit beta, ... Authors: Ehara, H, Kujirai, T, Fujino, Y, Shirouzu, M, Kurumizaka, H, Sekine, S. Deposit date: 2019-01-10 Release date: 2019-02-20 Last modified: 2024-03-27 Method: ELECTRON MICROSCOPY (4.3 Å) Cite: Structural insight into nucleosome transcription by RNA polymerase II with elongation factors. Science, 363, 2019
4ZYA	The N-terminal extension domain of human asparaginyl-tRNA synthetase Descriptor: Asparagine--tRNA ligase, cytoplasmic, CHLORIDE ION, ... Authors: Park, J.S, Park, M.C, Goughnour, P, Kim, H.S, Kim, S.J, Kim, H.J, Kim, S.H, Han, B.W. Deposit date: 2015-05-21 Release date: 2016-05-25 Last modified: 2019-04-24 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Unique N-terminal extension domain of human asparaginyl-tRNA synthetase elicits CCR3-mediated chemokine activity. Int. J. Biol. Macromol., 120, 2018
4I1Q	Crystal Structure of hBRAP1 N-BAR domain Descriptor: Bridging integrator 2 Authors: Sanchez-Barrena, M.J. Deposit date: 2012-11-21 Release date: 2013-02-06 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (2.53 Å) Cite: Bin2 Is a Membrane Sculpting N-BAR Protein That Influences Leucocyte Podosomes, Motility and Phagocytosis Plos One, 7, 2012
6KN5	Crystal structure of AFF4 C-terminal domain Descriptor: AF4/FMR2 family member 4 Authors: Chen, L.J, Yang, W.S, Xu, R.M. Deposit date: 2019-08-03 Release date: 2020-07-08 Last modified: 2024-05-29 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Acetylation of histone H3K27 signals the transcriptional elongation for estrogen receptor alpha. Commun Biol, 3, 2020
4J3I	X-ray crystal structure of bromodomain complex to 1.24 A resolution Descriptor: 1,2-ETHANEDIOL, 2-[4-(2-hydroxyethoxy)-3,5-dimethylphenyl]-5,7-dimethoxyquinazolin-4(3H)-one, Bromodomain-containing protein 4, ... Authors: Stein, A.J, White, A, Suto, R.K. Deposit date: 2013-02-05 Release date: 2014-01-15 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.24 Å) Cite: RVX-208, an Inducer of ApoA-I in Humans, Is a BET Bromodomain Antagonist. Plos One, 8, 2013
4J1P	X-ray crystal structure of bromodomain 2 of human brd2 in complex with rvx208 to 1.08 A resolution Descriptor: 1,2-ETHANEDIOL, 2-[4-(2-hydroxyethoxy)-3,5-dimethylphenyl]-5,7-dimethoxyquinazolin-4(3H)-one, Bromodomain containing 2, ... Authors: Stein, A.J, White, A, Suto, R.K. Deposit date: 2013-02-01 Release date: 2014-01-15 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.08 Å) Cite: RVX-208, an Inducer of ApoA-I in Humans, Is a BET Bromodomain Antagonist. Plos One, 8, 2013
5ANT	Potent and selective inhibitors of MTH1 probe its role in cancer cell survival Descriptor: 2-(2-methoxyethoxy)-6-(methylamino)-9-(phenylmethyl)-7H-purin-8-one, 7,8-DIHYDRO-8-OXOGUANINE TRIPHOSPHATASE Authors: Kettle, J.G, Alwan, H, Bista, M, Breed, J, Kack, H, Eckersley, K, Foote, K.M, Fillery, S, Goodwin, L, Jones, D, Lau, A, Nissink, J.W.M, Read, J, Scott, J, Taylor, B, Walker, G, Wissler, L. Deposit date: 2015-09-08 Release date: 2016-03-02 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2 Å) Cite: Potent and Selective Inhibitors of Mth1 Probe its Role in Cancer Cell Survival. J.Med.Chem., 59, 2016
4JNX	Crystal structure of RNA silencing suppressor p19 complexed with double-helical RNA 20mer pG(CUG)6C Descriptor: 5'-R(P*GP*CP*UP*GP*CP*UP*GP*CP*UP*GP*CP*UP*GP*CP*UP*GP*CP*UP*GP*C)-3', MAGNESIUM ION, RNA silencing suppressor p19, ... Authors: Katorcha, E, Popov, A.N, Malinina, L. Deposit date: 2013-03-16 Release date: 2014-03-19 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Procrustean bed of RNA silencing suppression To be Published
5B4O	Crystal structure of Macrophage Migration Inhibitory Factor in complex with BTZO-14 Descriptor: 1,2-ETHANEDIOL, 2-pyridin-3-yl-1,3-benzothiazin-4-one, Macrophage migration inhibitory factor, ... Authors: Oki, H, Igaki, S, Moriya, Y, Hayano, Y, Habuka, N. Deposit date: 2016-04-07 Release date: 2016-04-20 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.37 Å) Cite: BTZO-1, a cardioprotective agent, reveals that macrophage migration inhibitory factor regulates ARE-mediated gene expression Chem. Biol., 17, 2010
5ANU	MTH1 in complex with compound 15 Descriptor: 13-(METHYLAMINO)-23,24,25-TRIOXA-17,18,19,21-TETRAZATETRACYCLO-TRICOSA-1(3),2(10),4(11),12(14),13(18),16(19)-HEXAN-15-ONE, 7,8-DIHYDRO-8-OXOGUANINE TRIPHOSPHATASE, DIMETHYL SULFOXIDE Authors: Read, J.A, Breed, J. Deposit date: 2015-09-08 Release date: 2016-03-02 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Potent and Selective Inhibitors of Mth1 Probe its Role in Cancer Cell Survival. J.Med.Chem., 59, 2016
5ANV	MTH1 in complex with compound 15 Descriptor: 4-(4-CHLORO-2-FLUORO-ANILINO)-6,7-DIMETHOXY-N-METHYL-QUINOLINE-3-CARBOXAMIDE, 7,8-DIHYDRO-8-OXOGUANINE TRIPHOSPHATASE Authors: Read, J.A, Breed, J. Deposit date: 2015-09-08 Release date: 2016-03-02 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (1.16 Å) Cite: Potent and Selective Inhibitors of Mth1 Probe its Role in Cancer Cell Survival. J.Med.Chem., 59, 2016
5ANS	Potent and selective inhibitors of MTH1 probe its role in cancer cell survival Descriptor: 1-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]-2-methylpropan-2-ol, 7,8-DIHYDRO-8-OXOGUANINE TRIPHOSPHATASE Authors: Kettle, J.G, Alwan, H, Bista, M, Breed, J, Kack, H, Eckersley, K, Foote, K.M, Fillery, S, Goodwin, L, Jones, D, Lau, A, Nissink, J.W.M, Read, J, Scott, J, Taylor, B, Walker, G, Wissler, L. Deposit date: 2015-09-08 Release date: 2016-03-02 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Potent and Selective Inhibitors of Mth1 Probe its Role in Cancer Cell Survival. J.Med.Chem., 59, 2016
5ANW	MTH1 in complex with compound 24 Descriptor: 2-[4-(2-AMINOQUINAZOLIN-4-YL)PHENYL]-N,N-DIMETHYL-ACETAMIDE, 7,8-DIHYDRO-8-OXOGUANINE TRIPHOSPHATASE Authors: Read, J.A, Breed, J. Deposit date: 2015-09-08 Release date: 2016-03-02 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (1.37 Å) Cite: Potent and Selective Inhibitors of Mth1 Probe its Role in Cancer Cell Survival. J.Med.Chem., 59, 2016
3RIU	Crystal structure of Drosophila hexameric C3PO formed by truncated Translin and Trax Descriptor: Translin, Translin associated factor X, isoform B Authors: Tian, Y, Simanshu, D.K, Patel, D.J. Deposit date: 2011-04-14 Release date: 2011-05-11 Last modified: 2017-11-08 Method: X-RAY DIFFRACTION (3.4 Å) Cite: Multimeric assembly and biochemical characterization of the Trax-translin endonuclease complex. Nat.Struct.Mol.Biol., 18, 2011
4KRE	Structure of Human Argonaute-1 bound to endogenous Sf9 RNA Descriptor: Protein argonaute-1, RNA (5'-R(P*AP*AP*UP*AP*UP*UP*AP*AP*A*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') Authors: Faehnle, C.R, Elkayam, E, Joshua-Tor, L. Deposit date: 2013-05-16 Release date: 2013-06-19 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.754 Å) Cite: The making of a slicer: activation of human argonaute-1. Cell Rep, 3, 2013
4KRF	Structure of Human Argonaute-1 let-7 complex Descriptor: Protein argonaute-1, RNA (5'-R(P*UP*GP*AP*GP*GP*UP*AP*GP*UP*AP*GP*GP*UP*UP*GP*UP*AP*UP*AP*GP*UP*U)-3') Authors: Faehnle, C.R, Elkayam, E, Joshua-Tor, L. Deposit date: 2013-05-16 Release date: 2013-06-19 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.101 Å) Cite: The making of a slicer: activation of human argonaute-1. Cell Rep, 3, 2013
4KXT	Structure of human ARGONAUTE1 in complex with guide RNA Descriptor: Protein argonaute-1, RNA Authors: Nakanishi, K, Patel, D.J. Deposit date: 2013-05-28 Release date: 2013-07-31 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.294 Å) Cite: Eukaryote-Specific Insertion Elements Control Human ARGONAUTE Slicer Activity. Cell Rep, 3, 2013
6NBN	Structure of Aedes aegypti OBP22 in the complex with arachidonic acid Descriptor: AAEL005772-PA, ARACHIDONIC ACID Authors: Jones, D.N, Wang, J. Deposit date: 2018-12-07 Release date: 2018-12-19 Last modified: 2023-06-14 Method: SOLUTION NMR Cite: Aedes aegypti Odorant Binding Protein 22 selectively binds fatty acids through a conformational change in its C-terminal tail. Sci Rep, 10, 2020
4MQ2	The crystal structure of DYRK1a with a bound pyrido[2,3-d]pyrimidine inhibitor Descriptor: Dual specificity tyrosine-phosphorylation-regulated kinase 1A, PENTAETHYLENE GLYCOL, SULFATE ION, ... Authors: Lukacs, C.M, Janson, C.A, Garvie, C, Liang, L. Deposit date: 2013-09-15 Release date: 2013-12-11 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Pyrido[2,3-d]pyrimidines: Discovery and preliminary SAR of a novel series of DYRK1B and DYRK1A inhibitors. Bioorg.Med.Chem.Lett., 23, 2013
4NBO	Human steroid receptor RNA activator protein carboxy-terminal domain Descriptor: Steroid receptor RNA activator 1 Authors: Mckay, D.B, Xi, L, Barthel, K.K.B, Cech, T.C. Deposit date: 2013-10-23 Release date: 2014-02-05 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.807 Å) Cite: Structure and function of steroid receptor RNA activator protein, the proposed partner of SRA noncoding RNA. J.Mol.Biol., 426, 2014
4MQ1	The crystal structure of DYRK1a with a bound pyrido[2,3-d]pyrimidine inhibitor Descriptor: Dual specificity tyrosine-phosphorylation-regulated kinase 1A, N-(5-{[(1R)-3-amino-1-(3-chlorophenyl)propyl]carbamoyl}-2-chlorophenyl)-2-methoxy-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamide, PENTAETHYLENE GLYCOL, ... Authors: Lukacs, C.M, Janson, C.A, Garvie, C, Liang, L. Deposit date: 2013-09-15 Release date: 2013-12-11 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (2.35 Å) Cite: Pyrido[2,3-d]pyrimidines: Discovery and preliminary SAR of a novel series of DYRK1B and DYRK1A inhibitors. Bioorg.Med.Chem.Lett., 23, 2013
7WBX	RNA polymerase II elongation complex bound with Elf1 and Spt4/5, stalled at SHL(-3) of the nucleosome Descriptor: DNA (198-MER), DNA-directed RNA polymerase subunit, DNA-directed RNA polymerase subunit beta, ... Authors: Osumi, K, Kujirai, T, Ehara, H, Sekine, S, Takizawa, Y, Kurumizaka, H. Deposit date: 2021-12-17 Release date: 2023-07-05 Method: ELECTRON MICROSCOPY (4 Å) Cite: Structural Basis of Damaged Nucleotide Recognition by Transcribing RNA Polymerase II in the Nucleosome. J.Mol.Biol., 435, 2023
7WBV	RNA polymerase II elongation complex bound with Elf1 and Spt4/5, stalled at SHL(-4) of the nucleosome Descriptor: DNA (159-MER), DNA (198-MER), DNA-directed RNA polymerase subunit, ... Authors: Osumi, K, Kujirai, T, Ehara, H, Sekine, S, Takizawa, Y, Kurumizaka, H. Deposit date: 2021-12-17 Release date: 2023-07-05 Method: ELECTRON MICROSCOPY (4.1 Å) Cite: Structural Basis of Damaged Nucleotide Recognition by Transcribing RNA Polymerase II in the Nucleosome. J.Mol.Biol., 435, 2023
7WBW	RNA polymerase II elongation complex bound with Elf1 and Spt4/5, stalled at SHL(-3.5) of the nucleosome Descriptor: DNA (198-MER), DNA-directed RNA polymerase subunit, DNA-directed RNA polymerase subunit beta, ... Authors: Osumi, K, Kujirai, T, Ehara, H, Sekine, S, Takizawa, Y, Kurumizaka, H. Deposit date: 2021-12-17 Release date: 2023-07-05 Method: ELECTRON MICROSCOPY (7.1 Å) Cite: Structural Basis of Damaged Nucleotide Recognition by Transcribing RNA Polymerase II in the Nucleosome. J.Mol.Biol., 435, 2023

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