1TFR
| RNASE H FROM BACTERIOPHAGE T4 | Descriptor: | MAGNESIUM ION, T4 RNASE H | Authors: | Mueser, T.C, Nossal, N.G, Hyde, C.C. | Deposit date: | 1996-04-27 | Release date: | 1996-11-08 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.06 Å) | Cite: | Structure of bacteriophage T4 RNase H, a 5' to 3' RNA-DNA and DNA-DNA exonuclease with sequence similarity to the RAD2 family of eukaryotic proteins. Cell(Cambridge,Mass.), 85, 1996
|
|
1LBS
| LIPASE (E.C.3.1.1.3) (TRIACYLGLYCEROL HYDROLASE) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, LIPASE B, N-HEXYLPHOSPHONATE ETHYL ESTER | Authors: | Uppenberg, J, Jones, T.A. | Deposit date: | 1995-07-11 | Release date: | 1995-10-15 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Crystallographic and molecular-modeling studies of lipase B from Candida antarctica reveal a stereospecificity pocket for secondary alcohols. Biochemistry, 34, 1995
|
|
1NRJ
| |
1PN2
| Crystal structure analysis of the selenomethionine labelled 2-enoyl-CoA hydratase 2 domain of Candida tropicalis multifunctional enzyme type 2 | Descriptor: | 1,2-ETHANEDIOL, Peroxisomal hydratase-dehydrogenase-epimerase | Authors: | Koski, M.K, Haapalainen, A.M, Hiltunen, J.K, Glumoff, T. | Deposit date: | 2003-06-12 | Release date: | 2004-04-13 | Last modified: | 2021-10-27 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | A Two-domain Structure of One Subunit Explains Unique Features of Eukaryotic Hydratase 2. J.Biol.Chem., 279, 2004
|
|
7VWK
| The product template domain of AviM | Descriptor: | Polyketide synthase | Authors: | Feng, Y, Yang, X, Zheng, J. | Deposit date: | 2021-11-10 | Release date: | 2022-06-08 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The Streptomyces viridochromogenes product template domain represents an evolutionary intermediate between dehydratase and aldol cyclase of type I polyketide synthases. Commun Biol, 5, 2022
|
|
7BUP
| |
4R7P
| Human UDP-glucose pyrophosphorylase isoform 1 in complex with UDP-glucose | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, SULFATE ION, ... | Authors: | Fuehring, J, Cramer, J.T, Schneider, J, Baruch, P, Gerardy-Schahn, R, Fedorov, R. | Deposit date: | 2014-08-28 | Release date: | 2015-04-22 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (3.35 Å) | Cite: | A Quaternary Mechanism Enables the Complex Biological Functions of Octameric Human UDP-glucose Pyrophosphorylase, a Key Enzyme in Cell Metabolism. Sci Rep, 5
|
|
4R4S
| Crystal structure of chimeric beta-lactamase cTEM-19m at 1.1 angstrom resolution | Descriptor: | Beta-lactamase TEM,Beta-lactamase PSE-4, CHLORIDE ION, MAGNESIUM ION | Authors: | Park, J, Gobeil, S, Pelletier, J.N, Berghuis, A.M. | Deposit date: | 2014-08-19 | Release date: | 2015-11-11 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.1 Å) | Cite: | The Structural Dynamics of Engineered beta-Lactamases Vary Broadly on Three Timescales yet Sustain Native Function. Sci Rep, 9, 2019
|
|
7BYD
| Crystal structure of SN45 TCR in complex with lipopeptide-bound Mamu-B*05104 | Descriptor: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, B protein, ... | Authors: | Morita, D, Sugita, M, Iwashita, C. | Deposit date: | 2020-04-22 | Release date: | 2021-03-31 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.80003262 Å) | Cite: | Crystal structure of the ternary complex of TCR, MHC class I and lipopeptides. Int.Immunol., 32, 2020
|
|
7BTJ
| |
2YIW
| triazolopyridine inhibitors of p38 kinase | Descriptor: | 1-(3-tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(2-{[3-(1-methylethyl)[1,2,4]triazolo[4,3-a]pyridin-6-yl]sulfanyl}benzyl)urea, 2-fluoro-4-[4-(4-fluorophenyl)-1H-pyrazol-3-yl]pyridine, MITOGEN-ACTIVATED PROTEIN KINASE 14 | Authors: | Millan, D.S, Anderson, M, Bunnage, M.E, Burrows, J.L, Butcher, K.J, Dodd, P.G, Evans, T.J, Fairman, D.A, Hughes, S.J, Irving, S.L, Kilty, I.C, Lemaitre, A, Lewthwaite, R.A, Mahnke, A, Mathais, J.P, Philip, J, Phillips, C, Smith, R.T, Stefamiak, M.H, Yeadon, M. | Deposit date: | 2011-05-17 | Release date: | 2011-11-30 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Design and Synthesis of Inhaled P38 Inhibitors for the Treatment of Chronic Obstructive Pulmonary Disease. J.Med.Chem., 54, 2011
|
|
6STK
| |
6G4A
| FLN5 (full length) | Descriptor: | Gelation factor | Authors: | Waudby, C.A, Wlodarski, T, Karyadi, M.-E, Cassaignau, A.M.E, Chan, S.H.S, Wentink, A.S, Schmidt-Engler, J.M, Camilloni, C, Vendruscolo, M, Cabrita, L.D, Christodoulou, J. | Deposit date: | 2018-03-27 | Release date: | 2019-04-10 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Mapping energy landscapes of a growing filamin domain reveals an intermediate associated with proline isomerization during biosynthesis To Be Published
|
|
4QXM
| Crystal structure of the InhA:GSK_SB713 complex | Descriptor: | Enoyl-[acyl-carrier-protein] reductase [NADH], N-(2-chloro-4-fluorobenzyl)-4-[(3,5-dimethyl-1H-pyrazol-1-yl)methyl]benzamide, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | Authors: | Gulten, G, Sacchettini, J.C. | Deposit date: | 2014-07-21 | Release date: | 2015-07-22 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.196 Å) | Cite: | N-Benzyl-4-((heteroaryl)methyl)benzamides: A New Class of Direct NADH-Dependent 2-trans Enoyl-Acyl Carrier Protein Reductase (InhA) Inhibitors with Antitubercular Activity. Chemmedchem, 11, 2016
|
|
6THY
| Botulinum neurotoxin A3 Hc domain in complex with GD1a | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, BoNT/A3, ... | Authors: | Gregory, K.S, Acharya, K.R, Liu, S.M. | Deposit date: | 2019-11-21 | Release date: | 2020-01-29 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Crystal structure of botulinum neurotoxin subtype A3 cell binding domain in complex with GD1a co-receptor ganglioside. Febs Open Bio, 10, 2020
|
|
4R30
| |
7WCE
| Crystal structure of HIV-1 integrase catalytic core domain in complex with (2S)-2-(tert-Butoxy)-2-(10-fluoro-2-(2-hydroxy-4-methylphenyl)-1,4-dimethyl-5-(methylsulfonyl)-5,6-dihydrophenanthridin-3-yl)acetic acid | Descriptor: | (2S)-2-[10-fluoranyl-1,4-dimethyl-2-(4-methyl-2-oxidanyl-phenyl)-5-methylsulfonyl-6H-phenanthridin-3-yl]-2-[(2-methylpropan-2-yl)oxy]ethanoic acid, GLYCEROL, Integrase catalytic, ... | Authors: | Taoda, Y, Sekiguchi, Y. | Deposit date: | 2021-12-20 | Release date: | 2022-09-07 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Discovery of tricyclic HIV-1 integrase-LEDGF/p75 allosteric inhibitors by intramolecular direct arylation reaction. Bioorg.Med.Chem.Lett., 64, 2022
|
|
6GDA
| Cytochrome c in complex with Sulfonato-calix[8]arene, P43212 form soaked with Spermine | Descriptor: | Cytochrome c iso-1, HEME C, SPERMINE, ... | Authors: | Rennie, M.L, Fox, G.C, Crowley, P.B. | Deposit date: | 2018-04-23 | Release date: | 2019-05-01 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Tuning Protein Frameworks via Auxiliary Supramolecular Interactions. Acs Nano, 13, 2019
|
|
4RDP
| Crystal structure of Cmr4 | Descriptor: | CRISPR system Cmr subunit Cmr4 | Authors: | Shao, Y, Tang, L, Li, H. | Deposit date: | 2014-09-19 | Release date: | 2014-12-24 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Essential Structural and Functional Roles of the Cmr4 Subunit in RNA Cleavage by the Cmr CRISPR-Cas Complex. Cell Rep, 9, 2014
|
|
4F2N
| |
6GID
| High resolution crystal structure of substrate-free human neprilysin | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, DI(HYDROXYETHYL)ETHER, ... | Authors: | Moss, S, Subramanian, V, Acharya, K.R. | Deposit date: | 2018-05-10 | Release date: | 2018-06-27 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | High resolution crystal structure of substrate-free human neprilysin. J. Struct. Biol., 204, 2018
|
|
5KDK
| |
3LGB
| |
6TT3
| |
5KEH
| |