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6VZK	Crystal structure of human CaMKII-alpha (CAMK2A)kinase domain Descriptor: 4'-HYDROXYCINNAMIC ACID, Calcium/calmodulin-dependent protein kinase type II subunit alpha Authors: Ozden, C, Stratton, M.M, Garman, S.C. Deposit date: 2020-02-28 Release date: 2020-04-22 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.55 Å) Cite: Characterization of CaMKII alpha holoenzyme stability. Protein Sci., 29, 2020
3O78	The structure of Ca2+ Sensor (Case-12) Descriptor: CALCIUM ION, Myosin light chain kinase, smooth muscle,Green fluorescent protein,Green fluorescent protein,Calmodulin-1 Authors: Leder, L, Stark, W, Freuler, F, Marsh, M, Meyerhofer, M, Stettler, T, Mayr, L.M, Britanova, O.V, Strukova, L.A, Chudakov, D.M. Deposit date: 2010-07-30 Release date: 2010-09-29 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (2.6 Å) Cite: The structure of Ca2+ sensor Case16 reveals the mechanism of reaction to low Ca2+ concentrations Sensors (Basel), 10, 2010
6FEG	Solution Structure of CaM/Kv7.2-hAB Complex Descriptor: CALCIUM ION, Calmodulin-1, Potassium voltage-gated channel subfamily KQT member 2,Potassium voltage-gated channel subfamily KQT member 2 Authors: Bernardo-Seisdedos, G, Villarroel, A, Millet, O. Deposit date: 2018-01-02 Release date: 2018-02-21 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: Structural basis and energy landscape for the Ca2+gating and calmodulation of the Kv7.2 K+channel. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
2BKH	Myosin VI nucleotide-free (MDInsert2) crystal structure Descriptor: CALCIUM ION, CALMODULIN, GLYCEROL, ... Authors: Menetrey, J, Bahloul, A, Yengo, C, Wells, A, Morris, C, Sweeney, H.L, Houdusse, A. Deposit date: 2005-02-16 Release date: 2005-06-07 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.4 Å) Cite: The Structure of the Myosin Vi Motor Reveals the Mechanism of Directionality Reversal Nature, 435, 2005
6FEH	Solution Structure of CaM/Kv7.2-hAB Complex Descriptor: CALCIUM ION, Calmodulin-1, Potassium voltage-gated channel subfamily KQT member 2,Potassium voltage-gated channel subfamily KQT member 2 Authors: Bernardo-Seisdedos, G, Villarroel, A, Millet, O. Deposit date: 2018-01-02 Release date: 2018-02-21 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: Structural basis and energy landscape for the Ca2+gating and calmodulation of the Kv7.2 K+channel. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
8BV5	Focus refinement of soluble domain of Adenylyl cyclase 8 bound to stimulatory G protein, Forskolin, ATPalphaS, and Ca2+/Calmodulin in lipid nanodisc conditions Descriptor: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Adenylate cyclase type 8, FORSKOLIN, ... Authors: Khanppnavar, B, Korkhov, V.M. Deposit date: 2023-01-04 Release date: 2024-01-17 Last modified: 2024-06-12 Method: ELECTRON MICROSCOPY (3.54 Å) Cite: Regulatory sites of CaM-sensitive adenylyl cyclase AC8 revealed by cryo-EM and structural proteomics. Embo Rep., 25, 2024
8BFM	Crystal structure of human calmodulin-dependent protein kinase 1D (CAMK1D) in complex with FZ331 Descriptor: Calcium/calmodulin-dependent protein kinase type 1D, SULFATE ION, pyrazolo[5,1-a]phthalazin-6-amine Authors: Kraemer, A, Zhu, W.F, Hernandez-Olmos, V, Proschak, E, Knapp, S, Structural Genomics Consortium (SGC) Deposit date: 2022-10-26 Release date: 2022-11-23 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Structure of human WDR5 and pVHL:ElonginC:ElonginB bound to PROTAC with PEG linker (conformation #2) To Be Published
7REC	Structure of Thr354Asn, Glu355Gln, Thr412Asn, Ile414Met, Ile464His, and Phe467Met mutant human CaMKII alpha hub bound to 5-HDC Descriptor: 5-hydroxydiclofenac, Calcium/calmodulin-dependent protein kinase type II subunit alpha, SODIUM ION Authors: McSpadden, E.D, Chi, C.C, Gee, C.L, Kuriyan, J. Deposit date: 2021-07-12 Release date: 2021-07-21 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.2 Å) Cite: GHB analogs confer neuroprotection through specific interaction with the CaMKII alpha hub domain. Proc.Natl.Acad.Sci.USA, 118, 2021
8BUZ	Structure of Adenylyl cyclase 8 bound to stimulatory G-protein, Ca2+/Calmodulin, Forskolin and MANT-GTP Descriptor: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Adenylate cyclase type 8, FORSKOLIN, ... Authors: Khanppnavar, B, Korkhov, V.M, Mehta, V. Deposit date: 2022-12-01 Release date: 2023-12-13 Last modified: 2024-06-12 Method: ELECTRON MICROSCOPY (3.5 Å) Cite: Regulatory sites of CaM-sensitive adenylyl cyclase AC8 revealed by cryo-EM and structural proteomics. Embo Rep., 25, 2024
7SX3	Human NALCN-FAM155A-UNC79-UNC80 channelosome with CaM bound, conformation 1/2 Descriptor: (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE, (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Kschonsak, M, Chua, H.C, Weidling, C, Chakouri, N, Noland, C.L, Schott, K, Chang, T, Tam, C, Patel, N, Arthur, C.P, Leitner, A, Ben-Johny, M, Ciferri, C, Pless, S.A, Payandeh, J. Deposit date: 2021-11-22 Release date: 2021-12-29 Last modified: 2022-03-16 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: Structural architecture of the human NALCN channelosome. Nature, 603, 2022
7SX4	Human NALCN-FAM155A-UNC79-UNC80 channelosome with CaM bound, conformation 2/2 Descriptor: (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE, (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Kschonsak, M, Chua, H.C, Weidling, C, Chakouri, N, Noland, C.L, Schott, K, Chang, T, Tam, C, Patel, N, Arthur, C.P, Leitner, A, Ben-Johny, M, Ciferri, C, Pless, S.A, Payandeh, J. Deposit date: 2021-11-22 Release date: 2021-12-29 Last modified: 2022-03-16 Method: ELECTRON MICROSCOPY (3.5 Å) Cite: Structural architecture of the human NALCN channelosome. Nature, 603, 2022
6W4P	CaMKII alpha-30 Cryo-EM reconstruction - Class B Descriptor: Calcium/calmodulin-dependent protein kinase type II subunit alpha Authors: Chao, L.H, Stratton, M.M. Deposit date: 2020-03-11 Release date: 2020-07-15 Last modified: 2024-03-06 Method: ELECTRON MICROSCOPY (6.6 Å) Cite: Heterogeneity in human hippocampal CaMKII transcripts reveals allosteric hub-dependent regulation. Sci.Signal., 13, 2020
2BKI	Myosin VI nucleotide-free (MDinsert2-IQ) crystal structure Descriptor: CALCIUM ION, CALMODULIN, SULFATE ION, ... Authors: Menetrey, J, Bahloul, A, Yengo, C, Wells, A, Morris, C, Sweeney, H.L, Houdusse, A. Deposit date: 2005-02-16 Release date: 2005-06-07 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.9 Å) Cite: The Structure of the Myosin Vi Motor Reveals the Mechanism of Directionality Reversal Nature, 435, 2005
5X2E	Crystal structure of Calmodulin like domain of CsTAL3 (1-81aa) Descriptor: CALCIUM ION, Tegumental protein 20.8 kDa Authors: Jo, C.H, Hwang, K.Y. Deposit date: 2017-01-31 Release date: 2017-08-30 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (1.299 Å) Cite: Structural insights into a 20.8-kDa tegumental-allergen-like (TAL) protein from Clonorchis sinensis Sci Rep, 7, 2017
2BDW	Crystal Structure of the Auto-Inhibited Kinase Domain of Calcium/Calmodulin Activated Kinase II Descriptor: Hypothetical protein K11E8.1d Authors: Rosenberg, O.S, Kuriyan, J. Deposit date: 2005-10-20 Release date: 2005-12-13 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Structure of the Autoinhibited Kinase Domain of CaMKII and SAXS Analysis of the Holoenzyme Cell(Cambridge,Mass.), 123, 2005
3OXQ	Crystal Structure of Ca2+/CaM-CaV1.2 pre-IQ/IQ domain complex Descriptor: CALCIUM ION, Calmodulin, Voltage-dependent L-type calcium channel subunit alpha-1C Authors: Kim, E.Y, Rumpf, C.H, Van Petegem, F, Arant, R, Findeisen, F, Cooley, E.S, Isacoff, E.Y, Minor, D.L. Deposit date: 2010-09-21 Release date: 2010-11-03 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.55 Å) Cite: Multiple C-terminal tail Ca(2+)/CaMs regulate Ca(V)1.2 function but do not mediate channel dimerization. Embo J., 29, 2010
6CZQ	A V-to-F substitution in SK2 channels causes Ca2+ hypersensitivity and improves locomotion in a C. elegans ALS model Descriptor: CALCIUM ION, Calmodulin-1, SULFATE ION, ... Authors: Nam, Y.W, Zhang, M. Deposit date: 2018-04-09 Release date: 2018-08-01 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (2.2 Å) Cite: A V-to-F substitution in SK2 channels causes Ca2+hypersensitivity and improves locomotion in a C. elegans ALS model. Sci Rep, 8, 2018
8UXL	Structure of PKA phosphorylated human RyR2-R420W in the primed state in the presence of calcium and calmodulin Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, Calmodulin-1, ... Authors: Miotto, M.C, Marks, A.R. Deposit date: 2023-11-09 Release date: 2023-11-22 Method: ELECTRON MICROSCOPY (3.12 Å) Cite: Structural basis for ryanodine receptor type 2 leak in heart failure and arrhythmogenic disorders To Be Published
8UXM	Structure of PKA phosphorylated human RyR2-R420W in the open state in the presence of calcium and calmodulin Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, Calmodulin-1, ... Authors: Miotto, M.C, Marks, A.R. Deposit date: 2023-11-09 Release date: 2023-11-22 Method: ELECTRON MICROSCOPY (3.56 Å) Cite: Structural basis for ryanodine receptor type 2 leak in heart failure and arrhythmogenic disorders To Be Published
3EVR	Crystal structure of Calcium bound monomeric GCAMP2 Descriptor: CALCIUM ION, Myosin light chain kinase, Green fluorescent protein, ... Authors: Wang, Q, Shui, B, Kotlikoff, M.I, Sondermann, H. Deposit date: 2008-10-13 Release date: 2008-12-09 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural Basis for Calcium Sensing by GCaMP2. Structure, 16, 2008
3EVU	Crystal structure of Calcium bound dimeric GCAMP2 Descriptor: CALCIUM ION, Myosin light chain kinase, Green fluorescent protein, ... Authors: Wang, Q, Shui, B, Kotlikoff, M.I, Sondermann, H. Deposit date: 2008-10-13 Release date: 2008-12-09 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Structural Basis for Calcium Sensing by GCaMP2. Structure, 16, 2008
1MF8	Crystal Structure of human calcineurin complexed with cyclosporin A and human cyclophilin Descriptor: CALCINEURIN B SUBUNIT ISOFORM 1, CALCIUM ION, CALMODULIN-DEPENDENT CALCINEURIN A SUBUNIT, ... Authors: Jin, L, Harrison, S.C. Deposit date: 2002-08-09 Release date: 2002-10-16 Last modified: 2012-12-12 Method: X-RAY DIFFRACTION (3.1 Å) Cite: Crystal Structure of Human Calcineurin Complexed with Cyclosporin a and Human Cyclophilin Proc.Natl.Acad.Sci.USA, 99, 2002
2Y0A	Structure of DAPK1 construct residues 1-304 Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, DEATH-ASSOCIATED PROTEIN KINASE 1 Authors: Yumerefendi, H, Mas, P.J, Dordevic, N, McCarthy, A.A, Hart, D.J. Deposit date: 2010-12-01 Release date: 2011-12-14 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Library-Based Construct Screening of Death-Associated Protein Kinase 1 Identifies the Minimal Calmodulin Interaction Region and Autoinhibitory Conformation of the Catalytic Domain To be Published
1S6J	N-terminal Region of the Ca2+-saturated calcium regulatory domain (CLD) from Soybean Calcium-dependent Protein Kinase-alpha (CDPK) Descriptor: CALCIUM ION, Calcium-dependent protein kinase SK5 Authors: Weljie, A.M, Vogel, H.J. Deposit date: 2004-01-23 Release date: 2004-12-21 Last modified: 2024-05-22 Method: SOLUTION NMR Cite: Solution Structure and Backbone Dynamics of the N-Terminal Region of the Calcium Regulatory Domain from Soybean Calcium-Dependent Protein Kinase alpha Biochemistry, 42, 2004
7U9T	Structure of PKA phosphorylated human RyR2 in the closed state in the presence of Calmodulin Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Calmodulin-1, Peptidyl-prolyl cis-trans isomerase FKBP1B, ... Authors: Miotto, M.C, Marks, A.R. Deposit date: 2022-03-11 Release date: 2022-08-03 Method: ELECTRON MICROSCOPY (2.68 Å) Cite: Structural analyses of human ryanodine receptor type 2 channels reveal the mechanisms for sudden cardiac death and treatment. Sci Adv, 8, 2022

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