PDB: 80 resultsInfo pagesStatus searchChemie searchBIRD

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2YXR	The plug domain of the SecY protein stablizes the closed state of the translocation channel and maintains a membrane seal Descriptor: Preprotein translocase secG subunit, Preprotein translocase subunit secE, Preprotein translocase subunit secY Authors: Li, W, Schulman, S. Deposit date: 2007-04-27 Release date: 2007-08-14 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (3.6 Å) Cite: The plug domain of the SecY protein stabilizes the closed state of the translocation channel and maintains a membrane seal Mol.Cell, 26, 2007
2YXQ	The plug domain of the SecY protein stablizes the closed state of the translocation channel and maintains a membrane seal Descriptor: Preprotein translocase secG subunit, Preprotein translocase subunit secE, Preprotein translocase subunit secY Authors: Li, W, Schulman, S. Deposit date: 2007-04-27 Release date: 2007-08-14 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (3.5 Å) Cite: The plug domain of the SecY protein stabilizes the closed state of the translocation channel and maintains a membrane seal Mol.Cell, 26, 2007
2ZJS	Crystal Structure of SecYE translocon from Thermus thermophilus with a Fab fragment Descriptor: Fab56 (heavy chain), Fab56 (light chain), Preprotein translocase SecE subunit, ... Authors: Tsukazaki, T, Mori, H, Fukai, S, Ishitani, R, Perederina, A, Vassylyev, D.G, Ito, K, Nureki, O. Deposit date: 2008-03-08 Release date: 2008-10-14 Last modified: 2021-11-10 Method: X-RAY DIFFRACTION (3.2 Å) Cite: Conformational transition of Sec machinery inferred from bacterial SecYE structures Nature, 455, 2008
2ZQP	Crystal Structure of SecYE translocon from Thermus thermophilus Descriptor: Preprotein translocase SecE subunit, Preprotein translocase SecY subunit Authors: Tsukazaki, T, Nureki, O. Deposit date: 2008-08-14 Release date: 2008-10-14 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (6 Å) Cite: Conformational transition of Sec machinery inferred from bacterial SecYE structures Nature, 455, 2008
3JC2	The structure of the mammalian Sec61 channel opened by a signal sequence Descriptor: Prolactin, Protein transport protein Sec61 subunit alpha isoform 1, Protein transport protein Sec61 subunit beta, ... Authors: Voorhees, R.M, Hegde, R.S. Deposit date: 2015-11-15 Release date: 2016-01-13 Last modified: 2018-07-18 Method: ELECTRON MICROSCOPY (3.6 Å) Cite: Structure of the Sec61 channel opened by a signal sequence. Science, 351, 2016
7ZL3	Signal peptide mimicry primes Sec61 for client-selective inhibition Descriptor: Cyclic depsipeptide signal peptide mimic, Protein transport protein Sec61 subunit alpha, Protein transport protein Sec61 subunit beta, ... Authors: Rehan, S, Paavilainen O, V. Deposit date: 2022-04-13 Release date: 2023-03-22 Last modified: 2023-11-15 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Signal peptide mimicry primes Sec61 for client-selective inhibition. Nat.Chem.Biol., 19, 2023
8B6L	Subtomogram average of the human Sec61-TRAP-OSTA-translocon Descriptor: Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit, Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1, Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2, ... Authors: Gemmer, M, Fedry, J.M.M, Forster, F.G. Deposit date: 2022-09-27 Release date: 2022-12-07 Last modified: 2023-02-08 Method: ELECTRON MICROSCOPY (7.6 Å) Cite: Visualization of translation and protein biogenesis at the ER membrane. Nature, 614, 2023
8DNV	Cryo-EM structure of the human Sec61 complex in a partially-open apo state (Class 1) Descriptor: Protein transport protein Sec61 subunit alpha isoform 1, Protein transport protein Sec61 subunit beta, Protein transport protein Sec61 subunit gamma Authors: Park, E, Itskanov, S. Deposit date: 2022-07-12 Release date: 2023-05-24 Last modified: 2023-09-06 Method: ELECTRON MICROSCOPY (3.03 Å) Cite: A common mechanism of Sec61 translocon inhibition by small molecules. Nat.Chem.Biol., 19, 2023
8DO1	Cryo-EM structure of the human Sec61 complex inhibited by ipomoeassin F Descriptor: Protein transport protein Sec61 subunit alpha isoform 1, Protein transport protein Sec61 subunit beta, Protein transport protein Sec61 subunit gamma, ... Authors: Park, E, Itskanov, S. Deposit date: 2022-07-12 Release date: 2023-05-24 Last modified: 2023-09-06 Method: ELECTRON MICROSCOPY (3.01 Å) Cite: A common mechanism of Sec61 translocon inhibition by small molecules. Nat.Chem.Biol., 19, 2023
8DNZ	Cryo-EM structure of the human Sec61 complex inhibited by apratoxin F Descriptor: Apratoxin F peptide inhibitor, Protein transport protein Sec61 subunit alpha isoform 1, Protein transport protein Sec61 subunit beta, ... Authors: Park, E, Itskanov, S. Deposit date: 2022-07-12 Release date: 2023-05-24 Last modified: 2023-11-15 Method: ELECTRON MICROSCOPY (2.57 Å) Cite: A common mechanism of Sec61 translocon inhibition by small molecules. Nat.Chem.Biol., 19, 2023
8DNW	Cryo-EM structure of the human Sec61 complex in a partially-open apo state (Class 2) Descriptor: Protein transport protein Sec61 subunit alpha isoform 1, Protein transport protein Sec61 subunit beta, Protein transport protein Sec61 subunit gamma Authors: Park, E, Itskanov, S. Deposit date: 2022-07-12 Release date: 2023-05-24 Last modified: 2023-09-06 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: A common mechanism of Sec61 translocon inhibition by small molecules. Nat.Chem.Biol., 19, 2023
8DO2	Cryo-EM structure of the human Sec61 complex inhibited by cyclotriazadisulfonamide (CADA) Descriptor: 9-benzyl-1,5-bis(4-methylbenzene-1-sulfonyl)-3-methylidene-1,5,9-triazacyclododecane, Protein transport protein Sec61 subunit alpha isoform 1, Protein transport protein Sec61 subunit beta, ... Authors: Park, E, Itskanov, S. Deposit date: 2022-07-12 Release date: 2023-05-24 Last modified: 2023-09-06 Method: ELECTRON MICROSCOPY (2.95 Å) Cite: A common mechanism of Sec61 translocon inhibition by small molecules. Nat.Chem.Biol., 19, 2023
8DNX	Cryo-EM structure of the human Sec61 complex inhibited by cotransin Descriptor: Cotransin analogue peptide inhibitor, Protein transport protein Sec61 subunit alpha isoform 1, Protein transport protein Sec61 subunit beta, ... Authors: Park, E, Itskanov, S. Deposit date: 2022-07-12 Release date: 2023-05-24 Last modified: 2023-11-15 Method: ELECTRON MICROSCOPY (2.98 Å) Cite: A common mechanism of Sec61 translocon inhibition by small molecules. Nat.Chem.Biol., 19, 2023
8DNY	Cryo-EM structure of the human Sec61 complex inhibited by decatransin Descriptor: Decatransin peptide inhibitor, Protein transport protein Sec61 subunit alpha isoform 1, Protein transport protein Sec61 subunit beta, ... Authors: Park, E, Itskanov, S. Deposit date: 2022-07-12 Release date: 2023-05-24 Last modified: 2023-11-15 Method: ELECTRON MICROSCOPY (2.85 Å) Cite: A common mechanism of Sec61 translocon inhibition by small molecules. Nat.Chem.Biol., 19, 2023
8DO0	Cryo-EM structure of the human Sec61 complex inhibited by mycolactone Descriptor: Protein transport protein Sec61 subunit alpha isoform 1, Protein transport protein Sec61 subunit beta, Protein transport protein Sec61 subunit gamma, ... Authors: Park, E, Itskanov, S. Deposit date: 2022-07-12 Release date: 2023-05-24 Last modified: 2023-09-06 Method: ELECTRON MICROSCOPY (2.86 Å) Cite: A common mechanism of Sec61 translocon inhibition by small molecules. Nat.Chem.Biol., 19, 2023
8DO3	Cryo-EM structure of the human Sec61 complex inhibited by eeyarestatin I Descriptor: N'-(4-chlorophenyl)-N-[(4R)-3-(4-chlorophenyl)-5,5-dimethyl-1-(2-{(2E)-2-[(2E)-3-(5-nitrofuran-2-yl)prop-2-en-1-ylidene]hydrazinyl}-2-oxoethyl)-2-oxoimidazolidin-4-yl]-N-hydroxyurea, Protein transport protein Sec61 subunit alpha isoform 1, Protein transport protein Sec61 subunit beta, ... Authors: Park, E, Itskanov, S. Deposit date: 2022-07-12 Release date: 2023-05-24 Last modified: 2023-09-06 Method: ELECTRON MICROSCOPY (3.22 Å) Cite: A common mechanism of Sec61 translocon inhibition by small molecules. Nat.Chem.Biol., 19, 2023
8BF9	Molecular view of ER membrane remodeling by the Sec61/TRAP translocon. Descriptor: 60S ribosomal protein L39, Large ribosomal subunit protein eL31, Large ribosomal subunit protein eL38, ... Authors: Karki, S, Javanainen, M, Tranter, D, Rehan, S, Huiskonen, J, Happonen, L, Paavilainen, V. Deposit date: 2022-10-24 Release date: 2023-11-01 Last modified: 2023-12-20 Method: ELECTRON MICROSCOPY (2.69 Å) Cite: Molecular view of ER membrane remodeling by the Sec61/TRAP translocon. Embo Rep., 24, 2023
5GAE	RNC in complex with a translocating SecYEG Descriptor: 23S rRNA, 50S ribosomal protein L10, 50S ribosomal protein L11, ... Authors: Jomaa, A, Boehringer, D, Leibundgut, M, Ban, N. Deposit date: 2015-11-25 Release date: 2016-01-27 Last modified: 2019-12-11 Method: ELECTRON MICROSCOPY (3.33 Å) Cite: Structures of the E. coli translating ribosome with SRP and its receptor and with the translocon. Nat Commun, 7, 2016
7AFT	Cryo-EM structure of the signal sequence-engaged post-translational Sec translocon Descriptor: Mating factor alpha-1,Mating factor alpha-1, Protein translocation protein SEC63, Protein transport protein SBH1, ... Authors: Weng, T.-H, Beatrix, B, Berninghausen, O, Becker, T, Cheng, J, Beckmann, R. Deposit date: 2020-09-20 Release date: 2020-12-02 Last modified: 2024-05-01 Method: ELECTRON MICROSCOPY (4.4 Å) Cite: Architecture of the active post-translational Sec translocon. Embo J., 40, 2021
6W6L	Cryo-EM structure of the human ribosome-TMCO1 translocon Descriptor: 28S ribosomal RNA, 5.8S ribosomal RNA, 5S ribosomal RNA, ... Authors: Keenan, R.J, McGilvray, P.T. Deposit date: 2020-03-17 Release date: 2020-09-02 Method: ELECTRON MICROSCOPY (3.84 Å) Cite: An ER translocon for multi-pass membrane protein biogenesis. Elife, 9, 2020
6R7Q	Structure of XBP1u-paused ribosome nascent chain complex with Sec61. Descriptor: 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S12, ... Authors: Shanmuganathan, V, Cheng, J, Braunger, K, Berninghausen, O, Beatrix, B, Beckmann, R. Deposit date: 2019-03-29 Release date: 2019-07-10 Last modified: 2024-05-22 Method: ELECTRON MICROSCOPY (3.9 Å) Cite: Structural and mutational analysis of the ribosome-arresting human XBP1u. Elife, 8, 2019
5NCO	Quaternary complex between SRP, SR, and SecYEG bound to the translating ribosome Descriptor: 23S rRNA, 4.5S SRP RNA (Ffs), 50S ribosomal protein L10, ... Authors: Jomaa, A, Hwang Fu, Y, Boerhinger, D, Leibundgut, M, Shan, S.O, Ban, N. Deposit date: 2017-03-06 Release date: 2017-05-24 Last modified: 2018-03-28 Method: ELECTRON MICROSCOPY (4.8 Å) Cite: Structure of the quaternary complex between SRP, SR, and translocon bound to the translating ribosome. Nat Commun, 8, 2017
6N3Q	Cryo-EM structure of the yeast Sec complex Descriptor: Protein translocation protein SEC63, Protein transport protein SBH1, Protein transport protein SEC61, ... Authors: Park, E, Itskanov, S. Deposit date: 2018-11-16 Release date: 2018-12-19 Last modified: 2024-03-20 Method: ELECTRON MICROSCOPY (3.68 Å) Cite: Structure of the posttranslational Sec protein-translocation channel complex from yeast. Science, 363, 2019
7TM3	Structure of the rabbit 80S ribosome stalled on a 2-TMD Rhodopsin intermediate in complex with the multipass translocon Descriptor: 28S ribosomal RNA, 5.8S ribosomal RNA, 5S ribosomal RNA, ... Authors: Kim, M.K, Lewis, A.J.O, Keenan, R.J, Hegde, R.S. Deposit date: 2022-01-19 Release date: 2022-10-19 Last modified: 2024-06-05 Method: ELECTRON MICROSCOPY (3.25 Å) Cite: Mechanism of an intramembrane chaperone for multipass membrane proteins. Nature, 611, 2022
7TUT	Structure of the rabbit 80S ribosome stalled on a 4-TMD Rhodopsin intermediate in complex with the multipass translocon Descriptor: 28S ribosomal RNA, 5.8S ribosomal RNA, 5S ribosomal RNA, ... Authors: Kim, M.K, Lewis, A.J.O, Keenan, R.J, Hegde, R.S. Deposit date: 2022-02-03 Release date: 2022-10-19 Last modified: 2024-06-12 Method: ELECTRON MICROSCOPY (3.88 Å) Cite: Mechanism of an intramembrane chaperone for multipass membrane proteins. Nature, 611, 2022

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