7DL6
| The co-crystal structure of DYRK2 with a small molecule inhibitor 18 | Descriptor: | Dual specificity tyrosine-phosphorylation-regulated kinase 2, [2,7-dimethoxy-9-[[(3R)-pyrrolidin-3-yl]methylsulfanyl]acridin-4-yl]methanol | Authors: | Wei, T, Xiao, J. | Deposit date: | 2020-11-26 | Release date: | 2021-12-01 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.648 Å) | Cite: | Selective inhibition reveals the regulatory function of DYRK2 in protein synthesis and calcium entry. Elife, 11, 2022
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7EJV
| The co-crystal structure of DYRK2 with YK-2-69 | Descriptor: | Dual specificity tyrosine-phosphorylation-regulated kinase 2, [6-[[4-[2-(dimethylamino)-1,3-benzothiazol-6-yl]-5-fluoranyl-pyrimidin-2-yl]amino]pyridin-3-yl]-(4-ethylpiperazin-1-yl)methanone | Authors: | Li, Z, Xiao, Y, Yuan, K, Kuang, W, Xiuquan, Y, Yang, P. | Deposit date: | 2021-04-02 | Release date: | 2022-04-06 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Targeting dual-specificity tyrosine phosphorylation-regulated kinase 2 with a highly selective inhibitor for the treatment of prostate cancer. Nat Commun, 13, 2022
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7FDA
| CryoEM Structure of Reconstituted V-ATPase, state1 | Descriptor: | Fusion of yeast V-type proton ATPase subunit H(NT) and human V-type proton ATPase subunit H(CT), V-type proton ATPase subunit B, V-type proton ATPase subunit C, ... | Authors: | Khan, M.M, Lee, S, Oot, R.A, Couoh-Cardel, S, KIm, H, Wilkens, S, Roh, S.H. | Deposit date: | 2021-07-16 | Release date: | 2021-12-22 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | CryoEM Structures of Reconstituted V-ATPase and Oxr1-bound V1 Reveal a Novel Mechanism of Regulation. Embo J., 2021
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7FDB
| CryoEM Structures of Reconstituted V-ATPase,State2 | Descriptor: | Fusion of yeast V-type proton ATPase subunit H(NT) and human V-type proton ATPase subunit H(CT), V-type proton ATPase subunit B, V-type proton ATPase subunit C, ... | Authors: | Khan, M.M, Lee, S, Oot, R.A, Couoh-Cardel, S, KIm, H, Wilkens, S, Roh, S.H. | Deposit date: | 2021-07-16 | Release date: | 2021-12-22 | Method: | ELECTRON MICROSCOPY (4.8 Å) | Cite: | CryoEM Structures of Reconstituted V-ATPase and Oxr1-bound V1 Reveal a Novel Mechanism of Regulation. Embo J., 2021
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7FDC
| CryoEM Structures of Reconstituted V-ATPase, state3 | Descriptor: | Fusion of yeast V-type proton ATPase subunit H(NT) and human V-type proton ATPase subunit H(CT), V-type proton ATPase subunit B, V-type proton ATPase subunit C, ... | Authors: | Khan, M.M, Lee, S, Oot, R.A, Couoh-Cardel, S, KIm, H, Wilkens, S, Roh, S.H. | Deposit date: | 2021-07-16 | Release date: | 2021-12-22 | Method: | ELECTRON MICROSCOPY (6.6 Å) | Cite: | CryoEM Structures of Reconstituted V-ATPase and Oxr1-bound V1 Reveal a Novel Mechanism of Regulation. Embo J., 2021
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7FDE
| CryoEM Structures of Reconstituted V-ATPase, Oxr1 bound V1 | Descriptor: | Oxidation resistance protein 1, V-type proton ATPase subunit B, V-type proton ATPase subunit C, ... | Authors: | Khan, M.M, Lee, S, Oot, R.A, Couoh-Cardel, S, KIm, H, Wilkens, S, Roh, S.H. | Deposit date: | 2021-07-16 | Release date: | 2021-12-29 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | CryoEM Structures of Reconstituted V-ATPase and Oxr1-bound V1 Reveal a Novel Mechanism of Regulation. Embo J., 2021
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6UVQ
| Crystal structure of Apo AtmM | Descriptor: | ACETATE ION, D-glucose O-methyltransferase, MAGNESIUM ION | Authors: | Alvarado, S.K, Wang, Z, Miller, M.D, Thorson, J.S, Phillips Jr, G.N. | Deposit date: | 2019-11-04 | Release date: | 2020-11-25 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.84 Å) | Cite: | Structure of Apo AtmM To Be Published
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6UWD
| Crystal structure of Apo AtmM | Descriptor: | ACETATE ION, D-glucose O-methyltransferase, MAGNESIUM ION | Authors: | Alvarado, S.K, Wang, Z, Miller, M.D, Thorson, J.S, Phillips Jr, G.N. | Deposit date: | 2019-11-05 | Release date: | 2020-11-25 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.04 Å) | Cite: | Structure of Apo AtmM To Be Published
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6UV6
| AtmM with bound rebeccamycin analogue | Descriptor: | 12-beta-D-glucopyranosyl-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione, D-glucose O-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE | Authors: | Alvarado, S.K, Wang, Z, Miller, M.D, Thorson, J.S, Phillips Jr, G.N. | Deposit date: | 2019-11-01 | Release date: | 2020-11-25 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.72 Å) | Cite: | Structure of AtmM Bound with Glycosylated Indolocarbazole To Be Published
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6V4H
| Crystal Structure Analysis of Zebra Fish MDMX | Descriptor: | Protein Mdm4, Stapled Peptide LSQETF(0EH)DLWKLL(MK8)EN(NH2) | Authors: | Seo, H.-S, Dhe-Paganon, S. | Deposit date: | 2019-11-27 | Release date: | 2020-04-22 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.53 Å) | Cite: | Identification of a Structural Determinant for Selective Targeting of HDMX. Structure, 28, 2020
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6V4F
| Crystal Structure Analysis of Zebra Fish MDMX | Descriptor: | Protein Mdm4, SULFATE ION, Stapled Peptide LSQETF(0EH)DLWKLE(MK8)EN(NH2) | Authors: | Seo, H.-S, Dhe-Paganon, S. | Deposit date: | 2019-11-27 | Release date: | 2020-04-22 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.35 Å) | Cite: | Identification of a Structural Determinant for Selective Targeting of HDMX. Structure, 28, 2020
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3SQD
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1DY7
| Cytochrome cd1 Nitrite Reductase, CO complex | Descriptor: | CARBON MONOXIDE, GLYCEROL, HEME C, ... | Authors: | Sjogren, T, Svensson-Ek, M, Hajdu, J, Brzezinski, P. | Deposit date: | 2000-01-28 | Release date: | 2000-09-24 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Proton-Coupled Structural Changes Upon Binding of Carbon Monoxide to Cytochrome Cd(1): A Combined Flash Photolysis and X-Ray Crystallography Study Biochemistry, 39, 2000
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1E9D
| Mutant human thymidylate kinase (F105Y) complexed with AZTMP and ADP | Descriptor: | 3'-AZIDO-3'-DEOXYTHYMIDINE-5'-MONOPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Ostermann, N, Lavie, A, Padiyar, S, Brundiers, R, Veit, T, Reintein, J, Goody, R.S, Konrad, M, Schlichting, I. | Deposit date: | 2000-10-10 | Release date: | 2001-10-11 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Potentiating Azt Activation: Structures of Wildtype and Mutant Human Thymidylate Kinase Suggest Reasons for the Mutants' Improved Kinetics with the HIV Prodrug Metabolite Aztmp J.Mol.Biol., 304, 2000
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1E99
| Human thymidylate kinase complexed with AZTMP and ADP | Descriptor: | 3'-AZIDO-3'-DEOXYTHYMIDINE-5'-MONOPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Ostermann, N, Lavie, A, Padiyar, S, Brundiers, R, Veit, T, Reinstein, J, Goody, R.S, Konrad, M, Schlichting, I. | Deposit date: | 2000-10-10 | Release date: | 2001-10-05 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Potentiating Azt Activation: Structures of Wildtype and Mutant Human Thymidylate Kinase Suggest Reasons for the Mutants' Improved Kinetics with the HIV Prodrug Metabolite Aztmp J.Mol.Biol., 304, 2000
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1E9B
| Human thymidylate kinase complexed with AZTMP and APPNP | Descriptor: | 3'-AZIDO-3'-DEOXYTHYMIDINE-5'-MONOPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Ostermann, N, Lavie, A, Padiyar, S, Brundiers, R, Veit, T, Reintein, J, Goody, R.S, Konrad, M, Schlichting, I. | Deposit date: | 2000-10-10 | Release date: | 2001-10-05 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Potentiating Azt Activation: Structures of Wildtype and Mutant Human Thymidylate Kinase Suggest Reasons for the Mutants' Improved Kinetics with the HIV Prodrug Metabolite Aztmp J.Mol.Biol., 304, 2000
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1E98
| Wild type human thymidylate kinase complexed with AZTMP and ADP | Descriptor: | 3'-AZIDO-3'-DEOXYTHYMIDINE-5'-MONOPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Ostermann, N, Lavie, A, Padiyar, S, Brundiers, R, Veit, T, Reintein, J, Goody, R.S, Konrad, M, Schlichting, I. | Deposit date: | 2000-10-10 | Release date: | 2001-10-05 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Potentiating Azt Activation: Structures of Wildtype and Mutant Human Thymidylate Kinase Suggest Reasons for the Mutants' Improved Kinetics with the HIV Prodrug Metabolite Aztmp J.Mol.Biol., 304, 2000
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3UMZ
| Crystal Structure of the human MDC1 FHA Domain | Descriptor: | Mediator of DNA damage checkpoint protein 1 | Authors: | Luo, S, Ye, K. | Deposit date: | 2011-11-15 | Release date: | 2012-01-25 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Structural mechanism of the phosphorylation-dependent dimerization of the MDC1 forkhead-associated domain Nucleic Acids Res., 40, 2012
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1FP4
| CRYSTAL STRUCTURE OF THE ALPHA-H195Q MUTANT OF NITROGENASE | Descriptor: | 3-HYDROXY-3-CARBOXY-ADIPIC ACID, CALCIUM ION, FE-MO-S CLUSTER, ... | Authors: | Sorlie, M, Christiansen, J, Lemon, B.J, Peters, J.W, Dean, D.R, Hales, B.J. | Deposit date: | 2000-08-30 | Release date: | 2002-11-20 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Mechanistic features and structure of the nitrogenase alpha-Gln195 MoFe protein Biochemistry, 40, 2001
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3UNM
| Crystal Structure of The Human MDC1 FHA Domain | Descriptor: | Mediator of DNA damage checkpoint protein 1 | Authors: | Luo, S, Ye, K. | Deposit date: | 2011-11-16 | Release date: | 2012-01-25 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural mechanism of the phosphorylation-dependent dimerization of the MDC1 forkhead-associated domain Nucleic Acids Res., 40, 2012
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1GGW
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3VA4
| Crystal structure of the mammalian MDC1 FHA domain complexed with CHK2 pThr68 peptide | Descriptor: | Mediator of DNA damage checkpoint protein 1, Serine/threonine-protein kinase Chk2 | Authors: | Wu, H.H, Wu, P.Y, Huang, K.F, Kao, Y.Y, Tsai, M.D. | Deposit date: | 2011-12-28 | Release date: | 2012-02-01 | Method: | X-RAY DIFFRACTION (1.54 Å) | Cite: | Structural Delineation of MDC1-FHA Domain Binding with CHK2-pThr68. Biochemistry, 2012
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1GXX
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1H6O
| Dimerisation domain from human TRF1 | Descriptor: | TELOMERIC REPEAT BINDING FACTOR 1 | Authors: | Fairall, L, Chapman, L, Rhodes, D. | Deposit date: | 2001-06-20 | Release date: | 2001-09-05 | Last modified: | 2024-04-24 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structure of the TRFH dimerization domain of the human telomeric proteins TRF1 and TRF2. Mol.Cell, 8, 2001
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3WGW
| Structure of PCNA bound to a small molecule inhibitor | Descriptor: | 4-{4-[(2S)-2-amino-3-hydroxypropyl]-2,6-diiodophenoxy}phenol, Proliferating cell nuclear antigen, SULFATE ION | Authors: | Hashimoto, H. | Deposit date: | 2013-08-12 | Release date: | 2014-02-05 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | A small molecule inhibitor of monoubiquitinated Proliferating Cell Nuclear Antigen (PCNA) inhibits repair of interstrand DNA cross-link, enhances DNA double strand break, and sensitizes cancer cells to cisplatin. J.Biol.Chem., 289, 2014
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