PDB: 45853 resultsInfo pagesStatus searchChemie searchBIRD

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6MGH	X-ray structure of monomeric near-infrared fluorescent protein miRFP670nano Descriptor: 3-[2-[(~{Z})-[5-[(~{Z})-[(3~{S},4~{R})-3-ethenyl-4-methyl-5-oxidanylidene-pyrrolidin-2-ylidene]methyl]-3-(3-hydroxy-3-oxopropyl)-4-methyl-pyrrol-2-ylidene]methyl]-5-[(~{Z})-(4-ethenyl-3-methyl-5-oxidanylidene-pyrrol-2-ylidene)methyl]-4-methyl-1~{H}-pyrrol-3-yl]propanoic acid, GLYCEROL, ISOPROPYL ALCOHOL, ... Authors: Pletnev, S. Deposit date: 2018-09-13 Release date: 2018-12-19 Last modified: 2024-10-23 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Smallest near-infrared fluorescent protein evolved from cyanobacteriochrome as versatile tag for spectral multiplexing. Nat Commun, 10, 2019
6PJ4	Time-resolved structural snapshot of proteolysis by GlpG inside the membrane Descriptor: Peptide aldehyde inhibitor, Rhomboid protease GlpG Authors: Urban, S, Cho, S. Deposit date: 2019-06-27 Release date: 2019-10-02 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Ten catalytic snapshots of rhomboid intramembrane proteolysis from gate opening to peptide release. Nat.Struct.Mol.Biol., 26, 2019
7R23	Crystal structure of human Arc CTD in complex with two anti-Arc nanobodies Descriptor: ARC, Chains: B, Chains: C Authors: Markusson, S, Kursula, P. Deposit date: 2022-02-04 Release date: 2022-06-01 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (2.77 Å) Cite: Crystal structure of human Arc CTD in complex with two anti-Arc nanobodies To Be Published
6MIT	LptBFGC from Enterobacter cloacae Descriptor: CHLORIDE ION, LPS export ABC transporter permease LptF, Lipopolysaccharide export system ATP-binding protein, ... Authors: Owens, T.W, Kahne, D, Kruse, A.C. Deposit date: 2018-09-20 Release date: 2019-03-27 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (3.2 Å) Cite: Structural basis of unidirectional export of lipopolysaccharide to the cell surface. Nature, 567, 2019
7AJV	Structure of DYRK1A in complex with compound 38 Descriptor: 4-(2,3-dibutylimidazo[4,5-b]pyridin-5-yl)pyridine-2,6-diamine, CHLORIDE ION, Dual specificity tyrosine-phosphorylation-regulated kinase 1A Authors: Dokurno, P, Surgenor, A.E, Kotschy, A. Deposit date: 2020-09-29 Release date: 2021-05-26 Last modified: 2024-10-09 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Structure-Guided Discovery of Potent and Selective DYRK1A Inhibitors. J.Med.Chem., 64, 2021
6YQ6	Promiscuous Reductase LugOII Catalyzes Keto-reduction at C1 during Lugdunomycin Biosynthesis Descriptor: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, Monooxygenase, ... Authors: Xiao, X, Elsayed, S.S, Wu, C, van der Heul, H, Prota, A, Huang, J, Guo, R, Abrahams, J.P, van Wezel, G.P. Deposit date: 2020-04-16 Release date: 2020-09-16 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.08 Å) Cite: Functional and Structural Insights into a Novel Promiscuous Ketoreductase of the Lugdunomycin Biosynthetic Pathway. Acs Chem.Biol., 15, 2020
6Y68	Structure of Maporal virus envelope glycoprotein Gc in postfusion conformation Descriptor: CADMIUM ION, Envelope polyprotein, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose Authors: Serris, A, Rey, F.A, Guardado-Calvo, P. Deposit date: 2020-02-26 Release date: 2020-10-14 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (2.4 Å) Cite: The Hantavirus Surface Glycoprotein Lattice and Its Fusion Control Mechanism. Cell, 183, 2020
8T35	Crystal structure of K51 acetylated LC3A in complex with the LIR of TP53INP2/DOR Descriptor: 1,2-ETHANEDIOL, Tumor protein p53-inducible nuclear protein 2,Microtubule-associated proteins 1A/1B light chain 3A Authors: Ali, M.G.H, Wahba, H.M, Cyr, N, Omichinski, J.G. Deposit date: 2023-06-07 Release date: 2024-05-22 Last modified: 2024-10-23 Method: X-RAY DIFFRACTION (1.902 Å) Cite: Structural and functional characterization of the role of acetylation on the interactions of the human Atg8-family proteins with the autophagy receptor TP53INP2/DOR. Autophagy, 20, 2024
7AQM	ADP-ribosylserine hydrolase ARH3 of Latimeria chalumnae in complex with alpha-1''-O-methyl-ADP-ribose (meADPr) Descriptor: ADP-ribosylhydrolase like 2, Adenosine 5'-diphosphoric acid beta-[(3beta,4beta-dihydroxy-5beta-methoxytetrahydrofuran-2alpha-yl)methyl] estere, MAGNESIUM ION Authors: Rack, J.G.M, Zorzini, V, Ahel, I. Deposit date: 2020-10-22 Release date: 2021-06-16 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Mechanistic insights into the three steps of poly(ADP-ribosylation) reversal. Nat Commun, 12, 2021
7AXN	14-3-3 sigma in complex with Pin1 binding site pS72 and covalently bound TCF521-026 Descriptor: 14-3-3 protein sigma, 3-chloranyl-4-imidazol-1-yl-benzaldehyde, CALCIUM ION, ... Authors: Wolter, M, Dijck, L.v, Ottmann, C. Deposit date: 2020-11-10 Release date: 2021-06-16 Last modified: 2024-10-23 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions. J.Am.Chem.Soc., 143, 2021
7AYF	14-3-3 sigma with Pin1 binding site pS72 and covalently bound TCF521-110 Descriptor: 14-3-3 protein sigma, 6-(2-bromanylimidazol-1-yl)pyridine-3-carbaldehyde, CALCIUM ION, ... Authors: Wolter, M, Dijck, L.v, Ottmann, C. Deposit date: 2020-11-12 Release date: 2021-06-16 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.752 Å) Cite: Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions. J.Am.Chem.Soc., 143, 2021
7AZ1	14-3-3 sigma with Pin1 binding site pS72 and covalently bound LvD1013 Descriptor: 1-[4-methyl-3-(trifluoromethyl)phenyl]-2-phenyl-imidazole, 14-3-3 protein sigma, CALCIUM ION, ... Authors: Wolter, M, Dijck, L.v, Ottmann, C. Deposit date: 2020-11-14 Release date: 2021-06-16 Last modified: 2024-10-23 Method: X-RAY DIFFRACTION (1.15 Å) Cite: Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions. J.Am.Chem.Soc., 143, 2021
7R6V	Human EXOG complexed with dRP-containing DNA Descriptor: DNA (5'-D(*CP*GP*CP*AP*CP*GP*TP*CP*AP*GP*AP*A)-3'), DNA (5'-D(*CP*TP*GP*AP*CP*GP*TP*GP*CP*G)-3'), MAGNESIUM ION, ... Authors: Szymanski, M.R, Yin, Y.W. Deposit date: 2021-06-23 Release date: 2022-08-24 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.16 Å) Cite: Human EXOG possesses strong AP hydrolysis activity To Be Published
7AZ2	14-3-3 sigma with Pin1 binding site pS72 and covalently bound LvD1014 Descriptor: 1-[4-methyl-2-(trifluoromethyl)phenyl]-2-phenyl-imidazole, 14-3-3 protein sigma, CALCIUM ION, ... Authors: Wolter, M, Dijck, L.v, Ottmann, C. Deposit date: 2020-11-14 Release date: 2021-06-16 Last modified: 2024-10-23 Method: X-RAY DIFFRACTION (1.081 Å) Cite: Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions. J.Am.Chem.Soc., 143, 2021
7AOG	14-3-3 sigma in complex with Pin1 binding site pS72 Descriptor: 14-3-3 protein sigma, CALCIUM ION, CHLORIDE ION, ... Authors: Wolter, M, Dijck, L.v, Cossar, P.J, Ottmann, C. Deposit date: 2020-10-14 Release date: 2021-06-16 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions. J.Am.Chem.Soc., 143, 2021
6POI	Crystal Structure of EcDsbA in complex phenyl ether 25 Descriptor: (6-phenoxy-1-benzofuran-3-yl)acetic acid, COPPER (II) ION, Thiol:disulfide interchange protein DsbA Authors: Ilyichova, O.V, Scanlon, M.J. Deposit date: 2019-07-04 Release date: 2019-11-06 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (1.77 Å) Cite: The Fragment-Based Development of a Benzofuran Hit as a New Class of Escherichia coli DsbA Inhibitors. Molecules, 24, 2019
6POQ	Crystal Structure of EcDsbA in complex with anisidine 16 Descriptor: COPPER (II) ION, Thiol:disulfide interchange protein DsbA, {6-[(4-methoxyphenyl)amino]-1-benzofuran-3-yl}acetic acid Authors: Ilyichova, O.V, Scanlon, M.J. Deposit date: 2019-07-04 Release date: 2019-11-06 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.8 Å) Cite: The Fragment-Based Development of a Benzofuran Hit as a New Class of Escherichia coli DsbA Inhibitors. Molecules, 24, 2019
8T36	Crystal structure of K49 acetylated LC3A in complex with the LIR of TP53INP2/DOR Descriptor: 1,2-ETHANEDIOL, Tumor protein p53-inducible nuclear protein 2,Microtubule-associated proteins 1A/1B light chain 3A chimera Authors: Ali, M.G.H, Wahba, H.M, Cyr, N, Omichinski, J.G. Deposit date: 2023-06-07 Release date: 2024-05-22 Last modified: 2024-09-11 Method: X-RAY DIFFRACTION (1.852 Å) Cite: Structural and functional characterization of the role of acetylation on the interactions of the human Atg8-family proteins with the autophagy receptor TP53INP2/DOR. Autophagy, 20, 2024
7AYR	Crystal structure of DPP8 in complex with a 4-oxo-b-lactam based inhibitor, B115 Descriptor: Dipeptidyl peptidase 8, PHOSPHATE ION, trimethylamine oxide, ... Authors: Ross, B.H, Huber, R. Deposit date: 2020-11-13 Release date: 2021-06-30 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (2.69 Å) Cite: Chemoproteomics-Enabled Identification of 4-Oxo-beta-Lactams as Inhibitors of Dipeptidyl Peptidases 8 and 9. Angew.Chem.Int.Ed.Engl., 2022
8F7Z	VRC34.01_mm28 bound to fusion peptide Descriptor: HIV-1 Env Fusion Peptide, VRC34_m228 Light Chain, VRC34_mm28 Heavy Chain Authors: Olia, A.S, Kwong, P.D. Deposit date: 2022-11-21 Release date: 2023-11-01 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Antibody-directed evolution reveals a mechanism for enhanced neutralization at the HIV-1 fusion peptide site. Nat Commun, 14, 2023
7AX0	Crystal structure of the computationally designed Scone-E protein co-crystallized with STA form a Descriptor: Keggin (STA), PHOSPHATE ION, SconeE Authors: Mylemans, B, Vandebroek, L, Parac-Vogt, T.N, Voet, A.R.D. Deposit date: 2020-11-09 Release date: 2021-06-30 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Crystal structures of Scone: pseudosymmetric folding of a symmetric designer protein. Acta Crystallogr D Struct Biol, 77, 2021
7AYQ	Crystal structure of DPP8 in complex with a 4-oxo-b-lactam based inhibitor, B114 Descriptor: Dipeptidyl peptidase 8, GLYCEROL, PHOSPHATE ION, ... Authors: Ross, B, Huber, R. Deposit date: 2020-11-13 Release date: 2021-06-30 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (2.45 Å) Cite: Chemoproteomics-Enabled Identification of 4-Oxo-beta-Lactams as Inhibitors of Dipeptidyl Peptidases 8 and 9. Angew.Chem.Int.Ed.Engl., 2022
8T31	Crystal structure of GABARAP in complex with the LIR of TP53INP2/DOR Descriptor: Gamma-aminobutyric acid receptor-associated protein, Tumor protein p53-inducible nuclear protein 2 Authors: Ali, M.G.H, Wahba, H.M, Cyr, N, Omichinski, J.G. Deposit date: 2023-06-07 Release date: 2024-05-22 Last modified: 2024-09-11 Method: X-RAY DIFFRACTION (2.096 Å) Cite: Structural and functional characterization of the role of acetylation on the interactions of the human Atg8-family proteins with the autophagy receptor TP53INP2/DOR. Autophagy, 20, 2024
7QZO	Crystal structure of GacS D1 domain Descriptor: CADMIUM ION, GLYCEROL, Histidine kinase Authors: Fadel, F, Bassim, V, Botzanowski, T, Francis, V.I, Legrand, P, Porter, S.L, Bourne, Y, Cianferani, S, Vincent, F. Deposit date: 2022-01-31 Release date: 2022-07-06 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.45 Å) Cite: Insights into the atypical autokinase activity of the Pseudomonas aeruginosa GacS histidine kinase and its interaction with RetS. Structure, 30, 2022
6MYZ	Crystal structure of Tdp1 catalytic domain in complex with compound XZ520 Descriptor: 1,2-ETHANEDIOL, 4-oxo-8-phenyl-1,4-dihydroquinoline-3-carboxylic acid, Tyrosyl-DNA phosphodiesterase 1 Authors: Lountos, G.T, Zhao, X.Z, Kiselev, E, Tropea, J.E, Needle, D, Burke Jr, T.R, Pommier, Y, Waugh, D.S. Deposit date: 2018-11-02 Release date: 2019-11-06 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.661 Å) Cite: Structure of Tdp1 catalytic domain in complex with compound XZ520 To Be Published

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