7FBD
| De novo design protein D53 with MBP tag | Descriptor: | Maltodextrin-binding protein,De novo design protein D53 | Authors: | Bin, H. | Deposit date: | 2021-07-09 | Release date: | 2021-12-22 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | A backbone-centred energy function of neural networks for protein design. Nature, 602, 2022
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7FBC
| De novo design protein D22 with MBP tag | Descriptor: | Maltodextrin-binding protein,De novo design protein D22 | Authors: | Bin, H. | Deposit date: | 2021-07-09 | Release date: | 2021-12-22 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | A backbone-centred energy function of neural networks for protein design. Nature, 602, 2022
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7FBB
| De novo design protein D12 with MBP tag | Descriptor: | Maltodextrin-binding protein,de novo designed protein D12 | Authors: | Bin, H. | Deposit date: | 2021-07-09 | Release date: | 2021-12-22 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2.307 Å) | Cite: | A backbone-centred energy function of neural networks for protein design. Nature, 602, 2022
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6VFK
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4QKR
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8UMP
| T33-ml35 - Designed Tetrahedral Protein Cage Using Machine Learning Algorithms | Descriptor: | T33-ml35-redesigned-CutA-fold, T33-ml35-redesigned-TPR-domain-fold | Authors: | Castells-Graells, R, Meador, K, Sawaya, M.R, Yeates, T.O. | Deposit date: | 2023-10-18 | Release date: | 2023-11-15 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (2.92 Å) | Cite: | A suite of designed protein cages using machine learning and protein fragment-based protocols. Structure, 32, 2024
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8UF0
| T33-ml23 - Designed Tetrahedral Protein Cage Using Machine Learning Algorithms | Descriptor: | T33-ml23-redesigned-CutA-fold, T33-ml23-redesigned-tandem-BMC-T-fold | Authors: | Castells-Graells, R, Meador, K, Sawaya, M.R, Yeates, T.O. | Deposit date: | 2023-10-03 | Release date: | 2023-11-15 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (2.02 Å) | Cite: | A suite of designed protein cages using machine learning and protein fragment-based protocols. Structure, 32, 2024
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8UI2
| T33-ml28 - Designed Tetrahedral Protein Cage Using Machine Learning Algorithms | Descriptor: | T33-ml28-redesigned-CutA-fold, T33-ml28-redesigned-tandem-BMC-T-fold | Authors: | Castells-Graells, R, Meador, K, Sawaya, M.R, Yeates, T.O. | Deposit date: | 2023-10-09 | Release date: | 2024-03-06 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (2.73 Å) | Cite: | A suite of designed protein cages using machine learning and protein fragment-based protocols. Structure, 32, 2024
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8UKM
| T33-ml30 - Designed Tetrahedral Protein Cage Using Machine Learning Algorithms | Descriptor: | T33-ml30-redesigned-4-OT-fold, T33-ml30-redesigned-tandem-BMC-T-fold | Authors: | Castells-Graells, R, Meador, K, Sawaya, M.R, Yeates, T.O. | Deposit date: | 2023-10-14 | Release date: | 2024-03-06 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | A suite of designed protein cages using machine learning and protein fragment-based protocols. Structure, 32, 2024
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8UN1
| T33-ml23 Assembly Intermediate - Designed Tetrahedral Protein Cage Using Machine Learning Algorithms | Descriptor: | T33-ml23-redesigned-CutA-fold, T33-ml23-redesigned-tandem-BMC-T-fold | Authors: | Castells-Graells, R, Meador, K, Sawaya, M.R, Yeates, T.O. | Deposit date: | 2023-10-18 | Release date: | 2024-03-06 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | A suite of designed protein cages using machine learning and protein fragment-based protocols. Structure, 32, 2024
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8UMR
| T33-ml35 Assembly Intermediate - Designed Tetrahedral Protein Cage Using Machine Learning Algorithms | Descriptor: | T33-ml35-redesigned-CutA-fold, T33-ml35-redesigned-TPR-domain-fold | Authors: | Castells-Graells, R, Meador, K, Sawaya, M.R, Yeates, T.O. | Deposit date: | 2023-10-18 | Release date: | 2024-03-06 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (4.42 Å) | Cite: | A suite of designed protein cages using machine learning and protein fragment-based protocols. Structure, 32, 2024
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2GJF
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2HZ8
| QM/MM structure refined from NMR-structure of a single chain diiron protein | Descriptor: | De novo designed diiron protein, ZINC ION | Authors: | Calhoun, J.R, Liu, W, Spiegel, K, Dal Peraro, M, Klein, M.L, Wand, A.J, DeGrado, W.F. | Deposit date: | 2006-08-08 | Release date: | 2007-07-17 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Solution NMR structure of a designed metalloprotein and complementary molecular dynamics refinement. Structure, 16, 2008
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7DMF
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4ETK
| Crystal Structure of E6A/L130D/A155H variant of de novo designed serine hydrolase, Northeast Structural Genomics Consortium (NESG) Target OR186 | Descriptor: | De novo designed serine hydrolase, SODIUM ION | Authors: | Kuzin, A, Su, M, Seetharaman, J, Kornhaber, K, Kornhaber, G, Rajagopalan, S, Baker, D, Everett, J.K, Acton, T.B, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2012-04-24 | Release date: | 2012-06-13 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Design of activated serine-containing catalytic triads with atomic-level accuracy. Nat.Chem.Biol., 10, 2014
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2N8W
| Solution NMR Structure of Designed Protein DA05R1, Northeast Structural Genomics Consortium (NESG) Target OR690 | Descriptor: | Designed Protein DA05R1 | Authors: | Eletsky, A, Federizon, J.F, Xu, X, Pulavarti, S, Jacobs, T.M, Kuhlman, B, Szyperski, T, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2015-10-27 | Release date: | 2015-11-25 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Design of structurally distinct proteins using strategies inspired by evolution. Science, 352, 2016
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2N8I
| Solution NMR Structure of Designed Protein DA05, Northeast Structural Genomics Consortium (NESG) Target OR626 | Descriptor: | Designed Protein DA05 | Authors: | Xu, X, Eletsky, A, Federizon, J.F, Jacobs, T.M, Kuhlman, B, Szyperski, T, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2015-10-15 | Release date: | 2016-01-20 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Design of structurally distinct proteins using strategies inspired by evolution. Science, 352, 2016
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2LN3
| Solution NMR Structure of DE NOVO DESIGNED PROTEIN, IF3-like fold, Northeast Structural Genomics Consortium Target OR135 (CASD target) | Descriptor: | DE NOVO DESIGNED PROTEIN OR135 | Authors: | Liu, G, Koga, R, Koga, N, Xiao, R, Lee, H, Janjua, H, Kohan, E, Acton, T.B, Everett, J.K, Baker, D, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2011-12-15 | Release date: | 2012-02-15 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Principles for designing ideal protein structures. Nature, 491, 2012
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5VLI
| Computationally designed inhibitor peptide HB1.6928.2.3 in complex with influenza hemagglutinin (A/PuertoRico/8/1934) | Descriptor: | 2,5,8,11-TETRAOXATRIDECANE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Bernard, S.M, Wilson, I.A. | Deposit date: | 2017-04-25 | Release date: | 2017-09-27 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.799 Å) | Cite: | Massively parallel de novo protein design for targeted therapeutics. Nature, 550, 2017
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5U9U
| De Novo Three-stranded Coiled Coil Peptide Containing a Tris-thiolate Site Engineered by D-Cysteine Ligands | Descriptor: | Apo-(CoilSer L16(DCY))3, CHLORIDE ION, POLYETHYLENE GLYCOL (N=34), ... | Authors: | Ruckthong, L, Stuckey, J.A, Pecoraro, V.L. | Deposit date: | 2016-12-18 | Release date: | 2017-04-26 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.69 Å) | Cite: | d-Cysteine Ligands Control Metal Geometries within De Novo Designed Three-Stranded Coiled Coils. Chemistry, 23, 2017
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5J9F
| Human GAR transformylase in complex with GAR and (4-{[2-(2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)ethyl]amino}benzoyl)-L-glutamic acid (AGF183) | Descriptor: | GLYCINAMIDE RIBONUCLEOTIDE, N-(4-{[2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)ethyl]amino}benzene-1-carbonyl)-L-glutamic acid, Trifunctional purine biosynthetic protein adenosine-3 | Authors: | Wong, J, Deis, S.M, Dann III, C.E. | Deposit date: | 2016-04-09 | Release date: | 2016-08-10 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Tumor Targeting with Novel 6-Substituted Pyrrolo [2,3-d] Pyrimidine Antifolates with Heteroatom Bridge Substitutions via Cellular Uptake by Folate Receptor alpha and the Proton-Coupled Folate Transporter and Inhibition of de Novo Purine Nucleotide Biosynthesis. J.Med.Chem., 59, 2016
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2GJH
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6O35
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6TJ1
| Crystal structure of a de novo designed hexameric helical-bundle protein | Descriptor: | De novo designed WSHC6, purification tag | Authors: | Xu, C, Pei, X.Y, Luisi, B.F, Baker, D. | Deposit date: | 2019-11-23 | Release date: | 2020-04-29 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Computational design of transmembrane pores. Nature, 585, 2020
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5NNN
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