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2AJG
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Crystal structure of the editing domain of E. coli leucyl-tRNA synthetase
Descriptor: Leucyl-tRNA synthetase
Authors:Liu, Y, Liao, J, Zhu, B, Wang, E.D, Ding, J.
Deposit date:2005-08-01
Release date:2006-01-24
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structures of the editing domain of Escherichia coli leucyl-tRNA synthetase and its complexes with Met and Ile reveal a lock-and-key mechanism for amino acid discrimination
Biochem.J., 394, 2006
2AJH
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Crystal structure of the editing domain of E. coli leucyl-tRNA synthetase complexes with methionine
Descriptor: Leucyl-tRNA synthetase, METHIONINE
Authors:Liu, Y, Liao, J, Zhu, B, Wang, E.D, Ding, J.
Deposit date:2005-08-02
Release date:2006-01-24
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structures of the editing domain of Escherichia coli leucyl-tRNA synthetase and its complexes with Met and Ile reveal a lock-and-key mechanism for amino acid discrimination
Biochem.J., 394, 2006
2CYA
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BU of 2cya by Molmil
Crystal structure of tyrosyl-tRNA synthetase from Aeropyrum pernix
Descriptor: SULFATE ION, Tyrosyl-tRNA synthetase
Authors:Kuratani, M, Sakai, H, Takahashi, M, Yanagisawa, T, Kobayashi, T, Murayama, K, Chen, L, Liu, Z.J, Wang, B.C, Kuroishi, C, Kuramitsu, S, Terada, T, Bessho, Y, Shirouzu, M, Sekine, S.I, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2005-07-06
Release date:2005-11-22
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal Structures of Tyrosyl-tRNA Synthetases from Archaea
J.Mol.Biol., 355, 2005
2HRA
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Crystal structures of the interacting domains from yeast glutamyl-tRNA synthetase and tRNA aminoacylation and nuclear export cofactor Arc1p reveal a novel function for an old fold
Descriptor: Glutamyl-tRNA synthetase, cytoplasmic, IODIDE ION
Authors:Simader, H, Hothorn, M, Suck, D.
Deposit date:2006-07-20
Release date:2006-09-05
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structures of the interacting domains from yeast glutamyl-tRNA synthetase and tRNA-aminoacylation and nuclear-export cofactor Arc1p reveal a novel function for an old fold.
ACTA CRYSTALLOGR.,SECT.D, 62, 2006
2CYC
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Crystal structure of Tyrosyl-tRNA Synthetase complexed with L-tyrosine from Pyrococcus horikoshii
Descriptor: TYROSINE, tyrosyl-tRNA synthetase
Authors:Kuratani, M, Sakai, H, Takahashi, M, Yanagisawa, T, Kobayashi, T, Sakamoto, K, Terada, T, Shirouzu, M, Sekine, S, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2005-07-06
Release date:2005-11-22
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal Structures of Tyrosyl-tRNA Synthetases from Archaea
J.Mol.Biol., 355, 2006
2E3C
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Crystal structure of the catalytic domain of pyrrolysyl-tRNA synthetase
Descriptor: Pyrrolysyl-tRNA synthetase
Authors:Yanagisawa, T, Ishii, R, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2006-11-22
Release date:2007-12-11
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Crystallographic Studies on Multiple Conformational States of Active-site Loops in Pyrrolysyl-tRNA Synthetase
J.Mol.Biol., 378, 2008
2I4N
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Rhodopseudomonas palustris prolyl-tRNA synthetase in complex with CysAMS
Descriptor: 5'-O-(N-(L-CYSTEINYL)-SULFAMOYL)ADENOSINE, Proline-tRNA ligase
Authors:Crepin, T, Yaremchuk, A, Tukalo, M, Cusack, S.
Deposit date:2006-08-22
Release date:2006-10-24
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Structures of Two Bacterial Prolyl-tRNA Synthetases with and without a cis-Editing Domain.
Structure, 14, 2006
2I4M
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Rhodopseudomonas palustris prolyl-tRNA synthetase in complex with ProAMS
Descriptor: '5'-O-(N-(L-PROLYL)-SULFAMOYL)ADENOSINE, Proline-tRNA ligase
Authors:Crepin, T, Yaremchuk, A, Tukalo, M, Cusack, S.
Deposit date:2006-08-22
Release date:2006-10-24
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structures of Two Bacterial Prolyl-tRNA Synthetases with and without a cis-Editing Domain.
Structure, 14, 2006
2ZTG
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Crystal structure of Archaeoglobus fulgidus alanyl-tRNA synthetase lacking the C-terminal dimerization domain in complex with Ala-SA
Descriptor: '5'-O-(N-(L-ALANYL)-SULFAMOYL)ADENOSINE, Alanyl-tRNA synthetase, ZINC ION
Authors:Naganuma, M, Sekine, S, Fukunaga, R, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2008-10-01
Release date:2009-06-30
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Unique protein architecture of alanyl-tRNA synthetase for aminoacylation, editing, and dimerization.
Proc.Natl.Acad.Sci.USA, 106, 2009
7RDN
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Crystal structure of S. cerevisiae pre-mRNA leakage protein 39 (Pml39)
Descriptor: Pre-mRNA leakage protein 39, ZINC ION
Authors:Hashimoto, H, Ramirez, D.H, Pawlak, N, Blobel, G, Palancade, B, Debler, E.W.
Deposit date:2021-07-09
Release date:2022-07-27
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (2.49 Å)
Cite:Structure of the pre-mRNA leakage 39-kDa protein reveals a single domain of integrated zf-C3HC and Rsm1 modules.
Sci Rep, 12, 2022
1H4T
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Prolyl-tRNA synthetase from Thermus thermophilus complexed with L-proline
Descriptor: PROLINE, PROLYL-TRNA SYNTHETASE, ZINC ION
Authors:Yaremchuk, A, Tukalo, M, Cusack, S.
Deposit date:2001-05-14
Release date:2001-06-18
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:A Succession of Substrate Induced Conformational Changes Ensures the Amino Acid Specificity of Thermus Thermophilus Prolyl-tRNA Synthetase: Comparison with Histidyl-tRNA Synthetase
J.Mol.Biol., 309, 2001
2ODR
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Methanococcus Maripaludis Phosphoseryl-tRNA synthetase
Descriptor: phosphoseryl-tRNA synthetase
Authors:Steitz, T.A, Kamtekar, S.
Deposit date:2006-12-26
Release date:2007-02-13
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (3.228 Å)
Cite:Toward understanding phosphoseryl-tRNACys formation: the crystal structure of Methanococcus maripaludis phosphoseryl-tRNA synthetase.
Proc.Natl.Acad.Sci.Usa, 104, 2007
2Q5I
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Crystal structure of apo S581L Glycyl-tRNA synthetase mutant
Descriptor: Glycyl-tRNA synthetase, SULFATE ION
Authors:Cader, M.Z, Ren, J, James, P.A, Bird, L.E, Talbot, K, Stammers, D.K, Oxford Protein Production Facility (OPPF)
Deposit date:2007-06-01
Release date:2007-06-19
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of human wildtype and S581L-mutant glycyl-tRNA synthetase, an enzyme underlying distal spinal muscular atrophy.
Febs Lett., 581, 2007
2PME
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The Apo crystal Structure of the glycyl-tRNA synthetase
Descriptor: Glycyl-tRNA synthetase
Authors:Xie, W.
Deposit date:2007-04-21
Release date:2007-05-22
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Long-range structural effects of a Charcot-Marie- Tooth disease-causing mutation in human glycyl-tRNA synthetase.
Proc.Natl.Acad.Sci.Usa, 104, 2007
7AP4
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Thermus thermophilus Aspartyl-tRNA Synthetase in Complex with Compound AspS7HMDDA
Descriptor: (3~{S})-3-azanyl-4-[[(2~{R},3~{S},4~{R},5~{R})-5-[7-azanyl-5-(hydroxymethyl)benzimidazol-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxysulfonylamino]-4-oxidanylidene-butanoic acid, Aspartate--tRNA(Asp) ligase
Authors:De Graef, S, Pang, L, Strelkov, S.V, Weeks, S.D.
Deposit date:2020-10-15
Release date:2020-12-09
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Synthesis and Biological Evaluation of 1,3-Dideazapurine-Like 7-Amino-5-Hydroxymethyl-Benzimidazole Ribonucleoside Analogues as Aminoacyl-tRNA Synthetase Inhibitors.
Molecules, 25, 2020
2Q7H
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Pyrrolysyl-tRNA synthetase bound to adenylated pyrrolysine and pyrophosphate
Descriptor: (2R)-2-AMINO-6-({[(2S,3R)-3-METHYLPYRROLIDIN-2-YL]CARBONYL}AMINO)HEXANOYL [(2S,3R,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL HYDROGEN (R)-PHOSPHATE, 1,2-ETHANEDIOL, PYROPHOSPHATE 2-, ...
Authors:Kavran, J.M, Steitz, T.A.
Deposit date:2007-06-06
Release date:2007-07-24
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure of pyrrolysyl-tRNA synthetase, an archaeal enzyme for genetic code innovation.
Proc.Natl.Acad.Sci.Usa, 104, 2007
7AP1
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Klebsiella pneumoniae Seryl-tRNA synthetase in Complex with Compound SerS7HMDDA
Descriptor: 1,2-ETHANEDIOL, CALCIUM ION, Serine-tRNA ligase, ...
Authors:Pang, L, De Graef, S, Strelkov, S.V, Weeks, S.D.
Deposit date:2020-10-15
Release date:2020-11-11
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:Synthesis and Biological Evaluation of 1,3-Dideazapurine-Like 7-Amino-5-Hydroxymethyl-Benzimidazole Ribonucleoside Analogues as Aminoacyl-tRNA Synthetase Inhibitors.
Molecules, 25, 2020
2Q5H
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Crystal structure of apo-wildtype Glycyl-tRNA synthetase
Descriptor: Glycyl-tRNA synthetase
Authors:Cader, M.Z, Ren, J, James, P.A, Bird, L.E, Talbot, K, Stammers, D.K, Oxford Protein Production Facility (OPPF)
Deposit date:2007-06-01
Release date:2007-06-19
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structure of human wildtype and S581L-mutant glycyl-tRNA synthetase, an enzyme underlying distal spinal muscular atrophy.
Febs Lett., 581, 2007
3O0A
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BU of 3o0a by Molmil
Crystal structure of the wild type CP1 hydrolitic domain from Aquifex Aeolicus leucyl-trna
Descriptor: Leucyl-tRNA synthetase subunit alpha
Authors:Cura, V, Olieric, N, Wang, E.-D, Moras, D, Eriani, G, Cavarelli, J.
Deposit date:2010-07-19
Release date:2010-11-17
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Crystal Structure of the Wild Type and Two Mutants of the Cp1 Hydrolytic Domain from Aquifex Aeolicus Leucyl-tRNA Synthetase
To be Published
1HTT
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BU of 1htt by Molmil
HISTIDYL-TRNA SYNTHETASE
Descriptor: ADENOSINE MONOPHOSPHATE, HISTIDINE, HISTIDYL-TRNA SYNTHETASE
Authors:Arnez, J.G, Harris, D.C, Mitschler, A, Rees, B, Francklyn, C.S, Moras, D.
Deposit date:1996-03-09
Release date:1997-01-27
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure of histidyl-tRNA synthetase from Escherichia coli complexed with histidyl-adenylate.
EMBO J., 14, 1995
1GPJ
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Glutamyl-tRNA Reductase from Methanopyrus kandleri
Descriptor: (2R,3R,4S,5S)-4-AMINO-2-[6-(DIMETHYLAMINO)-9H-PURIN-9-YL]-5-(HYDROXYMETHYL)TETRAHYDRO-3-FURANOL, CITRIC ACID, GLUTAMIC ACID, ...
Authors:Moser, J, Schubert, W.-D, Beier, V, Bringemeier, I, Jahn, D, Heinz, D.W.
Deposit date:2001-11-05
Release date:2002-01-04
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:V-shaped structure of glutamyl-tRNA reductase, the first enzyme of tRNA-dependent tetrapyrrole biosynthesis.
EMBO J., 20, 2001
1WK8
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Isoleucyl-tRNA synthetase editing domain complexed with the pre-transfer editing substrate analogue, Val-AMS
Descriptor: 5'O-[N-(L-VALYL)SULPHAMOYL]ADENOSINE, Isoleucyl-tRNA synthetase
Authors:Fukunaga, R, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2004-05-30
Release date:2005-09-27
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural basis for substrate recognition by the editing domain of isoleucyl-tRNA synthetase
J.Mol.Biol., 359, 2006
1WKA
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Structural basis for non-cognate amino acid discrimination by the valyl-tRNA synthetase editing domain
Descriptor: Valyl-tRNA synthetase
Authors:Fukunaga, R, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2004-05-30
Release date:2005-06-28
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural Basis for Non-cognate Amino Acid Discrimination by the Valyl-tRNA Synthetase Editing Domain
J.Biol.Chem., 280, 2005
1X55
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Crystal structure of asparaginyl-tRNA synthetase from Pyrococcus horikoshii complexed with asparaginyl-adenylate analogue
Descriptor: 5'-O-[N-(L-ASPARAGINYL)SULFAMOYL]ADENOSINE, Asparaginyl-tRNA synthetase, MAGNESIUM ION, ...
Authors:Iwasaki, W, Sekine, S, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2005-05-15
Release date:2006-05-23
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural Basis of the Water-assisted Asparagine Recognition by Asparaginyl-tRNA Synthetase.
J.Mol.Biol., 360, 2006
1X54
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Crystal structure of asparaginyl-tRNA synthetase from Pyrococcus horikoshii complexed with asparaginyl-adenylate
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 4-AMINO-1,4-DIOXOBUTAN-2-AMINIUM ADENOSINE-5'-MONOPHOSPHATE, Asparaginyl-tRNA synthetase, ...
Authors:Iwasaki, W, Sekine, S, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2005-05-15
Release date:2006-05-23
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Structural Basis of the Water-assisted Asparagine Recognition by Asparaginyl-tRNA Synthetase.
J.Mol.Biol., 360, 2006

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