7UKF
| Human Kv4.2-KChIP2 channel complex in a putative resting state, transmembrane region | Descriptor: | MERCURY (II) ION, POTASSIUM ION, Potassium voltage-gated channel subfamily D member 2 | Authors: | Zhao, H, Dai, Y, Lee, C.H. | Deposit date: | 2022-04-01 | Release date: | 2022-06-29 | Last modified: | 2024-02-14 | Method: | ELECTRON MICROSCOPY (3.02 Å) | Cite: | Activation and closed-state inactivation mechanisms of the human voltage-gated K V 4 channel complexes. Mol.Cell, 82, 2022
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7UKE
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7UKD
| Human Kv4.2-KChIP2 channel complex in an inactivated state, class 2, transmembrane region | Descriptor: | POTASSIUM ION, Potassium voltage-gated channel subfamily D member 2 | Authors: | Zhao, H, Dai, Y, Lee, C.H. | Deposit date: | 2022-04-01 | Release date: | 2022-06-29 | Last modified: | 2024-02-14 | Method: | ELECTRON MICROSCOPY (2.88 Å) | Cite: | Activation and closed-state inactivation mechanisms of the human voltage-gated K V 4 channel complexes. Mol.Cell, 82, 2022
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7UKC
| Human Kv4.2-KChIP2 channel complex in an inactivated state, class 1, transmembrane region | Descriptor: | POTASSIUM ION, Potassium voltage-gated channel subfamily D member 2 | Authors: | Zhao, H, Dai, Y, Lee, C.H. | Deposit date: | 2022-04-01 | Release date: | 2022-06-29 | Last modified: | 2024-02-14 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Activation and closed-state inactivation mechanisms of the human voltage-gated K V 4 channel complexes. Mol.Cell, 82, 2022
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7UK5
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7UHG
| Human L-type voltage-gated calcium channel Cav1.3 at 3.0 Angstrom resolution | Descriptor: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Gao, S, Yao, X, Yan, N. | Deposit date: | 2022-03-26 | Release date: | 2022-05-11 | Last modified: | 2022-10-12 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structural basis for pore blockade of human voltage-gated calcium channel Ca v 1.3 by motion sickness drug cinnarizine. Cell Res., 32, 2022
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7UHF
| Human L-type voltage-gated calcium channel Cav1.3 in the presence of cinnarizine at 3.1 Angstrom resolution | Descriptor: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, 1-(diphenylmethyl)-4-[(2E)-3-phenylprop-2-en-1-yl]piperazine, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Gao, S, Yao, X, Yan, N. | Deposit date: | 2022-03-26 | Release date: | 2022-05-11 | Last modified: | 2022-10-12 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural basis for pore blockade of human voltage-gated calcium channel Ca v 1.3 by motion sickness drug cinnarizine. Cell Res., 32, 2022
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7UGG
| Cryo-EM structure of TRPV3 in complex with the anesthetic dyclonine | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Dyclonine, SODIUM ION, ... | Authors: | Neuberger, A, Nadezhdin, K.D, Sobolevsky, A.I. | Deposit date: | 2022-03-24 | Release date: | 2022-06-08 | Last modified: | 2024-02-14 | Method: | ELECTRON MICROSCOPY (3.16 Å) | Cite: | Structural mechanism of TRPV3 channel inhibition by the anesthetic dyclonine. Nat Commun, 13, 2022
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7UA9
| Structure of dephosphorylated human RyR2 in the open state | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, Peptidyl-prolyl cis-trans isomerase FKBP1B, ... | Authors: | Miotto, M.C, Marks, A.R. | Deposit date: | 2022-03-11 | Release date: | 2022-08-03 | Method: | ELECTRON MICROSCOPY (3.59 Å) | Cite: | Structural analyses of human ryanodine receptor type 2 channels reveal the mechanisms for sudden cardiac death and treatment. Sci Adv, 8, 2022
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7UA5
| Structure of dephosphorylated human RyR2 in the closed state | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Peptidyl-prolyl cis-trans isomerase FKBP1B, Ryanodine receptor 2, ... | Authors: | Miotto, M.C, Marks, A.R. | Deposit date: | 2022-03-11 | Release date: | 2022-08-03 | Method: | ELECTRON MICROSCOPY (2.83 Å) | Cite: | Structural analyses of human ryanodine receptor type 2 channels reveal the mechanisms for sudden cardiac death and treatment. Sci Adv, 8, 2022
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7UA4
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7UA3
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7UA1
| Structure of PKA phosphorylated human RyR2-R2474S in the closed state in the presence of ARM210 | Descriptor: | 4-[(7-methoxy-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)methyl]benzoic acid, ADENOSINE-5'-TRIPHOSPHATE, Peptidyl-prolyl cis-trans isomerase FKBP1B, ... | Authors: | Miotto, M.C, Marks, A.R. | Deposit date: | 2022-03-11 | Release date: | 2022-08-03 | Method: | ELECTRON MICROSCOPY (2.99 Å) | Cite: | Structural analyses of human ryanodine receptor type 2 channels reveal the mechanisms for sudden cardiac death and treatment. Sci Adv, 8, 2022
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7U9Z
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7U9X
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7U9T
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7U9R
| Structure of PKA phosphorylated human RyR2 in the open state | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, Peptidyl-prolyl cis-trans isomerase FKBP1B, ... | Authors: | Miotto, M.C, Marks, A.R. | Deposit date: | 2022-03-11 | Release date: | 2022-08-03 | Method: | ELECTRON MICROSCOPY (3.69 Å) | Cite: | Structural analyses of human ryanodine receptor type 2 channels reveal the mechanisms for sudden cardiac death and treatment. Sci Adv, 8, 2022
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7U9Q
| Structure of PKA phosphorylated human RyR2 in the closed state | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Peptidyl-prolyl cis-trans isomerase FKBP1B, Ryanodine receptor 2, ... | Authors: | Miotto, M.C, Marks, A.R. | Deposit date: | 2022-03-11 | Release date: | 2022-08-03 | Method: | ELECTRON MICROSCOPY (3.11 Å) | Cite: | Structural analyses of human ryanodine receptor type 2 channels reveal the mechanisms for sudden cardiac death and treatment. Sci Adv, 8, 2022
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7TZC
| A drug and ATP binding site in type 1 ryanodine receptor | Descriptor: | (2S)-3-(octadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 4-[(7-methoxy-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)methyl]benzoic acid, ADENOSINE-5'-TRIPHOSPHATE, ... | Authors: | Melville, Z, Dridi, H, Yuan, Q, Reiken, S, Anetta, W, Liu, Y, Clarke, O.B, Marks, A.R. | Deposit date: | 2022-02-15 | Release date: | 2022-05-18 | Last modified: | 2022-07-20 | Method: | ELECTRON MICROSCOPY (2.45 Å) | Cite: | A drug and ATP binding site in type 1 ryanodine receptor. Structure, 30, 2022
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7TJ9
| Cryo-EM structure of the human Nax channel in complex with beta3 solved in GDN | Descriptor: | (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Noland, C.L, Kschonsak, M, Ciferri, C, Payandeh, J. | Deposit date: | 2022-01-14 | Release date: | 2022-03-30 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structure-guided unlocking of Na X reveals a non-selective tetrodotoxin-sensitive cation channel. Nat Commun, 13, 2022
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7TJ8
| Cryo-EM structure of the human Nax channel in complex with beta3 solved in nanodiscs | Descriptor: | (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Noland, C.L, Kschonsak, M, Ciferri, C, Payandeh, J. | Deposit date: | 2022-01-14 | Release date: | 2022-03-30 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structure-guided unlocking of Na X reveals a non-selective tetrodotoxin-sensitive cation channel. Nat Commun, 13, 2022
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7TDK
| Rabbit RyR1 with AMP-PCP and high Ca2+ embedded in nanodisc in closed-inactivated conformation class 3 (Dataset-A) | Descriptor: | CALCIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, Ryanodine receptor 1,Ryanodine receptor 1,RyR1, ... | Authors: | Nayak, A.R, Samso, M. | Deposit date: | 2021-12-31 | Release date: | 2022-03-09 | Last modified: | 2022-03-16 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Ca 2+ -inactivation of the mammalian ryanodine receptor type 1 in a lipidic environment revealed by cryo-EM. Elife, 11, 2022
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7TDJ
| Rabbit RyR1 with AMP-PCP and high Ca2+ embedded in nanodisc in closed-inactivated conformation class 1(Dataset-A) | Descriptor: | CALCIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, Ryanodine receptor 1,Ryanodine receptor 1,RyR1, ... | Authors: | Nayak, A.R, Samso, M. | Deposit date: | 2021-12-31 | Release date: | 2022-03-09 | Last modified: | 2022-03-16 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Ca 2+ -inactivation of the mammalian ryanodine receptor type 1 in a lipidic environment revealed by cryo-EM. Elife, 11, 2022
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7TDI
| Rabbit RyR1 with AMP-PCP and high Ca2+ embedded in nanodisc in closed-inactivated conformation class 2 (Dataset-A) | Descriptor: | CALCIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, Ryanodine receptor 1,Ryanodine receptor 1,RyR1, ... | Authors: | Nayak, A.R, Samso, M. | Deposit date: | 2021-12-31 | Release date: | 2022-03-09 | Last modified: | 2022-03-16 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Ca 2+ -inactivation of the mammalian ryanodine receptor type 1 in a lipidic environment revealed by cryo-EM. Elife, 11, 2022
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7TDH
| Rabbit RyR1 with AMP-PCP and high Ca2+ embedded in nanodisc in open conformation | Descriptor: | CALCIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, Ryanodine receptor 1,Ryanodine receptor 1,RyR1, ... | Authors: | Nayak, A.R, Samso, M. | Deposit date: | 2021-12-31 | Release date: | 2022-03-09 | Last modified: | 2024-02-28 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Ca 2+ -inactivation of the mammalian ryanodine receptor type 1 in a lipidic environment revealed by cryo-EM. Elife, 11, 2022
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