5ANU

MTH1 in complex with compound 15

Summary for 5ANU

Entry DOI	10.2210/pdb5anu/pdb
Related	5ANV 5ANW
Descriptor	7,8-DIHYDRO-8-OXOGUANINE TRIPHOSPHATASE, DIMETHYL SULFOXIDE, 13-(METHYLAMINO)-23,24,25-TRIOXA-17,18,19,21-TETRAZATETRACYCLO-TRICOSA-1(3),2(10),4(11),12(14),13(18),16(19)-HEXAN-15-ONE, ... (4 entities in total)
Functional Keywords	hydrolase, nudt1, inhibitor
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Isoform p18: Cytoplasm. Isoform p26: Cytoplasm: P36639
Total number of polymer chains	1
Total formula weight	18535.09
Authors	Read, J.A.,Breed, J. (deposition date: 2015-09-08, release date: 2016-03-02, Last modification date: 2016-04-06)
Primary citation	Kettle, J.G.,Alwan, H.,Bista, M.,Breed, J.,Davies, N.L.,Eckersley, K.,Fillery, S.,Foote, K.M.,Goodwin, L.,Jones, D.R.,Kack, H.,Lau, A.,Nissink, J.W.,Read, J.,Scott, J.S.,Taylor, B.,Walker, G.,Wissler, L.,Wylot, M. Potent and Selective Inhibitors of Mth1 Probe its Role in Cancer Cell Survival. J.Med.Chem., 59:2346-, 2016 Cited by PubMed: 26878898 DOI: 10.1021/ACS.JMEDCHEM.5B01760 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation