7AYR

Crystal structure of DPP8 in complex with a 4-oxo-b-lactam based inhibitor, B115

Summary for 7AYR

• Entry DOI: 10.2210/pdb7ayr/pdb
• Descriptor: Dipeptidyl peptidase 8, trimethylamine oxide, PHOSPHATE ION, ... (5 entities in total)
• Functional Keywords: dpp8, protease, hydrolase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 208307.72

Authors

Ross, B.H.,Huber, R. (deposition date: 2020-11-13, release date: 2021-06-30, Last modification date: 2024-01-31)

• Primary citation: Carvalho, L.A.R.,Ross, B.,Fehr, L.,Bolgi, O.,Wohrle, S.,Lum, K.M.,Podlesainski, D.,Vieira, A.C.,Kiefersauer, R.,Felix, R.,Rodrigues, T.,Lucas, S.D.,Gross, O.,Geiss-Friedlander, R.,Cravatt, B.F.,Huber, R.,Kaiser, M.,Moreira, R.; Chemoproteomics-Enabled Identification of 4-Oxo-beta-Lactams as Inhibitors of Dipeptidyl Peptidases 8 and 9.; Angew.Chem.Int.Ed.Engl., :e202210498-e202210498, 2022; PubMed: 36089535; DOI: 10.1002/anie.202210498

Experimental method

X-RAY DIFFRACTION (2.69 Å)