7AYR
Crystal structure of DPP8 in complex with a 4-oxo-b-lactam based inhibitor, B115
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Dipeptidyl peptidase 8 | polymer | 898 | 103483.4 | 2 | UniProt (Q6V1X1) Pfam (PF19520) Pfam (PF00930) Pfam (PF00326) | Homo sapiens (Human) | DP8,Dipeptidyl peptidase IV-related protein 1,DPRP-1,Dipeptidyl peptidase VIII,DPP VIII,Prolyl dipeptidase DPP8 |
| 2 | C, F (A, B) | trimethylamine oxide | non-polymer | 75.1 | 2 | Chemie (TMO) | |||
| 3 | D, G (A, B) | PHOSPHATE ION | non-polymer | 95.0 | 2 | Chemie (PO4) | |||
| 4 | E, H (A, B) | ~{N}-[3-[[4-[(4-bromophenyl)methyl]piperazin-1-yl]methyl]phenyl]-4-methanoyl-oxane-4-carboxamide | non-polymer | 500.4 | 2 | Chemie (S9W) | |||
| 5 | I, J (A, B) | water | water | 18.0 | 7 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 206966.7 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1341.0 | |
| All* | Total formula weight | 208307.7 |
